The Burroughs Wellcome Fund Career Awards for Medical Scientists (CAMS) is a highly competitive grant from the Burroughs Wellcome Fund that provides $700,000 over five years to physician-scientists committed to academic careers, bridging advanced postdoctoral or fellowship training and the early years of faculty service. The program supports basic biomedical, disease-oriented, translational, or pharmacological research.

Eligible applicants hold an MD, DO, DDS, DVM, or equivalent clinical degree and are postdoctoral researchers or pre-tenure faculty at U.S. or Canadian degree-granting institutions. Applicants may not concurrently hold NIH K99/R00 or DP5 awards. The 2025-2026 cycle deadline was October 7, 2025, with detailed requirements available in the program's RFP on ProposalCentral.

Career Awards for Medical Scientists - Burroughs Wellcome Fund Career Awards for Medical Scientists Share this Grant Apply Now The Career Awards for Medical Scientists (CAMS) is a highly competitive program that provides $700,000 awards over five years for physician-scientists, who are committed to an academic career, to bridge advanced postdoctoral/fellowship training and the early years of faculty service.

For more information about the CAMS award, please view this webinar recording from the 2024-2025 application cycle. In this webinar, CAMS Program Officer Dr. Paige Cooper Byas provided an overview of the application process, eligibility, and award components. Any dates mentioned in this recording refer to the 2024-2025 application cycle.

For updated deadline and notification dates, please see the 2025-2026 RFP. Progress and financial reports are required of all BWF grants and are due on the date(s) specified in ProposalCentral. Advisory Committee and staff depend heavily upon progress and financial reports to evaluate progress.

Late reports inconvenience advisory committee reviewers and impede BWF's evaluation of its programs. Failure to submit progress or financial reports in a timely fashion will result in payments being withheld, and if submissions are missed repeatedly, will result in termination of the award. BWF provides the following progress report guidelines below to assist in the preparation and submission of Progress Reports in an acceptable manner.

The progress report and financial updates are to be submitted through Proposal Central. You can find required deliverables listed on the home page after logging in to Proposal Central. Failure to submit any portion of the report by the due date will result in an interruption or cancellation of your funds.

Progress Reporting for Awardees The progress report requires the awardee to submit a written report on the progress of the original or approved update to research project aims, an updated biographical sketch, a letter of support, and any recent publications. Details regarding each section are in Proposal Central. The progress report must be submitted annually on November 1st.

Awardees are required to update award spending in the Proposal Central budget summary. Awardees should update the financial report twice each year and provide up-to-date spending information from the previous six months. Details regarding financial reporting can be found in Proposal Central.

Financial reports are due biannually on February 1st and August 1st. All progress and financial reporting materials should be submitted through Proposal Central. If you have questions, please contact Lama Haidar ( lhaidar@bwfund.

org ). Can I contact BWF to determine my eligibility? It is the responsibility of applicants to read the published guidelines and FAQs to determine eligibility before contacting BWF staff.

If you have questions, a unique training path, or experiences that are not fully addressed, you may contact the CAMS team ( cams@bwfund. org ) for guidance. The FAQs are updated regularly in response to questions received.

BWF staff will do their best to respond to every inquiry but will prioritize questions not already clearly addressed in the published guidelines. Please do not contact BWF to request an exception to clearly stated guidelines. Do I need to be nominated by my institution to apply?

No, you do not need to be nominated; however, you must obtain approval from your institution. Since August 2015, eligible candidates may now self-nominate by submitting a full proposal by the deadline. All applications must be approved by an official at the institution responsible for sponsored programs (generally from the grants and contracts office, the office of research, or the sponsored programs office).

I hold a Ph. D. degree only.

Am I eligible to apply to the CAMS program? No. If your background is in the physical/mathematical/computational sciences or engineering and your work addresses biological questions, you may want to consider applying to BWF’s Career Awards at the Scientific Interface . I hold a Pharm.

D. or Pharm. D, Ph.

D. degree. Am I eligible to apply to the CAMS program?

Is 75 percent of the time devoted to researching a firm policy? Yes. Programs and department chairs must provide adequate protection for the candidate to conduct research.

