Aging Research on Stress and Resilience to Address Health Disparities in the United States (R01) is sponsored by National Institute on Aging (NIA) / NIH. This funding opportunity stimulates interdisciplinary health-disparities research related to aging, considering the role that stress, stress response, and stress resilience play in differential health outcomes in priority health disparity populations in the U.

Expired RFA-AG-16-022: Aging Research on Stress and Resilience to Address Health Disparities in the United States (R01) This notice has expired. Check the NIH Guide for active opportunities and notices. Department of Health and Human Services Part 1.

Overview Information Participating Organization(s) National Institutes of Health ( NIH ) of Participating Organizations National Institute on Aging ( NIA ) Funding Opportunity Title Aging Research on Stress and Resilience to Address Health Disparities in the United States (R01) R01 Research Project Grant Funding Opportunity Announcement (FOA) Number Companion Funding Opportunity Additional Information on Eligibility .

Catalog of Federal Domestic Assistance (CFDA) Number(s) Funding Opportunity Purpose The purpose of this Funding Opportunity Announcement (FOA) is to stimulate interdisciplinary health-disparities research related to aging that considers the role that stress, stress response, and stress resilience play in differential health outcomes in priority health disparity populations in the U.S. In particular, this FOA seeks applications proposing to clarify pathways linking stress and aging-relevant health outcomes (e.g. mortality, cognitive impairment, multiple chronic conditions, disability, quality of life) through the investigation of links between environmental, sociocultural, behavioral, and biological factors.

Open Date (Earliest Submission Date) Letter of Intent Due Date(s) January 13, 2016, by 5:00 PM local time of applicant organization. All types of non-AIDS applications allowed for this funding opportunity announcement are due on this date. No late applications will be accepted for this Funding Opportunity Announcement.

Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date. AIDS Application Due Date(s) January 13, 2016 by 5:00 PM local time of applicant organization. All types of non-AIDS applications allowed for this funding opportunity announcement are due on this date.

No late applications will be accepted for this Funding Opportunity Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.

Required Application Instructions It is critical that applicants follow the instructions in (R&R) Application Guide , except where instructed to do otherwise (in this FOA or in a Notice from the NIH Guide for Grants and Contracts ). Conformance to all requirements (both in the Application Guide and the FOA) is required and strictly enforced.

Applicants must read and follow all application instructions in the Application Guide as well as any program-specific instructions noted in Section IV . When the program-specific instructions deviate from those in the Application Guide, follow the program-specific instructions. Applications that do not comply with these instructions may be delayed or not accepted for review.

Part 1. Overview Information Part 2. Full Text of the Announcement I.

Funding Opportunity Description Section II. Award Information Section III. Eligibility Information Section IV.

Application and Submission Section V. Application Review Information Section VI. Award Administration Information Section VII.

Agency Contacts Section VIII. Other Information Full Text of Announcement Section I.

Funding Opportunity Description The purpose of this FOA is to stimulate interdisciplinary health disparities research related to aging that considers the role that stress - including responses to stressors and stress resilience - plays in differential health outcomes among aging populations in the U.S. Applications proposing to identify pathways linking stress and aging-relevant health outcomes (e.g. Mortality, Cognitive Impairment, Multiple Chronic Conditions, Disability, Quality of Life) by examining links between environmental, sociocultural or behavioral, and biological factors are particularly encouraged.

Priority populations for health disparities research related to aging - and this FOA- include American Indians, Alaska Natives, Asian Americans, Native Hawaiians and other Pacific Islanders, African Americans, Hispanic or Latinos, Socioeconomically Disadvantaged Populations, Sexual and Gender Minority (SGM) populations, persons with disabilities and rural populations.

NIA is interested in stimulating research to identify the causal mechanisms and pathways that account for how stress and resilience - induced by environmental, sociocultural and behavioral factors - become biologically embedded to create and sustain health disparities among priority aging Health-disparities research related to aging is the study of population-level health differences on environmental, sociocultural, behavioral and biological levels of analyses.

This research may use a number of approaches to identify the underlying determinants of population-level differences. Access to important health-protecting resources and individual health behaviors has been deemed an important factor in understanding population-level health differences.

It has also long been appreciated that states of stress induced by environmental and sociocultural factors can have deleterious effects on the general health and well-being of individuals by influencing behavioral and biological processes. Differential exposure and responses to stressors and resilience-based factors have been identified as central determinants across multiple levels of analysis.

