International Research Scientist Development Award (IRSDA) is sponsored by Fogarty International Center at NIH. Provides support and protected time for U.S. scientists to conduct mentored research in low- and middle-income countries.

Expired PAR-24-113: International Research Scientist Development Award (IRSDA) (K01) Independent Clinical Trial Not Allowed This notice has expired. For NIH, in limited situations, applications may be accepted on a case-by-case basis for a short period after expiration to accommodate NIH late or continuous submission policies . Contact the eRA Service Desk for any submission issues.

Check the NIH Guide for active opportunities and notices. Department of Health and Human Services Part 1.

Overview Information Participating Organization(s) National Institutes of Health ( NIH ) Components of Participating Organizations Fogarty International Center ( FIC ) National Eye Institute ( NEI ) Participation Added June 11, 2024 ( NOT-EY-24-011 ) National Institute on Deafness and Other Communication Disorders ( NIDCD ) National Cancer Institute ( NCI ) Funding Opportunity Title International Research Scientist Development Award (IRSDA) (K01) Independent Clinical Trial Not Allowed K01 Research Scientist Development Award - Research & Training Notices of Special Interest associated with this funding opportunity March 31, 2025 - This funding opportunity was updated to align with agency priorities.

Carefully reread the full funding opportunity and make any needed adjustments to your application prior to submission. April 04, 2024 - Overview of Grant Application and Review Changes for Due Dates on or after January 25, 2025. See Notice NOT-OD-24-084 June 14, 2024 - NEI Notice of Participation in PAR-24-113, "International Research Scientist Development Award (IRSDA) (K01) Independent Clinical Trial Not Allowed".

See Notice NOT-EY-24-012 June 11, 2024 - NEI Notice of Participation in PAR-24-113, "International Research Scientist Development Award (IRSDA) (K01) Independent Clinical Trial Not Allowed". See Notice NOT-EY-24-011 August 31, 2022 - Implementation Changes for Genomic Data Sharing Plans Included with Applications Due on or after January 25, 2023. See Notice NOT-OD-22-198 .

August 5, 2022 - Implementation Details for the NIH Data Management and Sharing Policy. See Notice NOT-OD-22-189 . Funding Opportunity Number (FON) Companion Notice of Funding Opportunity Research Scientist Development Award - Research & Training See Section III.

3. Additional Information on Eligibility . Assistance Listing Number(s) 93.

989, 93. 173, 93. 398, 93.

867 Funding Opportunity Purpose ?

The purpose of the International Research Scientist Development Award (IRSDA) is to provide support and protected time (three to five years) to advanced postdoctoral U.S. research scientists and recently-appointed U.S. junior faculty (applicants must be at least two years beyond conferral of doctoral degree) for an intensive, mentored research career development experience in a low- or middle-income country (LMIC), as defined by the World Bank ( http://data.

worldbank. org/about/country-classifications/country-and-lending-groups )? , including "low-income," "lower-middle-income," and "upper-middle-income" countries) leading to an independently-funded research career focused on global health.

This Notice of Funding Opportunity (NOFO) invites applications from postdoctoral research scientists and junior faculty from any health-related discipline who propose career development activities and a research project that is relevant to the health priorities of the LMIC under the mentorship of LMIC and U.S. mentors.

This Notice of Funding Opportunity (NOFO) is designed specifically for applicants proposing research that does not involve leading an independent clinical trial, a clinical trial feasibility study, or an ancillary study to a clinical trial. Applicants to this NOFO are permitted to propose research experience in a clinical trial led by a mentor or co-mentor.

Applicants proposing a clinical trial or an ancillary study to an ongoing clinical trial as lead investigator should apply to the companion NOFO ( PAR-24-114 ). Open Date (Earliest Submission Date) Letter of Intent Due Date(s) Renewal / Resubmission / Revision (as allowed) AIDS - New/Renewal/Resubmission/Revision, as allowed All applications are due by 5:00 PM local time of applicant organization.

Applications are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.

Required Application Instructions It is critical that applicants follow the instructions in the Career Development (K) Instructions in the How to Apply - Application Guide , except where instructed to do otherwise (in this NOFO or in a Notice from the NIH Guide for Grants and Contracts ). Conformance to all requirements (both in the Application Guide and the NOFO) is required and strictly enforced.

