DOE Grants

Small Business Innovation Research (SBIR) Program Phase I (DOE Genesis Mission) is sponsored by U.S. Department of Energy (DOE) Office of Technology Commercialization (OTC). This DOE SBIR Phase I opportunity focuses on the Genesis Mission, supporting breakthrough technologies in areas including "Scaling the Biotechnology Revolution." Projects related to Pichia pastoris, particularly in areas of biotechnology for energy production, biomaterials, or sustainable processes, would be relevant. This is a pitch-first application process.

Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs (Genesis Mission Phase I) is sponsored by U.S. Department of Energy (DOE) Office of Technology Commercialization (OTC). This Phase I opportunity, focused on DOE's Genesis Mission, supports technologies in four areas including "Scaling the Biotechnology Revolution." Pichia pastoris is a significant host for biotechnology, particularly in the production of enzymes, biopharmaceuticals, and other biomolecules. Proposals advancing biotechnology, especially those with strong commercial potential and alignment with DOE mission areas, would be relevant.

DOE Genesis Mission SBIR/STTR Phase I Funding Opportunity is sponsored by U.S. Department of Energy (DOE) Office of Technology Commercialization (OTC). This funding opportunity supports small businesses in developing breakthrough technologies that advance DOE's Genesis Mission. The opportunity targets four AI-driven topic areas: biotechnology, quantum computing, materials design, and autonomous laboratories.

Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs (aligned with Genesis Mission for AI) is sponsored by U.S. Department of Energy (DOE). The DOE SBIR/STTR programs, aligned with the Genesis Mission, invite American small businesses to develop breakthrough technologies that advance U. S. leadership in artificial intelligence (AI).

Funding for Optimal Comprehensive Universal Screeners (FOCUS) Cohort 2 Year 2 - Continuation is sponsored by New Jersey Department of Education (NJDOE). This continuation grant supports public Local Education Agencies (LEAs) that previously received FOCUS grants. The program focuses on high-quality literacy screening assessments aligned with the New Jersey Literacy Framework, professional development, and student support.

CAREER READY EARLY SCHOLARS PROGRAM (CRESP) GRANT is sponsored by District of Columbia Department of Employment Services (DOES). This grant supports District youth aged 9-13 by offering comprehensive career and educational exploration activities. These include occupational skills training, academic enrichment, life skills development, and work readiness training during the summer. This aligns with community training and youth development goals.

SBIR/STTR Topic 5: Critical Minerals and Materials Innovation is sponsored by Department of Energy (DOE). This Phase II opportunity supports eligible technologies originally associated with subtopics under Topic Area 5 of the DOE SBIR FY24 Phase I Release 2 opportunity. Projects should build on prior DOE-supported research and present a feasible plan for prototype development, technical validation, market entry, customer acquisition, strategic partnerships, and long-term competitive advantage. This is a Phase II opportunity, requiring completion of a qualifying DOE SBIR/STTR Phase I, Phase II, or follow-on Phase II award in FY24 or FY25. Projects focus on critical minerals and materials innovation, which can include rare earth recovery and potentially AI process control.

Continuations of Solicitation for the Office of Science Financial Assistance Program (DE-FOA-0003600) is sponsored by U.S. Department of Energy (DOE) Office of Science. This is an open solicitation from the DOE Office of Science that accepts proposals year-round in various research topic areas spanning the Office of Science program areas.

Science Undergraduate Laboratory Internships (SULI) program and Community College Internships (CCI) program is sponsored by U.S. Department of Energy (DOE) Isotope Program (DOE IP). These internship programs offer mentored research opportunities in science and engineering fields supporting the DOE mission, including nuclear energy and technology, for undergraduate and community college students.

