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Foundations for Digital Twins as Catalyzers of Biomedical Technological Innovation (FDT-BioTech) is sponsored by National Science Foundation (NSF) / National Institutes of Health (NIH) / Food and Drug Administration (FDA). This program supports interdisciplinary research projects that underpin the mathematical and engineering foundations behind the development and use of digital twins and synthetic data in biomedical and healthcare applications, with a particular focus on digital, in silico models…
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Foundations for Digital Twins as Catalyzers of Biomedical Technological Innovation (FDT-BioTech) | NSF - U.S. National Science Foundation Foundations for Digital Twins as Catalyzers of Biomedical Technological Innovation (FDT-BioTech) NSF's implementation of the revised 2 CFR NSF Financial Assistance awards (grants and cooperative agreements) made on or after October 1, 2024, will be subject to the applicable set of award conditions, dated October 1, 2024, available on the NSF website .
These terms and conditions are consistent with the revised guidance specified in the OMB Guidance for Federal Financial Assistance published in the Federal Register on April 22, 2024.
Important information for proposers All proposals must be submitted in accordance with the requirements specified in this funding opportunity and in the NSF Proposal & Award Policies & Procedures Guide (PAPPG) that is in effect for the relevant due date to which the proposal is being submitted. It is the responsibility of the proposer to ensure that the proposal meets these requirements.
Submitting a proposal prior to a specified deadline does not negate this requirement.
Updates to NSF Research Security Policies On July 10, 2025, NSF issued an Important Notice providing updates to the agency's research security policies, including a research security training requirement, Malign Foreign Talent Recruitment Program annual certification requirement, prohibition on Confucius institutes and an updated FFDR reporting and submission timeline.
Supports interdisciplinary research projects that explore the mathematical and engineering foundations behind the development and use of digital twins in biomedical and healthcare applications. Supports interdisciplinary research projects that explore the mathematical and engineering foundations behind the development and use of digital twins in biomedical and healthcare applications.
The Foundations for Digital Twins as Catalyzers of Biomedical Technological Innovation (FDT-BioTech) program supports inherently interdisciplinary research projects that underpin the mathematical and engineering foundations behind the development and use of digital twins and synthetic data in biomedical and healthcare applications, with a particular focus on digital, in silico models used in the evaluation of medical devices and the relevance of the developed models in addressing current and emerging challenges affecting the development and assessment of biomedical technologies.
The goal of the FDT-BioTech initiative is to catalyze biomedical technological innovation through new foundational development of methods and algorithms relevant to digital twins and synthetic humans.
May 15, 2024 - DMS Virtual Office Hour April 22, 2024 - FDT-BioTech webinar Awards made through this program Browse projects funded by this program Map of recent awards made through this program Directorate for Mathematical and Physical Sciences (MPS) Division of Mathematical Sciences (MPS/DMS) Directorate for Computer and Information Science and Engineering (CISE) Office of Advanced Cyberinfrastructure (CISE/OAC)
Based on current listing details, eligibility includes: Institutions of Higher Education, non-profit organizations, and other research institutions; collaborative multi-organization projects permitted with combined budget cap of $1,000,000. Applicants should confirm final requirements in the official notice before submission.
Current published award information indicates $4,000,000 to $5,000,000 Always verify allowable costs, matching requirements, and funding caps directly in the sponsor documentation.
The current target date is May 4, 2026. Build your timeline backwards from this date to cover registrations, approvals, attachments, and final submission checks.
Federal grant success rates typically range from 10-30%, varying by agency and program. Build a strong proposal with clear objectives, measurable outcomes, and a well-justified budget to improve your chances.
Requirements vary by sponsor, but typically include a project narrative, budget justification, organizational capability statement, and key personnel CVs. Check the official notice for the complete list of required attachments.
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