Applicants must read and follow all application instructions in the Application Guide as well as any program-specific instructions noted in Section IV . When the program-specific instructions deviate from those in the Application Guide, follow the program-specific instructions. Applications that do not comply with these instructions may be delayed or not accepted for review.

There are several options available to submit your application through Grants. gov to NIH and Department of Health and Human Services partners. You must use one of these submission options to access the application forms for this opportunity.

Use the NIH ASSIST system to prepare, submit and track your application online. Use an institutional system-to-system (S2S) solution to prepare and submit your application to Grants. gov and eRA Commons to track your application.

Check with your institutional officials regarding availability. Workspace to prepare and submit your application and eRA Commons to track your application. Part 1.

Overview Information Part 2. Full Text of Announcement Section I. Funding Opportunity Description Section II.

Award Information Other Award Budget Information Section III. Eligibility Information Section IV. Application and Submission Information Section V.

Application Review Information Section VI. Award Administration Information Section VII. Agency Contacts Section VIII.

Other Information Part 2. Full Text of Announcement Section I. Funding Opportunity Description The overall goal of the NIH Research Career Development program is to help ensure that a pool of highly trained scientists is available in appropriate scientific disciplines to address the Nation's biomedical, behavioral, and clinical research needs.

NIH Institutes and Centers (ICs) support a variety of mentored and non-mentored career development award programs designed to foster the transition of new investigators to research independence and to support established investigators in achieving specific objectives. Candidates should review the different career development (K) award programs to determine the best program to support their goals.

More information about Career programs may be found at the NIH Research Training and Career Development website.

The objective of the NIH Mentored Research Scientist Development Award (K01) is to provide salary and research support for a sustained period of “protected time” (3-5 years) for intensive research career development, under the guidance of an experienced mentor, or sponsor in the biomedical, behavioral or clinical sciences leading to research independence.

The expectation is that, through this sustained period of research career development and training, recipients will launch independent research careers and become competitive for new research project grant (e.g., R01) funding.

Opportunities to advance global health research careers are central to building a robust global health workforce, yet it remains a challenge for researchers to establish independent international research careers given the requisite time spent away from their home institutions.

Prolonged field experience is critical for global health research and for establishing sustained research partnerships, but gaining this field experience can be difficult for junior faculty, who are balancing administrative and teaching requirements, or for individuals in standard postdoctoral positions.

The International Research Scientist Development Award (IRSDA) program addresses this need and fills an important global health career development gap. The IRSDA program provides opportunities to conduct mentored global health research in low- and middle-income country (LMIC) settings and to foster long-term research collaborations that strengthen global health research.

The objective of the IRSDA program is to prepare qualified advanced postdoctoral research scientists and recently-appointed junior faculty (see Eligible Individuals) for research careers that will have a significant impact on the health-related research needs of LMICs.

IRSDA awardees will conduct their research and career development activities under the guidance of experienced U.S.-based and LMIC-based mentors, in any health-related discipline that is relevant to the health priorities of the LMIC. Awardees must spend a minimum of 50% of the cumulative effort over the project period (all years) physically in-country conducting collaborative research at the LMIC institution.

In addition, in each year of the award, the recipient must spend a minimum of three months in the LMIC (see In-country requirement under Eligible Individuals in Section III).

Awardees are expected to gain increased capabilities in collaborative research skills in low-resource settings, advanced research methodology, analysis and data management, research administrative skills, responsible conduct of research, scientific presentation, and manuscript and grant writing.

Through this program, it is expected that awardees will launch independent global health research careers, continue to collaborate with LMIC scientists on research that addresses the health needs of LMICs, and become competitive for new research project grant (e.g., R01) funding in global health.

LMICs are defined by the World Bank classification system (according to Gross National Income (GNI) per capita as "low-income," "lower-middle-income," and "upper-middle-income" ( http://data. worldbank. org/about/country-classifications/country-and-lending-groups ).

Interests of Participating NIH Institutes and Centers The National Cancer Institute (NCI) is interested in applications from individuals committed to an independent career in global cancer research, who propose mentored research projects in topics relevant to the LMIC where the research will be conducted.

NCI is interested in applications that include, but not limited to, studies in cancer biology and genetics, cancer epidemiology, research in cancer primary and secondary prevention, clinical and translational research, implementation science and health systems research, health surveillance and cancer informatics research, studies in integrative oncology and cancer survivorship as well as investigations that employ technology (including mHealth and eHealth) to address cancer control.

