Immunology (R21) is sponsored by National Institute of Allergy and Infectious Diseases (NIAID/NIH). Exploratory/developmental grants for high-risk, high-reward immunology research, including novel immune pathways and host-pathogen interactions.

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nih. gov is not being updated regularly. Please refer to clinicaltrials.

gov and nih. gov for the most up-to-date information on NIH research. Several NIAID investigators have graciously agreed to share their exceptional applications and summary statements as samples to help the research community.

Below the list of applications, you’ll also find example forms, sharing plans, letters, emails, and more. Find more guidance at NIAID’s Apply for a Grant . Always follow your funding opportunity's instructions for application format.

Although these applications demonstrate good grantsmanship, time has passed since these grant recipients applied. The samples may not reflect the latest format or rules. NIAID posts new samples periodically.

Freedom of Information Act (FOIA) . NIAID is strongly committed to protecting the integrity and confidentiality of the peer review process. When NIH responds to FOIA requests for grant applications and summary statements, the material will be subject to FOIA exemptions and include substantial redactions.

NIH must protect all confidential commercial or financial information, reviewer comments and deliberations, and personal privacy information. Note on Section 508 Conformance and Accessibility. We have reformatted these samples to improve accessibility for people with disabilities and users of assistive technology.

Find sample applications and summary statements below by type: Research grants. R01 , R03 , R15 , R21 , and R21/R33 Small business grants. R41, R42, R43, and R44 Training and career awards.

K01 , K08 , K23 , and F31 Extramural Associate Research Development Award. G11 Cooperative agreements. U01 Find additional resources in the NIAID and NIH Sample Forms, Plans, Letters, Emails, and More section.

R01 Sample Applications and Summary Statements The R01 is the NIH standard independent research project grant. An R01 is meant to give you 4 or 5 years of support to complete a project, publish, and reapply before the grant ends. Read more at NIAID’s Comparing Popular Research Project Grants: R01, R03, and R21 .

PI and Recipient Institution Application Resources George Liu, Ph. D. , of the University of California, San Diego “Interrogating human anti-staphylococcal antibody responses for S.

aureus vaccine insights” (Forms-H) Full Application Summary Statement Emily Troemel, Ph. D. , of the University of California, San Diego “Innate immunity against viral infection in intestinal epithelial cells of C.

elegans” (Forms-G) Full Application Summary Statement Vernita Gordon, Ph. D. , of the University of Texas at Austin “Assessing the roles of biofilm structure and mechanics in pathogenic, persistent infections” (Forms-D) Full Application Summary Statement Monica Gandhi, M.

D. , of the University of California, San Francisco “Hair Extensions: Using Hair Levels to Interpret Adherence, Effectiveness and Pharmacokinetics with Real-World Oral PrEP, the Vaginal Ring, and Injectables” (Forms-D) Full Application Summary Statement Tom Muir, Ph. D.

, of Princeton University "Peptide Autoinducers of Staphylococcal Pathogenicity" (Forms-D) Full Application Summary Statement William Faubion, Ph. D. , of the Mayo Clinic Rochester “Inflammatory cascades disrupt Treg function through epigenetic mechanisms” (Forms-C) Full Application Summary Statement Chengwen Li, Ph.

D. , and Richard Samulski, Ph. D.

, of University of North Carolina at Chapel Hill “Enhance AAV Liver Transduction with Capsid Immune Evasion” (Forms-C) Full Application Summary Statement Mengxi Jiang, Ph. D.

, of University of Alabama at Birmingham “Intersection of polyomavirus infection and host cellular responses” (Forms-C) Full Application Summary Statement R03 Sample Applications and Summary Statements The small grant (R03) supports new research projects that can be carried out in a short period of time with limited resources. They are awarded for up to 2 years and are not renewable. R03s are not intended for new investigators.

Read more at NIAID’s Comparing Popular Research Project Grants: R01, R03, and R21 . PI and Recipient Institution Application Resources Martin Karplus, Ph. D.

, of Harvard University "Modeling atomic structure of the EmrE multidrug pump to design inhibitor peptides" (Forms-B2) Full Application Chad A. Rappleye, Ph. D.

, of Ohio State University "Forward genetics-based discovery of Histoplasma virulence genes" (Forms-B2) Full Application Summary Statement R15 Sample Applications and Summary Statements The Research Enhancement Award (R15) program supports small-scale research projects to expose students to research and strengthen the research environment at educational institutions that have not been major recipients of NIH support.

