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Biological Technologies Grant (NSF SBIR) is sponsored by U.S. National Science Foundation (NSF). This grant supports projects focused on using or modifying living organisms, systems, or biological processes to develop new technologies, including bioengineering for improved function in molecules, cells, and tissues.
It also encourages proposals for enabling new technologies like tools for genomics, proteomics, drug discovery, and instruments for biological applications. Excludes clinical trials.
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Or search similar grants →According to the current listing, eligibility includes: Small businesses (fewer than 500 employees) located in the United States. At least 50% of the company's equity must be owned by U.S. citizens or permanent residents. The project's principal investigator (tech lead) must be legally employed at least 20 hours a week by the company. Confirm the full requirements in the official notice before applying.
Biological Technologies Grant (NSF SBIR) is funded by U.S. National Science Foundation (NSF). Verify program details on the funder's official page before applying.
Start from the official opportunity page linked in this listing — it carries the sponsor's submission instructions.
Past winners and funding trends for this program
NSF's restarted SBIR/STTR program carries two transition rules almost nobody has calendared. Project Pitch invitations issued on or after July 3, 2025 must be converted to a full proposal by November 4, 2026. Phase I awardees whose awards started on or after November 6, 2023 must submit Phase II by the same date. Both cohorts were created by the program lapse, and both cliffs are hard.
Read articleAI4OPT got $20 million through 2031. IAIFI got roughly $24.9 million. AI2ES got a no-cost extension and a shutdown. The NSF AI Institutes solicitation shows no due dates and reads 'waiting for new publication' — which makes the year-four renewal conversation the highest-stakes meeting in the program.
Read articleFuture CoRe (NSF 25-543) advertises $280 million and 400 to 600 awards across 11 programs, with a September 10, 2026 target date. The directorate behind it is running 43 percent below its own four-year average, $1 billion of NSF's budget is locked in a central account, and the two-proposal cap is enforced with no exceptions. Here is how to read the gap between what the solicitation promises and what the directorate is actually paying for.
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