The Combat Casualty Care Research Program (CCCRP) provides resources for advances in biotechnology research administered by the Telemedicine and Advanced Technology Research Center (TATRC), located at Fort Detrick, Maryland. TATRC facilitates interdisciplinary research partnerships led by industry (that may also include academia and government) that advance the development of emerging technologies and improvements in health care. With this Program Announcement/Funding Opportunity, the US Army Medical Research and Materiel Command (USAMRMC) is seeking to fund biotechnology research that culminates in outcomes and products that may qualify as advanced development activities within the Department of Defense (DoD). The results of this research will support medical protection and treatment requirements and needs by leveraging the skills and talents of US based businesses and teaching-research academic institutions. The intent is to create enduring initiatives and collaborations that will develop and support sustained business and enterprise solutions. The results of the research funded through this Program Announcement/Funding Opportunity are expected to increase the body of knowledge available to professionals and practitioners in health, medical science and related fields. The research impact is expected to benefit both civilian and military communities, particularly as it relates to the topic area of prehospital use of plasma for traumatic hemorrhage. Funding Opportunity Number: W81XWH-11-PUPTH-IIA. Assistance Listing: 12.420. Funding Instrument: CA,G. Category: ST. Award Amount: Up to $8M per award.

The intent of the Breakthrough Award is to support promising research that has high potential to lead to or make breakthroughs in breast cancer. The critical components of this award mechanism are: Impact: Research supported by the Breakthrough Award will have the potential for a major impact and accelerate progress toward ending breast cancer. The impact may be near-term or long-term, but must be significant and move beyond an incremental advancement. Applications must articulate the pathway to making a clinical impact for individuals with, or at risk for, breast cancer, even if clinical impact is not an immediate outcome. Research Scope: Research proposed under this award mechanism may be small- to large-scale projects, at different stages of idea and research development. Two different funding levels, based on the scope of the research, are available under this Program Announcement/Funding Opportunity. Funding Levels 3 and 4 are available under a different Program Announcement (W81XWH-14-BCRP-BREAKTHROUGH2_FL34). It is the responsibility of the Principal Investigator (PI) to select the funding level that is most appropriate for the research proposed. The following are general descriptions, although not all-inclusive, of the scope of research projects that would be appropriate to propose under each funding level: • Funding Level 1: Innovative, high-risk/high-reward research that is in the earliest stages of idea development. Research with potential to yield new avenues of investigation. Proof of concept. No preliminary data required. • Funding Level 2: Research that is already supported by preliminary data and has potential to make significant advancements toward clinical translation. Demonstration of efficacy in in vivo models, as applicable. Partnering PI Option: The Breakthrough Award encourages applications that include meaningful and productive collaborations between investigators. The Partnering PI Option is structured to accommodate two PIs, called the Initiating PI and the Partnering PI, each of whom will receive a separate award. The Initiating and Partnering PIs have different submission requirements; however, both PIs should contribute significantly to the development of the proposed research project including the Project Narrative, Statement of Work (SOW), and other required components. The PIs may have expertise in similar or disparate scientific disciplines, but each PI is expected to bring distinct contributions to the application. New collaborations are encouraged, but not required. It is the responsibility of the PIs to describe how their combined expertise will better address the research question and explain why the work should be done together rather than through separate efforts. To meet the intent of the Partnering PI Option, applicants are discouraged from submitting as a Partnering PI on multiple applications unless they are clearly addressing distinct research questions. Funding Opportunity Number: W81XWH-14-BCRP-BREAKTHROUGH2-FL12. Assistance Listing: 12.420. Funding Instrument: CA,G. Category: ST. Award Amount: $25M total program funding.