They are awarded for up to 3 years. PI and Recipient Institution Application Resources Artem Domashevskiy, Ph. D.

, of John Jay College of Criminal Justice “Development of a Novel Inhibitor of Ricin: A Potential Therapeutic Lead against Deadly Shiga and Related Toxins” (Forms-D) Full Application Summary Statement Rahul Raghavan, Ph. D.

, of Portland State University "Elucidating the evolution of Coxiella to uncover critical metabolic pathways" (Forms-D) Full Application Summary Statement R21 Sample Applications and Summary Statements The R21 funds novel scientific ideas, model systems, tools, agents, targets, and technologies that have the potential to substantially advance biomedical research.

R21s are not intended for new investigators, and there is no evidence that they provide a path to an independent research career. Read more at NIAID’s Comparing Popular Research Project Grants: R01, R03, and R21 . PI and Recipient Institution Application Resources Steven W.

Dow, D. V. M.

, Ph. D. , of Colorado State University, Fort Collins "Mechanisms of enteric Burkholderia psuedomallei infection" (Forms-B) Full Application Summary Statement Joseph M.

McCune, M. D. , Ph.

D. , of the University of California, San Francisco "Human immune system layering and the neonatal response to vaccines" (Forms-B) Full Application Summary Statement Peter John Myler, Ph. D.

, and Marilyn Parsons, Ph. D. , of the Seattle Biomedical Research Institute "Ribosome profiling of Trypanosoma brucei " (Forms-B) Full Application Summary Statement Howard T.

Petrie, Ph. D. , of Scripps Florida "Lymphoid signals for stromal growth and organization in the thymus."

(Forms-B) Full Application Summary Statement Michael N. Starnbach, Ph. D.

, of Harvard University Medical School "Alteration of host protein stability by Legionella" (Forms-B) Full Application Summary Statement R21/R33 Sample Application and Summary Statement The R21/R33 supports a two-phased award without a break in funding. It begins with the R21 phase for milestone-driven exploratory or feasibility studies with a possible transition to the R33 phase for expanded development.

Transition to the second phase depends on several factors, including the achievement of negotiated milestones. PI and Recipient Institution Application Resources Stephen Dewhurst, Ph. D.

, of the University of Rochester "The semen enhancer of HIV infection as a novel microbicide target" (Forms-B) Full Application Summary Statement Small Business Grants R41, R42, R43, and R44 – Small Business Sample Applications The SBIR (R43/R44) and STTR (R41/R42) programs support domestic small businesses to engage in research and development with the potential for commercialization. Read more about NIAID Small Business Programs .

PI and Recipient Institution Application Resources Ronald Harty, Ph. D. , of the University of Pennsylvania “Development of Small Molecule Therapeutics Targeting Hemorrhagic Fever Viruses” (STTR Phase II / R42, Forms-F) Full Application Summary Statement Iain James MacLeod, Ph.

D. , of Aldatu Biosciences, Inc. “PANDAA for universal, pan-lineage molecular detection of Lassa fever infection. ” (SBIR Phase I / R43, Forms-E) Full Application Summary Statement Benjamin Delbert Brooks, Ph.

D. , of Wasatch Microfluidics “High-throughput, multiplexed characterization and modeling of antibody:antigen binding, with application to HSV” (SBIR Phase I / R43, Forms-D) Full Application Summary Statement Yingru Liu, Ph. D.

, of TherapyX, Inc. “Experimental Gonococcal Vaccine” (SBIR Phase II / R44, Forms-D) Full Application Summary Statement James Smith, Ph. D. , of Sano Chemicals, Inc. “Lead Compound Discovery from Engineered Analogs of Occidiofungin” (STTR Phase I / R41, Forms-D) Full Application Summary Statement David H.

Wagner, Ph. D. , of OP-T-MUNE, Inc. “Developing a small peptide to control autoimmune inflammation in type 1 diabetes" (STTR Phase I / R41, Forms-D) Full Application Summary Statement Timothy C.

Fong, Ph. D. , of Cellerant Therapeutics, Inc. "Novel indication for myeloid progenitor use: Induction of tolerance" (STTR Phase I / R41, Forms-B2) Full Application Jose M.

