Limited Competition: National Primate Research Centers (P51) is a grant from the National Institutes of Health (NIH), administered through the Division of Program Coordination, Planning, and Strategic Initiatives (ORIP), that funds the operation of National Primate Research Centers providing shared research infrastructure and nonhuman primate models for biomedical research.

This is a limited competition open only to existing center grantees and does not allow clinical trials. The funding opportunity has been updated to align with current agency priorities. Eligible applicants include universities, nonprofits, state and local governments, and foreign institutions meeting the limited competition criteria.

The application deadline is May 25, 2026.

PAR-23-126: Limited Competition: National Primate Research Centers (P51) (Clinical Trials Not Allowed) This funding opportunity was updated to align with agency priorities. Carefully reread the full funding opportunity and make any needed adjustments to your application prior to submission. Department of Health and Human Services Part 1.

Overview Information Participating Organization(s) National Institutes of Health ( NIH ) Components of Participating Organizations Division of Program Coordination, Planning and Strategic Initiatives, Office of Research Infrastructure Programs ( ORIP ) Funding Opportunity Title Limited Competition: National Primate Research Centers (P51) (Clinical Trials Not Allowed) P51 Primate Research Center Grants September 9, 2025 - Notice of Extension of the Expiration Date for PAR-23-126 " Limited Competition: National Primate Research Centers (P51) (Clinical Trials Not Allowed)".

See Notice NOT-OD-25-149 March 31, 2025 - This funding opportunity was updated to align with agency priorities. Carefully reread the full funding opportunity and make any needed adjustments to your application prior to submission. April 04, 2024 - Overview of Grant Application and Review Changes for Due Dates on or after January 25, 2025.

See Notice NOT-OD-24-084 October 26, 2022 - Reminder: FORMS-H Grant Application Forms & Instructions Must be Used for Due Dates On or After January 25, 2023 - New Grant Application Instructions Now Available. See Notice NOT-OD-23-012 . August 31, 2022 - Implementation Changes for Genomic Data Sharing Plans Included with Applications Due on or after January 25, 2023.

See Notice NOT-OD-22-198 . August 8, 2022 - New NIH "FORMS-H" Grant Application Forms and Instructions Coming for Due Dates on or after January 25, 2023. See Notice NOT-OD-22-195 .

August 5, 2022 - Implementation Details for the NIH Data Management and Sharing Policy. See Notice NOT-OD-22-189 . Funding Opportunity Announcement (FOA) Number Companion Funding Opportunity See Section III.

3. Additional Information on Eligibility . Assistance Listing Number(s) Funding Opportunity Purpose This funding opportunity announcement (FOA) encourages grant applications that support the activities of the National Primate Research Centers (NPRCs).

Nonhuman primates (NHPs) are most closely related to humans, both physiologically and genetically. Therefore, NHPs are critical animal models for basic and translational research aimed at understanding human biology, both in normal and diseased states.

Proper husbandry and management of NHPs require specialized physical and intellectual resources, which are most effectively and economically provided in centralized primate centers, the resources of which are made available to investigators on a national basis.

The NPRCs provide these resources to investigators/grantees who utilize NHPs in biomedical research and thereby complement and help enable the missions of the NIH Institutes and Centers. Open Date (Earliest Submission Date) Letter of Intent Due Date(s) The following table includes NIH standard due dates marked with an asterisk.

Dates in bold and italics reflect changes per NOT-OD-25-149 Application Due Dates Review and Award Cycles New Renewal / Resubmission / Revision (as allowed) AIDS Scientific Merit Review Advisory Council Review Earliest Start Date Not Applicable September 25, 2023 * Not Applicable March 2024 May 2024 July 2024 Not Applicable January 25, 2024 * Not Applicable July 2024 October 2024 December 2024 Not Applicable May 25, 2024 * Not Applicable November 2024 January 2025 April 2025 Not Applicable September 25, 2024 * Not Applicable March 2025 May 2025 July 2025 Not Applicable January 25, 2025 * Not Applicable July 2025 October 2025 December 2025 Not Applicable May 25, 2025 * Not Applicable November 2025 January 2026 April 2026 Not Applicable September 25, 2025 * Not Applicable March 2026 May 2026 July 2026 Not Applicable January 25, 2026 * Not Applicable July 2026 October 2026 December 2026 Not Applicable May 25, 2026 * Not Applicable November 2026 January 2027 April 2027 Not Applicable September 25, 2026 * Not Applicable March 2027 May 2027 July 2027 All applications are due by 5:00 PM local time of applicant organization.

Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date. New Date September 26, 2026 per issuance of NOT-OD-25-149 .

(Original Expiration Date: May 26, 2026 ) Required Application Instructions It is critical that applicants follow the Multi-Project (M) Instructions in the SF424 (R&R) Application Guide , except where instructed to do otherwise (in this FOA or in a Notice from the NIH Guide for Grants and Contracts ). Conformance to all requirements (both in the Application Guide and the FOA) is required and strictly enforced.

Applicants must read and follow all application instructions in the Application Guide as well as any program-specific instructions noted in Section IV. When the program-specific instructions deviate from those in the Application Guide, follow the program-specific instructions. Applications that do not comply with these instructions may be delayed or not accepted for review.

There are several options available to submit your application through Grants. gov to NIH and Department of Health and Human Services partners. You must use one of these submission options to access the application forms for this opportunity.

Use the NIH ASSIST system to prepare, submit and track your application online. Use an institutional system-to-system (S2S) solution to prepare and submit your application to Grants. gov and eRA Commons to track your application.

Check with your institutional officials regarding availability. Part 1. Overview Information Part 2.

Full Text of Announcement Section I. Funding Opportunity Description Section II. Award Information Section III.

Eligibility Information Section IV. Application and Submission Information Section V. Application Review Information Section VI.

Award Administration Information Section VII. Agency Contacts Section VIII. Other Information Part 2.

Full Text of Announcement Section I. Funding Opportunity Description The Office of Research Infrastructure Programs (ORIP) of the National Institutes of Health (NIH) funds the National Primate Research Center (NPRC) program, the goal of which is to facilitate the effective use of nonhuman primates (NHPs) by scientists engaged in biomedical research.

The NPRC program complements and enables the missions of the NIH Institutes and Centers by providing the NHPs, expertise, and resources required to study specific diseases. ORIP’s Division of Comparative Medicine (DCM) funds seven NPRCs, which are centralized facilities in various parts of the country and are available to investigators on a national basis.

Individual NPRCs can have specific areas of emphasis, but each is expected to provide a variety of services, both individually and through inter-NPRC collaborations, to a wide range of investigators. Applicants to this FOA are limited to existing NPRCs. Investigators who want to use the resources available at the NPRCs should consult https://orip.

nih. gov/resource-directory/national-primate-research-centers . Objectives of the NPRC Program The overall objective of the NPRC program is to provide support for scientists who use NHPs in their research.

This is accomplished by funding NPRCs that provide the animals, facilities, and expertise needed to enable research using NHPs. More specifically, support is provided to: Develop and sustain national resources for normative data, consultative and collaborative expertise, biologic and genetic material, and specialized facilities, equipment, and capabilities that support NHP-related research.

Enhance rigor and reproducibility in NHP research by assisting investigators with experimental design, methodology, data analysis and interpretation, and standardized reporting of study results. Breed and provide animals suitable for research using NHPs. Study the biology of NHP species that are of potential research importance for the purpose of enhancing their scientific utility, health, and well-being.

Continue to develop and enhance practices of NHP breeding, husbandry, and methods to provide high quality animals to meet research needs for pedigreed, genetically defined, and disease-free animals (e.g., specific pathogen free). Develop additional methods to define animals in terms of phenotypic, immunological, or metabolic status. Develop and validate NHP models of human disease and facilitate their use.

Conduct pilot (basic and applied) biomedical research projects in areas requiring use of NHPs. Pilot projects are aimed at helping to solve problems related to human health, and they should lead to independent grant support related to the disease or health condition being studied.

Provide opportunities for local, national, and international research involvement and experience in primatology to graduate and undergraduate students, postdoctoral fellows, visiting scientists, and faculty members, as well as short-term learning assignments for students in the health professions.

Disseminate the findings of studies and technical advances in NHP research to the scientific community via reports published in internationally recognized, peer-reviewed journals and other appropriate media. NPRCs should promote data sharing, including providing leadership in novel data sharing models, such as the Open Lab Notebook initiative for emerging disease research.