As a surgeon scientist can I be considered with less than 75% research effort? No, currently for the CAMS award the 75% effort is the expectation regardless of specialty. However, if you do not currently have 75% protected time towards research, but it can be negotiated if CAMS were awarded, you may proceed with your application.

Please ensure a letter of support or offer letter can demonstrate this in writing before proceeding. Am I required to have 75% protected research time when applying? No, however it is the expectation that you can demonstrate that this time can be negotiated if CAMS is awarded either in letters of recommendation or an offer letter.

I may be changing institutions to complete additional postdoc training after I submit a proposal. Can I submit one? No. Invitations to finalists are based on the information submitted in the proposal.

The training environment (mentor and institution) is an integral part of this consideration and, therefore, cannot be changed after submitting the proposal. Thus, if you move to a new institution after submitting the proposal, you will not be eligible to interview, even if you are invited. If I have an NIH K08, K12, K21, or K23 award, am I eligible for the award?

If I have an NIH K99/R00 or Early Independence award, am I eligible for the award? I have applied to the NIH K99 and/or NIH DP5 programs, but the awards have not been selected. Can I apply to the BWF CAMS program?

Yes. However, awardees cannot receive funding simultaneously from both a K99 or DP5 and a CAMS award. My title is instructor, clinical lecturer, or assistant professor, non-tenure track.

Am I eligible for the award? Yes, if your junior faculty appointment is non-tenure track, and you meet all other eligibility criteria, you are eligible. How much is considered a “substantial” startup for a non-tenure track package?

BWF currently reviews non-tenure track offers on a case-by-case basis. To be considered for eligibility, please submit your full offer letter - including all details of any research startup package - to the BWF CAMS team ( cams@bwfund. org ) no later than 2 weeks prior to the application deadline.

You may redact any salary or confidential portions you need or prefer to keep private. Your letter will be kept confidential and only used for review of eligibility. I have submitted a first-author manuscript from my graduate (or undergraduate) studies, but it has not yet been published.

Am I eligible to apply? Possibly. If the manuscript is accepted for publication or in press, you can apply; otherwise, you are not eligible.

BioRxiv pre-prints do count and can be included. I have publications from my graduate (and undergraduate) studies, but I am not the first author of any of them. Am I eligible to apply ?

No. You must have at least one first-author publication to be competitive and eligible to apply for this program. This includes papers on which "first authorship" is shared. My field is health services research and policy.

Am I eligible for the award? No. The award is only for individuals in basic biomedical, disease-oriented, or translational research. Do I need a commitment from a university for a faculty appointment to apply for this award?

No. The award aims to help postdoctoral scientists obtain a faculty appointment at a degree-granting institution of their choosing. Candidates may be applying for faculty positions at the same time of application, but if you currently hold or have accepted, either verbally or in writing, a tenure-track faculty appointment, you are not eligible.

I have not yet decided whether to pursue a full-time research career as an independent investigator at a North American degree-granting institution. Can I apply to this program? Possibly.

As of 2024, public or private non-profit organizations in the United States and Canada, including degree-granting academic institutions, research institutes, and teaching hospitals affiliated with academic degree-granting institutions, are eligible to receive Burroughs Wellcome Fund support. My clinical degree was awarded outside of the US and Canada. Am I still eligible to apply?

I am based at a North American non-profit institution, but my primary postdoctoral mentor or faculty sponsor doesn't hold a faculty appointment at an accredited, degree-granting North American institution. Can I apply to this program? Yes.

Public or private non-profit organizations in the United States and Canada, including degree-granting academic institutions, research institutes, and teaching hospitals affiliated with academic degree-granting institutions, can receive Burroughs Wellcome Fund support. Applications from other nonprofit organizations may be considered subject to program officer approval. I currently hold a BWF award.

Am I eligible for this award? Possibly. Contact the program team via email to discuss eligibility.

I am a past BWF grant recipient. Am I eligible for this award? Possibly.

Contact the program team via email to discuss eligibility. I am at an independent research institute. Am I eligible for this award?

