•Note: Each funding opportunity description is a synopsis of information in the Federal Register application notice. For specific information about eligibility, please see the official application notice. The official version of this document is the document published in the Federal Register. Free Internet access to the official edition of the Federal Register and the Code of Federal Regulations is available on GPO Access at: http://www.access.gpo.gov/nara/index.html. Please review the official application notice for pre-application and application requirements, application submission information, performance measures, priorities and program contact information. Purpose of Program: The purpose of this program is to stimulate technological innovation in the private sector, strengthen the role of small business in meeting Federal research or research and development (R/R&D) needs, increase the commercial application of the U.S. Department of Education (Department) supported research results, and improve the return on investment from federally funded research for economic and social benefits to the Nation. Catalog of Federal Domestic Assistance (CFDA) Number: 84.133S-1. If you choose to submit your application electronically, you must use the Governmentwide Grants.gov Apply site at http://www.Grants.gov. Through this site, you will be able to download a copy of the application package, complete it offline, and then upload and submit your application. You may not e-mail an electronic copy of a grant application to us. You may access the electronic grant application for the SBIR Program at: http://www.Grants.gov. You must search for the downloadable application package for this competition by the CFDA number. Do not include the CFDA number's alpha suffix in your search (e.g. , search for 84.133, not 84.133S). The telephone number for the Grants.gov Helpdesk is 1-800-518-4726 or e-mail: support@grants.gov. Funding Opportunity Number: ED-GRANTS-090908-001. Assistance Listing: 84.133. Funding Instrument: G. Category: ED. Award Amount: Up to $75K per award.

Under this program, grants will be awarded to address significant disparities in perinatal health indicators in communities within 62 miles of the U.S. Mexico border or in Alaska and Hawaii. Communities must provide a scope of project services that will cover pregnancy and interconceptional phases for women and infants residing in the proposed project area. Services are to be given to both mother and infant for two years following delivery to promote longer interconceptional periods and prevent relapses of unhealthy risk behaviors. Funding Opportunity Number: HRSA-09-131. Assistance Listing: 93.926. Funding Instrument: G. Category: HL. Award Amount: $750K – $925K per award.

Purpose.This Funding Opportunity Announcement (FOA), issued by the National Institute of Mental Health (NIMH), solicits Exploratory/Developmental Phased Innovation (R21/R33) grant applications from institutions or organizations that propose to generate and characterize induced pluripotent stem (iPS) cells from human control and/or patient populations with cognitive, affective, social, sleep and developmental brain disorders. This can, but does not need to, include disorders in which a genetic linkage has already been inferred. Applications that combine expertise in stem cell biology, cortical development and the clinical study or treatment of mental disorders are strongly encouraged. Responsive applications will place an emphasis on appropriate validation of iPS cells and their derivatives, evaluating the hetero/homogeneity of any cell populations to be screened and use of cellular assays relevant to brain function and mental disorders. Studies involving the acquisition of tissue from new subjects should include provisions to archive and distribute non-induced (e.g., primary) cells. Since studies likely require several areas of expertise, applicants are encouraged to include multiple PIs on the application. Funding Opportunity Number: RFA-MH-09-130. Assistance Listing: 93.242. Funding Instrument: G. Category: HL. Award Amount: Up to $200K per award.

The National Institutes of Health (NIH) announces the opportunity for investigators and United States institutions/organizations with active NIH-supported research project grants (including SBIR and STTR) to submit revision applications (formerly termed competitive supplements) to support a significant expansion of the scope or research protocol of approved and funded projects. Support for these revision applications will come from funds provided to NIH through the American Recovery and Reinvestment Act of 2009 (“Recovery Act” or “ARRA”), Public Law 111-5. In addition, Recovery Act funds allocated to NIH specifically for comparative effectiveness research (CER) may be available to support supplements. Projects receiving these funds will need to meet this definition of CER: “a rigorous evaluation of the impact of different options that are available for treating a given medical condition for a particular set of patients. Such a study may compare similar treatments, such as competing drugs, or it may analyze very different approaches, such as surgery and drug therapy.” Such research may include the development and use of clinical registries, clinical data networks, and other forms of electronic health data that can be used to generate or obtain outcomes data as they apply to CER. This announcement is one of three ARRA administrative supplement/competitive revision notices issued by NIH. Approximately $1 billion of ARRA funds will be obligated by September 30, 2010 to support requests submitted in response to these three notices or any reissuance of these notices. Funding decisions and awards will be issued on or prior to September 30, 2009 for applications submitted in response to this notice, and on or prior to September 30, 2010 for applications submitted in response to any reissuance of this notice. The deadline for receipt of these revision applications is April 21, 2009. Resubmissions will only be accepted if this notice is reissued. Funding Opportunity Number: NOT-OD-09-058. Assistance Listing: 93.701,93.702. Funding Instrument: G. Category: HL,RA.

Purpose. This Funding Opportunity Announcement (FOA) solicits Small Business Innovation Research (SBIR) grant applications from small business concerns (SBCs) that propose to develop, enhance and validate translational tools to facilitate rigorous study of complementary and alternative medicine (CAM) approaches that are in wide use by the public. Recent data from the National Health Interview Survey [http://www.cdc.gov/nchs/nhis.htm] establish that Americans are utilizing CAM approaches to promote health and well-being, to treat or prevent disease, and for symptom relief. CAM approaches being widely used include massage and manipulative therapies, meditation, yoga, and acupuncture. Health conditions, particularly chronic pain, back pain and musculoskeletal pain, are the most commonly cited reasons for their use. This FOA focuses on encouraging the development of improved tools to study safety, efficacy, and clinical effectiveness of widely used CAM approaches, such as: mind-body interventions, manual therapies, yoga, and acupuncture. This FOA is not focused on tools for the study of natural products, such as herbal therapies. Mechanism of Support. This FOA will utilize the SBIR (R43/R44) grant mechanisms for Phase I, Phase II, and Fast-Track applications and runs in parallel with a FOA of identical scientific scope, RFA-AT-09-002, which solicits applications under the R01 grant mechanism. Funds Available and Anticipated Number of Awards. The estimated amount of funds available for support of 5 projects awarded as a result of this announcement is $1.25 million for fiscal year 2010. Future year amounts will depend on annual appropriations. Funding Opportunity Number: RFA-AT-09-004. Assistance Listing: 93.213. Funding Instrument: G. Category: HL. Award Amount: $1.3M total program funding.