DOE Office of Science Financial Assistance Program is a grant from the U.S. Department of Energy (DOE) Office of Science that funds basic and applied scientific research across multiple disciplines including Advanced Scientific Computing Research, Basic Energy Sciences, Biological and Environmental Research, Fusion Energy Sciences, High Energy Physics, Nuclear Physics, and Isotope R&D and Production. This continuing solicitation (DE-FOA-0003600) covers FY 2026 funding from September 30, 2025 through September 30, 2026. A pre-application is optional but encouraged, and may be required for consideration by certain review panels. Eligible applicants include universities, research institutions, national laboratories, and other entities engaged in scientific research within the DOE's priority areas. Applications are accepted on a rolling basis throughout the fiscal year under the Open Solicitation for the Office of Science Financial Assistance Program.

Continuations of Solicitation for the Office of Science Financial Assistance Program is sponsored by U.S. Department of Energy (DOE) Office of Science. This program issues announcements to solicit research proposals from various entities, including colleges and universities, non-profit and for-profit research organizations, DOE's national laboratories, small businesses, and other federal research organizations. Research topics must fall within the programmatic priorities of DOE's Office of Science.

The FY 2026 Continuation of Solicitation for the Office of Science Financial Assistance Program is an open annual grant from the U.S. Department of Energy (DOE) Office of Science that funds research across its core program areas, including Advanced Scientific Computing Research, Basic Energy Sciences, Biological and Environmental Research, Fusion Energy Sciences, High Energy Physics, Nuclear Physics, and Isotope R&D and Production. Any research within SC's Congressionally authorized mission may be proposed under this solicitation, which remains open throughout the fiscal year. Eligible applicants include colleges and universities, non-profit and for-profit research organizations, DOE national laboratories, small businesses, and other federal research organizations. Anticipated awards range from $750,000 to $3,000,000 per year; the solicitation closes September 30, 2026.

Continuations of Solicitation for the Office of Science Financial Assistance Program (DE-FOA-0003600) is sponsored by U.S. Department of Energy (DOE) - Office of Science (SC). This is an open solicitation from the DOE Office of Science that accepts proposals year-round in various research topic areas spanning the Office of Science program areas.

Storage Design Strategies to Ease Production (STEP) Prize is sponsored by U.S. Department of Energy (DOE). The STEP Prize is a two-phase competition explicitly designed to identify and foster innovative storage design strategies. This aligns with the focus on modular energy, particularly if the modularity contributes to easier production and deployment of energy storage systems.

Space Photovoltaics Research and Development Partnership Intermediary Agreement (PIA) is sponsored by U.S. Department of Energy (DOE) Integrated Energy Systems Office (IESO). This funding opportunity supports research and development (R&D) projects focused on lowering costs and expanding domestic manufacturing capabilities for solar panels in space applications. It aims to accelerate U.

Space Photovoltaics (PV) Research and Development Partnership Intermediary Agreement (PIA) opportunity is sponsored by U.S. Department of Energy (DOE) Office of Critical Minerals and Energy Innovation. This funding opportunity aims to accelerate technical innovation and expand domestic manufacturing capabilities for solar panels in space applications. It seeks projects focusing on next-generation cell innovation and rapid production and demonstration of space PV.

Industrial Training and Assessment Center (ITAC) program is sponsored by U.S. Department of Energy (DOE). The ITAC program provides no-cost technical assessments to small- and medium-sized manufacturers while training the next generation of skilled engineers and workers. The program identifies opportunities for manufacturers to save energy, improve productivity, and reduce waste.

The ASCR Leadership Computing Challenge (ALCC) is a grant from the Department of Energy (DOE) Office of Science that funds access to time on DOE's leadership-class supercomputers, including Frontier, Aurora, Polaris, and Perlmutter. The program prioritizes high-risk, high-payoff scientific computing projects aligned with DOE mission areas, responses to national emergencies, and efforts to broaden access to advanced HPC resources. Eligible applicants include researchers from universities, industry, and government agencies; DOE sponsorship is not required. Allocation periods run for one year from July 1, 2026 to June 30, 2027, with the application deadline on November 1, 2026. Renewals of up to three years are possible. This is a compute resource allocation, not a cash grant.

