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Find similar grantsBrain Repair of Any Injured Neural Structure (BRAINS) Exploratory Topic is sponsored by Advanced Research Projects Agency for Health (ARPA-H). The BRAINS exploratory topic is an ARPA-H initiative designed for targeted investments to rapidly accelerate research innovation in specific areas, focusing on brain repair for injured neural structures.
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BRAINS Exploratory Topic | ARPA-H Regrowing Damaged Brain Regions to Restore Lost Function Brain Repair of Any Injured Neural Structure (BRAINS) Exploratory Topic Many diseases and injuries can damage specific parts of the brain, leaving tens of millions of Americans with permanent disabilities and no real way to get back lost abilities or independence.
Today, there are no treatments that can replace damaged brain tissue and restore normal function. Instead, people rely on physical, psychological, and occupational therapies to manage their condition. As a result, many remain disabled and need lifelong care.
The Brain Repair of Any Injured Neural Structure (BRAINS) Exploratory Topic (ET) is the first effort to generate graftable precursor tissues for multiple parts of the brain – extending beyond the FRONT program's focus on the neocortex. BRAINS goal is to show it is possible to reverse damage and disease in any part of the brain.
BRAINS ET will target brain regions including, but not limited to, the hippocampus, amygdala, thalamus, hypothalamus, striatum, cingulate cortex, substantia nigra, brainstem, and cerebellum. Together, these areas control movement, balance, mood, autonomic body functions, memory formation, and other critical functions.
The BRAINS ET approach will address a wide range of disabilities caused by many forms of brain damage, including aging, congenital diseases, strokes, injuries, tumors, and infections.
Using natural brain development as a guide, BRAINS is focused on two technical areas, both essential for later steps in repairing damaged brain tissue with working tissue: Technical area 1: teams will design developmental mimicking or tissue engineering methods capable of generating precursor tissue for a part of the brain other than neocortex.
Technical area 2: teams will provide proof-of-concept for surgical engraftment into adult brains of non-human fetal precursor tissues for their selected brain area BRAINS ET will have two intake groups. Each group’s work will last 18 months from kickoff to completion and will include two 9-month phases.
BRAINS stands to transform the lives of millions of Americans affected by brain injury, disease, and aging by ultimately enabling the restoration of lost abilities and independence - something no current therapy can offer. Notice ID: ARPA-H-SOL-26-148 ARPA-H invites interested parties to review the solicitation, which is posted and maintained on SAM.
gov. The solicitation outlines the opportunity and its requirements, key dates and deadlines, submission documents and templates, evaluation criteria for submissions, and information on how to apply. Solution Summary due: July 9, 2026 at 5:00PM ET A solution summary is required to submit a full proposal.
Full Proposal due: August 6, 2026 at 5:00PM ET After submission of a solution summary, proposers will either be encouraged or discouraged from submission of a full proposal. It is strongly recommended that only proposers who are encouraged to submit a full proposal do so. Reminder: Dates are estimates and subject to change.
Please reference the solicitation for the most up-to-date information. Review Solicitation Details Ready to apply? To submit, sign-in to the ARPA-H Solutions Portal after June 25, 2026.
Frequently Asked Questions Review responses to common questions about this funding opportunity asked by others in the proposer community. You can also ask a question. Review FAQs and Ask A Question Proposers' Day Webinar and Sidebars This pre-recorded webinar is an optional event for the potential proposer community and is not intended for patients, patient advocates, media or general interest audiences.
BRAINS is hosting a live Q&A session and sidebars with the Program Manager and team. Please review the Special Notice and register in advance for these events. Notice ID: ARPA-H-SN-26-153 Event date: June 24 and 25, 2026 at 3:30-5:30PM ET
According to the current listing, eligibility includes: Eligible entities will be specified in the initiative's solicitation. Confirm the full requirements in the official notice before applying.
The published deadline was July 9, 2026, which has passed. Check the official notice for any future application windows before investing time in a proposal.
Brain Repair of Any Injured Neural Structure (BRAINS) Exploratory Topic is funded by Advanced Research Projects Agency for Health (ARPA-H). Verify program details on the funder's official page before applying.
Start from the official opportunity page linked in this listing — it carries the sponsor's submission instructions.
NCI Continuing Umbrella of Research Experiences (CURE) Academic Career Excellence (ACE) Award (K32) is a grant from the National Cancer Institute (NCI) that funds early postdoctoral fellows from diverse backgrounds, including underrepresented groups, to pursue research training in cancer-related fields. The K32 award supports fellows within 12 months prior to transitioning into, or within the first two years of, a postdoctoral position. The program, operated through NCI's Center to Reduce Cancer Health Disparities (CRCHD), aims to enhance the pool of qualified diverse cancer researchers. Beginning with the June 12, 2025 due date, the CURE ACE Award is available in both Independent Clinical Trial Required and Independent Clinical Trial Not Allowed versions. Eligible applicants must be U.S. citizens or permanent residents at time of award.
Smart Health and Biomedical Research in the Era of Artificial Intelligence and Advanced Data Science (SCH) is sponsored by National Science Foundation (NSF) & National Institutes of Health (NIH). This interagency program supports high-risk, high-reward interdisciplinary projects that leverage AI, machine learning, and advanced data science to address pressing questions in biomedical and public health research. It seeks to advance fundamental scientific and engineering contributions across disciplines to solve key health problems.
ARPA-H's 2026 SBIR/STTR BAA opens seven transformative health topics with $600K Phase I and $3.5M Phase II contracts — non-dilutive, milestone-driven money. The July 10 Solution Summary gate decides who ever gets to pitch. Here's how the ARPA-H model differs from NIH and how small health-tech firms actually get through the funnel.
Read articleARPA-H's FY2026 SBIR/STTR solicitation closes its Solution Summary stage July 10, with seven named topics spanning women's health, autoimmune diagnostics, toxin removal, and neurosurgical robotics. Awards run up to $600K for Phase I and $3.5M for Phase II — but they are contracts, not grants, and the four-to-six-page summary is the gate that filters out most applicants. Here is how ARPA-H's model actually works and how to win the first stage.
Read articleARPA-H's FY2026 SBIR/STTR solicitation opens with a Solution Summary due July 10, 2026, then a Technical Oral Presentation by September 9 for those invited. Awards run up to $600K (Phase I) and $3.5M (Phase II), with Direct-to-Phase-II and Fast Track options across seven health topic areas. Here is how the two-step, pitch-driven process differs from NIH SBIR — and how to win the first gate.
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