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The National Institutes of Health is the world's largest public funder of biomedical research, with a $47 billion annual budget distributed across 27 institutes and centers. Each institute has its own mission, payline, and review culture — a successful R01 at NIGMS looks different from one at NCI or NIMH. Understanding these differences is the first step toward a funded application.
NIH organizes its grants by activity code. R01s ($250K-$500K per year for 3-5 years) are the primary mechanism for investigator-initiated research and represent the majority of the extramural portfolio. R21 Exploratory/Developmental grants ($275K total over two years) fund early-stage projects. K-series career development awards support investigators at various career stages, from K08 mentored clinical scientist awards to K99/R00 pathway-to-independence grants for postdocs.
Success rates and paylines vary substantially by institute. Overall NIH success rates hover around 20-23%, but specific institutes range from 12% (NCI) to over 30% (NIGMS for certain mechanisms). Receipt dates follow a standard three-cycle calendar — February/March, June/July, and October/November — though many program announcements have their own deadlines. SBIR/STTR grants through NIH have notably higher success rates, often exceeding 20%.
Use Granted to search across all 27 institutes simultaneously, filtering by mechanism, institute, and deadline. Our NIH success rate data helps you target institutes and mechanisms where your research has the strongest chance of funding.
R01 Research Project ($250K-$500K/yr)
The gold-standard investigator-initiated grant supporting a discrete project for 3-5 years. Modular budgets up to $250K/yr or detailed budgets for larger awards.
R21 Exploratory ($275K total)
Two-year exploratory grants for novel ideas that lack preliminary data. Lower funding but faster turnaround. No renewal possible — designed as a stepping stone to R01.
K99/R00 Pathway to Independence
Up to 5 years total: 1-2 years mentored postdoctoral (K99) plus 3 years independent (R00). Explicitly designed to help postdocs transition to faculty positions.
NIH SBIR (20%+ success rate)
Small Business Innovation Research grants through NIH institutes. Phase I up to $275K, Phase II up to $1.75M. Higher success rates than academic R01s for strong applications.
Browse grants →100 matching grants · showing 30
Advancing Nutrition-related Research Across the Lifespan is a grant from the National Institute of Nursing Research (NINR) at NIH that funds rigorous research examining social determinants of health to improve nutrition-related health outcomes and reduce disparities across the full lifespan, from prenatal through aging populations. The initiative leverages nursing science to close critical gaps in nutritional health equity research. Eligible applicants include federally recognized tribal governments, public and private institutions of higher education, nonprofits with 501(c)(3) status, for-profit organizations, public housing authorities, and independent school districts. Applications are due April 27, 2026. Award amounts are unspecified and will be detailed in the forthcoming Notice of Funding Opportunity.
Notice of Special Interest (NOSI): Encouraging Women's Health Research within the NIDCD Mission Areas is sponsored by National Institute on Deafness and Other Communication Disorders (NIDCD) / National Institutes of Health (NIH). This notice solicits grant applications seeking to improve women's health across the lifespan within the scope of NIDCD's mission. Projects may include biological, behavioral, societal, or healthcare-related activities that may benefit women's quality of life.
NIAID and NIDDK Research Opportunities for New and "At-Risk" Investigators to Promote Workforce Diversity (R01 Clinical Trial Optional) is sponsored by National Institutes of Health (NIH). This funding opportunity encourages research project applications within the mission of either NIAID or NIDDK from New Investigators or 'At-Risk' investigators from diverse backgrounds, including those underrepresented in the health-related sciences.
Assay Development and Screening for Discovery of Validated Chemical Hits for Brain Disorders (R01) is an NIH/NIDA funding opportunity that supports the development and validation of screening assays for discovering chemical hits to be used in future drug discovery efforts targeting mental illness and brain disorders. Participating organizations include the National Institute of Mental Health (NIMH). The program seeks researchers who can identify compounds with desired activity profiles that may serve as candidates for treatment of psychiatric and neurological conditions. Clinical trials are not allowed under this mechanism. Eligible applicants include public and private institutions of higher education, nonprofits, and small businesses engaged in drug discovery research. The next application deadline is May 7, 2026.