For example, an environmental level of analysis encompasses geographical, political, and socioeconomic factors and characteristics of health care access and quality. Environmental exposure to poverty, crime and violence may disproportionally influence perceptions of stress among some populations and may be related to factors that are geographic and political.

Sociocultural factors such as cultural norms, values, traditions and collective responses shape important beliefs about environmental conditions and impact beliefs about institutional racism, social mobility, bias, self-concepts and financial hardship. Behavioral and/or psychological responses to stress and hardship may include diverse outcomes.

For example, on one hand, such outcomes may include heightened stress reactivity, increased negative affect, and adverse health behaviors. On the other hand, behavioral and/or psychological responses may also include resilience-based cognitive reframing, stress management, problem solving, and active coping.

Behavioral and/or psychological responses that may undermine health include smoking, anger, violence, alcohol abuse, illegal substance use, and poor nutrition.

These behaviors and psychological responses may impact biological aging processes and result in, for example, chronic inflammation, telomere attrition, and diminishing cellular function, communication, and accelerated senescence, which may result in population-level differences in various aging-related health outcomes.

Specific Area of Interest NIA encourages projects addressing the impact of stress and resilience on health disparities related to aging that span environmental, sociocultural and/or behavioral and biological domains of analysis.

Our specific interest is to motivate interdisciplinary health-disparities research Explains the role of stress/resilience in the pathway linking environmental, sociocultural, and psychological and/or behavioral factors to health outcomes (e.g. mortality, cognitive impairment, multiple chronic conditions, disability, and quality of life) through biological pathways that include cellular and molecular mechanisms of biological aging (e.g. inflammation, immune-senescence, genetics/epigenetics), metabolic, cardiovascular, and neurobiological pathways(e.g. neuroimmune, neuroendocrine, and autonomic/sympathetic).

Applicants are encouraged to utilize team-science approaches, which would include participation by researchers from multiple scientific disciplines to promote integrative investigations that incorporate environmental, sociocultural, behavioral and biological levels of analyses for understanding the pathways that create and sustain health disparities related to aging in Applicants are encouraged to form partnerships with institutions that have durable, sustained relationships with communities of priority health disparity populations (e.g. Tribally Controlled Colleges and Universities [TCCUs], Hispanic-Serving Institutions [HSIs], Historically Black Colleges and Universities [HBCUs], and community-based organizations).

These partnerships may assist recruitment and retention of traditionally underrepresented populations into proposed research projects. Also, because of the high utilization of mobile communications devices among potential study participants, applicants are encouraged to collaborate with technology firms with the capability of enhancing participation and retention.

Specific research questions that would be appropriate for this FOA and of interest to the NIA include, but are not limited to: Does increasing age confer increasing resilience or increasing vulnerability to stress? How do patterns of resilience and vulnerability to stress differ among priority health-disparity populations?

How do environmental, socicultural, and behavioral/psychological factors influence Is socioeconomic status (SES) a buffer to stress in late life for all priority-health disparities groups and/or populations? Do particular patterns of age-related chronic conditions and co-occurring conditions create vulnerability to age-related stressors? How does this vary among priority health disparity populations?

What is the role of What are the mechanisms by which psychosocial stress affects daily behaviors? Do these vary by life stage for priority health disparity populations?

How do patterns of neural and behavioral responses to psychosocial stressors contribute to biological embedding of vulnerability or How do psychosocial stressors exert their effects through multiple biological pathways, and what are the mechanisms that account for aging-related physiological dysregulation?

Do different psychosocial stressors have more relevance or impact at different life stages for different priority health-disparities groups and/or populations? Do these differ by priority population? What biological pathways are differentially involved?

How do various behavioral and psychological mechanisms involved in the transduction of stressors and elicitation of the stress response interact with age-associated biological changes and with specific diseases of aging? How can we distinguish normal age-related dysregulation from dysregulation due to the impact of psychosocial stressors? What are normal parameters of the psychosocial stress response in aging organisms?

What are the behavioral and psychological mechanisms linking environmental and sociocultural factors to stress-related biological processes and health outcomes?

How do these differ across health disparities priority What are the mechanisms (e.g., behavioral, psychological, neural, and biological) underlying differences in response to psychosocial stressors, and how are they responsible for resilience and vulnerability over the life course?

What are the linkages among and between environmental, sociocultural, behavioral, neurobiological, and genetic and epigenetic mechanisms of stress vulnerability and resilience? Section II. Award Information Grant: A support mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity.