Yes. Public or private non-profit organizations in the United States and Canada, including degree-granting academic institutions, research institutes, and teaching hospitals affiliated with academic degree-granting institutions, can receive Burroughs Wellcome Fund support. Applications from other nonprofit organizations may be considered subject to program officer approval.

If not awarded, can candidates resubmit their applications in the future? BWF does not currently have a cap on reapplying. As long as a candidate remains eligible, they can reapply in a future cycle(s) an unlimited number of times.

In prior RFPs candidates could not be more than 13 years past their clinical doctorate degree. Is that still true? No, the 13-year limit post clinical degree has been replaced to focus on career stage window rather than years to degree.

Can I have a co-investigator on this proposal? No. The CAMS grant program does not allow co-investigators. I have two postdoctoral mentors.

Can I submit two mentor recommendation letters? Only one mentor letter of recommendation may be submitted with your proposal application. This letter should be from the person designated as your primary postdoctoral mentor or faculty sponsor in the application.

If you have a co-mentor/secondary mentor, and if both your primary and secondary mentor wish to co-write and sign one mentor letter, that is also acceptable. Alternatively, if you have a co-mentor/secondary mentor and they would like to write one of your three additional recommendation letters, that is also acceptable. Can support letters be sent separately outside the grant application?

No. All support letters must be uploaded and attached to your application and submitted electronically by the application deadline. Emailed, mailed, or faxed letters will not be accepted. To whom should my letters of recommendation be addressed?

Letters of recommendation should be addressed to the CAMS Advisory Committee and must be uploaded and attached to your application and submitted electronically by the application deadline. Emailed, mailed, or faxed letters will not be accepted. If I attach a bibliography to my research plan, does it count toward the six-page maximum?

No. Also, glossaries of technical abbreviations and terms are acceptable and encouraged if they clarify the proposal to the general reader and do not count toward the page limit. Are figures, tables, graphs, diagrams, and pictures included in my research plan counted in the six-page limit, or can they be included separately?

Yes, all figures, tables, graphs, diagrams, pictures, etc., included in your research plan count toward the six-page limit. I would like to include additional materials as appendices to the application. Is this allowed?

No. You may not include materials beyond those requested by the application instructions. Including additional materials may disqualify you from the competition. Do I need to submit a proposed budget with my application?

Yes, a tentative budget associated with your project plan must be included. Are there limits to the salary and fringe amounts that can be budgeted? Yes, there are limits for the postdoc phase and faculty phase of the award.

If the awardee elects to utilize the postdoctoral portion of the award (up to two years of support) A maximum of $90,000 may be used for salary and fringe benefits combined during year one of the postdoctoral phase. A maximum of $95,000 may be used for salary and fringe benefits combined during year two of the postdoctoral phase.

During the faculty portion of this award, a maximum of $59,500 may be used annually towards the named investigators salary and fringe benefits combined. Can caregiver expenses be budgeted? Yes, up to $5,000/year may be applied towards caregiving expenses.

This is separate from the salary and fringe limits. This benefit can be utilized during any portion of the award. Are there font or margin requirements for the research plan?

Yes. Use standard 11- or 12-point type for the text and no smaller than 9 to 10-point type for figures, legends, and tables. The text must be single-spaced, with one inch or larger margins.

The font size requirement is strictly enforced. Is the BWF application deadline firm? Can I submit a paper application?

No. BWF requires that all applications for this program be submitted electronically by the application deadline. Paper applications will not be accepted. Can I submit more than one application?

Can I change my application once it is submitted? No. Once your application is submitted, it cannot be changed. What is a “signature block”?

A signature block is found at the end of a letter and includes the letter writer’s name, title(s), department(s), and institution. It is usually found just after the closing of the letter (e.g., just after the word ‘Sincerely,’ or ‘Yours truly,’) and just under the letter writer’s signature. Here is an example of a signature block: Jane Smith, M.

D. , Ph. D.

Chair and Professor, Department of Medicine ABC University Do I need to complete an application in one session? No, you can start an application and return later to complete it. When beginning a new application, you are required to log in with an existing or established proposal central log-in and password.