-Purpose. This Funding Opportunity Announcement (FOA) encourages Small Business Innovation Research (SBIR) grant applications from small business concerns (SBCs) that propose to develop, standardize, and validate new and innovative assays, integrated strategies, or batteries of assays that determine or predict specific organ toxicities (e.g., ocular, dermal, hematotoxicity, cardiotoxicity, gastrointestinal toxicity, hepatotoxicity, nephrotoxicity, ototoxicity, olfactory loss, bladder toxicity, neurotoxicity, pulmonary toxicity, endocrine toxicity, and pancreatic beta cell toxicity), resulting from both acute and chronic exposures to various chemicals, environmental pollutants, biologics and therapeutic molecules or drugs. In addition, this FOA encourages the development, standardization, and validation of new models of arthritis, convulsion, infection and shock. New approaches for high throughput toxicity screening that involves the use of molecular endpoints, computer modeling, proteomics, genomics and epigenomics and the development of virtual tissues are also encouraged as are development of 3-dimensional organ models for toxicity evaluation. -Mechanism of Support. This FOA will utilize the SBIR (R43/R44) grant mechanisms for Phase I, Phase II, and Fast-Track applications and runs in parallel with a FOA of identical scientific scope, PA-09-007, which encourages applications under the Small Business Technology Transfer (STTR) (R41/R42) grant mechanisms. Funding Opportunity Number: PA-09-006. Assistance Listing: 93.113,93.173,93.361,93.389,93.837,93.846,93.847,93.848,93.849,93.859,93.867. Funding Instrument: G. Category: ED,ENV,FN,HL.

-This Funding Opportunity Announcement (FOA) solicits Small Business Innovation Research (SBIR) grant applications from small business concerns (SBCs) for the modification or development of new screening technologies that are better able to consistently detect mild hearing loss (i.e., less than 40 dB Hearing Level or 40 dB HL) in one or both ears in infants and young children without significantly increasing the number of false positives (i.e., those who fail the screen but do not have hearing loss). -The Early Hearing Detection and Intervention (EHDI) program within the National Center for Birth Defects and Developmental Disabilities (NCBDDD) of the Centers for Disease Control and Prevention (CDC) and the National Institute on Deafness and Other Communication Disorders (NIDCD), NIH, are working to ensure infants and children with mild forms of hearing loss are identified as soon as possible. Part of this effort involves having screening technology available that can reliably detect these hearing losses. -This FOA will utilize the SBIR (R43/R44) grant mechanisms for Phase I, Phase II, and Fast-Track applications and runs in parallel with a FOA of identical scientific scope, PA-06-547, that solicits applications under the Small Business Technology Transfer (STTR [R41/R42]) grant mechanisms. Note,that CDC does not accept STTR applications so is participating only in PA-06-546. Funding Opportunity Number: PA-06-546. Assistance Listing: 93.173,93.283. Funding Instrument: G. Category: HL.

On behalf of the Department of the Interior, the U.S. Fish and Wildlife Service, in association with a number of federal partners, is seeking to create a comprehensive booklet in order to advance the public’s understanding of the various issues related to the Secretarial Determination (SD) on Klamath River dams. The booklet will be printed and distributed to the various federal agency offices located in the Klamath Basin for their use and public engagement activities. A non-editable electronic PDF version of the booklet will also be available. Background In February 2010, the Secretary of the U.S. Department of the Interior signed the Klamath Hydroelectric Settlement Agreement. Accordingly, it sets out a process whereby the Secretary of the Interior is asked to make a determination on whether four privately owned Klamath River dams should be removed. The criteria for this determination are (1) whether dam removal will benefit anadromous fish; and, (2) is dam removal in the public interest. The Secretary will make this determination by March 2012. The booklet will help the public become more fully informed about the key issues of the Klamath Basin and the SD process, which will enable meaningful public involvement. Specifically, this booklet will help inform the public on SD process by presenting a comprehensive overview of the various issues associated with the SD process and related processes. It will cover the history of the Klamath River with a special focus on the developments and controversies over the last 10 years, and how they helped to shape present day agreements. The booklet will then explain the Secretarial Determination process for dam removal, i.e. what studies will be conducted, on what timeline, etc. The booklet will also include a section that clarifies issues of confusion that have so far surfaced. For example, there are misconceptions about the dams – this booklet (while remaining neutral on the issue of whether dams should remain or come out) will correct common misconceptions about what will happen if the dams are removed, i.e. will the river run dry?; will locals lose their electricity?, etc. A section of the booklet will also outline key milestones in the process and those contemplated by the recent KBRA and KHSA. A list of internet resources including the soon to be launched klamathrestoration.gov website will be included. The booklet will present technical information in a user-friendly manner, it will contain photos, graphics and will be printed in color. Sample components of the Guide could include:• Table of Contents• Introduction and Geographic Setting• Chronology of Key Dates and Milestones• A History of Klamath River from 2000-2010• 2010 Agreements• Most common misconceptions about Klamath River• Future of Klamath RiverDeliverables – General The cooperator will work with a point-of-contact from the federal government to ensure delivery of a final product within the deadline (3 – 6 months after cooperative agreement is awarded). The contractor shall be prepared to meet/communicate with the federal point-of-contact as much as necessary to ensure the final product meets the reasonable expectations of the federal communications team overseeing the Secretarial Determination process. The cooperator will develop a list of required material/data/maps/agency contacts and other information and provide it to the federal point-of-contact within one week of contract award. The federal point of contact will provide the cooperator with the requested information within one week of the request. The cooperator will present updates and draft versions of the booklet – both text and design -- to the federal point-of-contact throughout the design phase and make reasonable adjustments/modifications upon request. In order to maintain the integrity of the publication and its usefulness to the federal point-of contact, the cooperator will retain editorial control, but will consider federal point-of-contact edits and suggestions, and will use them where appropriate.The federal point-of-contact will ensure that edits to the booklet are received in timely and orderly way and will work with the cooperator on an editorial calendar complete with federal/state review deadlines and other milestones such as print schedule and distribution schedule. Deliverables – designing the booklet The cooperator shall work with the federal point of contact to design and write a booklet that is well-designed, readable, eye-catching and well organized. The cooperators shall work with the federal point of contact to determine the basic contents, design and lay out to be used for this project.The federal point of contact will work with the cooperator on supplying access to information, data, agency personnel, graphics and photos and other information so the writers/designers can be fully informed of the process and related issues.TIMELINE:Upon award of contract, the Water Education Foundation could complete work on the Layperson’s Guide to the Klamath River in a 3-6 month period. Funding Opportunity Number: FWS-R8-YREKA-2010-SECDET-10. Assistance Listing: 15.608. Funding Instrument: G. Category: ST. Award Amount: Up to $42K per award.