Application Types Allowed Glossary and the SF424 (R&R) Application Guide provide details on Funds Available and Anticipated Number of Awards NIA intends to commit $2M in FY 2016 to fund 4-6 Application budgets should reflect the actual needs of the proposed project but direct costs should be limited to a maximum of $500,000 The scope of the proposed project should determine the project period. The maximum project period is 5 years.

Grants Policy Statement will apply to the applications submitted and awards made in response to this FOA.

Higher Education Institutions Public/State Controlled Institutions of Higher Education Private Institutions of Higher Education The following types of Higher Education Institutions are always encouraged to apply for NIH support as Public or Private Institutions of Higher Education: Hispanic-serving Institutions Historically Black Colleges and Universities (HBCUs) Tribally Controlled Colleges and Universities (TCCUs) Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Nonprofits Other Than Institutions of Higher Education Nonprofits with 501(c)(3) IRS Status (Other than Institutions of Nonprofits without 501(c)(3) IRS Status (Other than Institutions For-Profit Organizations (Other than Small Businesses) City or Township Governments Special District Governments Indian/Native American Tribal Governments (Federally Recognized) Indian/Native American Tribal Governments (Other than Federally U.S. Territory or Possession Independent School Districts Public Housing Authorities/Indian Housing Authorities Native American Tribal Organizations (other than Federally recognized tribal governments) Faith-based or Community-based Organizations Non-domestic (non-U.S.) Entities (Foreign Institutions) are Non-domestic (non-U.S.) components of U.S. Organizations are not eligible Foreign components, as defined in the NIH Grants Policy Statement , are not allowed.

Applicant organizations must complete and maintain the following registrations as described in the SF 424 (R&R) Application Guide to be eligible to apply for or receive an award. All registrations must be completed prior to the application being submitted.

Registration can take 6 weeks or more, so applicants should begin the registration process as soon as Policy on Late Submission of Grant Applications states that failure to complete registrations in advance of a due date is not a valid reason for a Universal Numbering System (DUNS) - All registrations require that applicants be issued a DUNS number.

After obtaining a DUNS number, applicants can begin both SAM and eRA Commons registrations. The same DUNS number must be used for all registrations, as well as on the grant application. System for Award Management (SAM) (formerly CCR) Applicants must complete and maintain an active registration, which requires renewal at least annually .

The renewal process may require as much time as the initial registration. SAM registration includes the assignment of a Commercial and Government Entity (CAGE) Code for domestic organizations which have not already been assigned a CAGE Code. Commercial and Government Entity (NCAGE) Code Foreign organizations must obtain an NCAGE code (in lieu of a CAGE code) in order to register in SAM.

must have an active DUNS number and SAM registration in order to complete the eRA Commons registration. Organizations can register with the eRA Commons as they are working through their SAM or Grants. gov registration.

eRA Commons requires organizations to identify at least one Signing Official (SO) and at least one Program Director/Principal Investigator (PD/PI) account in order to must have an active DUNS number and SAM registration in order to complete the Directors/Principal Investigators (PD(s)/PI(s)) All PD(s)/PI(s) must have an eRA Commons account.

PD(s)/PI(s) should work with their organizational officials to either create a new account or to affiliate their existing account with the applicant organization in eRA Commons. If the PD/PI is also the organizational Signing Official, they must have two distinct eRA Commons accounts, one for each role. Obtaining an eRA Commons account can take up to 2 weeks.

Eligible Individuals (Program Director/Principal Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with his/her organization to develop an application for support.

Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support.

For institutions/organizations proposing multiple PDs/PIs, visit the Multiple Program Director/Principal Investigator Policy and submission details in the Senior/Key Person Profile (Expanded) Component of the SF424 This FOA does not require cost sharing as defined in the NIH Grants Policy Statement . 3.

Additional Information on Eligibility Applicant organizations may submit more than one application, provided that each application is scientifically distinct. The NIH will not accept duplicate or highly overlapping applications under review at the same time.

This means that the NIH will A new (A0) application that is submitted before issuance of the summary statement from the review of an overlapping new (A0) or resubmission A resubmission (A1) application that is submitted before issuance of the summary statement from the review of the previous new (A0) application.

An application that has substantial overlap with another application pending appeal of initial peer review (see NOT-OD-11-101 ). Section IV. Application and Submission Information Applicants must download the SF424 (R&R) application package associated with this funding opportunity using the Apply for Grant Electronically button in this FOA or following the directions provided at Grants.

gov . 2. Content and Form of Application Submission It is critical that applicants follow the instructions in (R&R) Application Guide , including Supplemental Grant Application Instructions except where instructed in this funding opportunity announcement to do otherwise.