Provide outreach by publicizing their capabilities on a national level, as well as educating the public about research at the NPRCs and the link between animal research and improvements in human health. An NPRC receives funding from ORIP through a base grant using the NIH P51 activity code funded through this FOA (hereafter referred to as the P51 base grant). The P51 base grant provides the nucleus of support for the NPRC.

By accepting the grant award, the grantee institution agrees to make the facilities and resources available to affiliate and visiting scientists from other institutions, as well as to its own scientists. The P51 base grant is not intended to provide the total funding for the NPRC.

Funding of NPRC operations should be augmented by other sources such as program income, peer-reviewed research grants, contracts, or cooperative agreements and other sources, as appropriate. An NPRC is a distinct organizational and structural entity affiliated with a major research institution.

The grantee institution is the recipient of the P51 base grant funds and assumes legal responsibility and accountability for use and disposition of these funds in accordance with Public Health Service (PHS) policy. The grantee institution is responsible for the scientific programs being conducted at, with, or through the NPRC.

The grantee institution is responsible for the academic environment of the NPRC by providing access to joint appointments in appropriate departments and by encouraging cooperative activities and interchange between the NPRC and the grantee institution’s other scientific and technical staff.

The P51 base grant supports the specialized facilities, scientific and technical personnel, and NHP species needed for the conduct of biomedical and behavioral research. Activities and costs supported by the P51 base grant can include, but are not limited to: Personnel, including salaries for: The NPRC Director (i.e., Center Director) and Associate and Assistant Director(s).

Clinical veterinarians, veterinary technical support, and animal care staff. Administrative staff and support services if clearly justified and not included as Facilities and Administration (F&A) costs. Personnel, including pathologists and behaviorists, involved in monitoring and maintaining the health of the NPRC animals and providing for the care and well-being of those animals.

Core scientists and technical staff. Establishment, development, and maintenance of animal colonies, including the base breeding colony/colonies. Maintenance, operation, and renovation of the NPRC buildings and outdoor facilities, except for those costs reimbursed under F&A rates.

Central administration of the NPRC, except for those costs reimbursed under F&A rates. Pathology services, including surveillance of diseases in the colony. Clinical laboratory services related to colony health surveillance and support of research.

Genetic and genomic services used for colony management and characterization. Bioengineering, imaging, and computation services, with costs and charges consistent with grantee institution practices. The animal colony records systems.

Some NPRCs include databases and informational services associated with finance, administration, and operations in the animal colony records system. Other NPRC-specific information technology (IT) support services, except for those costs reimbursed under F&A rates. Activities and services associated with consortium-based activities.

Outreach activities directed toward the scientific community and public. Organizational Structure and Operating Procedures of the NPRC The specific content of the grant application will depend on the organizational structure of the NPRC. In general, an NPRC is comprised of major functional components, which may include individual units.

Individual NPRCs have latitude regarding functional organization, which may depend, in part, on the requirements of the grantee institution and on the specific activities of the NPRC.

A unit is defined as a functional group within an NPRC that has an internal organizational chart and reporting structure, as well as specific resources and responsibilities that make an essential contribution to the research activities and day-to-day operations of the NPRC. These units are described in the renewal application for the NPRC and are peer-reviewed.

The Center Director is a senior scientist appointed by the PD(s)/PI(s) and the grantee institution and approved by DCM/ORIP. The Center Director is responsible for the day-to-day management and scientific direction of the NPRC.

The Center Director must be an established scientist with a doctoral degree in one of the health sciences disciplines and must have a proven track record of scientific leadership related to NHP research (e.g., PI on peer-reviewed research grants and/or development and leadership of high-impact team science initiatives).

The Center Director must possess expertise and have demonstrated experience in both effective NHP-related administrative oversight and scientific leadership. The Center Director is responsible to the PD(s)/PI(s) and derives a significant portion of his or her salary for providing scientific leadership and administrative oversight of the NPRC.

Support for a Center Director from the P51 base grant is normally between 25 percent and 75 percent of a full-time equivalent for administrative responsibilities. Requests for exceptions must be approved by ORIP. The Center Director is considered key personnel for the purpose of the Notice of Award for the P51 grant.

DCM/ORIP must approve the appointment of the Center Director by the grantee institution. The Administration of the NPRC is covered by the required Governance Unit and Administrative Units, which should provide services across the entire NPRC. These units are usually under the direct supervision of the Center Director or his/her designee.