Purpose. This funding opportunity announcement (FOA) solicits Small Business Innovation Research (SBIR) grant applications that propose to develop novel pharmacologic agents for brain research related to mental disorders, including research aimed at discovering new drugs for these disorders. In addition, this FOA solicits SBIR grant applications that propose to take existing, promising compounds through the next step of drug discovery and development. Finally, this FOA also encourages SBIR grant applications designed to study the effectiveness of novel interventions. Mechanism of Support. This FOA will utilize the SBIR (R43/R44) grant mechanisms for Phase I, Phase II, and Fast-Track applications. Funds Available and Anticipated Number of Awards. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications. The total amount awarded and the number of awards will depend upon the quality, duration, and costs of the applications received. Budget and Project Period. Phase I awards normally may not exceed $100,000 total for a period normally not to exceed 6 months. Phase II awards normally may not exceed $750,000 total for a period normally not to exceed 2 years. However, for this funding opportunity, budgets up to $350,000 total costs per year and time periods up to two years for Phase I may be requested. Budgets up to $600,000 total costs per year and up to three years may be requested for Phase II. Eligible Institutions/Organizations: Only United States SBCs are eligible to receive SBIR applications. A SBC is one that, on the date of award for both Phase I and Phase II funding agreements, meets ALL of the criteria as described in Section III. Eligible Project Directors/Principal Investigators: Individuals with the skills, knowledge, and resources necessary to carry out the proposed research are invited to work with their organization to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support. On an SBIR application, the PD/PI must have his/her primary employment (more than 50%) with the SBC at the time of award and for the duration of the project. Number of Applications: Applicant SBCs may submit more than one application, provided each application is scientifically distinct. Resubmissions: Applicants may submit a resubmission application, but such application must include an Introduction addressing the previous peer review critique (Summary Statement). Number of PDs/PIs. More than one PD/PI, or multiple PDs/PIs, may be designated on the application. Funding Opportunity Number: PA-08-142. Assistance Listing: 93.242. Funding Instrument: G. Category: HL.

The National Aeronautics and Space Administration (NASA) Science Mission Directorate (SMD) is releasing a NASA Announcement of Opportunity (NNH10ZDA007O), Discovery 2010. NASA expects to select up to three Discovery mission proposals for a 9 month Phase A study. Following evaluation of Phase A reports, NASA expects to approve one Discovery mission to proceed into Phase B and subsequent mission phases. Launch Readiness Date (LRD) is to occur no later than December 31, 2017. The proposed missions may target any body in the Solar System, including Mars and Earth’s Moon, but excluding the Earth and Sun. Participation is open to all categories of organizations (U.S. and non-U.S), including educational institutions, industry, not-for-profit organizations, Federally Funded Research and Development Centers (FFRDCs), NASA Centers, the Jet Propulsion Laboratory (JPL), and other Government agencies. This solicitation will be open from June 7, 2010, through September 3, 2010. Upon the release date, the full text of the AO and all appendices will be available electronically at http://nspires.nasaprs.com/ . A preproposal conference will be held in late June or early July, in the Washington, DC, area; see http://discovery.larc.nasa.gov/ for details. Proposers should be aware of the following major changes in this AO from the Draft Discovery Program AO (NNH10ZDA003J) released in December 2009: • Launch vehicles in the “medium” and “high” performance classes with 4m fairings will be added as options. Costs to proposers for these options are currently being assessed. • Proposed missions will be required to be compatible through PDR with three families of launch vehicles: Atlas V, Delta IV, and Falcon 9. • The minimum requirements for taking advantage of technology-infusion cost cap incentives will be detailed in a new document in the Program Library entitled In-Space Propulsion Technologies Minimum Demonstration Requirements. • The costs associated with NEPA, NLSA, and nuclear launch services for missions proposing to use ASRGs will be reduced to a firm, fixed cost of $20M (FY10). • The justification for the use of X-band telecommunications for science data downlink will be clarified to explicitly follow Recommendation 23-1 of the Space Frequency Coordination Group: in deep-space X-band users will be limited to 12 MHz of bandwidth while at Mars X-band users will be limited to 8 MHz of bandwidth. Beyond these limits, missions will be required to use Ka-band. Aperture fees based on the standard formula will remain. • Missions to the Martian surface will no longer be required to carry the Electra-lite UHF radio package. However, any UHF package used will be required to be interoperable with the current Mars UHF relay network. • The latest allowable Launch Readiness Date (LRD) will be extended to December 31, 2017. In addition to the listed major changes, this AO incorporates a large number of additional changes relative to the previous Discovery Program AO and the Draft Discovery Program AO, including both policy changes and changes to proposal submission requirements. All proposers must read this AO carefully, and all proposals must comply with the requirements, constraints, and guidelines contained within this AO. Direct questions specifically regarding this solicitation to: Dr. Michael H. New, Discovery Program Scientist, Planetary Science Division, Science Mission Directorate, NASA Headquarters, Washington, DC 20546; Tel.: (202) 358-1766; E-mail: Michael.H.New@nasa.gov (subject line to read "DISCOVERY AO"). This notice constitutes a NASA Research Announcement as contemplated in FAR 6.102(d)(2). Funding Opportunity Number: NNH10ZDA007O. Assistance Listing: 00.000. Funding Instrument: CA,G. Category: ST.