You can save, exit the application, and return later at any time during the application process. I forgot my user ID and/or password. What should I do?

If you have forgotten your password or user ID, visit the BWF grant application system and click the forgotten password link. What is the Signature Page Form? How do I submit it?

The Signature Page Form provides a signature line for the Applicant. An application is not considered complete without the Signature Page form. You must upload the completed Signature Page form with your signature by the application deadline date.

An emailed, mailed, or faxed signature page will not be accepted. What is the Institutional Certification Form? How do I submit it?

It is a required form that must be completed and signed by an authorized signing official to certify (a) the university’s non-profit status as a degree-granting institution and (b) the applicant meets all eligibility and residency requirements for the CAMS program at the submission deadline. An application is not considered complete without the Institutional Certification form.

An emailed, mailed, or faxed institutional certification form will not be accepted. Can I change institutions during the award? The award is portable.

Most awardees will change institutions to begin a faculty appointment. However, transferring your award is not guaranteed. The institution that you wish to transfer to must demonstrate a commitment to you by offering you a tenure track or equivalent faculty appointment and significant start-up money.

In addition, BWF must approve the transfer. Transfers during the faculty portion of the award are discouraged. Can I interrupt the award because of family commitments?

Yes. BWF will allow you a no-cost extension of up to two years during the award term. Are awardees permitted to receive other simultaneous funding, such as from the National Institutes of Health or another foundation?

Award recipients may obtain funds from other sources for research in the same or similar areas as that conducted under these grants, so long as there is no conflict with meeting the terms of BWF’s award. Award recipients may not hold concurrent BWF awards or NIH K99/R00, NIH DP5, or similar Early Independence awards. What are my chances of receiving a Career Award for Medical Scientists?

There is no way to know definitively how many proposals we will receive each application cycle and, therefore, what the success rate will be. However, based on data from previous CAMS competitions, we estimate an award rate of 12 percent.