Conformance to the requirements in the Application Guide is required and strictly enforced.

Applications that are out of compliance with these instructions may be delayed or not accepted for For information on Application Submission and Receipt, visit Frequently Asked Questions Application Guide, Electronic Submission of Grant Although a letter of intent is not required, is not binding, and does not enter into the review of a subsequent application, the information that it contains allows IC staff to estimate the potential review workload and By the date listed in Part 1.

Overview Information , prospective applicants are asked to submit a letter of intent that includes the following information: Descriptive title of proposed activity Name(s), address(es), and telephone number(s) of the PD(s)/PI(s) Names of other key personnel Participating institution(s) Number and title of this funding opportunity The letter of intent should be sent to: Carl V. Hill, Ph. D.

, M. P. H.

Director, Office of Special Populations National Institute on Aging (NIA) All page limitations described in the SF424 Application Page Limits must be followed.

Instructions for Application Submission The following section supplements the instructions found in the SF424 (R&R) Application Guide and should be used for preparing an All instructions in the SF424 (R&R) Application Guide SF424(R&R) Project/Performance Site Locations All instructions in the SF424 (R&R) Application Guide SF424(R&R) Other Project Information All instructions in the SF424 (R&R) Application Guide SF424(R&R) Senior/Key Person Profile All instructions in the SF424 (R&R) Application Guide must be followed.

The Senior/Key Person must have sufficient training or expertise in leading interdisciplinary teams for the conduct of health-related research. The investigative team should have sufficient representation and expertise to conduct health disparities research related to aging at environmental, sociocultural, behavioral and biological levels of analyses.

Specifically, the investigative team should have appropriate basic science expertise for interdisciplinary health disparities research related to aging.

All instructions in the SF424 (R&R) Application Guide All instructions in the SF424 (R&R) Application Guide PHS 398 Cover Page Supplement All instructions in the SF424 (R&R) Application Guide All instructions in the SF424 (R&R) Application Guide must be followed, with the following additional instructions: Strategy: Applicants should propose a plan to explore pathways through environmental, sociocultural or behavioral and biological levels of analyses that create and/or sustain health disparities for priority health disparity populations.

Applicants should describe how the project will add significant scientific knowledge to the field of health-disparities research related to aging. In the research plan, applicants should describe the basic-science expertise of the interdisciplinary team members and link this expertise to the analytical plan and the proposed health domain.

Applicants should describe how the research environment encourages interdisciplinary collaboration for the conduct of health-disparities research related to aging.

Sharing Plan : Individuals are required to comply with the instructions for the Resource Sharing Plans as provided in the SF424 (R&R) Application Guide, with the following modification: All applications, regardless of the amount of direct costs requested for any one year, should address a Data Sharing Plan. Do not use the Appendix to circumvent page limits.

Follow all instructions for the Appendix as described in the SF424 (R&R) Application Planned Enrollment Report When conducting clinical research, follow all instructions for completing Planned Enrollment Reports as described in the SF424 (R&R) PHS 398 Cumulative Inclusion Enrollment Report When conducting clinical research, follow all instructions for completing Cumulative Inclusion Enrollment Report as described in the SF424 (R&R) Application Guide.

See Part I. Section III. 1 for information regarding the requirements for obtaining a Dun and Bradstreet Universal Numbering System (DUNS) Number and for completing and maintaining an active System for Award Management (SAM) registration.

Part I. Overview Information contains information about Key Dates. Applicants are encouraged to submit applications before the due date to ensure they have time to make any application corrections that might be necessary for successful submission.

Organizations must submit applications to Grants. gov (the online portal to find and apply for grants across all Federal agencies). Applicants must then complete the submission process by tracking the status of the application in the eRA Commons , NIH’s electronic system for grants administration.

NIH and Grants. gov systems check the application against many of the application instructions upon submission. Errors must be corrected and a changed/corrected application must be submitted to Grants.

gov on or before the application due date. If a Changed/Corrected application is submitted after the deadline, the application will be considered late. are responsible for viewing their application before the due date in the eRA Commons to ensure accurate and successful submission.

Information on the submission process and a definition of on-time submission are provided in the SF424 (R&R) Application Guide. 4. Intergovernmental Review This initiative is not subject to intergovernmental All NIH awards are subject to the terms and conditions, cost principles, and other considerations described in the NIH Grants Policy Statement .