Applications that propose capacity development in research methods across disciplines that might be relevant to LMIC settings including, but not limited to, clinical and translational research, behavioral and social sciences research, patient reported outcomes research, are encouraged.

The career development plan should include training in advanced scientific skills, research methodology, data management and analysis, grant and manuscript writing, and research administration skills that are appropriate for the LMIC. The proposed career development and mentoring must be focused on developing independent researchers in the field of cancer in a manner that increases the research capacity at the LMIC institution.

Mentors should have a track record of research in cancer. For applications proposing HIV/AIDS research projects, applicants are encouraged to review the NIH HIV/AIDS Research Priorities , and the NIH Plan for HIV-Related Research for the year they are applying. Candidates are encouraged to review answers to frequently asked questions about the IRSDA K01 program at IRSDA FAQs , which will be updated on a regular basis.

Individuals who are unable to meet the requirement to spend a minimum of 50% of the cumulative effort over the total project period (all years) and the additional requirement to spend a minimum of three months each year conducting research physically in the LMIC are encouraged to consider other NIH career development awards (see https://researchtraining. nih.

gov/programs/career-development ), many of which support global health research in LMICs. Individuals from LMICs (individuals who are not U.S. citizens, non-citizen nationals or permanent residents) are not eligible for the IRSDA but may be eligible for the Fogarty Emerging Global Leader Award (K43) .

Applications Not Responsive to this NOFO Applications that do not include both a U.S. primary mentor based at the applicant institution and an LMIC primary mentor whose primary appointment is at the collaborating LMIC institution. Applications from candidates whose doctoral degree was conferred less than two years before the application deadline.

Applications that do not provide a plan to meet the in-country time requirement (at least 50% of requested effort over grant period and at least 3 months each year must be at the LMIC research site). Note: This Notice of Funding Opportunity (NOFO) is designed specifically for proposing research that does not involve leading an independent clinical trial, a clinical trial feasibility study, or an ancillary clinical trial.

Under this NOFO are permitted to propose a research experience in a clinical trial led by a mentor or co-mentor. Those proposing a clinical trial or an ancillary clinical trial as lead investigator, should apply to the companion NOFO ( PAR-24-114 ). See Section VIII.

Other Information for award authorities and regulations. Section II. Award Information Grant: A financial assistance mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity.

Application Types Allowed The OER Glossary and the SF424 (R&R) Application Guide provide details on these application types. Not Allowed: Only accepting applications that do not propose clinical trials. Note: Applicants may propose to gain experience in a clinical trial led by a mentor/co-mentor as part of their research career development.

Need help determining whether you are doing a clinical trial? Funds Available and Anticipated Number of Awards The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications. Award budgets are composed of salary and other program-related expenses, as described below.

The total project period should be a minimum of 3 years and may not exceed 5 years. Other Award Budget Information NIH will contribute salary support of up to $100,000 per year plus fringe benefits for the career award recipient. Further guidance on budgeting for career development salaries is provided in the SF424 (R&R) Application Guide.

The total NIH contribution to salary may not exceed the legislatively mandated salary cap. See: http://grants. nih.

gov/grants/policy/salcap_summary. htm . Other Program-Related Expenses NIH will contribute up to $40,000 per year toward the research development costs of the award recipient, which must be justified and consistent with the stage of development of the candidate and the proportion of time to be spent in research or career development activities.

Research development costs include, but are not limited to, supplies, equipment, technical personnel, non-degree related tuition or registration fees for activities related to the proposed career development plan, fees for statistical and computational services, and travel to research sites, research meetings, or training, as detailed in Section IV. Salary for mentors, secretarial and administrative assistants, etc. is not allowed.

Indirect Costs (also known as Facilities & Administrative [F&A] Costs) are reimbursed at 8% of modified total direct costs. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO. Section III.

Eligibility Information Higher Education Institutions Public/State Controlled Institutions of Higher Education Private Institutions of Higher Education Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement , are allowed.

Applicant organizations must complete and maintain the following registrations as described in the SF 424 (R&R) Application Guide to be eligible to apply for or receive an award. All registrations must be completed prior to the application being submitted. Registration can take 6 weeks or more, so applicants should begin the registration process as soon as possible.

Failure to complete registrations in advance of a due date is not a valid reason for a late submission, please reference NIH Grants Policy Statement 2. 3. 9.