United States Department of the Interior National park Service (NPS) NOTICE OF INTENT TO AWARD. THIS IS NOT A REQUEST FOR APPLICATIONS. This funding announcement is to provide public notice of the NPS�s intention to fund the following project activities without full and open competition: Task Agreement Number No. 5 P11AT40447 (R1818-11-0058) to Cooperative Agreement H1818-08-0011with cooperator The University of Vermont and State Agricultural College. For complete details, see attachment under �Full Announcement� at the top of this page. Funding Opportunity Number: NPS-11-NERO-0056. Assistance Listing: 00.000. Funding Instrument: CA. Category: ENV. Award Amount: Up to $83K per award.

United States Department of the Interior National Park Service (NPS) NOTICE OF INTENT TO AWARD. THIS IS NOT A REQUEST FOR APPLICATIONS. This funding announcement is to provide public notice of the NPS's intention to fund the following project activities without full and open competition: Cooperative Agreement P11AC40717 with cooperator Dry Stone Conservancy, Inc. For complete details, see attachment under "Full Announcement" at the top of this page. Funding Opportunity Number: NPS-11-NERO-0101. Assistance Listing: 00.000. Funding Instrument: CA. Category: ENV. Award Amount: Up to $29K per award.

This Funding Opportunity Announcement (FOA) solicits Small Business Innovation Research (SBIR) grant applications from small business concerns (SBCs) that propose the development and translation of technologies to improve hearing healthcare outcomes. Responsive applications must seek to increase utilization of hearing health care technology by underserved patients and thus reduce health disparities. Funding Opportunity Number: RFA-DC-12-001. Assistance Listing: 93.173. Funding Instrument: G. Category: HL. Award Amount: Up to $150K per award.

This action will result in a task agreement award under the National Park Service Rocky Mountain Cooperative Ecosystem Studies Unit (CESU). This is a notice of intent and a noncompetitive award in accordance with the Department of Interior 505 Departmental Manual 2.12C. Please see attached announcement for more information. Funding Opportunity Number: NPS-NOIR9260120005. Assistance Listing: 15.945. Funding Instrument: CA. Category: NR. Award Amount: $41K total program funding.

This phase of work addresses and seeks to build on UCASS Phase I accomplishments and allow the performer to expedite efforts to: •Prepare a widely-usable demonstration version of a prototype decision support tool •Work with users to refine the prototype tool and educate the users, to lay the groundwork for transition •Incorporate into the decision support tool early versions of pre- and post-processing components that will be able to incorporate the risk and economic modeling done by our partners at CREATE •Enhance data gathering and analysis needed for the CCICADA and CREATE modeling. Funding Opportunity Number: DHS-12-ST-061-002-SUPP1. Assistance Listing: 97.061. Funding Instrument: CA. Category: IS. Award Amount: Up to $77K per award.

Funding may be available through the USFWS Anadromous Fish Restoration Program to complete Phase I of the Lower Deer Creek Falls Fish Passage Project. Deer Creek is a tributary to the Upper Sacramento River near Vina, CA, in southeastern Tehama County. An initial passage assessment completed by the California Department of Fish and Game (CDFG) within the last two years determined that the existing ladder structure on Deer Creek did not meet CDFG/National Marine Fisheries Service (NMFS) fish passage criteria. The USFWS requests submission of proposals for 1) a fish passage assessment; 2) development of a range of alternatives to implement any needed repairs and/or modifications; 3) completion of a final engineered design and an engineer’s cost estimate for repairs and/or modifications based upon selection of a preferred alternative by a Technical Advisory Committee; and 4) development of a Quality Control plan for the proposed data collection/analysis. A field visit is scheduled for March 30, 2012. If you are planning on submitting a proposal, it is strongly encouraged that you attend. Funding Opportunity Number: F12AS00095. Assistance Listing: 15.648. Funding Instrument: G. Category: NR. Award Amount: Up to $80K per award.