The National Robotics Initiative 3.0 (NRI-3.0) supports fundamental research on integrated robotics systems that combine AI, machine learning, perception, and control to enable robots to work alongside or on behalf of people across sectors such as manufacturing, agriculture, healthcare, and infrastructure. The program emphasizes integration of multiple robotics capabilities and ubiquitous collaborative robots, with awards varying by track up to roughly $3 million per project. A multi-agency effort, NRI-3.0 draws support from NSF alongside partners such as USDA-NIFA and DOE.

Office of Science Graduate Student Research (SCGSR) Program is sponsored by U.S. Department of Energy (DOE). The SCGSR program provides supplemental awards to outstanding U.S. graduate students to pursue part of their graduate thesis research at a DOE national laboratory/facility in areas that address scientific challenges central to the Office of Science mission. This includes basic research in biology and environmental sciences.

Quantum High Performance Computing Validation and Verification Testbed is sponsored by U.S. Department of Energy (DOE) Office of Science. This opportunity, offered by the DOE Office of Science, is specifically for DOE National Laboratories and focuses on quantum high-performance computing validation and verification. It aims to advance scientific computing capabilities.

The Genesis Mission is sponsored by U.S. Department of Energy (DOE) Office of Technology Commercialization. This funding opportunity, part of the DOE's SBIR and STTR Phase I programs, is specifically aimed at small businesses to join the Genesis Mission. It focuses on four areas: scaling biotechnology, leveraging AI for quantum computing and networking, designing materials with predictable functionality, and achieving AI-driven autonomous laboratories.

DE-FOA-0003612 The Genesis Mission: Transforming Science and Energy with AI is a grant from the U.S. Department of Energy (DOE) Office of Science that funds AI-driven research across strategic science and energy topic areas. DOE is soliciting FY26 Phase I small team and Phase II large team applications covering advanced manufacturing, biotechnology, critical materials, nuclear fission, nuclear fusion, quantum information science, semiconductors and microelectronics, discovery science, and energy. Eligible applicants include colleges and universities, non-profit and for-profit research organizations, DOE national laboratories, small businesses, and other federal research organizations. The deadline is December 17, 2026.

The Department of Energy Genesis Mission is a presidential executive order establishing a national effort to accelerate AI-driven scientific discovery. Led by the Secretary of Energy, the Mission creates the American Science and Security Platform, integrating DOE national laboratory supercomputers, secure cloud-based AI environments, and federally curated scientific datasets to train foundation models and develop AI agents for automated research. The initiative targets at least 20 national science and technology challenges spanning advanced manufacturing, critical materials, nuclear energy, quantum information science, and semiconductors. The Mission facilitates interagency coordination, public-private partnerships through cooperative research agreements, and competitive fellowship programs for researchers at national laboratories. Annual reporting to the President tracks platform capabilities, research outcomes, and technology commercialization progress across participating federal agencies and external partners.

Transforming Science and Energy with AI is sponsored by Department of Energy (DOE) Office of Science (SC). This program seeks applications from interdisciplinary teams to accelerate scientific discovery and research and development (R&D) workflows using novel artificial intelligence (AI) models and frameworks. While broad, research in graph learning and spectral network diffusion dynamics could contribute to AI advancements in scientific domains relevant to energy and other critical areas.

The Genesis Mission: Transforming Science and Energy with AI (DE-FOA-0003612) is sponsored by U.S. Department of Energy (DOE) Office of Science, Office of Critical Minerals and Energy Innovation, Office of Environmental Management, Office of Nuclear Energy, Office of Electricity, and Hydrocarbons and Geothermal Office. This opportunity supports mission-aligned projects and measurable outcomes.

The Genesis Mission: Transforming Science and Energy with AI is sponsored by U.S. Department of Energy (DOE), Office of Science, Basic Energy Sciences (BES). This program focuses on integrating artificial intelligence (AI) to transform science and energy research. While specific to AI, it aligns with BES's mission to advance fundamental science.