Updated: 30 September 2025 Children’s Hospital of Philadelphia Novel mechanisms of acute myeloid leukemia resistance to cell therapy University of California-San Francisco Overcoming Pediatric Viral-Induced Critical Illness University of Texas Southwestern Medical Center Defining the functions of uncharacterized organellar proteins Unraveling genetic determinants of thermogenic adipose tissue in humans Boston Children’s Hospital Mechanisms and treatability of neurodevelopmental disorders of chromatin biology On the origin of ALK-driven lung cancer University of California-San Francisco Immunological modulation of pain Kaitlin Katsura, DDS, PhD Children’s Hospital of Philadelphia Macrophages in tooth development Sumeet Khetarpal, MD, PhD Massachusetts General Hospital Mining and modulating the heart secretome of exercise for therapeutic gain in heart failure University of California-San Francisco Autoimmune Regulation of Cognition in Encephalitis, Neurodegeneration, and Aging Define the role of Treponema pallidum-specific humoral responses during infection Lymphatic control of neural and ocular immune responses Massachusetts General Hospital Bayesian Mixture Models for Genetic Discovery of Complex Disease over Time University of California – San Francisco Inspiration from Yeast: SREBP1 as an Evolutionarily Conserved Oxygen Sensor University of California – San Francisco Nutritional Control of the Immune Response Terminal type-specific cannabinoid CB1 receptor alterations in schizophrenia and cannabis use Dana–Farber Cancer Institute Targeting metabolic vulnerabilities in clonal hematopoiesis Memorial Sloan Kettering Cancer Center Exploring the Impact of Macrophages in Squamous Cell Carcinoma’s Invasive Front Memorial Sloan Kettering Cancer Center Tracking Genomic Evolution and Therapeutic Implication of Oncogene Amplification in Cancer Salvador Alonso Martinez, MD Memorial Sloan Kettering Cancer Center Detecting and targeting therapy-resistant cancer cell states University of California – Berkeley Deciphering the role of Endoplasmic Reticulum structure in fatty liver disease La Jolla Institute for Immunology University of California – San Diego Implications of upper airway adaptive immune memory in vaccine responsiveness and protection from respiratory pathogens Personalized synthetic immune cell engineering across diverse cancer patients Massachusetts General Hospital The role of upper gastrointestinal tract innervating mechanosensory DRG sensory neurons in controlling motility and feeding behavior Lineage programs that promote tumorigenesis in the developing liver University of California – Los Angeles Dynamic FOXP3 Expression in the Development of Regulatory T cells from Induced Pluripotent Stem Cells University of Pennsylvania The Molecular Regulation of a Novel Distal Airway Progenitor in COPD University of Texas Southwestern Medical Center-Dallas The Role for PHF7 in Adult Fibroblast to Cardiomyocyte Reprogramming Developmental Origins and Molecular Mechanisms of Somatic Mutations in Mesial Temporal Lobe Epilepsy Beth Israel Deaconess Medical Center Blood-Brain Barrier Disruption as a Biomarker for Early Course Psychosis: An In Vivo/Ex Vivo Investigation Cognitive and Circuit Mechanisms Underlying Spontaneous Cortical States University of Texas-Houston Health Science Center Maternal COVID-19 and Placental Mechanisms of Preeclampsia University of Pennsylvania Using person-specific networks to uncover sex differences in vulnerability to internalizing symptoms Molecular Dynamics of Glioma Formation and DNA Damage Response by Mutant IDH1 Massachusetts Institute of Technology Biologic regulators: a paradigm shift for cancer nanomedicine Icahn School of Medicine at Mount Sinai Neuroeconomic investigation of the computational and molecular mechanisms underlying depression The Role of Dendritic Cell Metabolism in Regulating Adaptive Immune Responses Memorial Sloan-Kettering Cancer Center Reprogramming Drug Resistance in Cancer Cells Engineering a synthetic microbial community for research and treatment of Nonalcoholic steatohepatitis Theodore George Drivas, MD, PhD University of Pennsylvania Discovering molecular and genetic mechanisms of ciliary signaling in common disease William Allen Freed-Pastor, MD, PhD Overcoming T cell exclusion to augment immunotherapy in pancreatic cancer Alexander Gitlin, MD, PhD Insights from complex immune disorders: how an apoptotic caspase unleashes inflammation University of California-Los Angeles Imaging transcriptomics across developmental stages of early psychotic illness Identifying key regulators of the neuronal-like malignant phenotype and tumornerve crosstalk in pancreatic cancer Maya Evelyn Kotas, MD, PhD University of California-San Francisco Understanding the role of tuft cells in allergic airway disease Memorial Sloan-Kettering Cancer Center Optimization of Fc Effector Activity of Anti-CD47 Antibodies for Cancer Immunotherapy Kartik Pattabiraman, MD, PhD Developmental disruption of prefrontal circuits as the neurodevelopmental etiology of schizophrenia Jessica Renee Queen, MD, PhD Johns Hopkins University School of Medicine A Microbiota-Induced Switch to Immune Checkpoint Inhibitor Responsiveness in Colon Cancer Carolyn Sangokoya, MD, PhD University of California-San Francisco Illuminating post-transcriptional control of stem cell fate and function Fred Hutchinson Cancer Research Center Interrogation of Pathological Histone Dynamics to Identify Drivers of Tumor Heterogeneity and Therapeutic Vulnerabilities Christina Theodoris, MD, PhD Transfer learning leveraging large-scale single cell transcriptomics to enable predictions in settings with limited data Josephine Wanjiru Thinwa, MD, PhD University of Texas Southwestern Medical Center-Dallas The Function of CDKL5 in autophagy and host antiviral defense Dana-Farber | Boston Children’s Hospital Cancer and Blood Disorders Center Hematopoietic stem cell clonal diversity in GATA2 deficiency associated blood disorders David Benjamin Beck, MD, PhD National Institutes of Health (NIH)* Understanding the Role of Somatic Mutations in Severe Adult-Onset Inflammatory Diseases *Funding will be received by faculty institute TBD Neural bases of conceptual generalization and transfer learning: mechanisms that go awry in psychiatric illness Jeeyeon Monica Cha, MD, PhD Understanding sexually dimorphic responses of the pancreatic beta cell in diabetes Raghu Ram Chivukula, MD, PhD Massachusetts Institute of Technology Elucidating the Role of Lysosome Dysfunction in Pulmonary Fibrosis Carlos Antonio Diaz-Balzac, MD, PhD Transcriptional regulation of neural circuit formation in intellectual disabilities Dopamine and serotonin at the intersection of reward and aggression Russell Paul Goodman, MD, DPhil Massachusetts General Hospital Targeting Hepatic Reductive Stress to Treat Fatty Liver Disease Brian Christopher Miller, MD, PhD Dana-Farber Cancer Institute Targeting Myeloid Cells as a Personalized Immunotherapy Approach to Cancer Lymphatic regulation of the intestinal stem cell niche Celestine N.

