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Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) Programs (National Center for Complementary and Integrative Health - NCCIH) is sponsored by National Institutes of Health (NIH) / National Center for Complementary and Integrative Health (NCCIH). The NCCIH SBIR/STTR programs support innovative research conducted by small businesses or small businesses in partnership with a research institution, focusing on complementary and integrative health interventions.
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Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) Programs | NCCIH U.S. Department of Health and Human Services National Institutes of Health Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) Programs Get Weekly Emails or the Semimonthly NCCIH Update e-Newsletter NCCIH’s Small Business Program The National Center for Complementary and Integrative Health (NCCIH) offers two distinct funding mechanisms that advance small businesses: The Small Business Innovation Research (SBIR) program The Small Business Technology Transfer (STTR) program Together, these programs are known as America’s Seed Fund.
The SBIR and STTR programs are one of the largest sources of early-stage capital for technology commercialization in the United States. Both programs allow U.S.-owned and -operated small businesses to engage in Federal research and development that has a strong potential for commercialization.
The National Institutes of Health’s (NIH) SBIR and STTR programs invest over 1 billion dollars each year into health and life science companies that are creating innovative technologies that align with NIH’s mission to improve health and save lives. A key objective is to translate promising technologies to the private sector and enable lifesaving innovations to reach consumer markets.
You can search for examples of projects currently funded by NCCIH by using NIH RePORTER . Understanding the SBIR/ STTR Programs Both the SBIR and STTR programs are divided into the three phases listed below. NIH has special Technical Assistance Programs to help small businesses move their technologies from the lab into the hands of customers.
The NIH Niche Assessment Program and the I-Corps at NIH program are for Phase I awardees, and the NIH Commercialization Accelerator Program is for Phase II or Phase IIB awardees. Phase I: Feasibility and Proof of Concept.
The objective of Phase I is to establish the technical merit, feasibility, and commercial potential of the proposed research/research and development (R/R&D) efforts and to determine the quality of performance of the small business awardee organization prior to providing further Federal support in Phase II. Click on “See More” below to view NCCIH-Specific Budget and Duration Policies. Phase II: Research/Research and Development.
The objective of Phase II is to continue the R/R&D efforts initiated in Phase I. Funding is based on the results achieved in Phase I and the scientific and technical merit and commercial potential of the project proposed in Phase II. Only Phase I awardees are eligible for a Phase II award.
Click on “See More” below to view NCCIH-Specific Budget and Duration Policies. Phase III: Commercialization. The objective of Phase III, where appropriate, is for the small business to pursue commercialization objectives resulting from the Phase I/II R/R&D activities.
The NIH SBIR/STTR programs do not fund Phase III, and NIH does not generally provide any Phase III funding to small businesses.
NIH also has a Fast-Track application that allows small businesses to submit one application for Phase I and Phase II, a Direct SBIR Phase II solicitation that permits small businesses to bypass a Phase I award if they have already proved the feasibility of their technology, and a Commercialization Readiness Pilot Program solicitation that can help support commercialization activities.
For more information about which solicitation is best suited for your small business, view the Funding page and speak to the appropriate SBIR/STTR program manager . NCCIH Participation in Fast-Track: NCCIH does not participate in the Fast-Track option through NCCIH-issued SBIR/STTR Funding Opportunity Announcements (FOAs).
If interested in pursuing a Fast-Track option via the Omnibus solicitations, please contact a member of the NCCIH SBIR/STTR team.
As listed in NOT-AT-20-017 , “NCCIH Policy Change to Budget Limit and Grant Durations for SBIR/STTR Phase I and Phase II Applications,” for budgetary, administrative or programmatic reasons, NCCIH may decide not to fund an application or may decrease the length of an award and/or the budget recommended by a review committee.
Through this Notice, NCCIH has revised its budget and duration policies for SBIR/STTR Phase I and Phase II applications. Generally, NCCIH will not fund: Phase I applications greater than $256,580 total costs for the duration of the project or project periods greater than 2 years. Phase II applications greater than $1,710,531 total costs for the duration of the project or project periods greater than 3 years.
For “ National Institutes of Health SBA-Approved SBIR/STTR Topics for Awards Over Statutory Budget Limitations ,” the Small Business Administration (SBA) has approved an NIH SBIR/STTR Topic Waiver list for which NCCIH generally will not fund: Phase I applications greater than $325,000 total costs per year or project periods greater than 2 years.
Phase II applications greater than $2,000,000 total costs for the duration of the project or project periods greater than 3 years. How To Apply: Step-By-Step Instructions This interactive infographic from the NIH SEED website provides step-by-step instructions on how to apply for SBIR and STTR grants. Click to view the full infographic .
Based on current listing details, eligibility includes: U. S. -owned and -operated small businesses. SBIR: permits partnering; STTR: requires a non-profit research institution partner. Applicants should confirm final requirements in the official notice before submission.
Current published award information indicates Phase I: up to $325,000; Phase II: up to $2,000,000 Always verify allowable costs, matching requirements, and funding caps directly in the sponsor documentation.
The current target date is April 9, 2026. Build your timeline backwards from this date to cover registrations, approvals, attachments, and final submission checks.
Federal grant success rates typically range from 10-30%, varying by agency and program. Build a strong proposal with clear objectives, measurable outcomes, and a well-justified budget to improve your chances.
Requirements vary by sponsor, but typically include a project narrative, budget justification, organizational capability statement, and key personnel CVs. Check the official notice for the complete list of required attachments.
Yes — AI tools like Granted can help research funders, draft proposal sections, and check compliance. However, always review and customize AI-generated content to reflect your organization's unique strengths and the specific requirements of the solicitation.
Review timelines vary by funder. Federal agencies typically take 3-6 months from submission to award notification. Foundation grants may be faster, often 1-3 months. Check the program's timeline in the official solicitation for specific dates.
Many federal programs offer multi-year funding or allow competitive renewals. Check the official solicitation for continuation and renewal policies. Non-competing continuation applications are common for multi-year awards.