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PAR-26-121 (EI/NI): multiple windows in 2026-2028. PAR-23-145 (ESI): through February 3, 2026.
Maximizing Investigators' Research Award (MIRA) (R35) is a National Institute of General Medical Sciences (NIGMS) grant mechanism designed to provide researchers with greater stability, flexibility, and resources to pursue high-impact science aligned with NIGMS's mission. Awards range from ,000 to ,000 per year over a five-year period, supporting both established investigators (PAR-26-121) and Early Stage Investigators (PAR-23-145).
Unlike project-specific R01 grants, MIRA funds the investigator's overall research program, enabling more agile and exploratory work. The program also advances NIGMS's goal of distributing research funding more broadly across the scientific community, reducing funding concentration and expanding opportunities for talented investigators nationwide.
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Maximizing Investigators' Research Award (MIRA) (R35) | National Institute of General Medical Sciences MIRA provides support for research in an investigator's laboratory that falls within the mission of NIGMS . The goal of MIRA is to increase the efficiency of NIGMS funding by providing investigators with greater stability and flexibility, thereby enhancing scientific productivity and the chances for important breakthroughs.
The program will also help distribute funding more widely among the nation's highly talented and promising investigators. MIRA grants will generally be for 5 years, for both established investigators/ new investigators and early stage investigators .
With the publication of PAR-26-121 , the program has now expanded to include established investigators who currently hold an NIGMS R01-equivalent grant or who wish to renew a MIRA, as well as new investigators who are not serving as a subproject leader on any multicomponent awards and propose research in the NIGMS mission. Early stage investigators should apply through PAR-23-145 .
MIRA for Established and New Investigators (EIs and NIs) New NOFO Published: PAR-26-121 See below for MIRA for Early-Stage Investigators (ESIs). PAR-26-121 – Applications accepted in 2026-2028 FAQs About MIRA PAR-22-180 MIRA Eligibility for Administrative Supplements MIRA Eligibility Decision Tree EI and NI MIRA Applicant Slides For more information on MIRA for established investigators contact Ashley Barnes, Ph. D.
, and Baishali Maskeri, Ph. D. , at NIGMS_EINIMIRA@nigms.
nih. gov MIRA for Early Stage Investigators (ESIs) PAR-26-032 – MIRA for ESIs Forecast Announcement FAQs About MIRA PAR-23-145 MIRA ESI Applicant Slides PAR-23-145 - Applications accepted through February 3, 2026 Eligibility: NIH Definitions of Early Stage Investigators and Related Policies and Procedures For more information on MIRA for ESIs contact Michelle R. Bond, Ph.
D. , and Marc Rigas, Ph. D.
, at NIGMS-ESIMIRA@nigms. nih. gov .
Virtual Office Hours - Navigating NIGMS Grants MIRA Awards Reflect Innovation of UConn Scientists ASBMB Today Article on MIRA Program This page last updated on
Based on current listing details, eligibility includes: Established investigators, new investigators, and early stage investigators (ESIs) at universities and nonprofits conducting biomedical research within NIGMS mission. Applicants should confirm final requirements in the official notice before submission.
Current published award information indicates Varies (typically $250,000-$750,000/year for 5 years) Always verify allowable costs, matching requirements, and funding caps directly in the sponsor documentation.
The current target date is rolling deadlines or periodic funding windows. Build your timeline backwards from this date to cover registrations, approvals, attachments, and final submission checks.
Federal grant success rates typically range from 10-30%, varying by agency and program. Build a strong proposal with clear objectives, measurable outcomes, and a well-justified budget to improve your chances.
Requirements vary by sponsor, but typically include a project narrative, budget justification, organizational capability statement, and key personnel CVs. Check the official notice for the complete list of required attachments.
Yes — AI tools like Granted can help research funders, draft proposal sections, and check compliance. However, always review and customize AI-generated content to reflect your organization's unique strengths and the specific requirements of the solicitation.
Review timelines vary by funder. Federal agencies typically take 3-6 months from submission to award notification. Foundation grants may be faster, often 1-3 months. Check the program's timeline in the official solicitation for specific dates.
Many federal programs offer multi-year funding or allow competitive renewals. Check the official solicitation for continuation and renewal policies. Non-competing continuation applications are common for multi-year awards.