The Genesis Mission: Transforming Science and Energy with AI is sponsored by U.S. Department of Energy (DOE) Office of Science (SC) Advanced Scientific Computing Research (ASCR). This funding opportunity focuses on leveraging AI to transform science and energy. It aligns with ASCR's mission to discover, develop, and deploy computational and networking capability to analyze, model, simulate and predict complex phenomena important to the Department of Energy and the advancement of science.

This request for applications, issued as DE-FOA-0003612 by the DOE Office of Science, is the main competitive vehicle of the Genesis Mission, the Department of Energy's push to use artificial intelligence to accelerate scientific discovery across its mission space. It anticipates 293.76 million US dollars in awards against twenty-one named national challenge areas, including reenvisioning advanced manufacturing and industrial productivity, scaling the biotechnology revolution, securing America's critical minerals supply, delivering nuclear energy that is faster, safer and cheaper, achieving AI-driven autonomous laboratories and designing materials with predictable functionality, alongside further topics spanning quantum information science, semiconductors, discovery science and energy systems. The two-phase design funds a nine-month Phase I at 500,000 to 750,000 dollars to establish feasibility, then a three-year Phase II at 6 to 15 million dollars to build and deploy. The mandatory team composition is the defining feature: Phase I teams must include at least two of DOE or NNSA national laboratories, industry, or higher education and non-profit organisations, and Phase II teams must include at least one national laboratory partner and at least one industry partner, with higher education participation strongly encouraged. That requirement makes this a partnership instrument rather than a single-investigator grant, and it routes access to DOE's data, computing facilities and experimental infrastructure through the laboratory partner. Phase I applications and Phase II letters of intent were due 28 April 2026; full Phase II applications are due 17 December 2026.

Genesis Mission: Transforming Science and Energy with AI is sponsored by U.S. Department of Energy (DOE) Office of Science (SC). Supports interdisciplinary teams addressing national science and technology challenges to accelerate scientific discovery and research and development (R&D) workflows using novel artificial intelligence (AI) models and frameworks, with a focus on advancing DOE's mission in areas…

DE-FOA-0003612: The Genesis Mission: Transforming Science and Energy with AI is sponsored by U.S. Department of Energy (DOE) Office of Science, Office of Fusion Energy Sciences (FES). FES is interested in applications for preliminary design studies exploring the creation of volumetric neutron sources (VNS) based on the next generation of fusion concepts, with the potential for significant cost share through public-private partnerships.

The Genesis Mission: Transforming Science and Energy with AI, DE-FOA-0003612 is sponsored by U.S. DOE Office of Science (SC), Basic Energy Sciences (BES). This funding opportunity focuses on new grant applications from universities and other research institutions for basic energy sciences, with an emphasis on transforming science and energy with AI.

Technology Commercialization Fund (TCF) Core Laboratory Infrastructure for Market Readiness (CLIMR) Technology-Specific Topics is sponsored by U.S. Department of Energy's Office of Technology Commercialization (DOE). This funding opportunity advances the commercialization of promising technologies in five priority areas, including advanced transportation technologies and fuels production (within the Office of Critical Minerals and Energy Innovation, formerly Bioenergy Technologies Office). It creates opportunities for industry, entrepreneurs, investors, universities, nonprofits, and other organizations to engage with DOE National Laboratories to move technologies from R&D to market.

ORNL Manufacturing Demonstration Facility (MDF) Technical Collaboration Program is sponsored by U.S. Department of Energy (DOE), Office of Energy Efficiency and Renewable Energy (EERE), Advanced Materials and Manufacturing Technologies Office. This program engages industry partners in short-term, collaborative projects with Oak Ridge National Laboratory (ORNL) staff to accelerate the development and deployment of new manufacturing technologies, materials, or processes for the benefit of U.