Wanjalla, MD, PhD Understanding the role of CD4+ T helper cells in cardiovascular disease progression in persons with HIV Brigham and Women’s Hospital Notch3 as a therapeutic target in rheumatoid arthritisM Alexander George Bick, MD, PhD Targeting clonal hematopoiesis using human genetics Julia Catherine Carnevale, MD University of California-San Francisco Targeting SOCS1 and RASA2 to engineer more potent adoptive T cell therapies for cancer treatment University of Pennsylvania Using EEG network alterations to diagnose epilepsy Emily Anne Ferenczi, MB, ChB, PhD Direct projections from globus pallidus externa (GPe) to cortex: a novel role in basal ganglia-cortical circuit function Ryan Alexander Flynn, MD, PhD Defining the regulation of RNA by glycosylation Weill Medical College of Cornell University Defining the impact of somatic mutations on human hematopoiesis via single-cell multi-omics University of Pennsylvania Determinants of bacterial biofilm formation at the intestinal mucosal interface and their roles in pathogen exclusion Xilma Rosa Ortiz-Gonzalez, MD, PhD University of Pennsylvania Looking at Neuroegenerative Disorders Through a Pediatric Lens Leveraging single-cell genomics for the development of novel pain treatments Andrew Ben Stergachis, MD, PhD Single-molecule chromatin architectures of disease-associated non-coding genetic variants Jonathan R Brestoff, MD, PhD Role of Cell-to-Cell Transfer of Mitochondria in Regulating Metabolism Gaurav Das Gaiha, DPhil, MD Using Network Theory to Suppress the Latent HIV-1 Reservoir Memorial Sloan-Kettering Cancer Center Emergence of Regenerative Plasticity in Metastasis Stem Cells University of California-San Francisco Modeling Pathogen Cell-free DNA Dynamics in Acute Infections Marie A Guerraty, MD, PhD University of Pennsylvania The interplay between cardiomyocyte FOG2 and HIF pathway in Coronary Microvascular Disease University of Texas Southwestern Medical Center-Dallas Regulation of Cancer Cachexia Wasting by a Tumor-Adipose-Hypothalamic Axis Michael George Kattah, MD, PhD University of California-San Francisco A20 and ABIN-1 cooperatively preserve intestinal integrity Closing the loop: development of real-time, personalized brain stimulation Robert M Samstein, MD, PhD Memorial Sloan-Kettering Cancer Center Immunogenicity of Homologous Recombination Defects and Response to Immunotherapy Regulation of Host Immunity via Microbially-derived Metabolites Santosha A.

Vardhana, MD, PhD Memorial Sloan-Kettering Cancer Center Investigating metabolic susceptibilities of exhausted T-cells Andrew Sean Venteicher, MD, PhD Uncovering drivers of immortality in human CNS tumors University of California-San Francisco Using adaptive neurostimulation to understand and enhance motor skill learning in Parkinson’s Disease Samuel F Bakhoum, M. D. , Ph.

D. Memorial Sloan-Kettering Cancer Center Probing the role of chromosomal instability in tumor evolution Elizabeth Joyce Bhoj, M. D.

, Ph. D. University of Pennsylvania A novel pediatric neurodegenerative disorder caused by histone 3.

