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Nonprofit organizations sit at the center of the American funding ecosystem. Federal agencies distributed over $750 billion in grants in FY 2025, and 501(c)(3) organizations are eligible applicants for the vast majority of discretionary programs. On the private side, U.S. foundations gave more than $100 billion annually in recent years, with community foundations alone accounting for $9 billion.
The landscape divides into three tiers. Formula grants flow automatically to states and localities (Title I, CDBG, Medicaid), and nonprofits access these as sub-recipients. Competitive discretionary grants from agencies like HHS, DOE, EPA, USDA, and the Department of Education require applications reviewed on merit. Foundation grants from entities like the Ford Foundation, Robert Wood Johnson Foundation, and MacArthur Foundation operate on their own timelines and review processes, often with shorter applications but more relationship-driven selection.
Typical federal awards for nonprofits range from $50,000 for targeted community programs to $5 million or more for multi-year demonstration projects. Foundation grants tend to cluster between $25,000 and $500,000. The key to success is matching your organizational capacity to the right program size and aligning your mission statement with the funder's theory of change.
Granted tracks thousands of active opportunities across federal and foundation sources. Start by browsing the categories below or searching for grants that match your organization's focus area, geographic scope, and budget range.
Community Development Block Grants (CDBG)
HUD formula grants ($3.3B/yr) supporting housing, infrastructure, and economic development in low-income communities. Nonprofits apply through local governments.
Browse grants →AmeriCorps Grants
Corporation for National and Community Service awards ($800M+/yr) funding national service programs, VISTA placements, and volunteer mobilization through nonprofits.
21st Century Community Learning Centers
Department of Education formula grants ($1.3B/yr) supporting before- and after-school programs operated by nonprofits and school districts.
Browse grants →USDA Community Facilities Grants
Direct grants ($50K-$1M) for essential community facilities in rural areas including healthcare clinics, childcare centers, and public safety buildings.
Browse grants →Path to a Cure Research Grant is a grant from Cystic Fibrosis Foundation that funds basic science research aimed at restoring CFTR protein function or developing gene-based approaches to treat cystic fibrosis. The program specifically targets projects proposing restoration of CFTR protein function or approaches to fix or replace the defective CFTR gene. Awards provide up to $150,000 per year (plus 12% indirect costs) for up to two years, with grants competitively renewable for additional funding. Eligible applicants are independent investigators at for-profit and nonprofit institutions. Proposals must be hypothesis-driven with sufficient preliminary data. The fall cycle deadline is November 15, 2026.
Youth Opportunities Program (YOP) is a grant from the Missouri Department of Economic Development that funds nonprofit organizations running positive youth development and crime prevention projects. The program allocates state tax credits to approved organizations, enabling them to secure community contributions for eligible projects including internships, apprenticeships, adopt-a-school initiatives, mentorship programs, and substance abuse prevention. Contributors to approved projects receive 70% tax credits for monetary donations and wages paid to youth interns, and 30% tax credits for property or equipment donations. Eligible applicants are Missouri nonprofits serving disadvantaged youth. The CY2027 application cycle opens in December 2026.
Tennessee Nonpoint Source Program (319 Program) is sponsored by Tennessee Department of Agriculture (TDA). This program provides funding for projects that address nonpoint source pollution and improve or protect water quality across Tennessee. Priority is given to projects targeting waters identified as impaired by NPS on Tennessee's most recent list of impaired waters.
16 matching grants
Path to a Cure Research Grant is a grant from Cystic Fibrosis Foundation that funds basic science research aimed at restoring CFTR protein function or developing gene-based approaches to treat cystic fibrosis. The program specifically targets projects proposing restoration of CFTR protein function or approaches to fix or replace the defective CFTR gene. Awards provide up to $150,000 per year (plus 12% indirect costs) for up to two years, with grants competitively renewable for additional funding. Eligible applicants are independent investigators at for-profit and nonprofit institutions. Proposals must be hypothesis-driven with sufficient preliminary data. The fall cycle deadline is November 15, 2026.
