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Collaborative Awards to Support Microphysiological System Pilot Studies in Type 2 Diabetes Research is a grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) that funds collaborative research pairing microphysiological system (MPS) experts with traditional biology laboratories to advance type 2 diabetes research.
The program supports patient-on-a-chip and clinical-trial-on-a-chip studies using patient samples and human iPSC-derived cells to model metabolic tissue crosstalk, study T2D mechanisms, and test treatment strategies. Eligible applicants include universities, research institutions, private and public higher education institutions, federally recognized Native American tribes, and special district governments.
Awards total $1,000,000, with applications due July 5, 2026.
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Collaborative Awards to Support Microphysiological System Pilot Studies in Diabetes Research - NIDDK Advisory & Coordinating Committees National Diabetes & Digestive & Kidney Diseases Advisory Council Collaborative Awards to Support Microphysiological System Pilot Studies in Diabetes Research Return to Concept Clearances Collaborative Awards to Support Microphysiological System Pilot Studies in Diabetes Research Advances in biomaterials, microfluidics, and tissue engineering have resulted in microphysiological systems (MPSs) that allow for greater control of three-dimensional cell cultures containing multiple cell types and constituting more physiological tissue organization.
The use of patient samples and human induced pluripotent stem cell–derived cells coupled with MPSs will enable patient-on-a-chip or clinical-trial-on-a-chip studies of type 2 diabetes development and treatment that is currently not possible.
The utility of these systems lends themselves to powerful in vitro modeling of metabolic tissue crosstalk, study of basic mechanisms of human type 2 diabetes, and the testing of prevention and treatment strategies. MPSs are especially useful for investigating the heterogeneity of human T2D biology and clinical responses.
However, adoption of such systems as a complementary research tool by traditional basic biology laboratories requires additional MPS expertise and resources. Opportunities exist for NIDDK to incentivize collaborative studies to encourage pairings of engineering and biology labs.
The current initiative will support small pilot studies to conceptualize aspects of T2D biology for modeling with MPSs, to support feasibility studies, and to generate preliminary data. It is anticipated that these pilot awards may pave the way to enhance the success of future R01 submissions and broaden the use of MPSs in human T2D research.
Based on current listing details, eligibility includes: Independent school districts, private institutions of higher education, public and state institutions of higher education, public and Indian housing authorities, special district governments, federally recognized Native… Applicants should confirm final requirements in the official notice before submission.
Current published award information indicates $1,000,000 Always verify allowable costs, matching requirements, and funding caps directly in the sponsor documentation.
The current target date is July 5, 2026. Build your timeline backwards from this date to cover registrations, approvals, attachments, and final submission checks.
Federal grant success rates typically range from 10-30%, varying by agency and program. Build a strong proposal with clear objectives, measurable outcomes, and a well-justified budget to improve your chances.
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New Generation of Glucose Control Technologies Incorporating AI/ML is a funding announcement from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) at NIH that will solicit applications for research to improve open- and closed-loop diabetes control systems for Type 1 diabetes. Research priorities include innovations in analyte sensing, novel hormone formulation and delivery, AI and machine learning-driven algorithms, and digital twin modeling to enhance glycemic control and quality of life. Awards will use the R01 research project grant activity code. Applications are not yet being solicited but the notice was issued to allow potential applicants time to develop meaningful collaborations. Eligible applicants include universities, nonprofits, Tribal governments, for-profit organizations, and federal agencies.
National K12 Program for the Career Development of Clinician-Scientists in Diabetes Research (Diabetes-DOCS) is sponsored by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). This program supports the career development of physicians committed to a career in diabetes research, with a focus on Type 1 Diabetes research. It aims to increase the number of physician-scientists with independent research careers in NIDDK's mission, which includes understanding the consequences of diabetes, potentially encompassing diabetic retinopathy.