This Horizon Europe call funds projects developing AI-powered autonomous laboratory automation for scientific research. The focus is on autonomous experiment planning, execution, and analysis with enhanced data management capabilities. Projects should target laboratories with existing digital infrastructure and develop AI systems that can autonomously design experiments, control laboratory instruments, analyze results, and iteratively refine research hypotheses. This is part of the European Commission's broader AI in Science strategy pilot, which allocates nearly €100 million across five dedicated topics in the 2026-2027 Horizon Europe work programme. The initiative serves as a foundation for the creation of RAISE (Resource for AI Science in Europe), a virtual institute envisioned as a CERN for AI in scientific research.