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Diabetes, Digestive, Kidney Extramural Research - Research Centers is sponsored by HEALTH AND HUMAN SERVICES, DEPARTMENT OF. To promote extramural basic and clinical biomedical research that improves the understanding of the mechanisms underlying disease and leads to improved preventions, diagnosis, and treatment of diabetes, digestive, and kidney diseases. Programmatic areas within the National Institute of Diabetes and Digestive and Kidney Diseases include diabetes, digestive, endocrine, hematologic, liver, metabolic, nephrologic, nutrition, obesity, and urologic diseases. Specific programs areas of interest include the following: (a) For diabetes, endocrine, and metabolic diseases areas: Fundamental and clinical studies including the etiology, pathogenesis, prevention, diagnosis, treatment and cure of diabetes mellitus and its complications; Normal and abnormal function of the pituitary, thyroid, parathyroid, adrenal, and other hormone secreting glands; Hormonal regulation of bone, adipose tissue, and liver; on fundamental aspects of signal transduction, including the action of hormones, coregulators, and chromatin remodeling proteins; Hormone biosynthesis, secretion, metabolism, and binding; and on hormonal regulation of gene expression and the role(s) of selective receptor modulators as partial agonists or antagonists of hormone action; and Fundamental studies relevant to metabolic disorders including membrane structure, function, and transport phenomena and enzyme biosynthesis; and basic and clinical studies on the etiology, pathogenesis, prevention, and treatment of inherited metabolic disorders (such as cystic fibrosis). (b) For digestive disease and nutrition areas: Genetics and genomics of the GI tract and its diseases; Genetics and genomics of liver/pancreas and diseases; Genetics and genomics of nutrition; genetics and genomics of obesity; Bariatric surgery; Clinical nutrition research; Clinical obesity research; Complications of chronic liver disease; Fatty liver disease; Genetic liver disease; HIV and liver; Cell injury, repair, fibrosis and inflammation in the liver; Liver cancer; Liver transplantation; Pediatric liver disease; Viral hepatitis and infectious diseases; Gastrointestinal and nutrition effects of AIDS; Gastrointestinal mucosal and immunology; Gastrointestinal motility; Basic neurogastroenterology; Gastrointestinal development; Gastrointestinal epithelial biology; Gastrointestinal inflammation; Digestive diseases epidemiology and data systems; Nutritional epidemiology and data systems; Autoimmune liver disease; Bile, Bilirubin and cholestasis; Bioengineering and biotechnology related to digestive diseases, liver, nutrition and obesity; Cell and molecular biology of the liver; Developmental biology and regeneration; Drug-induced liver disease; Gallbladder disease and biliary diseases; Exocrine pancreas biology and diseases; Gastrointestinal neuroendocrinology; Gastrointestinal transport and absorption; Nutrient metabolism; Pediatric clinical obesity; Clinical trials in digestive diseases; Liver clinical trials; Obesity prevention and treatment; and Obesity and eating disorders. (c) For kidney, urologic and hematologic diseases areas: Studies of the development, physiology, and cell biology of the kidney; Pathophysiology of the kidney; Genetics of kidney disorders; Immune mechanisms of kidney disease; Kidney disease as a complication of diabetes; Effects of drugs, nephrotoxins and environmental toxins on the kidney; Mechanisms of kidney injury repair; Improved diagnosis, prevention and treatment of chronic kidney disease and end-stage renal disease; Improved approaches to maintenance dialysis therapies; Basic studies of lower urinary tract cell biology, development, physiology, and pathophysiology; Clinical studies of bladder dysfunction, incontinence, pyelonephritis, interstitial cystitis, benign prostatic hyperplasia, urolithiasis, and vesicoureteral reflux; Development of novel diagnostic tools and improved therapies, including tissue engineering strategies, for urologic disorders; Research on hematopoietic cell differentiation; metabolism of iron overload and deficiency; Structure, biosynthesis and genetic regulation of hemoglobin; as well as Research on the etiology, pathogenesis, and therapeutic modalities for the anemia of inflammation and chronic diseases. This listing is currently active. Program number: 93.KRC. Last updated on 2026-01-30.
Application snapshot: target deadline rolling deadlines or periodic funding windows; published funding information Recent federal obligations suggest $100,611,000 (2026).; eligibility guidance Eligible Organizations: Universities, colleges, medical, dental and nursing schools, schools of public health, laboratories, hospitals, State and local health departments, other public or private institutions, both non-profit and for-profit, and individuals who propose to establish, expand, and improve research activities in health sciences and related fields. Eligible Individuals (Program Director/Principal Investigator): Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with his/her organization to develop an application for support. Eligible applicant types include: Federally Recognized Indian/Native American/Alaska Native Tribal Government, Nonprofit Organization, U.S. State Government (including the District of Columbia), Small Business Person, Not-for-Profit Organization.
Use the official notice and source links for final requirements, attachment checklists, allowable costs, and submission instructions before applying.
Based on current listing details, eligibility includes: Eligible Organizations: Universities, colleges, medical, dental and nursing schools, schools of public health, laboratories, hospitals, State and local health departments, other public or private institutions, both non-profit and for-profit, and individuals who propose to establish, expand, and improve research activities in health sciences and related fields. Eligible Individuals (Program Director/Principal Investigator): Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with his/her organization to develop an application for support. Eligible applicant types include: Federally Recognized Indian/Native American/Alaska Native Tribal Government, Nonprofit Organization, U.S. State Government (including the District of Columbia), Small Business Person, Not-for-Profit Organization. Applicants should confirm final requirements in the official notice before submission.
