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Find similar grantsEDIC Research Center for Type 1 Diabetes Complications is sponsored by National Institutes of Health (NIH). This opportunity supports mission-aligned projects and measurable outcomes.
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Opportunity Listing - Single Source for the Continuation of the Epidemiology of Diabetes Interventions and Complications (EDIC) Study Research Center (Collaborative U01 Clinical Trial Not Allowed) Single Source for the Continuation of the Epidemiology of Diabetes Interventions and Complications (EDIC) Study Research Center (Collaborative U01 Clinical Trial Not Allowed) Agency: National Institutes of Health Assistance Listings: 93.
847 -- Diabetes, Digestive, and Kidney Diseases Extramural Research Last Updated: May 13, 2026 View version history on Grants. gov The primary purpose of this FOA is to support the EDIC Research Center in continuing long-term follow-up of the EDIC cohort to study the development and progression of complications in type 1 diabetes (T1D).
The research will address severe microvascular disease, cardiovascular and liver disease, sleep disorders, mortality, and other comorbidities. The goals are to investigate the trajectory of age-related morbidities such as cognition, physical function, and frailty, and to identify their associations with risk factors that affect quality of life, self-management, and caregiver burden.
Particular emphasis will be placed on evaluating the impact of emerging therapies, including SGLT2 inhibitors and GLP-1 receptor agonists, on renal and cardiovascular outcomes. The initiative also encourages the application of advanced statistical methods, including machine learning and artificial intelligence, to identify phenotypes that are either susceptible or resilient to diabetes-related complications.
Modern technologies, such as continuous glucose monitoring, coronary calcification imaging, and vascular tonometry, will be used and compared with data from existing cohorts. In addition, the program will support assessments of obesity-related outcomes and comorbidities—including metabolic-associated steatotic liver disease (MASLD) and obstructive sleep apnea (OSA)—within the increasingly overweight/obese T1D population.
Multi-omic approaches to identify biochemical signatures associated with complications are also expected. Finally, the leveraging of external databases to examine the cost-effectiveness and quality-of-life impact of intensive therapy across the lifespan will be encouraged. This is a Forecast for a single source competition that will invite application(s) from eligible organization(s) to apply.
Please see Eligibility Section for additional information. In accordance with NIH standard peer-review processes, the application(s) will be peer-reviewed, and only meritorious application(s) will be considered for funding. Public and state institutions of higher education Private institutions of higher education This is a Forecast for a single source competition that will invite application(s) from eligible organization(s) to apply.
Please see Eligibility Section for additional information. In accordance with NIH standard peer-review processes, the application(s) will be peer-reviewed, and only meritorious application(s) will be considered for funding. Grantor contact information Division of Diabetes, Endocrinology and Metabolic Diseases No documents are currently available.
Link to additional information Estimated Application Due Date : Estimated Due Date Description : Estimated Project Start Date : Funding opportunity number : Cost sharing or matching requirement : Funding instrument type : Opportunity Category Explanation : Category of Funding Activity :
Based on current listing details, eligibility includes: This is a forecast for a single source competition. Eligible organizations will be invited to apply. Applicants should confirm final requirements in the official notice before submission.
Current published award information indicates Not Specified Always verify allowable costs, matching requirements, and funding caps directly in the sponsor documentation.
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