Youth Opportunities Program (YOP) is a grant from the Missouri Department of Economic Development that funds nonprofit organizations running positive youth development and crime prevention projects. The program allocates state tax credits to approved organizations, enabling them to secure community contributions for eligible projects including internships, apprenticeships, adopt-a-school initiatives, mentorship programs, and substance abuse prevention. Contributors to approved projects receive 70% tax credits for monetary donations and wages paid to youth interns, and 30% tax credits for property or equipment donations. Eligible applicants are Missouri nonprofits serving disadvantaged youth. The CY2027 application cycle opens in December 2026.
Tennessee Nonpoint Source Program (319 Program) is sponsored by Tennessee Department of Agriculture (TDA). This program provides funding for projects that address nonpoint source pollution and improve or protect water quality across Tennessee. Priority is given to projects targeting waters identified as impaired by NPS on Tennessee's most recent list of impaired waters.
Verizon Small Business Digital Ready $10,000 National Grant is sponsored by Verizon, in partnership with LISC (Local Initiatives Support Corporation). This program is part of Verizon's commitment to equip small businesses with tools and resources to thrive in the digital economy. Ten small businesses are selected monthly to receive $10,000 grants. Applicants need to complete any two free courses or events on the Digital Ready platform to unlock the application.
USSOCOM Engage SOF (eSOF) is a Commercial Solutions Opening providing a rolling pathway for companies to submit AI and autonomous systems technologies aligned with Special Operations Forces capability needs across 14 domains including AI, ISR, cyber, mobility, weapons/electronic attack, command and control, ISR, and human performance. Selected vendors gain direct access to USSOCOM Program Executive Offices and rapid acquisition pathways. The program emphasizes AI, autonomy, drone warfare, and human-machine teaming as SOF transforms into the Pentagon's lead integrator of these technologies, with a portfolio of 487 active CRADAs and 832 active BAA submissions.
St. Joseph Foundation Grants is sponsored by Community Foundation for the Central Savannah River Area. The St. Joseph Foundation Grants aim to support nonprofit organizations addressing the evolving healthcare needs of individuals in the CSRA. The foundation prioritizes initiatives related to health service education, medical uninsured populations, and hospice care.
Minnesota Legacy Grants (State Historical and Cultural Grants) is sponsored by Minnesota Historical Society (MNHS). Provides funding for history projects, historic preservation pre-development, and building preservation work. Religious properties and historic houses of worship listed in or eligible for the National Register of Historic Places frequently utilize these state-funded grants to execute essential exterior restoration, structural stabilization, and historical documentation.
Ryan White HIV/AIDS Program Part C Capacity Development Program (Forecasted HRSA-27-069) is sponsored by Health Resources and Services Administration (HRSA). The purpose of this program is to strengthen the capacity of community-based organizations to improve health outcomes and reduce HIV transmission, especially for people not yet in regular HIV care. Activities fall under HIV Care Innovation and Infrastructure Development.
Gratis Foundation Grant is sponsored by Gratis Foundation. Supports organizations focused on education, health care, humanitarian services, and at-risk youth. Applications are accepted in specific periods: October 1 to January 31 for health and medical research; February 1 to May 31 for education; and June 1 to September 30 for military and animal welfare.
Community Impact Grant Program is sponsored by Atrium Health Floyd–Polk Foundation. The Atrium Health Floyd–Polk Foundation's Community Impact Grant Program supports nonprofits addressing pressing health-related needs in Northwest Georgia and Northeast Alabama, including access to care, mental and behavioral health, food security, and safe and stable housing. While not directly focused on global health security surveillance, proposals that incorporate surveillance and rapid response within these community health priorities could be considered.
Digital Health Technology and Reciprocal Innovation to Improve Clinical and Public Health Outcomes is sponsored by Fogarty International Center (FIC) - National Institutes of Health (NIH). This initiative supports research on the development, validation, feasibility, and effectiveness of innovative digital health interventions or tools (including mobile health) specifically suited for underserved settings in the U.S. and globally. It emphasizes reciprocal innovation methodologies.