The Governance Unit covers the NPRC administrative leadership that oversees the functions of the NPRC, including obtaining input from advisory committees. Examples of Administrative Units include the following: Director's Office, Business Office, Environmental Health and Safety, Information Technology, Bioengineering Services, Machine Shop, Education and Training Programs, and Public Affairs Office.

The specific titles of these units may differ among NPRCs. Each NPRC must have a National Scientific Advisory Board (NSAB), which provides guidance to the PD(s)/PI(s) and Center Director on all aspects of the NPRC, including scientific direction. The NSAB reports to the PD(s)/PI(s) of the NPRC.

The NSAB must consist of at least six experts in NHP research, such as senior scientists or relevant administrators, from outside the NPRC and grantee institution. Overall, the composition of the NSAB must reflect the range of technical subjects that are pursued at the NPRC. It is permissible to have limited representation (maximum of two members) on the NSAB from other NPRCs, which may facilitate NPRC consortium activities.

Individuals serving on the NSAB are appointed annually (1-year terms), are typically reappointed for 3-5 consecutive terms and may serve concurrently on the NSAB of, at most, one other NPRC.

The NSAB must meet at the NPRC as a full group or as specialty subgroups, at least on an annual basis, to review and provide advice regarding the development and conduct of the NPRC’s scientific programs, resource programs and general policies.

Periodic teleconferences or videoconferences involving the entire NSAB or a subcommittee may be scheduled between annual meetings to address continuing or unanticipated scientific or administrative issues at the NPRC. The NSAB must have a chairperson, who is appointed by the NPRC Director, in consultation with the PD/PI.

A record of the conclusions of the NSAB must be maintained in the office of the Center Director and made available for review site visits and DCM program staff visits. Each NPRC also must have a Research Advisory Committee (RAC), which provides advice to the Center Director regarding prioritization of projects and resources. Final decisions regarding prioritization are at the discretion of the Center Director.

The RAC must consist of at least four members appointed by the Center Director. Members of the RAC must be core scientists, who represent the functional units within the NPRC. The RAC must meet at least monthly to discuss the research programs of the NPRC and to review all new project proposals that will use NPRC resources regarding feasibility in the context of NPRC capabilities.

In addition, the RAC must review the scientific merit of all new project proposals that have not undergone NIH peer review and that will use NPRC resources. Records summarizing the recommendations of the RAC must be maintained in the office of the Center Director and made available at review site visits and DCM program staff visits.

Animal Resources are maintained by the NPRC through the Colony Management Unit and Animal Resources Units. Each NPRC is required to have a Colony Management Unit to support efficient and humane management of NHP breeding colonies, which serve several units of the NPRC as well as meeting national needs. The Colony Management Unit operates under the direct supervision of the Center Director or his/her designee (e.g., Associate Director).

NPRCs that have limited space for breeding colonies can fund breeding colonies at other sites. In this case, the NPRC that funds the off-site breeding colony will have the primary responsibility for decisions regarding its management. The NPRC must be able to provide animals upon request from existing pools of research animals while maintaining an appropriate number of animals for breeding purposes.

A computer-based system for tracking animals in the research and breeding colonies must be well-established. Additional Animal Resource units vary widely among the various NPRCs. Many units within Animal Resources function across several or all units of the NPRC.

Some units sustain animal well-being, clinical care, or animal research procedures and, therefore, serve several specific units of the NPRC. Various NHP species can be accommodated at an NPRC. Generally, demand on a national level and availability are necessary for support of a given species through the P51 base grant.

The major support for infrastructure, space, and resources should be used for maintenance and husbandry of those species for which there is major national demand. Additional factors, such as conditions and practices to allow social interactions that contribute to the psychological well-being of the animals may also influence resource allocation for a given species.

The NPRC must have programs in place to maintain the genetic diversity of animal colonies and for environmental enrichment. Animal colonies must meet the following criteria: The NPRC must maintain an exemplary program of animal care and use consistent with current PHS policy. Basic evidence for this is accreditation by the Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC) International.

All animals must be procured, owned, and quarantined by the NPRC, unless a specific exemption is authorized by the Center Director. To the extent feasible, the NPRC must breed and characterize the NHPs needed for its programs. In cases where facilities for breeding are limited, an NPRC’s animals can be bred at another facility.

