Discovery Research Grants in Bipolar Disorder - Cycle 4 is sponsored by BD² (Breakthrough Discoveries for Thriving with Bipolar Disorder). This program supports innovative and collaborative groups of multidisciplinary scientists to improve the understanding of the biological mechanisms that underlie bipolar disorder, examining genetic, molecular, cellular, circuit, and/or behavioral mechanisms.

RFA Opportunities - Breakthrough Discoveries (BD²) BD²: Breakthrough Discoveries for thriving with Bipolar Disorder funds science in search of ways to help every person with bipolar disorder thrive. We seek multidisciplinary teams to collaborate and explore the fundamental mechanisms, heterogeneity, progression, and underlying biology of the disorder to dramatically improve systems of care and accelerate research.

Since launch, BD² has invested $105M+ in research commitments. BD² Data Science Fellowship The BD² Data Science Fellowship supports postdoctoral researchers applying data science expertise to existing BD² datasets.

Fellows will work within BD²-funded teams or institutions to advance projects that generate new insights, develop computational tools, and strengthen the network’s ability to better understand the biology, trajectory, and mechanisms of bipolar disorder. Requests for Applications (RFAs) BD² Data Science Fellowship The BD² Data Science Fellowship supports postdoctoral researchers applying data science expertise to existing BD² datasets.

Fellows will work within BD²-funded teams or institutions to advance projects that generate new insights, develop computational tools, and strengthen the network’s ability to better understand the biology, trajectory, and mechanisms of bipolar disorder.

BD² Integrated Network Learning Health Network (LHN) Consultant BD² seeks applications from qualified organizations to serve as a consultant to the Integrated Network’s Learning Health Network (LHN).

The selected partner will provide strategic guidance and implementation support to help advance the LHN into a coordinated system that leverages real-world data and shared learning to improve care and outcomes for people living with bipolar disorder.

Discovery Research, Cycle 4 The Discovery Research program supports an innovative and collaborative group of researchers working together to improve our understanding of the biological mechanisms that underlie bipolar disorder.

For this funding cycle, we especially encourage applications that address the cellular and molecular mechanisms of mood-state switching; biological mechanisms by which manic or depressive episodes are induced by external risk factors; or using experimental pharmacology to test causality of a molecular or circuit-level mechanism underlying mood-state switching.

BD² Integrated Network Mobile Application Partner BD² seeks applications from qualified organizations or teams to develop and manage a comprehensive mobile application system for data collection, monitoring, and analysis for the Integrated Network. The BD² Integrated Network is part of a multidisciplinary initiative to increase the scientific understanding and, ultimately, to improve care and interventions for bipolar disorder.

BD² Integrated Network Site, Wave 2 The BD² Integrated Network, in partnership with people living with bipolar disorder and their care teams, engages a network of collaborating investigators and clinicians to build an unprecedented data ecosystem for bipolar disorder, implement and inform data-driven improvements in care, and generate novel insights for interventional approaches.

Discovery Research, Cycle 3 The Discovery Research program aims to delineate the etiology and biological mechanisms of bipolar disorder, allowing the development of effective interventions. We fund multidisciplinary teams of scientists and clinicians who generate new hypotheses and drive innovation in the exploration of causal mechanisms of bipolar disorder with an eye toward novel treatments.

Discovery Research, Cycle 2 The Discovery Research program supports an innovative and collaborative group of researchers working together to improve our understanding of the biological mechanisms that underlie bipolar disorder.

We seek multidisciplinary teams of scientists to develop targeted and groundbreaking research applications that will examine the genetic, molecular, cellular, circuit, and/or behavioral mechanisms of bipolar disorder.

BD² Integrated Network Clinical Coordinating Center (CCC) As part of the BD² Integrated Network, the CCC provides expert guidance and logistical support including key diagnostics and clinical assessments, Institutional Review Board activities, a rigorous study monitoring plan, and coordination of clinical care activities.