2 Electronically Submitted Applications for additional information. System for Award Management (SAM)– Applicants must complete and maintain an active registration, which requires renewal at least annually . The renewal process may require as much time as the initial registration.

SAM registration includes the assignment of a Commercial and Government Entity (CAGE) Code for domestic organizations which have not already been assigned a CAGE Code. NATO Commercial and Government Entity (NCAGE) Code – Foreign organizations must obtain an NCAGE code (in lieu of a CAGE code) in order to register in SAM. Unique Entity Identifier (UEI)- A UEI is issued as part of the SAM.

gov registration process. The same UEI must be used for all registrations, as well as on the grant application. eRA Commons - Once the unique organization identifier is established, organizations can register with eRA Commons in tandem with completing their Grants.

gov registration; all registrations must be in place by time of submission. eRA Commons requires organizations to identify at least one Signing Official (SO) and at least one Program Director/Principal Investigator (PD/PI) account in order to submit an application. Grants.

gov – Applicants must have an active SAM registration in order to complete the Grants. gov registration. Program Directors/Principal Investigators (PD(s)/PI(s)) All PD(s)/PI(s) must have an eRA Commons account.

PD(s)/PI(s) should work with their organizational officials to either create a new account or to affiliate their existing account with the applicant organization in eRA Commons. If the PD/PI is also the organizational Signing Official, they must have two distinct eRA Commons accounts, one for each role. Obtaining an eRA Commons account can take up to 2 weeks.

All PD(s)/PI(s) must be registered with ORCID . The personal profile associated with the PD(s)/PI(s) eRA Commons account must be linked to a valid ORCID ID. For more information on linking an ORCID ID to an eRA Commons personal profile see the ORCID topic in our eRA Commons online help .

The primary mentor at the U.S. institution and the primary LMIC mentor must have eRA Commons accounts. Obtaining an eRA Commons account can take up to 2 weeks.

Eligible Individuals (Program Director/Principal Investigator) Any candidate with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director/Principal Investigator (PD/PI) is invited to work with his/her mentor and organization to develop an application for support. Multiple PDs/PIs are not allowed.

By the time of award, the individual must be a citizen or a non-citizen national of the United States or have been lawfully admitted for permanent residence (i.e., possess a currently valid Permanent Resident Card USCIS Form I-551, or other legal verification of such status).

Current and former PDs/PIs (including Multiple PDs/PIs) on NIH research project (R01), program project (P01), research training (D43), or center (P50) grants, sub-projects of program project (P01) or center (P50) grants, other major individual career development awards (e.g., K01, K07, K08, K22, K23, K25, K76, K99/R00), or the equivalent to these grants/awards (including non-NIH equivalent grants/awards from other research funding organizations) are not eligible.

Current and former PDs/PIs (including Multiple PDs/PIs) of an NIH Small Grant (R03), Exploratory/Developmental Grant (R21/R33), Dissertation Award (R36), or SBIR/STTR (R41, R42, R43, R44) remain eligible. Individuals supported by institutional K awards (K12 or KL2) remain eligible but cannot exceed 6 years of combined institutional K plus individual K01 funding.

Candidates for this award must have a research or health-professional doctoral degree (including PhD, MD, DO, DC, ND, DDS, DMD, DVM, ScD, DNS, PharmD or equivalent doctoral degrees) received at least two years prior to the application deadline and have research experience beyond their doctoral training. This NOFO does not require cost sharing as defined in the NIH Grants Policy Statement Section 1. 2 Definition of Terms .

3. Additional Information on Eligibility Applicant organizations may submit more than one application, provided that each application is scientifically distinct, and each is from a different candidate. NIH will not accept duplicate or highly overlapping applications under review at the same time per NIH Grants Policy Statement Section 2.

3. 7. 4 Submission of Resubmission Application .

An individual may not have two or more competing NIH career development applications pending review concurrently. In addition, NIH will not accept: A new (A0) application that is submitted before issuance of the summary statement from the review of an overlapping new (A0) or resubmission (A1) application.

A resubmission (A1) application that is submitted before issuance of the summary statement from the review of the previous new (A0) application. An application that has substantial overlap with another application pending appeal of initial peer review. (See NIH Grants Policy Statement 2.

3. 9. 4 Similar, Essentially Identical, or Identical Applications ).

Candidates may submit research project grant (RPG) applications concurrently with the K application. However, any concurrent RPG application may not have substantial scientific and/or budgetary overlap with the career award application.