Assay Development and Screening for Discovery of Validated Chemical Hits for Brain Disorders (R01) is a grant from the National Institutes of Health (NIH/NIDA) that funds assay development, high-throughput screening, and drug discovery research targeting brain disorders including neurological and psychiatric conditions. Supported by NIMH and NIDA, the program seeks to identify and validate small molecule chemical hits that may serve as leads for new therapeutics. Eligible applicants include public and private institutions of higher education, nonprofit organizations, and small businesses engaged in drug discovery research. Awards vary based on the scope of the proposed research. The application deadline is May 7, 2026. Clinical trials are not allowed under this funding opportunity.
Early Immune System Development and Ontogency (R01 Clinical Trial Optional) is sponsored by National Institutes of Health (NIH). Supports research elucidating mechanisms of early immune development in utero, postnatal period, and early childhood, including in neonates with or without HIV/ART exposure, focusing on immune cells at maternal-fetal interface and T/B cell maturation.
Advancing Bioinformatics, Translational Bioinformatics and Computational Biology Research (R01 Clinical Trial Optional) is sponsored by National Library of Medicine (NLM), National Institutes of Health (NIH). This grant supports research projects focused on innovative bioinformatics, translational bioinformatics, and computational biology, particularly those leveraging AI, machine learning, and large-scale computational platforms to extract actionable knowledge from biomedical datase…
LAUNCH Program is sponsored by National Institutes of Health (NIH). The LAUNCH program supports the training of future global health researchers by providing early career researchers in the U.S. an opportunity for immersion in the wide-ranging health conditions and challenges experienced in international low-resource settings and to partner with local health researchers.
NLM Information Resource Grants to Reduce Health Disparities and Promote Health for All (G08 Clinical Trial Not Allowed) is sponsored by National Library of Medicine (NIH). This funding opportunity supports the development of information resources and services that provide accurate health information to populations experiencing health disparities and their providers, to improve health literacy, decision-making, and reduce disparities.
Blueprint MedTech Translator (UG3/UH3) is a multi-institute NIH cooperative agreement that funds the translation of medical devices from early-stage concepts toward clinical application. Structured as a phased Exploratory/Developmental award, the program supports up to ,000 per year for qualifying projects. The UG3 phase funds initial exploratory and developmental work, with successful projects advancing to the UH3 phase for more intensive translational activity. The application deadline is May 28, 2026. This mechanism is intended for investigators pursuing novel medical device innovations with a clear path toward clinical use and commercial viability.
Novel Experiential Technologies Assisting Individual Learning (NExT AI) Hubs is a grant from the National Institutes of Health (NIH), specifically the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), that funds Centers conducting high-risk, innovative research on the impact of Artificial Intelligence technologies on developmental outcomes in children at risk for or diagnosed with specific learning disabilities affecting reading, writing, and mathematics. The program uses a Centers structure to support understudied research topics and advance NICHD's mission to improve child health and human development. Eligible applicants include universities, nonprofits, federally recognized Native American tribal governments, for-profit organizations, and public and private institutions of higher education. The estimated application due date is June 4, 2026.
Unveiling Health and Healthcare Disparities in Non-Communicable and Chronic Diseases in Latin America: Setting the Stage for Better Health Outcomes Across the Hemisphere (R01 - Clinical Trials Not Allowed) is sponsored by National Institutes of Health (NIH). This Notice of Funding Opportunity (NOFO) supports innovative, collaborative, and interdisciplinary research focused on clinical epidemiology, evaluation of public and/or healthcare policies, and validation of measurements that address health and healthcare disparities related to non-communicable and chronic diseases (NCDs) with the highest disease burden and mortality in Latin America and among U.S. Hispanics/Latinos.
Research Grants in Clinical Informatics (R01 Clinical Trial Optional) is sponsored by National Institutes of Health (NIH). Research Grants in Clinical Informatics (R01 Clinical Trial Optional) is a grant from the National Institutes of Health (NIH) that funds innovative research in clinical informatics through the National Library of Medicine (NLM).