Galarza, Ph. D. , of Technovax, Inc. "Broadly protective (universal) virus-like particle (VLP) based influenza vaccine" (SBIR Phase I / R43, Forms-B2) Full Application Michael J.

Lochhead, Ph. D. , of MBio Diagnostics, Inc. "Point-of-Care HIV Antigen/Antibody Diagnostic Device" (SBIR Phase II / R44, Forms-B2) Full Application Kenneth Coleman, Ph.

D. , of Arietis Corporation "Antibiotics for Recalcitrant Infection" (SBIR Fast-Track, Forms-B1) Full Application Patricia Garrett, Ph. D.

, of Immunetics, Inc. "Rapid Test for Recent HIV Infection" (SBIR Phase II / R44, Forms-B1) Full Application Raymond Houghton, Ph. D. , of InBios International, and David AuCoin, Ph.

D. , of University of Nevada School of Medicine "Antigen Detection assay for the Diagnosis of Melioidosis" (STTR Phase II / R42, Forms-B1) Full Application Mark Poritz*, Ph. D.

, of BioFire Diagnostics, LLC. "Rapid, automated, detection of viral and bacterial pathogens causing meningitis" (SBIR Phase I / R43, Forms-B1) Full Application *Dr. Mark Poritz submitted the original grant application. In the course of the first year of funding, Dr. Andrew Hemmert took on increasing responsibility for the work.

For the grant renewal, Dr. Poritz proposed that Dr. Hemmert replace him as the PI. Training and Career Awards K01 Sample Applications and Summary Statements The Research Scientist Development Award (K01) supports those with a research or health-professional doctoral degree and research development plans in any areas of the NIAID scientific mission. Read more about NIAID Research Career Development (K) Awards .

PI and Recipient Institution Application Resources Jennifer M Ross, Ph. D. , of the University of Washington “Modeling approaches to prioritize TB prevention among people with HIV in Uganda” (Forms-E) Full Application Summary Statement Lilliam Ambroggio, Ph.

D. , of the Cincinnati Children’s Hospital Medical Center “Metabolomics Evaluation of the Etiology of Pneumonia” (Forms-D) Full Application Summary Statement Peter Rebeiro, Ph. D.

, of the Vanderbilt University Medical Center "The HIV Care Continuum and Health Policy: Changes through Context and Geography" (Forms-D) Full Application Summary Statement K08 Sample Applications and Summary Statements The Mentored Clinical Scientist Research Career Development Award (K08) supports those with current work in biomedical or behavioral research, including translational research, a clinical doctoral degree such as M. D.

, D. V. M.

, or O. D. , and a professional license to practice in the United States.

Read more about NIAID Research Career Development (K) Awards . PI and Recipient Institution Application Resources David Al-Adra, MD, Ph. D.

, of University of Wisconsin-Madison “Targeting Donor Regulatory Dendritic Cells During Normothermic Ex Vivo Liver Perfusion to Overcome Rejection after Liver Transplant” (Forms-F) Full Application Summary Statement Annukka Antar, M. D. , Ph.

D. , of Johns Hopkins University “The HIV Latent Reservoir, Suboptimal Immune Response on Antiretroviral Therapy, and Exogenous Cytokine Therapies" (Forms-E) Full Application Summary Statement Lenette Lu, M. D.

, Ph. D. , of the Massachusetts General Hospital “Antibody Mediated Mechanisms of Immune Modulation in Tuberculosis” (Forms-D) Full Application Summary Statement Tuan Manh Tran, M.

D. , Ph. D.

, of the Indiana University-Purdue University at Indianapolis “Defining clinical and sterile immunity to Plasmodium falciparum infection using systems biology approaches” (Forms-D) Full Application Summary Statement K23 Sample Applications and Summary Statements The Mentored Patient-Oriented Research Career Development Award (K23) supports those with a clinical doctoral degree, who have the potential to develop into productive, clinical investigators, and who have made a commitment to focus their research endeavors on patient-oriented research.

Read more about NIAID Research Career Development (K) Awards . PI and Recipient Institution Application Resources DeAnna Friedman-Klabanoff, M. D.

, of University of Maryland, Baltimore “Serological markers of natural immunity to Plasmodium falciparum infection” (Forms-F) Full Application Summary Statement F31 Sample Applications and Summary Statements National Research Service Award (NRSA) individual fellowship (F31) grants provide research experience to predoctoral scientists. Read more about NIAID Fellowship Grants (F) .

