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Find similar grantsBiosecurity & Pandemic Preparedness Fund is sponsored by Coefficient Giving (formerly Open Philanthropy). This fund focuses on building resilience against biological risks, including pandemic preparedness. Coefficient Giving is a philanthropic funder that partners with donors to maximize their impact across various areas, including biosecurity and pandemic preparedness.
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We’re a philanthropic funder that partners with leading donors to multiply their impact. Coefficient has directed over $5 billion in grants since 2014. Our mission is to help others as much as we can with the resources available to us.
Accelerating growth and scientific progress Improving health through cleaner air Biosecurity & Pandemic Preparedness Building resilience against biological risk Effective Giving & Careers Empowering people to maximize their impact Improving the lives of farmed animals Improving how critical decisions are made Encouraging generous and cost-effective aid Global Catastrophic Risks Opportunities Countering threats to civilization Supporting growth to reduce global poverty Global Health & Wellbeing Opportunities Improving health and wellbeing for all people Lead Exposure Action Fund Accelerating progress toward a lead-free world Navigating Transformative AI Ensuring AI is safe and well-governed Science and Global Health R&D Supporting lifesaving ideas and discoveries Accelerating development of Strep A vaccines Strategic Cause Selection We believe the most important decision a philanthropist makes is choosing which causes to support.
We conduct in-depth research to identify the areas where our funding can help others the most. Coefficient Giving directed over $1 billion in 2025, the most in our history. This significant milestone is the result of extraordinary dedication from our funders, staff, and grantees, who share the conviction that effective philanthropy can be a powerful lever for making the world a much better place.
Open Philanthropy Is Now Coefficient Giving Our new name marks our next chapter as we double down on our longstanding goal of helping more funders increase their impact. We believe philanthropy can be a far more vital force for progress than it is today.
Cool Things Our Global Health & Wellbeing Grantees Accomplished in 2025 Our GHW grantees made remarkable progress in 2025: a diagnostics company we supported reached 3 million sickle cell tests distributed across 40 countries, advocacy groups secured welfare improvements for hundreds of millions of chickens in Europe, and researchers advanced promising approaches to treating tuberculosis and preventing malaria.
Science and Global Health R&D Using AI to create more effective vaccines Professors David Baker and Neil King use advanced protein modeling software and nanoparticle technology to develop better vaccines. Their approach has already led to an approved COVID-19 vaccine and more effective flu vaccine that has completed Phase I trials. David Baker won the Nobel Prize in Chemistry in 2024.
Eliminating lead paint, one country at a time In dozens of low- and middle-income countries, much of the paint supply contains dangerous amounts of lead. The Lead Exposure Elimination Project is working to end this public health crisis, which has received little attention from the global health community relative to its devastating effects.
Making social science more robust and reliable The Institute for Replication addresses a core problem in social science by replicating highly cited studies to check whether the results hold up. This helps ensure that research influencing public policy is reliable, and gives scientists stronger incentives to avoid manipulative practices and produce robust findings.
Freeing hundreds of millions of chickens from cages The Open Wing Alliance (OWA), a coalition of advocacy groups, has persuaded more than 3,000 food companies worldwide to shift to using cage-free eggs, through a mix of negotiation and public campaigns. Thanks to OWA and other advocates, over 250 million hens have been spared from confinement.
Science and Global Health R&D Expanding access to clean water through a low-cost device The TuriTap is an automatic water-chlorination device that operates without electricity. It helps communities without reliable water treatment infrastructure access clean water, which could reduce the spread of infectious disease. The device has been installed in health care facilities across Kenya.
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Based on current listing details, eligibility includes: Not explicitly detailed, but generally supports organizations working on biosecurity and pandemic preparedness. Applicants should confirm final requirements in the official notice before submission. Applicants should confirm final requirements in the official notice before submission.
Current published award information indicates Not specified (Coefficient Giving has directed over $5 billion in grants since 2014) Always verify allowable costs, matching requirements, and funding caps directly in the sponsor documentation.
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Coefficient Giving (formerly Open Philanthropy) is a grant from Coefficient Giving that funds evidence-based programs and research in global health, animal welfare, scientific research, and effective altruism causes where philanthropic dollars can achieve high impact per dollar. The fund supports organizations demonstrating rigorous evidence of effectiveness and scalable potential. Eligible applicants include nonprofits, research institutions, and projects aligned with Coefficient Giving's priority cause areas. The fund emphasizes transparency, cost-effectiveness analysis, and funding gaps not addressed by government or traditional philanthropy.