Current published award information indicates Recent federal obligations suggest $100,611,000 (2026). Always verify allowable costs, matching requirements, and funding caps directly in the sponsor documentation.
The current target date is rolling deadlines or periodic funding windows. Build your timeline backwards from this date to cover registrations, approvals, attachments, and final submission checks.
Oral Diseases and Disorders Research - R & D Contracts is sponsored by HEALTH AND HUMAN SERVICES, DEPARTMENT OF. NIDCR research provides Research and Development Contracts to support basic, translational, and clinical research in dental, oral, and craniofacial health and disease. The Research and Development Contracts programs plan, develop, and manage scientific priorities through portfolio analyses and consultation with stakeholders, encouraging the most promising discoveries and emerging technologies for rapid translation to clinical applications. The Integrative Biology and Infectious Diseases programs support basic and translational research programs on oral microbiology; salivary biology and immunology; oral and salivary gland cancers; neuroscience of orofacial pain and temporomandibular disorders; mineralized tissue physiology; dental biomaterials; and tissue engineering and regenerative medicine. The branch aims to accelerate progress in basic and translational research in these areas and further stimulate the discovery pipeline based on clinical needs. The Translational Genomics Research programs support basic and translational research in genetics, genomics, developmental biology, and data science toward the goal of improving dental, oral, and craniofacial health. The focus is on deciphering the genetic, molecular, and cellular mechanisms underlying dental, oral, and craniofacial development and anomalies. The Behavioral and Social Sciences Research programs support basic and applied research to promote oral health, to prevent oral diseases and related disabilities, and to improve management of craniofacial conditions, disorders, and injury. The program prioritizes mechanistic research that contributes to a cumulative science of behavior change, to maximize the rigor, relevance, and dissemination of efficacious behavior change interventions. The Clinical Research programs supports patient-oriented, population, and community based research aimed at improving the dental, oral, and craniofacial health of the nation. This listing is currently active. Program number: 93.DE7. Last updated on 2026-01-14. Application snapshot: target deadline rolling deadlines or periodic funding windows; published funding information Recent federal obligations suggest $3,668,600 (2026).; eligibility guidance Eligible applicant types include: Other. Use the official notice and source links for final requirements, attachment checklists, allowable costs, and submission instructions before applying.
Health Careers Opportunity Program (HCOP) is sponsored by HEALTH AND HUMAN SERVICES, DEPARTMENT OF. The Health Careers Opportunity Program (HCOP), also known as the National HCOP Academies, strives to develop a more competitive applicant pool to build the health professions. The Program's goal is to provide students from economically and educationally disadvantaged backgrounds who are interested in pursuing a health profession to develop the needed skills to compete for, enter, and graduate from a health or allied health professions program, graduate program in behavioral and mental health, and/or programs for the training of physician assistants. HCOP strives to improve retention, matriculation and graduation rates by implementing tailored enrichment programs designed to address the academic and social needs of trainees from disadvantaged backgrounds. It also provides opportunities for community-based health professions training, emphasizing experiences in underserved communities. HCOP focuses on three key milestones of education: (1) graduation from high school; (2) retention and graduation from college; and (3) acceptance, retention, and completion of a health career’s degree program. This listing is currently active. Program number: 93.822. Last updated on 2026-01-05. Application snapshot: target deadline rolling deadlines or periodic funding windows; published funding information Funding amounts vary by year and recipient.; eligibility guidance Eligible applicants include accredited schools of medicine, osteopathic medicine, public health, dentistry, veterinary medicine, optometry, pharmacy, allied health, chiropractic, podiatric medicine, public and nonprofit private schools that offer graduate programs in behavioral and mental health, programs for the training of physician assistants, and other public or private nonprofit health or educational entities including community, technical and tribal colleges. HCOP grant programs may only operate in the fifty (50) states, the District of Columbia, Commonwealth of Puerto Rico, Commonwealth of Northern Mariana Islands, the U.S. Virgin Islands, Guam, American Samoa, the Republic of Palau, Republic of the Marshall Islands, and the Federated States of Micronesia. Federally Recognized Indian Tribal Government and Native American Organizations may apply if they are otherwise eligible. Eligible applicant types include: U.S. State Government (including the District of Columbia), Local, Nonprofit Organization. Use the official notice and source links for final requirements, attachment checklists, allowable costs, and submission instructions before applying.
Centers for Medicare and Medicaid Services (CMS) Research, Demonstrations and Evaluations is sponsored by HEALTH AND HUMAN SERVICES, DEPARTMENT OF. The Centers for Medicare & Medicaid Services (CMS) conducts research, demonstrations, and evaluations in support of CMS' key role as a beneficiary-centered purchaser of high-quality health care at a reasonable cost. These grants are awarded are in the form of research grants and cooperative agreements; Hispanic health services grants; historically black colleges and university grants. For fiscal years 2010 and 2011, CMS research, demonstrations and evaluations will focus on expanding agency efforts to improve the efficiency of payment, delivery, access and quality of our health care programs that serve millions of beneficiaries. This listing is currently active. Program number: 93.779. Last updated on 2026-01-09. Application snapshot: target deadline rolling deadlines or periodic funding windows; published funding information Funding amounts vary by year and recipient.; eligibility guidance Grants or cooperative agreements may be made to private, or public agencies or organizations, including State agencies that administer the Medicaid program. Private profit organizations may apply. Eligible applicant types include: Local, Territorial, For-Profit Organization, State. Use the official notice and source links for final requirements, attachment checklists, allowable costs, and submission instructions before applying.