This Funding Opportunity Announcement (FOA) issued by the National Institutes of Health (NIH) invites eligible United States small business concerns (SBCs) to submit Small Business Technology Transfer (STTR) grant applications. United States SBCs that have the research capabilities and technological expertise to contribute to the R&D mission(s) of the NIH awarding components identified in this FOA are encouraged to submit STTR grant applications in response to identified topics (see PHS 2012-2 SBIR/STTR Program Descriptions and Research Topics for NIH.) Funding Opportunity Number: PA-12-089. Assistance Listing: 93.113,93.121,93.136,93.172,93.173,93.213,93.242,93.273,93.279,93.286,93.307,93.350,93.351,93.361,93.389,93.393,93.394,93.395,93.396,93.399,93.837,93.838,93.839,93.846,93.847,93.853,93.855,93.856,93.859,93.865,93.866,93.867,93.879. Funding Instrument: G. Category: ED,ENV,FN,HL,ISS.

The United States Agency for International Development (USAID)’s Bureau for Food Security (BFS) under the management of the Office of Country Strategy and Implementation Support (CSI) is continuing USAID’s long-term support for the Farmer-to-Farmer (F2F) Program. This RFA is issued to solicit applications to manage F2F volunteer programs under Leader with Associate Cooperative Agreements (LWAs). The LWAs resulting from this RFA will enable USAID to continue its support for US voluntary assistance for economic growth in the agricultural sector at regional and country levels. The LWA mechanism will facilitate USAID Mission funding to expand volunteer assistance and impact on agricultural program element objectives.Issuance of this RFA does not constitute an award commitment on the part of the Government, nor does it commit the Government to pay for costs incurred in the preparation and/or submission of an application. Applicants who come under consideration for an award that have never received USAID funding will be subject to a pre-award audit to determine fiscal responsibility, ensure adequacy of financial controls, and establish an indirect cost rate (if applicable). For the purposes of this RFA, the term “Grant” is synonymous with “Cooperative Agreement”; "Grantee" is synonymous with "Recipient;" and "Grant Officer" is synonymous with "Agreement Officer". The authority for this RFA is found in the Foreign Assistance Act of 1961, as amended. USAID intends to award up to eight (8) Leader with Associate Awards in the form of Cooperative Agreements with each base program in the amount of $8 Million subject to the availability of funds. Each Leader Award will have a period of performance of up to five (5) years. Applicants may propose implementation periods of less than five (5) years (cost efficiencies and project effectiveness should be considered) but no more than five (5) years. Additional associate award(s) may be placed at a future time under a separate RFA process. Projects proposed with an implementation period of more than five (5) years will not be considered. Competition under this RFA will be conducted in two phases: • Phase I: Concept Note • Phase II: Full ApplicationEach applicant shall initially provide USAID with a Concept Note. The Concept Note shall be competitively evaluated against the pre-determined evaluation criterion. The most highly technically qualified Concept Notes will be invited to submit Part II Full Application under this RFA. Unsuccessful applicants will be notified in a timely manner and provided written feedback. Funding Opportunity Number: SOL-OAA-13-00006. Assistance Listing: 98.009. Funding Instrument: CA. Category: AG. Award Amount: Up to $8M per award.

Purpose. This Funding Opportunity Announcement (FOA), issued by the National Cancer Institute (NCI), National Institutes of Health (NIH), invites Small Business Innovation Research (SBIR) cooperative agreement applications from small business concerns (SBCs) that propose to develop new, or to improve existing application(s) of nanotechnology-based therapeutics or/and in vivo diagnostics. This FOA will specifically support pre-clinical optimization and testing of these cancer-relevant nanotechnology applications against the intended cancer type. The proposed projects must be milestone-driven and must be clearly directed toward development of an ultimate commercial product. The outcomes are expected to advance the discovery and pre-clinical optimization phase so that an Investigational New Drug (IND) or Investigational Device Exemptions (IDE) application could be submitted to the Food and Drug Administration (FDA) by the end or shortly after completion of the Phase II project period. To facilitate these steps, the NCI will assist the awardees in various ways, including the support through the NCI-sponsored Nanotechnology Characterization Laboratory. This FOA will NOT support basic research projects, studies on disease mechanisms, and clinical trials. Mechanism of Support. This FOA will utilize the SBIR (U43/U44) cooperative agreement mechanisms for Phase I and Phase II applications. Funds Available and Anticipated Number of Awards. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications. The total amount awarded and the number of awards will depend upon the quality, duration, and costs of the applications received. Funding Opportunity Number: PAR-10-286. Assistance Listing: 93.393,93.394,93.395,93.396. Funding Instrument: CA. Category: ED,HL. Award Amount: Up to $150K per award.

The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) and participating components invite grant applications for research on the development of safe, real-time, non-invasive (or minimally invasive), in vivo methods to assess the development and function of the human placenta. Funding Opportunity Number: RFA-HD-14-005. Assistance Listing: 93.286,93.865. Funding Instrument: G. Category: HL,ISS.

NIST invites applications for a program involving technical and business engagement activities directed at small businesses participating in NIST’s Small Business Innovation Research Program. The TCAP recipient will provide NIST SBIR Phase I and/or Phase II recipients with technical and business expertise and resources to identify optimum pathways to promote successful transition of the Phase I and/or Phase II results to commercialization. Funding Opportunity Number: 2014-NIST-SBIR-02. Assistance Listing: 11.620. Funding Instrument: CA. Category: ST.

Pursuant to the Disaster Relief Appropriations Act, 2013 (Public Law No. 113-2, January 29, 2013) the National Passenger Railroad Corporation (Amtrak) is eligible to receive up to $81,291,500.00 in support of efforts to improve resiliency and mitigate potential impacts of future disasters in the Northeast Corridor. In order to receive these funds, Amtrak must complete the grant application and submit the following items electronically: Cover Letter; Application for Federal Assistance SF-424; SF-424D Assurances - Construction Programs; and signed copies of the U.S. Department of Transportation Federal Railroad Administration Assurances and Certification forms (http://www.fra.dot.gov/downloads/admin/assurancesandcertifications.pdf) Funding Opportunity Number: FR-SAN-13-004. Assistance Listing: 20.323. Funding Instrument: G. Category: T. Award Amount: Up to $50M per award.