Request for Proposals: AI Governance is sponsored by Coefficient Giving (formerly Open Philanthropy). Coefficient Giving funds research projects that improve strategic clarity on AI governance, enhance scientific understanding of AI's developmental trajectory, flesh out policy options and governance mechanisms, and distill existing research to make it more accessible. They also offer general support grants to established organizations with a proven track record in reducing catastrophic risks from advanced AI systems.
Coefficient Giving (formerly Open Philanthropy), the largest funder in existential risk reduction, has issued a Request for Proposals for Technical AI Safety Research focused on alignment, interpretability, and control of advanced AI systems. The RFP accepts proposals on a rolling basis with no fixed deadline. Coefficient Giving expects to spend roughly $40 million on this initiative and is open to spending substantially more depending on application quality. The program funds a wide range of activities including fundamental alignment research, interpretability and mechanistic understanding of AI systems, AI control and containment strategies, evaluation and benchmarking of AI safety properties, scalable oversight methods, and seed funding for new AI safety research organizations. This is distinct from Coefficient Giving's separate AI Governance Research RFP which focuses on policy and governance questions.
-Purpose. This Funding Opportunity Announcement (FOA) encourages Small Business Innovation Research (SBIR) grant applications from small business concerns (SBCs) that propose to develop, standardize, and validate new and innovative assays, integrated strategies, or batteries of assays that determine or predict specific organ toxicities (e.g., ocular, dermal, hematotoxicity, cardiotoxicity, gastrointestinal toxicity, hepatotoxicity, nephrotoxicity, ototoxicity, olfactory loss, bladder toxicity, neurotoxicity, pulmonary toxicity, endocrine toxicity, and pancreatic beta cell toxicity), resulting from both acute and chronic exposures to various chemicals, environmental pollutants, biologics and therapeutic molecules or drugs. In addition, this FOA encourages the development, standardization, and validation of new models of arthritis, convulsion, infection and shock. New approaches for high throughput toxicity screening that involves the use of molecular endpoints, computer modeling, proteomics, genomics and epigenomics and the development of virtual tissues are also encouraged as are development of 3-dimensional organ models for toxicity evaluation. -Mechanism of Support. This FOA will utilize the SBIR (R43/R44) grant mechanisms for Phase I, Phase II, and Fast-Track applications and runs in parallel with a FOA of identical scientific scope, PA-09-007, which encourages applications under the Small Business Technology Transfer (STTR) (R41/R42) grant mechanisms. Funding Opportunity Number: PA-09-006. Assistance Listing: 93.113,93.173,93.361,93.389,93.837,93.846,93.847,93.848,93.849,93.859,93.867. Funding Instrument: G. Category: ED,ENV,FN,HL.
Purpose. This Funding Opportunity Announcement (FOA), issued by the National Cancer Institute (NCI), National Institutes of Health (NIH), invites Small Business Innovation Research (SBIR) cooperative agreement applications from small business concerns (SBCs) that propose to develop new, or to improve existing application(s) of nanotechnology-based therapeutics or/and in vivo diagnostics. This FOA will specifically support pre-clinical optimization and testing of these cancer-relevant nanotechnology applications against the intended cancer type. The proposed projects must be milestone-driven and must be clearly directed toward development of an ultimate commercial product. The outcomes are expected to advance the discovery and pre-clinical optimization phase so that an Investigational New Drug (IND) or Investigational Device Exemptions (IDE) application could be submitted to the Food and Drug Administration (FDA) by the end or shortly after completion of the Phase II project period. To facilitate these steps, the NCI will assist the awardees in various ways, including the support through the NCI-sponsored Nanotechnology Characterization Laboratory. This FOA will NOT support basic research projects, studies on disease mechanisms, and clinical trials. Mechanism of Support. This FOA will utilize the SBIR (U43/U44) cooperative agreement mechanisms for Phase I and Phase II applications. Funds Available and Anticipated Number of Awards. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications. The total amount awarded and the number of awards will depend upon the quality, duration, and costs of the applications received. Funding Opportunity Number: PAR-10-286. Assistance Listing: 93.393,93.394,93.395,93.396. Funding Instrument: CA. Category: ED,HL. Award Amount: Up to $150K per award.
This Funding Opportunity Announcement (FOA) invites Small Business Innovation Research (SBIR) grant applications from small business concerns (SBCs) for funding to perform research leading to the development of innovative technologies that may advance progress for early detection and assessment of individuals at risk and for early diagnosis, prognosis and follow-up of type 1 diabetes (T1D). Funding Opportunity Number: RFA-DK-15-024. Assistance Listing: 93.847. Funding Instrument: G. Category: FN,HL. Award Amount: $2M total program funding.