Animals may be exchanged among NPRCs as appropriate. The NPRC must maintain control of all of its animals, either physically or through appropriate contractual arrangements. This includes space assignment of animals, removal or reentry of NHPs to the NPRC, animal health and care, including humane treatment and attention to psychological well-being, and all other aspects of the use of animals within the NPRC.

Non-primate species can be used and housed at an NPRC if at least one of the following conditions is met: a) The non-primate species is appropriate for preliminary or pilot studies on development of techniques and procedures in preparation for definitive studies in NHPs; b) Use of the non-primate species will conserve NHP resources and the endpoint studies will be conducted in NHPs; c) The non-primate species is used to develop expertise and technology in newly developing fields of research that can be applied to NHPs; d) The non-primate species is used to study inter-species relationships with NHPs, and it is reasonable to assume that the studies may have direct applicability to NHP research; and/or e) The non-primate species is used as an adjunct to studies on NHP species.

An NPRC must have a pilot research program and must fund at least one pilot research project per year. The number of pilot research projects supported by the P51 base grant can vary, depending on the availability of funds and is at the discretion of the Center Director. Pilot research must include activities related to the use of NHPs for biomedical research or for studies enhancing the welfare or husbandry of NHPs.

Pilot research should be developmental or high risk and should be used to generate preliminary data or results necessary to apply for support from sources of funding such as NIH R01 grants. From time to time, specific areas of research (for example, genetics or regenerative medicine) may be emphasized by researchers using NHPs. The NPRCs can specifically solicit pilot projects in particular topical areas.

All of the funded pilot project grant applications should be available to reviewers at the time of the site visit. The following guidelines apply to the use of P51 base grant funds to support pilot research projects: All activities related to the use of NHPs must be conducted on-site at the NPRC. Other activities can be performed at other sites, depending on the nature of the pilot project.

As relevant, a subcontracting mechanism within the pilot project can be used to support a portion of the pilot project performed outside of the grantee institution. Pilot research funds may not be used to provide interim support for established projects or for investigations funded from other sources. All pilot research projects must be planned, conducted, and carried out under the supervision of at least one core scientist at the NPRC.

A core scientist must assume responsibility for overall management, coordination, and progress reports. Pilot projects can be performed either by NPRC personnel or by qualified personnel who are not NPRC core scientists. The lead investigator of a pilot project need not be an NPRC core scientist.

However, NPRC personnel must be involved in some capacity in the pilot project. At least one-half of funded pilot projects over the award period must involve the active participation of investigators external to the NPRC and grantee institution. Targeting investigators who have not previously used NHPs is encouraged.

A portion of the funded pilot projects should involve non-tenured early stage investigators (individuals who have completed their terminal research degree or end of post-graduate clinical training, whichever date is later, within the past 10 years and who have not previously competed successfully as PD/PI for a substantial NIH independent research award).

Projects from early stage scientists should be given priority in the selection process. The NPRC must publicize its pilot research program on a national level beyond the NPRC and grantee institution, for example, through a website, providing information at national meetings, etc. Individual NPRCs are given discretion regarding the format and length of the pilot proposal.

However, the proposal must contain sufficient information to allow evaluation of merit from the written application alone by the NPRC’s review committee. The research project plan and budget must be reviewed and approved by the Center Director or his/her designee.

The Center Director must appoint a review committee of not less than four members, who will evaluate proposals and provide advice to either the Center Director or his/her designee as Director of the Pilot Program regarding priorities for support. At least two of the four reviewers must be from outside the NPRC and the grantee institution but can be affiliate scientists.

Each NPRC should institute a scoring system for evaluation and a means for obtaining short written critiques of the proposal from the review committee. The written critiques and scores must be maintained by the Center Director and made available to DCM staff during a programmatic site visit or to an NIH peer review committee during a site visit.

The NPRC may propose an expedited review process to be used under ORIP-approved exceptional circumstances. This exception involves urgently needed research that will use NHPs to understand the pathology of and/or development of vaccines or therapies for infection of an emerging pathogen that involves significant public health risk. ORIP Program staff will approve the exception request from the NPRCs to invoke the expedited review.

Prioritizing Requests for NPRC Resources Requests for use of available NPRC resources (including animals, space, core facilities, etc.) must be prioritized from highest to lowest priority as follows, with investigators funded by: 1. NIH extramural grants (highest priority). 2.

NIH intramural funding. 3. Other Federal Agency or State funding.

4. Nonprofit or not-for-profit funding. If a proposed project is funded by more than one source, the highest priority source should be used for determining priorities.

