Systems Biology Research to Advance Bioenergy Crop Production

Systems Biology Research to Advance Bioenergy Crop Production is sponsored by DOE Office of Science, Biological and Environmental Research Program (BER). This program supports fundamental research to advance bioenergy crop production, focusing on molecular mechanisms for bioenergy and investigations into microbial communities. It aims to develop cost-effective biofuels and bioproducts.

Opportunity Listing - Systems Biology Research to Advance Bioenergy Crop Production Systems Biology Research to Advance Bioenergy Crop Production Agency: Office of Science Assistance Listings: 81. 049 -- Office of Science Financial Assistance Program Last Updated: May 13, 2026 View version history on Grants.

gov The DOE SC program in Biological and Environmental Research (BER) announces it is receiving applications for research within the Biological Systems Science Division’s (BSSD) Genomic Science Program (GSP) ( https://genomicscience. energy. gov ) mission-space.

In this NOFO, applications are requested for: · Systems-level research to improve understanding of the molecular mechanisms underlying bioenergy feedstock productivity under changing and at times suboptimal environmental conditions, · Systems biology-enabled investigations into the role(s) of microbes and microbial communities (including rhizosphere consortia, e.g. bacteria, fungi, diazotrophs, endophytes, viruses) in supporting plant productivity and vigor are also solicited.

SUPPLEMENTARY INFORMATION Two areas vital to the Nation’s energy and environmental security motivate the BER research agenda: developing cost-effective biofuels and bioproducts and improving our ability to understand, predict, and mitigate the impacts of energy production in the face of a variable environment.

BER has invested in plant and plant-microbe interactions research with the goal of advancing production of biofuels/bioproducts from domestic lignocellulosic and oilseed crop sources.

These efforts have increased our understanding of the biological mechanisms underlying feedstock productivity and facilitated development of next- generation bioenergy crops that utilize novel, efficient bioenergy strategies that can be replicated on a mass scale.

However, several knowledge gaps and challenges remain towards attaining the goal of developing vigorous crops with superior growth and yield under varying environmental conditions. A better understanding of the underlying genetic and physiological mechanisms influencing plant productivity, resource use efficiency, and adaptation and resilience to abiotic stress are needed.

Also of interest is how beneficial plant-microbe associations may enhance requisite plant processes to enable manipulation of these associations for improving plant traits.

Furthermore, available computational technologies and infrastructure may provide opportunities to connect and integrate information across multiple spatial and temporal scales to better understand the behavior of complex biological systems and to develop a predictive understanding of sustainability outcomes over a range of future climate scenarios [U.S. DOE. 2014.

Research for Sustainable Bioenergy: Linking Genomic and Ecosystem Sciences, Workshop Report, DOE/SC-0167. U.S. Department of Energy, Office of Science. https://www.

genomicscience. energy. gov/research-for-sustainable-bioenergy-linking-genomic-and-ecosystem-sciences/ ].

DOE-BER’s GSP ( https://genomicscience. energy. gov/ ) supports fundamental research to identify the basic principles that drive biological systems.

These principles govern translation of the genetic code into integrated networks of proteins, enzymes, regulatory elements, and metabolite pools underlying the functional processes of organisms.

The Genomic Science program aims to support the DOE’s bioenergy development mission by leveraging omics-driven tools and systems biology approaches to address key challenges facing the sustainable production of bioenergy crops as an economically and environmentally viable alternative resource for fuels, chemicals, and products currently produced from fossil fuel resources.

This NOFO aims to build upon the advances made since previous BER investments in this area, seeking to apply systems biology and omics technologies to map the complex networks and molecular mechanisms of bioenergy crop growth, development, and metabolism for sustainable and resilient bioenergy crop production.

Understanding the multi-organismal “biofuel crop+soil+microbe ecosystem” presents a unique challenge, which is further complicated by environmental impacts. The ability to predict plant and microbial species’ responses to a changing environment will be critical to understanding potential environmental impacts as well as for optimizing feedstock production.

Applications are solicited for systems biology-driven basic research on the fundamental principles of bioenergy crop production in relationship to the associated environmental context. Species of interest include but are not limited to candidate bioenergy plants (e.g., sorghum, energy cane, Miscanthus, switchgrass, Populus) and non-food oilseed crops (e.g., Camelina).

Proposed projects should be hypothesis-driven and focus on understanding productivity and the effects of abiotic stresses and nutrient availability. Such deep understanding will enable the development of bioenergy crops that are tolerant to environmental stressors, require less agronomic inputs, and are resilient and/or adaptable to varying environmental conditions.

All types of domestic applicants are eligible to apply, except nonprofit organizations described in section 501(c)(4) of the Internal Revenue Code of 1986 that engaged in lobbying activities after December 31, 1995. DOE/NNSA National Laboratories are not eligible to submit applications under this NOFO but may be proposed as subrecipients under another organization’s application.

If recommended for funding as a proposed subrecipient, the value of the proposed subaward will be removed from the prime applicant’s award and will be provided to the laboratory through the DOE Field-Work Proposal System and work will be conducted under the laboratory’s contract with DOE. No administrative provisions of this NOFO will apply to the laboratory or any laboratory subcontractor.

Additional instructions for securing authorization from the cognizant Contracting Officer are found in Section IX of this NOFO. 2. Non-DOE/NNSA Funded Research and Development Centers (FFRDC) Non-DOE/NNSA FFRDCs are not eligible to submit applications under this NOFO but may be proposed as subrecipients under another organization’s application.

If recommended for funding as a proposed subrecipient, the value of the proposed subaward may be removed from the prime applicant’s award and may be provided through an interagency agreement to the FFRDC’s sponsoring Federal Agency. Additional instructions for securing authorization from the cognizant Contracting Officer are found in Section IX of this NOFO. 3.

Other Federal Agencies Other Federal Agencies are not eligible to submit applications under this NOFO but may be proposed as subrecipients under another organization’s application. If recommended for funding as a proposed subrecipient, the value of the proposed subaward may be removed from the prime applicant’s award and may be provided through an interagency agreement.

Additional instructions for providing statutory authorization are found in Section IX of this NOFO. Grantor contact information SC. GrantsandContracts@science.

doe. gov SC. GrantsandContracts@science.

doe. gov SC. GrantsandContracts@science.

doe. gov File name Description Last updated DE-FOA-0003453. 000001.

pdf Full NOFO Jan 27, 2025 08:28 PM UTC Link to additional information Funding opportunity number : Cost sharing or matching requirement : Funding instrument type : Opportunity Category Explanation : Category of Funding Activity : Science technology and other research and development Your account requires additional identity verification.