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HEAL Initiative - Development of Interventions to Prevent and Treat Substance Use Disorders and Overdose (UG3/UH3 - Clinical Trial Optional) is sponsored by National Institutes of Health (NIH). The NIH HEAL Initiative invests in research to accelerate scientific solutions to address the national opioid overdose crisis and improve pain management.
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Search similar grants →Extracted from the official opportunity page/RFP to help you evaluate fit faster.
Opportunity or Forecast ID HEAL Initiative-Early-Stage Discovery of New Pain Targets Within the Understudied Druggable Proteome (R03 Clinical Trial Not Allowed) Blueprint Neurotherapeutics Network (BPN): Small Molecule Drug Discovery and Development of Disorders of the Nervous System (UG3/UH3 Clinical Trial Optional) HEAL Initiative: Pain Research Enhancement Program (PREP) (R15 Clinical Trial Optional) HEAL Initiative: Studies to Enable Analgesic Discovery (R61/R33 - Clinical Trial Not Allowed) Mentored Patient-Oriented Research Career Development Award (Parent K23 Independent Clinical Trial Not Allowed) NIH Pathway to Independence Award (Parent K99/R00 Independent Clinical Trial Not Allowed) Mentored Research Scientist Development Award (Parent K01 - Independent Clinical Trial Not Allowed) Mentored Clinical Scientist Research Career Development Award (Parent K08 Independent Clinical Trial Required) Mentored Clinical Scientist Research Career Development Award (Parent K08 Independent Clinical Trial Not Allowed) Mentored Clinical Scientist Research Career Development Award (Parent K08 Independent Basic Experimental Studies with Humans Required) Pilot Health Services and Economic Research on the Treatment of Drug, Alcohol, and Tobacco Use Disorders (R34 Clinical Trial Optional) Implementation & Health Services, Recovery Services D-START: Data Science Track Award for Research Transition (D/START) (R03-Clinical Trial Optional) Data Dissemination & Secondary Analysis Accelerating the Pace of Substance Use Research Using Existing Data (R01 Clinical Trial Not Allowed) Data Dissemination & Secondary Analysis Accelerating the Pace of Substance Use Research Using Existing Data (R21 Clinical Trial Not Allowed) Data Dissemination & Secondary Analysis NIH Small Research Grant Program (Parent R03 Clinical Trial Not Allowed) Preclinical, Therapeutics Development, Prevention, Recovery Services, Implementation & Health Services, Life Course & Population, Data Dissemination & Secondary Analysis NIH Exploratory/Developmental Research Project Grant (Parent R21 Clinical Trial Not Allowed) Preclinical, Therapeutics Development, Prevention, Recovery Services, Implementation & Health Services, Life Course & Population, Data Dissemination & Secondary Analysis NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed) Preclinical, Therapeutics Development, Prevention, Recovery Services, Implementation & Health Services, Life Course & Population, Data Dissemination & Secondary Analysis Development of Interventions to Prevent and Treat Substance Use Disorders and Overdose (UG3/UH3 - Clinical Trial Optional) Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional) Preclinical, Therapeutics Development, Prevention, Recovery Services, Implementation & Health Services, Life Course & Population, Data Dissemination & Secondary Analysis Forecast for HEAL Initiative: Non-addictive Analgesic Therapeutics Development [Small Molecules and Biologics] to Treat Pain (UG3/UH3 Clinical Trial Optional), HEAL Initiative: Pain Management Effectiveness Research Network: Clinical Trial Planning and Implementation Cooperative Agreement (UG3/UH3 Clinical Trial Required) Therapeutics Development, Implementation & Health Services Limited Competition: HEAL Initiative Resource Centers for the Pain Management Effectiveness Network (ERN) (Clinical Trial Not Allowed) Therapeutics Development, Implementation & Health Services HEAL: Translating Addiction Epidemiology, Prevention, Treatment, and Recovery Research into Practice (R61/R33 - Clinical Trial Optional) Prevention, Recovery Services, Implementation & Health Services HEAL Initiative: Integrative Management of Chronic Pain and Opioid Use Disorder (OUD) for Whole Recovery: Health Systems Implementation & Health Services HEAL Initiative: Integrative Management of chronic Pain and OUD for Whole Recovery (IMPOWR) - Building Engagement, Assistance, Capacity, Outreach, and Networks (BEACON) Center Implementation & Health Services Limited Competition for the HEAL Initiative: HEALthy Brain and Child Development (HBCD) Study (Collaborative U01- Clinical Trial Not Allowed) Limited Competition for the HEAL Initiative: HEALthy Brain and Child Development (HBCD) Study – Coordinating Administrative Core and Data Coordinating Center (U24 Clinical Trial Not Allowed) Restoring Joint Health and Function to Reduce Pain (RE-JOIN) 2.
0 HEAL Initiative: Program to Reveal and Evaluate Cells-to-gene Information that Specify Intricacies, Origins and the Nature of (PRECISION) Human Pain Network NIH RePORTER Link to active HEAL-funded grants. For questions regarding HEAL-funded research projects please contact healquestion@od. nih.
gov . This page last reviewed on March 13, 2026 Looking for U.S. government information and services?
Based on current listing details, eligibility includes: Researchers and institutions focused on scientific solutions to address the opioid overdose crisis. Applicants should confirm final requirements in the official notice before submission.
Current published award information indicates Up to $3,000,000 per year in direct costs Always verify allowable costs, matching requirements, and funding caps directly in the sponsor documentation.
The current target date is August 21, 2028. Build your timeline backwards from this date to cover registrations, approvals, attachments, and final submission checks.
Federal grant success rates typically range from 10-30%, varying by agency and program. Build a strong proposal with clear objectives, measurable outcomes, and a well-justified budget to improve your chances.
Requirements vary by sponsor, but typically include a project narrative, budget justification, organizational capability statement, and key personnel CVs. Check the official notice for the complete list of required attachments.
Yes — AI tools like Granted can help research funders, draft proposal sections, and check compliance. However, always review and customize AI-generated content to reflect your organization's unique strengths and the specific requirements of the solicitation.
Review timelines vary by funder. Federal agencies typically take 3-6 months from submission to award notification. Foundation grants may be faster, often 1-3 months. Check the program's timeline in the official solicitation for specific dates.
Many federal programs offer multi-year funding or allow competitive renewals. Check the official solicitation for continuation and renewal policies. Non-competing continuation applications are common for multi-year awards.