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The Alzheimer's Drug Discovery Foundation Drug Development RFP provides substantial funding of up to $5 million for IND-enabling studies and early-phase clinical trials targeting Alzheimer's disease and related dementias. The program operates as a venture philanthropy model, supporting novel drug development approaches including AI-driven computational drug discovery, target identification, and molecular modeling. Priority research areas include combination therapies, epigenetics, inflammation, mitochondrial function, neuroprotection, proteostasis, and aging-related mechanisms. The ADDF accepts proposals for Phase 0, Phase 1, and biomarker-based proof-of-concept studies, as well as pharmacology, toxicology, and manufacturing studies. The foundation funds novel, repurposed, and repositioned drugs, natural products, and devices. Both academic medical centers and biotechnology companies (including new AI-driven drug discovery startups) are eligible. The program uses a two-stage review process with letters of intent due September 14, 2026, followed by invited full proposals. As a mission-related investment, funding may include return-on-investment requirements based on scientific and business milestones, distinguishing it from traditional grants.

The AWS Imagine Grant is Amazon Web Services' flagship unrestricted-cash programme for nonprofits, and the 2026-2027 cycle restructured the top tier explicitly around frontier AI. The Pathfinder Award funds groundbreaking, mission-critical projects at the frontier of artificial intelligence - generative AI, agentic AI and autonomous systems - and the solicitation is specific that frontier AI capability must be a core workload of the project within the one-year grant term, not an incidental feature. That requirement is the single most common reason applications fail: a project that uses a chatbot at the edge of an otherwise conventional service-delivery programme is a Go Further, Faster application, not a Pathfinder one. AWS states plainly that Pathfinder is designed for organisations with a strong existing data practice that are already in the planning phase, meaning the review favours applicants who can show data readiness and a concrete build plan over those pitching an idea. The cycle runs two rounds - Round One opened 19 March 2026 and closed 5 June 2026, and Round Two closes 14 September 2026 - with winners announced 1 December 2026. All three tiers pair unrestricted cash with AWS promotional credit, and no prior AWS usage is required, which keeps the programme genuinely open to organisations not already in the AWS ecosystem.

FY 2026-27 Bullying and Violence in School Advocacy (XB) Program Supplemental is sponsored by Governor's Office of Emergency Services. The purpose of the Program is to provide counseling, advocacy, and other support services to children/teenagers who have been victimized by bullying and /or school violence. Funding provided under this Program must not be used to support prevention-focused activities or initiatives.