3 mutations: unique insights into the histone code Hsiao-Tuan Chao, M. D. , Ph.

D. Baylor College of Medicine Mechanisms of COE-transcriptional dysfunction in neurodevelopmental disorders Johns Hopkins University School of Medicine Genomic analysis of drug resistance determinants in nontuberculous mycobacteria University of California-San Francisco Targeting viral mechanisms of oncogenesis in liver cancer Sarah Emily Henrickson, M. D.

, Ph. D. University of Pennsylvania Directly interrogating mechanisms of human T cell dysfunction in the setting of chronic inflammation and atopy Benjamin Izar, M.

D. , Ph. D.

Functional validation of resistance mechanisms to immunotherapies at single-cell resolution Corrine RaShelle Kliment, M. D. , Ph.

D. The role of adenine nucleotide translocase in the protection of airway epithelial cells in Chronic Obstructive Pulmonary Disease (COPD) Albert Russell Powers, M. D.

, Ph. D. Yale University School of Medicine Computational markers for psychosis: toward early diagnosis and intervention Deepak Angara Rao, M.

D. , Ph. D.

Peripheral helper T cells in autoimmunity Ansuman Satpathy, M. D. , Ph.

D. Epigenetic mechanisms of immunotherapy resistance in tumor-specific T cells Mark A Sellmyer, M. D.

, Ph. D. University of Pennsylvania Engineering digital logic for cell-cell interactions Reward processing in striatal projection neurons during goal directed behaviors Vijay Garud Bhoj, M.

D. , Ph. D.

University of Pennsylvania Development of CAR T-cell immunotherapy for prevention and eradication of FVIII inhibitors in Hemophilia A Lindsay Catherine Burrage, M. D. , Ph.

D. Baylor College of Medicine Impaired glycogen metabolism and chronic liver disease in urea cycle disorders Aaron Foster Carlin, M. D.

, Ph. D. University of California-San Diego Deciphering human innate immune responses to Zika virus infection Alejandro Chavez, M.

D. , Ph. D.

Novel technologies and their application to neurodegenerative diseases Whitney Elizabeth Harrington, M. D. , Ph.

D. Defining the role of maternal cells in fetal and infant immunity to malaria Tamia Alisha Harris-Tryon, M. D.

, Ph. D. University of Texas Southwestern Medical Center-Dallas The Function of Resistin Like Molecule alpha (RELMalpha) in Cutaneous Host Defense Kara Noelle Maxwell, M.

D. , Ph. D.

University of Pennsylvania A genotype-phenotype study of tumors from patients with inherited mutations in DNA repair genes Kent William Mouw, M. D. , Ph.

D. Investigating the effect of ERCC2 mutations on DNA repair capacity and chemo-radiotherapy response in muscle-invasive bladder cancer Deep interrogation and modeling of intratumoral heterogeneity, plasticity, and tumor evolution in glioblastoma Tamer Sallam, M. D.

, Ph. D. University of California-Los Angeles Spatial control of nuclear receptor regulatory circuits in cardiovascular disease Zuzana Tothova, M.

D. , Ph. D.

Elucidating the mechanisms of cohesinopathy in myelodysplastic syndromes Craig Brian Wilen, M. D. , Ph.

D. Role of virus-receptor interactions in determining norovirus tropism and pathogenesis Jonathan Abraham, M. D.

, Ph. D. Profiling the human antibody response in survivors of viral hemorrhagic fevers Heidi Leigh Cook-Andersen, M.

D. , Ph. D.

University of California-San Diego Post-transcriptional gene regulation during the mammalian oocyte-to-embryo transition Mariella Gruber Filbin, M. D. , Ph.

D. Discovering novel epigenetic dependencies in pediatric high-grade glioma Andrew Michael Intlekofer, M. D.

, Ph. D. Memorial Sloan-Kettering Cancer Center Investigating L-2-hydroxyglutarate production and its relevance to normal hematopoiesis and leukemogenesis Siddhartha Jaiswal, M.

D. , Ph. D.

Elaborating the causal link between clonal hematopoiesis and atherosclerosis Devanand Sadanand Manoli, M. D. , Ph.