This Funding Opportunity Announcement (FOA) solicits Small Business Technology Transfer (STTR) grant applications from small business concerns (SBCs) to develop medium- to high-throughput assays to evaluate the effects of toxicants on pluripotent or induced pluripotent cells with respect to cell differentiation and the resulting differentiated cell populations. The ability to incorporate genetic diversity in these assays would be useful.These assays will provide information on mechanisms of chemically-induced biological activity, help to prioritize chemicals for more extensive toxicological evaluation, support more predictive models of in vivo biological response, and potentially inform on the role of genetic diversity in toxicological effects. Funding Opportunity Number: RFA-ES-15-005. Assistance Listing: 93.113. Funding Instrument: G. Category: ENV,HL. Award Amount: Up to $225K per award.

This is a funding opportunity for NGO programs benefiting Colombian Refugees and Internally Displaced Persons (IDPs) in Colombia, Ecuador, Venezuela, Panama, and Costa Rica. For Colombian refugees, PRM seeks proposals that fill critical gaps in humanitarian assistance and local integration support for particularly vulnerable asylum seekers and refugees, including women, Afro-Colombians, and indigenous populations. Proposals should aim to improve beneficiaries’ self-reliance and increase the capacity of government institutions to provide basic services to address refugees’ needs. Programs offering basic humanitarian assistance, protection mechanisms, capacity building and institution strengthening, livelihoods, integration, and infrastructure development will be considered. For Colombian IDPs, PRM is looking to fund proposals that present comprehensive programs addressing immediate and emergency humanitarian assistance; capacity building and institution strengthening at the local and national level; and the provision of protection mechanisms. Proposals should include phase-out indicators and knowledge-sharing strategies for local authorities/ organizations to continue initiatives beyond the programs’ timelines.Proposals should be submitted separately for each country. The full announcement provides detailed guidance on the objectives that PRM seeks to meet. Funding Opportunity Number: PRM-PRMOAPWH-15-001. Assistance Listing: 19.518. Funding Instrument: CA. Category: O. Award Amount: $500K – $4.5M per award.

NOTICE OF INTENT TO AWARD This Funding Announcement is not a request for applications. This announcement is to provide public notice of the National Park Service (NPS), intention to fund the following project activities without competition. ABSTRACT Funding Announcement P15AS00371 Project Title The Role of Wildlife Health in Management of Wildlife as a Public Trust Resource Recipient Cornell University Total Anticipated Award Amount $37,661.00 Cost Share none Anticipated Length of Agreement From date of final signature to December 31, 2018 Anticipated Period of Performance From date of final signature to December 31, 2018 Award Instrument Cooperative Agreement Statutory Authority 54 USC 101702(a) & (b); 54 USC 100703 CFDA # and Title 15.945 Cooperative Research & Training Programs-Resources of NPS CESUs Single Source Justification Criteria Cited (2) Continuation Point of Contact June Zastrow 303-987-6718 june_zastrow@nps.gov OVERVIEW Project Description: Recently, elements of public trust thinking and good governance have been merged to produce a broad set of Wildlife Governance Principles (WGPs) that provide a concise framework agencies can use to ensure they meet these dual requirements in managing wildlife as a public trust resource. While the WGPs were developed in the general context of conservation, application to current governance practices of specific agencies or to specific topics is yet to occur. This task agreement will investigate the applicability of the WGPs to wildlife health management STATEMENT OF JOINT OBJECTIVES/PROJECT MANAGEMENT PLAN Through literature review and a series of sessions involving wildlife health professionals, wildlife managers, and human dimensions specialists, an explanation of how wildlife health is essential to long-term sustainability of the wildlife resource and addressing how wildlife health is imperative to management of wildlife as a public trust resource. This agreement will apply the WGPs as a framework for considering multiple perspectives and adopting processes that enable NPS to address wildlife health challenges that span social and ecological boundaries. This process is to be applied to a broad model of wildlife health and tiered to specific issue(s), such as management of zoonotic diseases (diseases shared between humans and other animals), diseases shared between wildlife and domestic livestock (e.g., brucellosis), or even the reproductive control of wildlife. Project schedule and objectives: Literature review (September 2015) Workshop to evaluate current NPS wildlife health governance practices in relation to WGPs (August 2016) Dependent on the availability of funds to add to this agreement through a modification, conduct a second workshop to apply a general model to specific NPS wildlife health issues (December 2016) Prepare a report on findings for submission to scientific journal(s) (March 2017) RECIPIENT INVOLVEMENT ��� Collaboratively undertake a project titled ���The Role of Wildlife Health in Management of Wildlife as a Public Trust Resource��� as described in this task agreement. ��� Work cooperatively with NPS to develop workshop agenda and participant list, and to implement the workshop. ��� Conduct follow-up discussions with NPS to identify specific NPS wildlife health issues for investigation, and if funds exist, conduct second workshop cooperatively with NPS. ��� Work cooperatively with NPS to write-up project findings for publication. NATIONAL PARK SERVICE INVOLVEMENT ��� Identify appropriate NPS employees for participation in workshop(s). ��� Collaborate on all phases of scientific investigation, including preparation of the manuscript for publication. ��� Provide funding any workshop(s) that may be held for this project. ��� Provide for the cost of publication of reports and manuscripts related to this project. SINGLE-SOURCE JUSTIFICATION DEPARTMENT OF THE INTERIOR SINGLE SOURCE POLICY REQUIREMENTS Department of the Interior Policy (505 DM 2) requires a written justification which explains why competition is not practicable for each single-source award. The justification must address one or more of the following criteria as well as discussion of the program legislative history, unique capabilities of the proposed recipient, and cost-sharing contribution offered by the proposed recipient, as applicable. In order for an assistance award to be made without competition, the award must satisfy one or more of the following criteria: (1) Unsolicited Proposal ��� The proposed award is the result of an unsolicited assistance application which represents a unique or innovative idea, method, or approach which is not the subject of a current or planned contract or assistance award, but which is deemed advantageous to the program objectives; (2) Continuation ��� The activity to be funded is necessary to the satisfactory completion of, or is a continuation of an activity presently being funded, and for which competition would have a significant adverse effect on the continuity or completion of the activity; (3) Legislative intent ��� The language in the applicable authorizing legislation or legislative history clearly indicates Congress��� intent to restrict the award to a particular recipient of purpose; (4) Unique Qualifications ��� The applicant is uniquely qualified to perform the activity based upon a variety of demonstrable factors such as location, property ownership, voluntary support capacity, cost-sharing ability if applicable, technical expertise, or other such unique qualifications; (5) Emergencies ��� Program/award where there is insufficient time available (due to a compelling and unusual urgency, or substantial danger to health or safety) for adequate competitive procedures to be followed. NPS did not solicit full and open competition for this award based the following criteria: (2) Continuation This is a Task Agreement (P15AC01712) under Cooperative Agreement (P12AC31164) in the amount of $37,661.00 with a period of performance from date of award until 12/31/2018. "This proposed project between Cornell University and the NPS is authorized to go through the Great Lakes Northern Forest CESU at the negotiated overhead rate of 17.5% because it passes the test of substantial involvement by the NPS, public purpose and consistency with the mission of the CESU Network". Funding Opportunity Number: P15AS00371. Assistance Listing: 15.945. Funding Instrument: CA. Category: ED,ELT,ENV,IS,NR,RD,ST. Award Amount: $1 – $38K per award.