National Fund for Sacred Places is sponsored by National Trust for Historic Preservation / Partners for Sacred Places. Provides financial and technical support to congregations preserving historic houses of worship that serve their communities. The program supports significant capital projects while building congregations' capacity to steward historic religious properties and sustain their role as community centers.
Chronic Care Telehealth Centers for Excellence Program is sponsored by Health Resources and Services Administration (HRSA). This program will fund academic medical centers to integrate innovative telehealth technologies into the full spectrum of services included in chronic care models. These centers will disseminate findings through research publications and serve as national models for integrating telehealth technology into chronic care services.
Racial Justice Initiative Project Grants is sponsored by Ohio State Bar Foundation. These grants support nonprofit and community organizations in Ohio that are advancing racial and ethnic justice. The funding is intended for initiatives that challenge systemic racism, educate the public, collaborate with legal systems, and remove legal barriers for BIPOC communities, with a focus on long-term, structural change.
Right Now Grants is sponsored by BECU Foundation. Supports community partners addressing scholarships, job training, housing, homeownership, and access to financial services. Relevant to nonprofit workforce-training scholarships and homeownership or financial-literacy initiatives, although the published material describes the current awards as grants to selected partners rather than an open application cycle.
The goal of this NOFO is to fund veterinary diagnostic laboratories in the Vet-LIRN network for grants associated with projects and equipment. Specific objectives include:1. Supporting the development, adaptation, or verification/validation of new methods associated with animal food issues or antimicrobial resistance.2. Short-term surveillance or monitoring efforts aligned with the CVM mission.3. Supporting equipment for testing or developing tests associated with animal food-related issues or antimicrobial resistance, including those for emerging technologies.4. Developing projects related to antimicrobial stewardship, in alignment with CVM's key initiatives in this area.5. Contributing as part of Vet-LIRN's AMR monitoring program, including sequencing isolates.6. Supporting work associated with One Health, including emerging diseases such as COVID-19, when funding is available. Funding Opportunity Number: PAR-23-202. Assistance Listing: 93.103. Funding Instrument: CA. Category: AG,CP,FN. Award Amount: $225K – $2.5M per award.
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On October 29, 2026, the Boston Celtics ownership group announced a $200 million gift to Boston Children's Hospital, the largest in the hospital's history. It began as Rob and Karen Hale's $100 million for a $640 million pediatric psychiatric campus in Brighton and grew into a match from roughly two dozen owners. Where the money goes, why the hospital called it timely, what it does not replace, and how New England mental health and youth nonprofits should respond.
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Read articleOn October 27, 2026, Micron announced more than $67 million for Idaho: $45 million-plus in $250 deposits to 181,000 children's Trump Accounts, $11.6 million for Valley Regional Transit and $10.5 million for housing through LEAP Housing and Boise's Lusk District. The Micron Foundation is not accepting unsolicited proposals. Here is what the split shows about where corporate community dollars are heading.
Read articleConnecticut OPM's ninth Nonprofit Grant Program round offers $19.5 million in capital funding for state-funded 501(c)(3) health and human service providers, opening October 27, 2026 and due January 5, 2027. Here's the round history, who qualifies, what it pays for, and how to compete for a shrinking pool.
Read articleOn October 14, 2026 Google.org announced 17 recipients sharing $36 million from the Impact Challenge: AI for Science. The winner list reveals exactly what the reviewers rewarded — and it is not what most nonprofit applicants assumed a philanthropy open call would fund.
Read articleThe Nonprofit Sustainability Initiative San Diego went live September 2, 2026 with more than $1 million committed from Prebys, Alliance Healthcare, San Diego Foundation and the Avila Fund. It offers exploratory and implementation grants for collaborations up to full mergers — and the entry point is a Readiness and Alignment Conversation, not a deadline.
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