D. University of California-San Francisco Genetic models of social attachment in development and mental illness Alexander Marson, M. D.

, Ph. D. University of California-San Francisco Molecular characterization of non-coding genetic variants that promote human autoimmunity Seth Rakoff-Nahoum, M.

D. , Ph. D.

Gut microbiota ecological interaction networks in health and disease Dhakshin Ramanathan, M. D. , Ph.

D. University of California-San Francisco Role of spindle oscillations in modulating neural plasticity and procedural memory consolidation Tiffany Crawford Scharschmidt, M. D.

University of California-San Francisco Elucidating mechanisms of immune tolerance to skin commensal bacteria Alexander Spektor, M. D. , Ph.

D. The mechanism of DNA damage and chromothripsis from chromosome segregation errors Bruce Mao Zheng Wang, M. D.

University of California-San Francisco Wnt signaling and hepatocyte stem cells in liver homeostasis and cancer Jennifer M Alexander-Brett, M. D. , Ph.

D. Targeting the Regulatory Mechanism of the Nucleokine IL-33 Daniel Evan Bauer, M. D.

, Ph. D. Functional Characterization of Trait-Associated Enhancers James Toliver Bennett, M.

D. , Ph. D.

Impact of Somatic Mutations on Birth Defects Shadmehr Demehri, M. D. , Ph.

D. Local and Systemic Effects of TSLP on Cancer University of Tennessee Health Science Center College of Medicine Defining the Cellular and Genetic Origins of Childhood Acute Lymphoblastic Leukemia using Single-Cell Genomics Matthew Blake Greenblatt, M. D.

, Ph. D. Weill Cornell Medical College Novel Mechanisms of Bone Formation University of Pennsylvania Perelman School of Medicine Nuclear lamina-chromatin interactions are drivers of cardiac progenitor cell commitment Matthew Stern Kayser, M.

D. , Ph. D.

University of Pennsylvania Perelman School of Medicine A role for sleep in synapse development and susceptibility to neuropsychiatric disorders Dan Avi Landau, M. D. , Ph.

D. Weill Cornell Medical College Genetic and Epigenetic Determinants of Chronic Lymphocytic Leukemia Evolution Kory Joshua Lavine, M. D.

, Ph. D. Washington University School of Medicine Distinct Macrophage Lineages Govern Cardiac Recovery and Heart Failure Progression Bluma J.

Lesch, M. D. , Ph.

D. Massachusetts Institute of Technology Evolutionary and functional characterization of poised chromatin in the mammalian germ line Joseph Douglas Mancias, M. D.

, Ph. D. Role of ferritinophagy in iron metabolism and pancreatic cancer Anna Victoria Rotberg Molofsky, M.

D. , Ph. D.

University of California-San Francisco Astrocyte-Encoded Regional cues in Developmental Synapse Formation Sahar Nissim, M. D. , Ph.

D. Discovery, Validation, and Characterization of Novel Familial Pancreatic Cancer Genes Theresa Alenghat, D. V.

M. , Ph. D.

Epigenomic regulation of the host-commensal relationship Christina Eleanor Barkauskas, M. D. Epithelial-mesenchymal crosstalk in lung fibrosis and alveolar homeostasis James Edward Cassat, M.

D. , Ph. D.

Vanderbilt University School of Medicine The contribution of host and pathogen to altered bone homeostasis and bacterial survival during overseas Elucidating the role of K14+ leader cells in breast cancer invasion and metastasis Ethan Michael Goldberg, M. D. , Ph.

D. University of Pennsylvania Perelman School of Medicine Analysis of circuit function informs novel therapeutic interventions in an epilepsy model Malay Haldar, M. D.

, Ph. D. Washington University School of Medicine Transcription factor SPI-C at the interface of iron homeostasis and innate immunity Marcin Imielinski, M.

D. , Ph. D.

Reconstructing complex loci in lung adenocarcinoma with large-insert whole genome sequencing Jeffery M Klco, M. D. , Ph.

D. Role of notch signaling in