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The United States Department of Agriculture, Animal Health Protection Inspection Service announces this funding opportunity to support the sweeping plan to combat New World screwworm (NWS) as described in the U.S. Secretary of Agriculture’s August 15, 2025, press release, titled USDA Announces Sweeping Plans to Protect the United States from New World Screwworm. Through this Grand Challenge, APHIS is making up to $100,000,000 available to combat NWS and prevent its northward spread. APHIS is making rapid progress on the construction of additional sterile insect production facilities with full capacity of 300 million sterile flies per week expected to come online in March 2029. Through the Grand Challenge, APHIS hopes to identify both projects that will augment our rapid response to the growing threat of NWS to serve as an interim step while production increases, but also long-term investments that expand our ability to respond to the parasite now and into the future – technologies that, perhaps, could have applicability with other animal disease response programs.APHIS will support projects that enhance sterile NWS fly production, develop novel NWS traps and lures, develop and increase understanding of NWS therapeutics/treatments in animals, or develop other tools to bolster preparedness or response to NWS.Funding Priorities: APHIS will support projects that:Topic 1: Enhance sterile NWS fly production.Topic 2: Develop novel NWS traps and lures.Topic 3: Develop and increase understanding of NWS therapeutic/treatments (i.e. products that could treat, prevent, or control NWS) for animals and that could be stockpiled and used in animals should NWS reach the United States.Topic 4: Develop other tools to bolster preparedness or response to NWS.Awards are not anticipated to exceed $5,000,000; however, APHIS reserves the right to award proposals in excess of $5,000,000 if the proposal significantly contributes to the prevention of NWS’ northward spread. This anticipated award amount should not deter new innovations; Major projects with a demonstrable ability to rapidly advance animal health outcomes and/or delay the spread of NWS will be considered in excess of this amount. You can See Appendix I for funding priority topics. APHIS may award less than the requested amount for a project. In these cases, applicants may accept or decline the award that is offered. If applicants accept a reduced funding level, applicants will be asked to submit a revised application that addresses reviewer concerns and aligns with the award amount. APHIS will provide additional guidance to applicants in these situations.Key Dates: Applications must be received through ezFedGrants for non-Federal applicants or via email to NWS.Grand.Challenge@usda.gov for Federal and Non-domestic applicants by February 23, 2026, 11:59 PM ET. Applications received after this deadline will not be considered for funding.Anticipated Award Start Date: APHIS anticipates that work covered under these agreements will start no sooner than May 1, 2026, and no later than June 1, 2026. Projects will end no later than 2 years after the start date, unless otherwise approved in writing by APHIS.Period of Performance: Projects should be completed within 2 years unless an extension has been approved in writing by APHIS. Pre-award costs and activities are not authorized under this program.For questions about the NWS Grand Challenge program, this funding opportunity, required documents, or the ezFedGrants application process, please refer to the detailed information provided on the NWS Grand Challenge webpage or contact NWS.Grand.Challenge@usda.gov.
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New World Screwworm Grand Challenge: USDA-APHIS-10025-OA000000-26-0001 New World Screwworm Grand Challenge Agency: Animal and Plant Health Inspection Service Assistance Listings: 10. 025 -- Plant and Animal Disease, Pest Control, and Animal Care Last Updated: February 5, 2026 View version history on Grants.
gov The United States Department of Agriculture, Animal Health Protection Inspection Service announces this funding opportunity to support the sweeping plan to combat New World screwworm (NWS) as described in the U. S. Secretary of Agriculture’s August 15, 2025, press release, titled USDA Announces Sweeping Plans to Protect the United States from New World Screwworm.
Through this Grand Challenge, APHIS is making up to $100,000,000 available to combat NWS and prevent its northward spread. APHIS is making rapid progress on the construction of additional sterile insect production facilities with full capacity of 300 million sterile flies per week expected to come online in March 2029.