Pre-award costs are allowable only as described in the NIH Grants Policy Statement . Requirements and Information Applications must be submitted electronically following the instructions described in the SF424 (R&R) Application Guide. Paper applications will not be accepted.

Applicants must complete all required registrations before the application due date. Section III. Eligibility Information contains information about registration.

For assistance with your electronic application or for more information on the electronic submission Electronically . If you encounter a system issue beyond your control that threatens your ability to complete the submission process on-time, you must for Applicants Experiencing System Issues .

All PD(s)/PI(s) must include their eRA Commons ID in the Credential field of the Senior/Key Person Profile Component of the SF424(R&R) Application Package . Failure to register in the Commons and to include a valid PD/PI Commons ID in the credential field will prevent the successful submission of an electronic application to NIH. See Section III of this FOA for information on registration requirements.

The applicant organization must ensure that the DUNS number it provides on the application is the same number used in the organization s profile in the eRA Commons and for the System for Award Management. Additional information may be found in the SF424 (R&R) Application Guide. See more tips for avoiding common errors.

Upon receipt, applications will be evaluated for completeness and compliance with application instructions by the Center for Scientific Review, NIH and responsiveness by the National Institute on Aging. Applications that are incomplete, non-responsive or non-compliant will not be In order to expedite review, applicants are requested to notify Carl V. Hill, Ph.

D. , M. P.

H. by email at { [email protected] } when the application has been submitted. Please include the FOA number and title, PD/PI name, and title of the application.

Post Submission Materials Applicants are required to follow the instructions for post-submission materials, as described in NOT-OD-13-030. Section V. Application Review Information Only the review criteria described below will be considered in the review process.

As part of the NIH mission , all applications submitted to the NIH in support of biomedical and behavioral research are evaluated for scientific and technical merit through the NIH peer review Reviewers will provide an overall impact score to reflect their assessment of the likelihood for the project to exert a sustained, powerful influence on the research field(s) involved, in consideration of the following review criteria and additional review criteria (as applicable for the Reviewers will consider each of the review criteria below in the determination of scientific merit, and give a separate score for each.

An application does not need to be strong in all categories to be judged likely to have major scientific impact. For example, a project that by its nature is not innovative may be essential to advance a field. Does the project address an important problem or a critical barrier to progress in the field?

If the aims of the project are achieved, how will scientific knowledge, technical capability, and/or clinical practice be improved? How will successful completion of the aims change the concepts, methods, technologies, treatments, services, or preventative interventions that drive this field?

Will the project add significant scientific knowledge to the field of health-disparities research Are the PD(s)/PI(s), collaborators, and other researchers well suited to the project? If Early Stage Investigators or New Investigators, or in the early stages of independent careers, do they have appropriate experience and training?

If established, have they demonstrated an ongoing record of accomplishments that have advanced their field(s)? If the project is collaborative or multi-PD/PI, do the investigators have complementary and integrated expertise; are their leadership approach, governance and organizational structure appropriate for the project?

Does the investigative team have sufficient expertise to conduct health-disparities research related to aging across environmental, sociocultural, behavioral and biological domains of analysis? Does the investigative team have appropriate basic-science expertise? Does the investigative team have appropriate content-area expertise for the analytical plan and relevant health domain(s)?

Does the application challenge and seek to shift current research or clinical practice paradigms by utilizing novel theoretical concepts, approaches or methodologies, instrumentation, or interventions? Are the concepts, approaches or methodologies, instrumentation, or interventions novel to one field of research or novel in a broad sense?

Is a refinement, improvement, or new application of theoretical concepts, approaches or methodologies, instrumentation, or interventions proposed? Are the overall strategy, methodology, and analyses well-reasoned and appropriate to accomplish the specific aims of the project? Are potential problems, alternative strategies, and benchmarks for success presented?

If the project is in the early stages of development, will the strategy establish feasibility and will particularly risky aspects be managed?

Do the applicant(s) propose to explore pathways through environmental, sociocultural or behavioral and biological levels of analyses that create and/or sustain health disparities in priority health disparity If the project involves human subjects and/or NIH-defined clinical research, are the plans to address 1) the protection of human subjects from research risks, and 2) inclusion (or exclusion) of individuals on the basis of sex/gender, race, and ethnicity, as well as the inclusion or exclusion of children, justified in terms of the scientific goals and research strategy proposed?