The intent of the FY14 Military Risk Factors Research Award (MRFA) is to facilitate high-impact, systematic, population-based research investigating the association between TBI and the subsequent development of AD. Applications should describe how the association of TBI and subsequent AD will be characterized. Applications should also describe how the proposed study will work with well-defined, already identified study cohorts. Applications should carefully consider how their studies will characterize the cognitive and behavioral symptoms that result in functional impairments in the proposed cohort. Studies that use combinations of measures (e.g., neuropsychological assessments, imaging, genomics, and cerebral spinal fluid) are encouraged. Applications that develop interdisciplinary teams or consortia as part of the support plan for executing the research are encouraged. Important Note: Applications must detail and demonstrate expedited access to a well-defined, already identified study cohort. Preliminary data that supports how the cohort will be used in the study is also required. The preliminary data must strongly support the proposed research hypothesis (or hypotheses). Refer to the Review Criteria in this Program Announcement/ Funding Opportunity for details. Overarching Challenge: This MRFA funding opportunity requires applications to address the following PRARP Overarching Challenge: Paucity of Clinical Studies: The paucity of clinical studies and other research resources to examine the interrelationship between TBI and subsequent AD for military Veterans/other individuals affected by TBI. Focus Areas: In addition to addressing the Overarching Challenge, applications must also address at least one of the following FY14 PRARP Focus Areas in support of the Overarching Challenge. An application that proposes research outside of these Focus Areas is acceptable, as long as the applicant provides a strong rationale: Genomics/Proteomics/Bioinformatics: Studies or technologies (e.g., genetic, proteomic and epigenetic strategies) intended to characterize neurological change associated with TBI and subsequent AD. In addition to studies, relevant technologies or tests may be considered under this focus area. Imaging: Development and application of anatomic and molecular imaging strategies to characterize neurological changes associated with TBI and subsequent AD While the MRFA mechanism can be used to support clinical research, the following is specifically discouraged under the FY14 PRARP: Pharmacologic Interventions: Clinical or Basic research requiring investigational or FDA-approved drugs or medicines. Drug Discovery and Development: Clinical or Basic research directly leading to the development of investigational medicines, drugs, or agents. Funding Opportunity Number: W81XWH-14-PRARP-MRFA. Assistance Listing: 12.420. Funding Instrument: CA,G. Category: ST. Award Amount: $5.5M total program funding.

The Indian Health Service (IHS) announces a limited competition for funding based on a bona-fide need within a specific geographical location. Grant applications are being accepted for the American Indians into Psychology Program from colleges and universities within the State of Montana. This grant is established under the authority of 25 U.S.C. 1621p(a-d), Indian Health Care Improvement Act, (Pub. L.) 94-437, as amended by Pub. L. 102-573. The agency's justification for limiting the funding to the Montana geographical location is supported by the fact that 54 of the 57 counties in the state of Montana are included in the Health Professions Shortage Area for Mental Health. Additionally, the IHS has Congressional support to fund the American Indians into Psychology Program in the state of Montana. The purpose of the Indians into Psychology Program is to augment the number of Indian health professionals serving Indians by encouraging Indians to enter the health professions and removing the multiple barriers to their entrance into the IHS and private practice among American Indian communities. Congressional report language in fiscal years 2007 and 2008 specifically supports funding for an American Indians into Psychology Program in the state of Montana. This program is described at 93.970 in the Catalog of Federal Domestic Assistance (CFDA). Costs will be determined in accordance with applicable Office of Management and Budget Circulars. The Public Health Service (PHS) is committed to achieving the health promotion and disease prevention objectives of Healthy People 2010, a PHS-led activity for setting priority areas. This program announcement is related to the priority area of Educational and Community-based programs. Potential applicants may obtain a copy of Healthy People 2010, summary report in print, Stock No. 017-001-00547-9, or via CD-ROM, Stock No. 107-001-00549-5, through the Superintendent of Documents, Government Printing Office, P.O. Box 371954, Pittsburgh, PA 15250-7945, (202) 512-1800. You may also access this information via the Internet at the following website: www.health.gov/healthypeople. The PHS strongly encourages all grant and contract recipients to provide a smoke-free workplace and promote the non-use of all tobacco products. In addition, Pub. L. 103-227, the Pro-Children Act of 1994, prohibits smoking in certain facilities (or in some cases, any portion of the facility) in which regular or routine education, library, day care, health care, or early childhood development services are provided to children. This is consistent with the PHS mission to protect and advance the physical and mental health of the American people. Funding Opportunity Number: HHS-2009-IHS-INPSY-0001. Assistance Listing: 93.970. Funding Instrument: G. Category: HL. Award Amount: Up to $250K per award.