Through the Grand Challenge, APHIS hopes to identify both projects that will augment our rapid response to the growing threat of NWS to serve as an interim step while production increases, but also long-term investments that expand our ability to respond to the parasite now and into the future – technologies that, perhaps, could have applicability with other animal disease response programs.
APHIS will support projects that enhance sterile NWS fly production, develop novel NWS traps and lures, develop and increase understanding of NWS therapeutics/treatments in animals, or develop other tools to bolster preparedness or response to NWS. Funding Priorities: APHIS will support projects that: Topic 1: Enhance sterile NWS fly production. Topic 2: Develop novel NWS traps and lures.
Based on current listing details, eligibility includes: Eligible applicants: State governments; County governments; City or township governments; Public and State controlled institutions of higher education; Native American tribal governments (Federally recognized); Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education; Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education; Private institutions of higher education; Small businesses. Application packages must meet the initial screening criteria to be eligible to receive further review. Proposals that do not meet these initial screening criteria will not receive further review. Any application package with missing or incomplete documents or forms will not be eligible to receive further review.1. Proposals must be submitted by eligible entities with an active Unique Entity Identifier (UEI) in SAM.gov. 2. Proposals must address one of the funding priorities listed in Section 1 and described in detail in Appendix 1 of the Notice of Funding Opportunity.3. All required documents and forms listed in Section 4 of the Notice of Funding Opportunity must (a) be included in the application package, and (b) comply with the submission instructions described in Section 5 of the Notice of Funding Opportunity.4. Proposals, including all associated documents and forms, must be received on or before the proposal submission deadline. Proposals received after the submission deadline will not be eligible to receive further review. Applicants should confirm final requirements in the official notice before submission.
Current published award information indicates Up to $5M per award Always verify allowable costs, matching requirements, and funding caps directly in the sponsor documentation.
The current target date is February 23, 2026. Build your timeline backwards from this date to cover registrations, approvals, attachments, and final submission checks.
Past winners and funding trends for this program
Community Development Block Grant: Recovery Housing Program (RHP) is sponsored by Indiana Office of Community and Rural Affairs (OCRA). State-administered HUD funds specifically for establishing or expanding transitional recovery housing services for individuals in recovery from substance use disorder. Application snapshot: target deadline February 22, 2026; published funding information $50,000 - $750,000; eligibility guidance Indiana local units of government (who may partner with 501(c)(3) nonprofit recovery residence operators). Use the official notice and source links for final requirements, attachment checklists, allowable costs, and submission instructions before applying.
Agency Information Collection Activities; Submission to the Office of Management and Budget for Review and Approval; Tribal Education Department Grant Program is sponsored by Interior Department; Indian Affairs Bureau. In accordance with the Paperwork Reduction Act of 1995, the Bureau of Indian Education (BIE, we) is proposing to renew an information collection without change. Action: Notice of information collection; request for comment. Published in the Federal Register on 2026-01-22. Federal Register document number: 2026-01190. Application snapshot: target deadline February 23, 2026; published funding information See Federal Register notice for funding amount details.; eligibility guidance See Federal Register notice for complete eligibility requirements. Use the official notice and source links for final requirements, attachment checklists, allowable costs, and submission instructions before applying.
Funding Opportunity Number: USDA-APHIS-10025-OA000000-26-0001. Assistance Listing: 10.025. Funding Instrument: CA. Category: AG. Award Amount: Up to $5M per award.
Topic 3: Develop and increase understanding of NWS therapeutic/treatments (i. e. products that could treat, prevent, or control NWS) for animals and that could be stockpiled and used in animals should NWS reach the United States.
Topic 4: Develop other tools to bolster preparedness or response to NWS. Awards are not anticipated to exceed $5,000,000; however, APHIS reserves the right to award proposals in excess of $5,000,000 if the proposal significantly contributes to the prevention of NWS’ northward spread.
This anticipated award amount should not deter new innovations; Major projects with a demonstrable ability to rapidly advance animal health outcomes and/or delay the spread of NWS will be considered in excess of this amount. You can See Appendix I for funding priority topics. APHIS may award less than the requested amount for a project.