Will the scientific environment in which the work will be done contribute to the probability of success? Are the institutional support, equipment and other physical resources available to the investigators adequate for the project proposed? Will the project benefit from unique features of the scientific environment, subject populations, or collaborative arrangements?

Does the research environment encourage interdisciplinary team science, specifically collaboration with basic scientists to explore biological pathways and mechanisms that create and sustain health disparities Additional Review Criteria As applicable for the project proposed, reviewers will evaluate the following additional items while determining scientific and technical merit, and in providing an overall impact score, but will not give separate scores for these items.

Protections for Human Subjects For research that involves human subjects but does not involve one of the six categories of research that are exempt under 45 CFR Part 46, the committee will evaluate the justification for involvement of human subjects and the proposed protections from research risk relating to their participation according to the following five review criteria: 1) risk to subjects, 2) adequacy of protection against risks, 3) potential benefits to the subjects and others, 4) importance of the knowledge to be gained, and 5) data and safety monitoring for clinical trials.

For research that involves human subjects and meets the criteria for one or more of the six categories of research that are exempt under 45 CFR Part 46, the committee will evaluate: 1) the justification for the exemption, 2) human subjects involvement and characteristics, and 3) sources of materials.

For additional information on review of the Human Subjects section, please refer to the Guidelines for the Review of Human Inclusion of Women, Minorities, When the proposed project involves human subjects and/or NIH-defined clinical research, the committee will evaluate the proposed plans for the inclusion (or exclusion) of individuals on the basis of sex/gender, race, and ethnicity, as well as the inclusion (or exclusion) of children to determine if it is justified in terms of the scientific goals and research strategy proposed.

For additional information on review of the Inclusion section, please refer to the Guidelines for the Review of Inclusion The committee will evaluate the involvement of live vertebrate animals as part of the scientific assessment according to the following five points: 1) proposed use of the animals, and species, strains, ages, sex, and numbers to be used; 2) justifications for the use of animals and for the appropriateness of the species and numbers proposed; 3) adequacy of veterinary care; 4) procedures for limiting discomfort, distress, pain and injury to that which is unavoidable in the conduct of scientifically sound research including the use of analgesic, anesthetic, and tranquilizing drugs and/or comfortable restraining devices; and 5) methods of euthanasia and reason for selection if not consistent with the AVMA Guidelines on Euthanasia.

For additional information on review of the Vertebrate Animals section, please refer to the Worksheet for Review of the Vertebrate Reviewers will assess whether materials or procedures proposed are potentially hazardous to research personnel and/or the environment, and if needed, determine whether adequate Additional Review Considerations As applicable for the project proposed, reviewers will consider each of the following items, but will not give scores for these items, and should not consider them in providing an overall impact score.

Applications from Foreign Organizations Reviewers will assess the information provided in this section of the application, including 1) the Select Agent(s) to be used in the proposed research, 2) the registration status of all entities where Select Agent(s) will be used, 3) the procedures that will be used to monitor possession use and transfer of Select Agent(s), and 4) plans for appropriate biosafety, biocontainment, and security of the Select Agent(s).

Reviewers will comment on whether the following Resource Sharing Plans, or the rationale for not sharing the following types of resources, are reasonable: 1) Data Sharing Plan ; 2) Sharing Model Organisms ; and 3) Genomic Wide Association Studies (GWAS) /Genomic Data Sharing Plan .

Budget and Period of Support Reviewers will consider whether the budget and the requested period of support are fully justified and reasonable in relation to the proposed research. Applications will be evaluated for scientific and technical merit by (an) appropriate Scientific Review Group(s) convened by the National Institute on Aging in accordance with NIH peer review policy and procedures , using the stated review criteria .

Assignment to a Scientific Review Group will be shown in the eRA As part of the scientific peer review, all applications: May undergo a selection process in which only those applications deemed to have the highest scientific and technical merit (generally the top half of applications under review) will be discussed and assigned an overall impact Will receive a written critique.

Appeals of initial peer review will not be accepted for applications submitted in Applications will be assigned on the basis of established PHS referral guidelines to the appropriate NIH Institute or Center. Applications will compete for available funds with all other recommended applications submitted in response to this FOA.

Following initial peer review, recommended applications will receive a second level of review by the National Advisory Council on Aging. The following will be considered in making funding decisions: Scientific and technical merit of the proposed project as determined by scientific peer review. Relevance of the proposed project to program priorities.

3. Anticipated Announcement After the peer review of the application is completed, the PD/PI will be able to access his or her Summary Statement