Advancing Bioinformatics, Translational Bioinformatics and Computational Biology Research (R01 Clinical Trial Optional) is sponsored by National Institutes of Health (NIH). This grant supports innovative, scalable bioinformatics research to transform biomedical data science and health outcomes. AI pathology heavily relies on bioinformatics and computational biology for image analysis, data integration, and predictive modeling.
BRAIN Initiative: New Concepts and Early-Stage Research for Recording and Modulation in the Nervous System (R21) (Clinical Trial Not Allowed) is sponsored by National Institutes of Health (NIH). A central goal of the BRAIN Initiative is to understand how electrical and chemical signals code information in neural circuits and give rise to sensations, thoughts, emotions, and actions.
Neuromodulation/Neurostimulation Device Development for Mental Health Applications (R21 Clinical Trial Not Allowed) is sponsored by National Institutes of Health (NIH). This funding opportunity encourages applications seeking to develop the next generation of brain stimulation devices for treating mental health disorders. It focuses on the development or significant enhancement of novel tools (hardware and/or software) for brain stimulation in humans. Applications should be engineering/pre-clinical based and focus on hardware and software development and validation.
BRAIN Initiative: Promoting Equity Through BRAIN Technology Partnerships (R34) is a grant from NIH BRAIN Initiative that funds partnerships between resource-limited institutions and BRAIN technology developers to increase equitable access to cutting-edge neuroscience tools. The program supports dissemination and adoption of BRAIN Initiative tools at underserved institutions, strengthening research capacity and broadening participation in neuroscience. Eligible applicants include universities and institutions eligible for NIH funding, with particular emphasis on resource-limited institutions. Awards approximate $450,000 over three years under the R34 mechanism. Applications are due by June 18, 2026.
This NIH funding opportunity (PAR-25-170) supports rigorous development and validation of digital health technology (DHT)-derived biomarkers and clinical outcome assessments for remote patient monitoring and clinical trial endpoint development. Administered through a two-phase UG3/UH3 cooperative agreement structure, the program involves NCI, NINDS, and NIA, with co-funding from OBSSR. Eligible applicants include academic and research institutions; partnerships with nonprofit patient advocacy organizations are required. Applications are due June 22, 2026. The program was updated in March 2025 to align with revised agency priorities.
Pilot Projects Enhancing Utility and Usage of Common Fund Data Sets (R03) is a grant from the NIH Common Fund Data Ecosystem Program that funds pilot research demonstrating and enhancing the utility of NIH Common Fund data sets, including generating new hypotheses and catalyzing discoveries. Award recipients are expected to provide feedback on the usability and value of Common Fund data resources. Eligible applicants include universities, public and private institutions of higher education, nonprofits, independent school districts, tribal governments, and other organizations eligible for NIH R03 awards. Foreign organizations are not eligible. The application deadline is June 23, 2026.
NIMHD Comprehensive Centers of Excellence (P60) is a grant from the National Institute on Minority Health and Health Disparities (NIMHD/NIH) that funds multi-disciplinary and trans-disciplinary research centers dedicated to promoting minority health and reducing health disparities. Awards range from $3 million to $6 million and support innovative research, training, and education activities to develop well-trained researchers from minority and health-disparity populations. Each Center of Excellence focuses on a specific theme with direct impact on addressing minority health disparities, which may include disease areas disproportionately affecting underserved populations or cross-cutting prevention topics. The program also supports community engagement activities aimed at sustainably improving health outcomes in minority communities. Funded centers include institutions such as Johns Hopkins University, Duke University, and Arizona State University.
Global Infectious Disease Research Training Program is a grant from the Fogarty International Center at NIH that funds research training programs focused on infectious diseases predominantly endemic in or significantly impacting people in low- and middle-income countries (LMICs). The program (D43 Clinical Trial Optional, PAR-24-174) supports training in areas such as neglected tropical diseases, HIV co-infections, emerging life-threatening infections, and infections associated with noncommunicable diseases of public health importance. The ultimate goal is to build a critical mass of independent researchers and support staff at developing country institutions. Eligible applicants include U.S. institutions with demonstrated LMIC collaborations and foreign institutions in LMICs. Applications with non-U.S. subawards will not be accepted. The application deadline is August 6, 2026.