In these cases, applicants may accept or decline the award that is offered. If applicants accept a reduced funding level, applicants will be asked to submit a revised application that addresses reviewer concerns and aligns with the award amount. APHIS will provide additional guidance to applicants in these situations.
Key Dates: Applications must be received through ezFedGrants for non-Federal applicants or via email to NWS. Grand. Challenge@usda.
gov for Federal and Non-domestic applicants by February 23, 2026, 11:59 PM ET . Applications received after this deadline will not be considered for funding. Anticipated Award Start Date: APHIS anticipates that work covered under these agreements will start no sooner than May 1, 2026, and no later than June 1, 2026.
Projects will end no later than 2 years after the start date, unless otherwise approved in writing by APHIS. Period of Performance: Projects should be completed within 2 years unless an extension has been approved in writing by APHIS. Pre-award costs and activities are not authorized under this program.
For questions about the NWS Grand Challenge program, this funding opportunity, required documents, or the ezFedGrants application process, please refer to the detailed information provided on the NWS Grand Challenge webpage or contact NWS. Grand. Challenge@usda.
gov. Federally recognized Native American tribal governments City or township governments Private institutions of higher education Public and state institutions of higher education Nonprofits non-higher education without 501(c)(3) Nonprofits non-higher education with 501(c)(3) Application packages must meet the initial screening criteria to be eligible to receive further review.
Proposals that do not meet these initial screening criteria will not receive further review. Any application package with missing or incomplete documents or forms will not be eligible to receive further review. 1.
Proposals must be submitted by eligible entities with an active Unique Entity Identifier (UEI) in SAM. gov. 2.
Proposals must address one of the funding priorities listed in Section 1 and described in detail in Appendix 1 of the Notice of Funding Opportunity. 3. All required documents and forms listed in Section 4 of the Notice of Funding Opportunity must (a) be included in the application package, and (b) comply with the submission instructions described in Section 5 of the Notice of Funding Opportunity.
4. Proposals, including all associated documents and forms, must be received on or before the proposal submission deadline. Proposals received after the submission deadline will not be eligible to receive further review.
Grantor contact information NWS. Grand. Challenge@usda.
gov File name Description Last updated NWS_Grand_Challenge_NOFO_2. 5. 26.
pdf Detailed Notice of Funding Opportunity Feb 5, 2026 09:21 PM UTC SF-LLL. pdf SF-LLL Lobbying Form Jan 21, 2026 10:06 PM UTC Lobbying_Certification. docx Lobbying Certification Jan 21, 2026 10:06 PM UTC nws-work-plan-template.
docx Work Plan Template Jan 21, 2026 09:25 PM UTC nws-financial-plan-template. xlsx Financial Plan Template Jan 21, 2026 10:06 PM UTC SAM_Reps_and_Certs_Financial_Assistance_Notice. pdf SAM.
GOV Reps and Certs Help Feb 5, 2026 05:24 PM UTC SAM_Entity_Registration_Checklist. pdf SAM. GOV Registration Job Aid Feb 5, 2026 05:25 PM UTC SF424_4_0-V4.
0. pdf SF-424 Feb 5, 2026 06:00 PM UTC SF424_4_0-V4. 0-Instructions.
pdf SF 424 Instructions Feb 5, 2026 06:00 PM UTC SF424A-V1. 0.
pdf SF 424 A Budget Information - Totals should match financial plan Link to additional information New World Screwworm Grand Challenge Website Closing: February 23, 2026 Funding opportunity number : USDA-APHIS-10025-OA000000-26-0001 Cost sharing or matching requirement : Funding instrument type : Opportunity Category Explanation : Category of Funding Activity : United States Department of Agriculture (USDA), Animal and Plant Health Inspection Service (APHIS), New World Screwworm Directorate To give feedback, contact: simpler@grants.
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