The USAMRDC’s mission is to provide solutions to medical problems of importance to the American Service Member at home and abroad, as well as to the general public at large. The scope of this effort and the priorities attached to specific projects are influenced by changes in military and civilian medical science and technology (S&T), operational requirements, military threat assessments, and national defense strategies. Extramural research and development programs play a vital role in the fulfillment of the objectives established by the USAMRDC. General information on the USAMRDC can be obtained at https://mrdc.health.mil/.This BAA is intended to solicit extramural research and development ideas using the authority provided by 10 USC 4001. The BAA is issued under the provisions of the Competition in Contracting Act of 1984 (Public Law 98-369), as implemented in FAR 6.102(d)(2) and 35.016 and in Department of Defense Grant and Agreement Regulations (DoDGARs) 22.315. In accordance with FAR 35.016, projects funded under this BAA must be for basic and applied research to support scientific study and experimentation directed toward advancing the state-of-the-art or increasing knowledge or understanding rather than focusing on development of a specific system or hardware solution. Research and development funded through this BAA are intended and expected to benefit and inform both military and civilian medical practice and knowledge. This BAA utilizes competitive procedures in accordance with 10 USC 3012 for the selection for award of S&T proposals/applications. For the purposes of this BAA, S&T includes activities involving basic research, applied research, advanced technology development, and, under certain conditions, may include activities involving advanced component development and prototypes.The selection process is highly competitive, and the quantity of meaningful submissions (both pre-proposals/pre-applications and full proposals/applications) received typically exceeds the number of awards that available funding can support.This BAA provides a general description of USAMRDC’s research and development programs, including Research Areas of Interest, evaluation and selection criteria, pre-proposal/ pre-application and full proposal/application preparation instructions, and general administrative information. Specific submission information and additional administrative requirements can be found in the document titled, “General Submission Instructions,” which is available on Grants.gov along with this BAA.The FY23-FY27 USAMRDC BAA is continuously open for a 5-year period, from October 1, 2022 through September 30, 2027, at 11:59 p.m. Eastern Time. Submission of a pre-proposal/pre-application is required and must be submitted through the electronic Biomedical Research Application Portal (eBRAP) (https://eBRAP.org/). Pre-proposals/pre-applications may be submitted at any time throughout the 5-year period. If the USAMRDC is interested in receiving a full proposal/application, the Principal Investigator will be sent an invitation to submit via eBRAP. A full proposal/application must be submitted through Grants.gov (http://www.grants.gov/). Invited full proposals/applications can be submitted under this FY23-FY27 BAA through September 30, 2027. Funding Opportunity Number: HT942523SBAA1. Assistance Listing: 12.420. Funding Instrument: CA,G,O,PC. Category: ST.

The Defense Advanced Research Projects Agency (DARPA) Defense Sciences Office issued solicitation DARPA-PA-25-07-02 for the Compositional Learning-And-Reasoning for AI Complex Systems Engineering (CLARA) program on February 10, 2026. CLARA aims to develop high-assurance AI systems that tightly integrate machine learning (ML) and automated reasoning (AR) through hierarchical composition of Bayesian models, neural networks, and logic programs. The program seeks to create a theory-driven, highly reusable, scalable foundation for high-assurance AI by merging machine learning's speed and flexibility with automated reasoning's verifiability and logical explainability. Technical Area 1 (TA1) focuses on developing new high-assurance ML/AR composition approaches including theory, algorithms, and open-source software implementations. Technical Area 2 (TA2) creates a software composition library to integrate validated TA1 tools into a common framework. Application domains include course-of-action planning, multi-condition medical guidance, supply chain and logistics, autonomous systems and command & control, wargaming, and science and technology design. Awards are expected to be executed by June 9, 2026. Proposals must be submitted via the DARPA BAA Tool at baa.darpa.mil.

The DARPA CLARA program seeks to create high-assurance AI by tightly integrating machine learning with automated reasoning. Rather than the current industry approach of loosely coupling ML with reasoning as an afterthought, CLARA funds research into deep compositional integration that produces AI systems with strong logical explainability and computational tractability. The program targets applications in autonomous systems, command and control, kill web operations, supply chain logistics, wargaming, and medical, financial, and legal domains. TA1 funds development of new high-assurance ML/AR composition approaches including theory, algorithms, and open-source code. TA2 builds a software composition library that integrates validated TA1 tools into a common framework. All software deliverables must use permissive open-source licenses. The program is managed by Benjamin Grosof in DARPA's Defense Sciences Office. Solicitation DARPA-PA-25-07-02 was published February 10, 2026, with full proposals due April 17, 2026 (extended from April 10 via Amendment 1).