This project will provide biostatistical support for Inventory and Monitoring Projects. The UWY, Department of Statistics will provide specialized statistical assistance through tenured, tenured track, and adjunct faculty, as well as graduate and post-doctoral students for a particular statistical problem, with Dr. Robinson serving as the principal investigator. Upon request, UWY will provide expertise in biological/ecological monitoring and research study designs and data analyses. They will provide support through the identification or review of study designs, consulting on preliminary sampling and sample size determination, consulting on all phases of project planning, work, analysis, and write ups including the review of reports or manuscripts for statistical methods used and interpretation of data. FWS will provide goals and objectives, data, plans, and the context of available Service resources for each individual request to allow UWY to provide the most valid and effective biostatistical consultation. Funding Opportunity Number: F16AS00020. Assistance Listing: 15.655. Funding Instrument: CA. Category: O. Award Amount: $2K – $95K per award.

This Funding Opportunity Announcement (FOA) invites Small Business Innovation Research (SBIR) grant applications from small business concerns (SBCs) for funding to perform research leading to the development of innovative technologies that may advance progress for early detection and assessment of individuals at risk and for early diagnosis, prognosis and follow-up of type 1 diabetes (T1D). Funding Opportunity Number: RFA-DK-15-024. Assistance Listing: 93.847. Funding Instrument: G. Category: FN,HL. Award Amount: $2M total program funding.

The FY15/16 Vision Research Program (VRP) Clinical Trial Award (CTA) supports research with the potential to have a major impact on the treatment or management of visual injury and/or dysfunction. Funding from this award mechanism must support a clinical trial and should not be used for preclinical research studies. To meet the intent of the FY15/16 VRP CTA, the research proposals must address one or more of the Capability Gaps listed below: Inadequate mitigation and treatment of damage to ocular structures and the visual system consequent to military-relevant injuries and diseases incident to military service. Research into ocular damage that occurs in the general public will also be considered, as there may be similarities and related treatments in the two populations. This includes but is not limited to: inadequate treatments and technologies for injuries and diseases to ocular structures and visual systems to include, optic neuropathy, retinal injury, lid and adnexal injuries and ocular polytrauma; inadequate strategies and techniques for controlling scarring and/or pathological healing response in traumatized ocular tissues. Inadequate vision restoration and regeneration: inability to restore form and function of lids, adnexal, orbital and ocular tissues (optic nerve, cornea, retina, and uvea) following injury; inadequate vision surrogates and appropriate rehabilitation. Lack of knowledge, capabilities, and equipment for early responders to diagnose and mitigate military-relevant eye injuries and diseases in austere or remote environments: lack of methods and/or devices to assist in the location of entrance wounds and rupture sites in traumatic eye injuries; lack of portable diagnostic tools and technologies for field use to detect ocular injuries and diseases. The five Focus Areas are listed below and have been developed to address the Capability Gaps listed above. All applications are highly encouraged to address at least one of the following Focus Areas: Phase I/Phase II clinical trials to evaluate safety and/or efficacy of treatments or technologies to reduce/control scarring and/or pathological healing response(s) after military-relevant ocular/visual system injury; Phase I/Phase II clinical trials to evaluate safety and/or efficacy of treatments or technologies restoring form and function to: (1) orbit and ocular tissues (optic nerve, retina, and uvea), (2) eyelid, and/or (3) adnexal structures; Phase I/Phase II clinical trials to demonstrate feasibility and safety and/or efficacy of vision surrogates for those with low or no vision post-injury and appropriate rehabilitation; Phase I/Phase II clinical trials for evaluation of technologies to identify the location of entrance wounds and rupture sites in traumatic eye injuries; Phase I/Phase II clinical trials for evaluation of technologies to detect and quantify white blood cells, red blood cells and proteins in both the aqueous and vitreous humor. Funding Opportunity Number: W81XWH-15-VRP-CTA. Assistance Listing: 12.420. Funding Instrument: CA,G. Category: ST. Award Amount: $6M total program funding.