PI and Recipient Institution Application Resources Nicole Putnam, Ph. D. , of Vanderbilt University “The impact of innate immune recognition of Staphylococcus aureus on bone homeostasis and skeletal immunity” Full Application Summary Statement Nico Contreras, Ph.

D. , of University of Arizona "The Immunological Consequences of Mouse Cytomegalovirus on Adipose Tissue" Full Application Summary Statement Samantha Lynne Schwartz, Ph. D.

, of Emory University “Regulation of 2'-5'-oligoadenylate synthetase 1 (OAS1) by dsRNA” Full Application Summary Statement G11 Sample Applications and Summary Statements The Extramural Associate Research Development Award (EARDA) (G11) provides funds to institutions eligible to participate in the NIH Extramural Associates Program for establishing or enhancing an office of sponsored research and for other research infrastructure needs.

Search for NIAID G11 Opportunities . PI and Recipient Institution Application Resources Oye Nana Akuffo, M. B.

A. , of the Noguchi Memorial Institute for Medical Research, University of Ghana, Legon “Capacity Building for Enhanced Research Administration (CaBERA- II) in Africa” (Forms-E) Summary Statement Andres Jaramillo Zuluaga, M. B.

A. , Centro Internacional de Entrenamiento e Investigaciones Medicas (CIDEIM) “Implementing Strategies for Building Capacity in Research Administration at CIDEIM, and Subsequent Dissemination Within Colombia and the Latin American Region” (Forms-E) Full Application Summary Statement Stella Kakeeto, M. B.

A. , Makerere University “Strengthening Makerere University's Research Administration Capacity for Efficient Management of NIH Grant Awards (SMAC)” (Forms-E Full Application Summary Statement U01 Sample Application and Summary Statement The U01 research project cooperative agreement supports a discrete, specified, circumscribed project for investigators to perform in their areas of specific interest and competency.

Learn more about NIAID Cooperative Agreements (U) . PI and Recipient Institution Application Resources Aaron Meyer, Ph. D.

, of the University of California, Los Angeles Falk Nimmerjahn, Ph. D.

, of Friedrich-Alexander University Erlangen-Nuremberg, Germany "Mapping the effector response space of antibody combinations" (Forms-E) Full Application Summary Statement NIAID and NIH Sample Forms, Plans, Letters, Emails, and More Sample Model Organism Sharing Plans Complex Model Organisms Sharing Plan Model Organisms Sharing Plan for Mice Simple Model Organisms Sharing Plan Sample Letter to Document Training in the Protection of Human Subjects Withdrawal of an Application Sample Form Letter Sample NIAID Request for Just-in-Time Information Preparing for a Foreign Organization System (FOS) Review Subaward Templates and Tools from the Federal Demonstration Partnership DMID Quality Management Guidance and Tools Sample grant applications from the National Cancer Institute Sample Cancer Epidemiology Grant Applications Sample Behavioral Research Grant Applications Sample Implementation Science Research Applications Sample grant applications from the National Institute on Aging K99/R00 Sample Applications Annotated SF 424 Grant Application Forms Biosketch Format Pages, Instructions and Samples Sample Data Tables for Training Grant Applications Additional Senior/Key Person Profile Format – for over 100 senior/key people Additional Performance Site Format – for over 300 performance sites Other Support Format Page Rigor and Reproducibility Scientific Rigor Examples Authentication Plan Examples Sample Data Management and Sharing Plans Examples of Project Leadership Plans for Multiple PI Grant Applications Example calculations in the Usage of Person Months questions and answers Examples of Allowable Appendix Materials Sample Project Outcomes Description for RPPR OLAW's Sample Documents for animal research assurances and reports Worksheet for Review of the Vertebrate Animal Section (VAS) Sample Animal Study Proposal A program officer in your area of science can give you application advice, NIAID's perspective on your research, and confirmation that your proposed research fits within NIAID’s mission.

Find contacts and instructions at When to Contact an NIAID Program Officer . Content last reviewed on September 8, 2025 Website Policies & Notices Freedom of Information Act (FOIA) HHS Vulnerability Disclosure Policy Related Government Websites National Institutes of Health Health and Human Services