National Centers for Biomedical Imaging and Bioengineering (NCBIB) is a grant from the National Institutes of Health (NIH) that funds national resource centers for conducting research and development on new technologies driven by the needs of basic, translational, and clinical researchers. NCBIB centers make their technologies available to other investigators and train members of the research community in their use. Eligible applicants include higher education institutions, nonprofits with 501(c)(3) status, for-profit organizations, state and local governments, and tribal governments. Awards provide $600,000 to $750,000 per year in direct costs with up to $500,000 for special-purpose equipment over a five-year period.
NLM Institutional Grants for Research Training in Biomedical Informatics, Data Science, and AI is sponsored by National Institutes of Health (NIH). The National Institutes of Health (NIH) is inviting applications for the NLM Institutional Grants for Research Training in Biomedical Informatics, Data Science, and AI. These grants aim to foster innovative predoctoral and postdoctoral training programs to prepare the next generation of researchers to tackle complex health and biomedical challenges through advanced computational approaches, with a focus on interdisciplinary integration of methods across various fields. The estimated total program funding is $12 million, with approximately 25 grants anticipated to be awarded.
NHLBI Program Project Grants (P01) is a funding opportunity from the National Heart, Lung, and Blood Institute (NHLBI/NIH) that supports large-scale, investigator-initiated research programs addressing heart, blood vessel, lung, blood, and sleep disorder biology and disease. Programs must include a minimum of three interrelated research projects sharing common scientific goals. Eligible applicants include universities, medical colleges, and domestic research centers. Awards support up to $1,515,000 in direct costs per year, with a deadline of September 25, 2026. Clinical trials are optional under this mechanism.
Academic Research Enhancement Award (AREA) for Undergraduate-Focused Institutions (R15 Clinical Trial Not Allowed) is sponsored by National Institutes of Health (NIH). This grant supports small-scale research projects at institutions that have not been major recipients of NIH funding. It provides opportunities for faculty to conduct research and to expose undergraduate students to research environments. While not exclusively focused on diversity, it supports institutions that serve a significant number of undergraduate students.
Ethical, Legal and Social Implications (ELSI) Small Research Grant (R03 Clinical Trial Optional) is sponsored by National Institutes of Health (NIH). This Notice of Funding Opportunity (NOFO) invites Small Research Grant (R03) applications that propose to study the ethical, legal and social implications (ELSI) of human genetic or genomic research.
This NIH highlighted research topic encourages multidisciplinary, mechanistic investigations of the human microbiome and its role in host physiology across health and disease states. Rather than a standalone funding announcement, researchers apply through an appropriate NIH Parent Funding Opportunity. The initiative aims to expand the microbiome field in new directions, support novel microbiome-based interventions, and advance disease prevention, detection, and prognosis. Proposals should emphasize mechanistic rigor and cross-disciplinary approaches. This topic remains active through January 15, 2027, after which it will expire.
Mentored Patient-Oriented Research Career Development Award (Parent K23 Independent Clinical Trial Required) is sponsored by National Institutes of Health (NIH). This award supports the career development of investigators who have a clinical doctorate and are committed to patient-oriented research. Pharmacogenetics research with a clinical trial component would be a strong fit.
NIH Pathway to Independence Award (Parent K99/R00 Independent Clinical Trial Not Allowed) is sponsored by National Institutes of Health (NIH). The K99/R00 Pathway to Independence Award provides an accelerated pathway for outstanding postdoctoral researchers to transition to independent research careers. This specific announcement is for projects that do not involve a clinical trial.
BRAIN Initiative: Brain Behavior Quantification and Synchronization—Next Generation Sensor Technology Development (U01) is a grant from NIH BRAIN Initiative that funds development of next-generation sensor technologies synchronized with brain recordings. The program aims to enable computational models of behavior in both humans and animals, advancing understanding of the neural basis of behavior. Eligible applicants include universities, research institutions, nonprofits, educational institutions, government agencies, small businesses, HBCUs, and tribal colleges. Funding is provided through a cooperative agreement (U01) mechanism. Applications are due by June 2027.
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