K award recipients are encouraged to obtain funding from NIH or other Federal sources either as a PD/PI on a competing research grant award or cooperative agreement, or as project leader on a competing multi-project award as described in NOT-OD-18-157 . At the time of award, the candidate must have a “full-time” appointment at the academic institution.

Candidates are required to commit a minimum of 75% of full-time professional effort (i.e., a minimum of 9 person-months) to their program of career development. Candidates may engage in other duties as part of the remaining 25% of their full-time professional effort not covered by this award, as long as such duties do not interfere with or detract from the proposed career development program.

Candidates who have VA appointments may not consider part of the VA effort toward satisfying the full time requirement at the applicant institution. Candidates with VA appointments should contact the staff person in the relevant Institute or Center prior to preparing an application to discuss their eligibility. After the receipt of the award, adjustments to the required level of effort may be made in certain circumstances.

See NOT-OD-18-156 and NIH Grants Policy Statement , Section 12. 3. 6.

4 Temporary Adjustments to the Percent Effort Requirement for more details. In-country requirement: Awardees must be able to spend a minimum of 50% of their cumulative effort over the total project period (all years) physically in-country conducting research at the LMIC institution. In addition, in each year of the award, awardees must spend a minimum of three months at the LMIC institution.

For example, a candidate with 75% effort on a 5-year IRSDA K01 must spend 22. 5 months at the LMIC institution. Before submitting the application, the candidate must identify a primary mentor based at the U.S. applicant institution and a primary mentor based at the collaborating LMIC institution who are accomplished investigators in the research area proposed and have experience in successful development of independent investigators.

Together, the two primary mentors will supervise the proposed career development and research experience. The LMIC primary mentor should hold a primary appointment at the collaborating LMIC institution and should not be a U.S. citizen who holds a joint appointment at the LMIC institution. The institutional affiliations of the mentors should be clear from the biosketches, mentor support letters, and institutional letters.

The mentors should be active investigators in the area of the proposed research and committed both to the career development of the candidate and direct supervision of the candidate's research. The primary mentors must document the availability of sufficient research support and facilities for the candidate's research.

Candidates are encouraged to identify additional co-mentors to form a mentoring team if this is deemed advantageous for providing expert advice in all aspects of the research career development plan. Additional mentors can be from other LMIC or high-income countries. The candidate must work with all mentors (primary and co-mentors) in preparing the application.

The mentor(s) or mentoring team must demonstrate appropriate expertise, experience, and ability to guide the applicant in the organization, management, and implementation of the proposed research and, if proposed, clinical trial experience.

Institutional Environment The U.S. and LMIC institutions must have a strong, well-established record of research and career development activities and faculty qualified to serve as mentors in biomedical, behavioral, or clinical research. Section IV. Application and Submission Information 1.

Requesting an Application Package Buttons to access the online ASSIST system or to download application forms are available in Part 1 of this NOFO. See your administrative office for instructions if you plan to use an institutional system-to-system solution. 2.

Content and Form of Application Submission It is critical that applicants follow the instructions in the Career Development (K) Instructions in the How to Apply - Application Guide except where instructed in this notice of funding opportunity to do otherwise. Conformance to the requirements in the Application Guide is required and strictly enforced.

Applications that are out of compliance with these instructions may be delayed or not accepted for review. For information on Application Submission and Receipt, visit Frequently Asked Questions – Application Guide, Electronic Submission of Grant Applications . All page limitations described in the How to Apply – Application Guide and the Table of Page Limits must be followed.

Instructions for Application Submission The following section supplements the instructions found in the How to Apply – Application Guide and should be used for preparing an application to this NOFO. All instructions in the SF424 (R&R) Application Guide must be followed. SF424(R&R) Project/Performance Site Locations All instructions in the SF424 (R&R) Application Guide must be followed.

The following additional instruction applies: Include the applicant institution and all of the collaborating institutions, both U.S. and LMIC, as performance sites. Other Project Information All instructions in the SF424 (R&R) Application Guide must be followed. SF424(R&R) Senior/Key Person Profile Expanded All instructions in the SF424 (R&R) Application Guide must be followed.

The following additional instructions apply: Both the primary US and primary LMIC mentor must insert "Other" or "Other Professional" in the Project Role field, and enter "Mentor" in the Other Project Role Category field.