The Fiscal Year 2015 (FY15) Joint Program Committee 8/Clinical and Rehabilitative Medicine Research Program (JPC-8/CRMRP) Extremity Regeneration Technology/Therapeutic Development Award (ERTTDA) is intended to support the translation of promising preclinical findings into products focused on extremity regeneration. The focus is on bone and soft tissue reconstruction, limb and tissue salvage technologies, and regenerative medicine technologies for the treatment of trauma-induced damage. All products in development should be responsive to the health care needs of military Service members, Veterans, and other Military Health System beneficiaries, as well as the general public. All applications must specifically and clearly address the military relevance of the proposed research.The product(s) to be developed may be a tangible item such as a pharmacologic agent (drugs or biologics) or device, or a knowledge-based product such as clinical guidance for standard of care. The Principal Investigator (PI) must provide a transition plan (including potential funding and resources) showing how the product will progress to the next level of development (e.g., clinical trials, delivery to the military or civilian market) after the completion of the award.Proof-of-concept demonstrating the potential utility of the proposed product, or a prototype/preliminary version of the proposed product, should already be established. Applicants must include relevant data that support the rationale for the proposed study. These data may be unpublished and/or from the published literature.Examples of the types of research that may be supported include, but are not limited to: Developing and validating clinical guidance/guidelines for standard of care; Testing new therapeutic modalities (agents, delivery systems, and chemical modification of lead compounds) using established or validated preclinical systems; Designing and implementing pilot or full-scale Good Manufacturing Practice (GMP) production of therapeutics and/or delivery systems for use in advanced preclinical and initial clinical trials; Developing pharmacologic agents through absorption, distribution, metabolism, excretion, and toxicity (ADMET) studies;Developing pharmacologic agents to Investigational New Drug (IND) stage for initiation of Phase I clinical trials; Developing prototype devices to Investigational Device Exemption (IDE) stage for initiation of clinical trials; Optimizing diagnostic or treatment devices for field deploymentTo meet the intent of the FY15 JPC-8/CRMRP ERTTDA, applicants must specifically address one or both of the Focus Areas listed below; (1) Treatments of soft tissue injury, specifically, nerve, muscle, and vascular injury to the extremities. The aim of these technologies is to: (a) maintain the structure and function of denervated end organs distal to a nerve injury; (b) restore functional muscle tissue; and (c) restore vascular perfusion. Both innovative definitive care solutions as well as innovative technologies that may better enable a definitive care solution to be delivered at some future time point, such as vascular shunting or stenting technologies, will be considered; (2) Treatments for bone healing, for example, technologies that create a wound environment more conducive to bone healing following injury to the extremities. Funding Opportunity Number: W81XWH-15-DMRDP-CRMRP-ERTTDA. Assistance Listing: 12.420. Funding Instrument: CA,G. Category: ST. Award Amount: $6.3M total program funding.

The Substance Abuse and Mental Health Services Administration, Center for Mental Health Services, is accepting applications for the fiscal year (FY) 2016 National Center for Child Traumatic Stress (NCCTS) grant. The purpose of the NCCTS is to develop and maintain a collaborative network structure, support resource and policy development and dissemination, and coordinate the network’s national child trauma education and training efforts. The NCCTS is part of the National Child Traumatic Stress Initiative (NCTSI). The purpose of NCTSI is to improve the quality of trauma treatment and services in communities for children, adolescents, and their families who experience or witness traumatic events, and to increase access to effective trauma-focused treatment and services for children and adolescents throughout the nation. The initiative is designed to address child trauma issues by creating a national network of grantees—the National Child Traumatic Stress Network (NCTSN) or Network—that works collaboratively to develop and promote effective trauma treatment and services for children, adolescents, and their families exposed to a wide array of traumatic events. The NCTSN is composed of three types of centers: • The National Center for Child Traumatic Stress (NCCTS) - (Category I) develops and maintains the collaborative network structure, supports resource development and dissemination, and coordinates the Network’s national child trauma education and training efforts. • The Treatment and Service Adaptation Centers - (Category II) provide national expertise and assume responsibility in the Network for specific areas of trauma, such as specific types of traumatic events, population groups, and service systems, and support the development and adaptation of effective trauma treatments and services for children, adolescents, and their families that can be implemented throughout the nation. • The Community Treatment and Services Centers - (Category III) are primarily service programs that implement and evaluate effective treatment and services in community settings and youth-serving service systems and collaborate with other NCTSN centers on clinical issues, service approaches, and policy, financing, and training issues. The NCCTS program seeks to address behavioral health disparities among racial and ethnic minorities by encouraging the implementation of strategies to decrease the differences in access, service use, and outcomes among the racial and ethnic minority populations served. (See PART II: Appendix F – Addressing Behavioral Health Disparities.) Children of deployed military personnel have more school, family, and peer-related emotional difficulties in comparison to national samples. Therefore, SAMHSA has identified military families as a priority population under this funding opportunity. The NCCTS is authorized under Section 582 of the Public Health Service Act, as amended. This announcement addresses Healthy People 2020 Mental Health and Mental Disorders Topic Area HP 2020-MHMD. Funding Opportunity Number: SM-16-003. Assistance Listing: 93.243. Funding Instrument: CA. Category: HL. Award Amount: Up to $6M per award.