Within the above categories, projects must be prioritized on a first-come, first-served basis, with no preference given to scientists within the grantee institution or NPRC versus scientists from outside the grantee institution. See Section VIII. Other Information for award authorities and regulations.

Section II. Award Information Grant: A support mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity. Application Types Allowed The OER Glossary and the SF424 (R&R) Application Guide provide details on these application types.

Only those application types listed here are allowed for this FOA. Not Allowed: Only accepting applications that do not propose clinical trials. Need help determining whether you are doing a clinical trial?

Funds Available and Anticipated Number of Awards The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications. Application budgets are not limited but need to reflect the actual needs of the proposed project. Renewal (Type 2) or Resubmission applications may propose no more than a 5 percent (direct cost) increase from the last non-competing year.

Budgets exceeding this amount will not be accepted. The scope of the proposed project should determine the project period. The maximum project period is 5 years.

NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this FOA. Section III. Eligibility Information Eligible Organizations Only grantees previously funded under PAR-17-144 or PAR-20-181 are eligible to apply.

Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement , are not allowed.

Applicant organizations must complete and maintain the following registrations as described in the SF 424 (R&R) Application Guide to be eligible to apply for or receive an award. All registrations must be completed prior to the application being submitted. Registration can take 6 weeks or more, so applicants should begin the registration process as soon as possible.

The NIH Policy on Late Submission of Grant Applications states that failure to complete registrations in advance of a due date is not a valid reason for a late submission. System for Award Management (SAM) Applicants must complete and maintain an active registration, which requires renewal at least annually . The renewal process may require as much time as the initial registration.

SAM registration includes the assignment of a Commercial and Government Entity (CAGE) Code for domestic organizations which have not already been assigned a CAGE Code. NATO Commercial and Government Entity (NCAGE) Code Foreign organizations must obtain an NCAGE code (in lieu of a CAGE code) in order to register in SAM. Unique Entity Identifier (UEI) - A UEI is issued as part of the SAM.

gov registration process. The same UEI must be used for all registrations, as well as on the grant application. eRA Commons - Once the unique organization identifier is established, organizations can register with eRA Commons in tandem with completing their Grants.

gov registration; all registrations must be in place by time of submission. eRA Commons requires organizations to identify at least one Signing Official (SO) and at least one Program Director/Principal Investigator (PD/PI) account in order to submit an application. Grants.

gov Applicants must have an active SAM registration in order to complete the Grants. gov registration. Program Directors/Principal Investigators (PD(s)/PI(s)) All PD(s)/PI(s) must have an eRA Commons account.

PD(s)/PI(s) should work with their organizational officials to either create a new account or to affiliate their existing account with the applicant organization in eRA Commons. If the PD/PI is also the organizational Signing Official, they must have two distinct eRA Commons accounts, one for each role. Obtaining an eRA Commons account can take up to 2 weeks.

Eligible Individuals (Program Director/Principal Investigator) Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with his/her organization to develop an application for support.

For institutions/organizations proposing multiple PDs/PIs, visit the Multiple Program Director/Principal Investigator Policy and submission details in the Senior/Key Person Profile (Expanded) Component of the SF424 (R&R) Application Guide. The PD/PI is designated by the grantee institution and has ultimate responsibility for the conduct of NPRC operations.

The NIH communicates with the PD/PI on broad institutional issues relating to the NPRC. The PD/PI should hold a position in the grantee institution that crosses organizational lines, for example, as the Vice President for Research or Dean of a graduate school, medical school or health sciences center.

The PD/PI must occupy a senior level position in the grantee institution to assure administrative continuity of the NPRC’s programs and to avoid dependence on individual departments within the grantee institution. The PD/PI of an NPRC is required to commit a measurable effort to the P51 base grant (at least 1% effort without salary support under the P51).

This FOA does not require cost sharing as defined in the NIH Grants Policy Statement . 3. Additional Information on Eligibility Applicant organizations may submit more than one application, provided that each application is scientifically distinct.

The NIH will not accept duplicate or highly overlapping applications under review at the same time, per 2. 3. 7.

4 Submission of Resubmission Application . This means that the NIH will not accept: A new (A0) application that is submitted before issuance of the summary statement from the review of an overlapping new (A0) or resubmission (A1) application. A resubmission (A1) application that is submitted before issuance of