When listing other individuals with a substantive role in the project, clearly label roles to distinguish "Co-Mentor", "Consultant", "Collaborator", etc. When listing the applicant's research support in the Biographical Sketch, clarify PD/PI status on awards (direct recipient). All instructions in the SF424 (R&R) Application Guide must be followed.

The following additional instructions apply: Applicants should identify specific expenses such as: (a) non-degree related tuition or registration fees for specific PD/PI career development activities; (b) research expenses such as supplies, equipment and technical personnel; (c) statistical and computational services, including technical personnel and computer time; (d) mentor and grantee communication costs; and (e) PD/PI travel and per diem expenses to field research sites, collaborating institutions, research or networking meetings, or research skills workshops or courses in the appropriate budget form category.

PHS 398 Cover Page Supplement All instructions in the SF424 (R&R) Application Guide must be followed.

PHS 398 Career Development Award Supplemental Form The PHS 398 Career Development Award Supplemental Form is comprised of the following sections: Other Candidate Information Mentor, Co-Mentor, Consultant, Collaborators Environment & Institutional Commitment to the Candidate Other Research Plan Sections All instructions in the SF424 (R&R) Application Guide must be followed.

All instructions in the SF424 (R&R) Application Guide must be followed, with the following additional instructions: Candidate Information and Goals for Career Development Describe the candidate's commitment to a global health-related research career. Describe prior training and research experience beyond doctoral training and how it relates to the objectives and long-term global health research career plans of the candidate.

Provide evidence of the candidate's potential to develop into a successful independent global health researcher (such as lead authorship of and/or significant contribution to research publications in peer-reviewed journals, presentations at international meetings, prior research interests and experience, and research fellowships) without duplicating information in the biosketches.

Describe all the candidate's professional responsibilities at the grantee institution and elsewhere and show the relation of these responsibilities to the proposed activities on the career development award.

Career Goals and Objectives​ Describe a systematic plan: (1) that shows a logical progression from prior research and training experiences to the research and career development experiences that will occur during the career award period and then to independent investigator status; and (2) that justifies the need for further career development to become an independent global health investigator.

Candidate’s Plan for Career Development/Training Activities During Award Period The candidate and the mentor(s) are jointly responsible for the preparation of the career development plan. A career development timeline is often helpful. The didactic (if any) and the research aspects of the plan must be designed to develop the necessary knowledge and research skills in scientific areas relevant to the candidate's career goals.

Describe the professional responsibilities/activities including other research projects beyond the minimum required 9 person months (75% full-time professional effort) commitment to the career award. Explain how these responsibilities/activities will help ensure career progression to achieve independence as an investigator.

Describe the candidate's career goals and the specific objectives to reach each goal under this award, indicating linkages to prior experience and current research support. Provide a detailed description of the career development activities, including plans to obtain the necessary research skills and experience to launch an independent global health research career.

The plan should include a description of the primary mentors, any secondary co-mentors, and any collaborators, contributors or consultants, as appropriate for the research and career development of the candidate. Describe how the plan utilizes the relevant field, clinical, research and educational resources of the U.S. and LMIC institutions.

The description of the career development plan should include items such as advanced level courses, seminars, and opportunities for collaboration and interaction with other scientists, especially in the proposed LMIC. Training in career skills such as grant-writing and making effective scientific presentations, is strongly encouraged.

The career development plan must be tailored to the needs of the individual candidate and the ultimate goal of achieving independence as a researcher. For junior faculty, describe how this award will relieve the candidate of current duties so that a greater portion of the candidate's effort (at least 9 person-months, equivalent to 75% full-time professional effort) may be devoted to research and related career development activities.

For postdocs, describe how the award would provide additional research and career development opportunities beyond the standard postdoctoral experience. Describe how the candidate plans to fulfill the requirements that he/she 1) spend at least 50% of cumulative effort over the total project period (all years) physically in-country conducting research at the LMIC site, and 2) spend a minimum of three months in the LMIC in each year.

A timeline outlining time in country is strongly recommended.

Applicants are encouraged to describe plans for outreach and dissemination of research findings both in the LMIC and in the U.S. All instructions in the SF424 (R&R) Application Guide must be followed, with the following additional instructions: A sound global health research project that addresses an area of scientific importance to the LMIC and is consistent with the candidate's level of research development and objectives of his/her career development plan must be provided.

The research description should demonstrate the quality of the candidate's research capabilities thus far, and the proposed research question, design and methodology should be novel, scientifically significant and creative in approach. The application must also describe the