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Multiple Sclerosis Research Program (MSRP) Clinical Trial Award is sponsored by Department of Defense (DoD), Congressionally Directed Medical Research Programs (CDMRP). The MSRP CTA supports rapid implementation of clinical trials with the potential to significantly impact multiple sclerosis treatment or management.
This includes evaluating new products, pharmacologic agents, devices, clinical guidance, and emerging approaches and technologies.
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Press Release: 2026 Multiple Sclerosis Research Program, Congressionally Directed Medical Research Program You are using an outdated browser. Please upgrade your browser to improve your experience. U.S. Department of War organization.
Lapse in Federal Appropriations The most recent appropriations for the Department of War expired at 11:59 p. m. EST on September 30, 2025.
Military personnel will continue in a normal duty status without pay until such time as a continuing resolution or appropriations are passed by Congress and signed into law. Civilian personnel not engaged in excepted activities will be placed in a non-work, non-pay status. Visit www.
dha. mil/shutdown for more information.
DEPARTMENT OF WAR - CONGRESSIONALLY DIRECTED MEDICAL RESEARCH PROGRAMS Transforming Health Care through Innovative and Impactful Research 2026 Multiple Sclerosis Research Program Released: February 18, 2026 Defense Health Agency Research and Development Medical Research and Development Command Congressionally Directed Medical Research Programs Multiple Sclerosis Research Program Applications submitted to the FY26 MSRP must address one or more of the following focus areas relevant to the award mechanisms as described in the table.
Independent investigators at all career levels. Supports rapid implementation of clinical trials with the potential to significantly impact multiple sclerosis. Funding Level 1: Supports small-scale, proof-of-principle clinical trials to demonstrate translational feasibility or inform the design of more advanced trials, or other clinical trials appropriate for this funding level.
Funding Level 2: Supports larger-scale clinical trials at phase 1 or 2 that seek to show preliminary evidence of safety or efficacy benefitting clinical or paraclinical outcomes in relevant patient populations. Applications must support clinical trials. Applications must include scientific rationale and preliminary data.
Applications must address at least one of the following focus areas: Promoting repair, neuroprotection, and remyelination in multiple sclerosis Treatment of multiple sclerosis symptoms The MSRP requires submission of a letter of intent prior to full application submission.
Maximum period of performance is 3 years Maximum allowable funding is $1 million for total costs* Maximum period of performance is 4 years Maximum allowable funding is $2M for total costs* Early Investigator Research Award Possess a doctoral degree from an accredited organization.
Demonstrate involvement in a postdoctoral training or medical residency program and possess at least 1 and up to 4 years continuous postdoctoral research experience. Commit at least 50% of their effort toward the project. Investigators may receive only one Early Investigator Research Award.
Supports multiple sclerosis-focused research opportunities for individuals in the early stages of their careers. Applications require mentorship. Investigators must name an experienced multiple sclerosis researcher as the designated mentor.
Applications cannot support clinical trials.
Applications must address at least one of the following focus areas: Central nervous system repair, protection and regenerative potential in multiple sclerosis Correlates of disease activity and progression in multiple sclerosis Biology and measurements of multiple sclerosis symptoms Mechanisms contributing to or associated with multiple sclerosis etiology, prodrome, onset and disease course The MSRP requires submission of a letter of intent prior to full application submission.
Maximum period of performance is 2 years Maximum allowable funding is $300,000 for total costs* Exploration – Hypothesis Development Award Established Investigators: Independent investigators at all career levels. Independent investigators with no more than 5 years from the start of their non-mentored position.
Investigators who received more than $300,000 in total direct costs for previous or concurrent multiple sclerosis research as an investigator of one or more non-mentored, peer-reviewed grants from any agency may not apply. Supports the initial exploration of innovative, high-risk, high-gain, and potentially groundbreaking concepts in the multiple sclerosis research field.
While the inclusion of preliminary data is not prohibited, the strength of the application should rely on the approach. Applications cannot support clinical trials. New Investigator Option: Supports applicants early in their faculty appointments.
Applications must address at least one of the following focus areas: Central nervous system repair, protection and regenerative potential in multiple sclerosis Correlates of disease activity and progression in multiple sclerosis Biology and measurements of multiple sclerosis symptoms Mechanisms contributing to or associated with multiple sclerosis etiology, prodrome, onset and disease course The MSRP requires submission of a letter of intent prior to full application submission.
Maximum period of performance is 2 years Maximum allowable funding is $250,000 for total costs* Investigator-Initiated Research Award Established Investigators: Independent investigators at all career levels. Independent investigators with no more than 5 years from the start of their non-mentored position.
Investigators who received more than $300,000 in total direct costs for previous or concurrent multiple sclerosis research as an investigator of one or more non-mentored, peer-reviewed grants from any agency may not apply. Supports highly rigorous, high-impact research with the potential to make an important contribution to MS research and/or patient care. Applications must include preliminary data.
Applications cannot support clinical trials. New Investigator Option: Supports applicants early in their faculty appointments.
Applications must address at least one of the following focus areas: Central nervous system repair, protection and regenerative potential in multiple sclerosis Correlates of disease activity and progression in multiple sclerosis Biology and measurements of multiple sclerosis symptoms Mechanisms contributing to or associated with multiple sclerosis etiology, prodrome, onset and disease course The MSRP requires submission of a letter of intent prior to full application submission.
Maximum period of performance is 3 years Maximum allowable funding is $1M for total costs* *Total costs include direct and indirect costs. dha. detrick.
cdmrp. mbx. public-affairs@health.
mil Last updated Wednesday, February 18, 2026
Based on current listing details, eligibility includes: Independent investigators at all career levels may apply; applications must include scientific rationale and preliminary data addressing MS repair/neuroprotection or symptom treatment. Applicants should confirm final requirements in the official notice before submission.
Current published award information indicates Up to $1M (Level 1, 3 years) or $2M (Level 2, 4 years) Always verify allowable costs, matching requirements, and funding caps directly in the sponsor documentation.
The current target date is rolling deadlines or periodic funding windows. Build your timeline backwards from this date to cover registrations, approvals, attachments, and final submission checks.
Federal grant success rates typically range from 10-30%, varying by agency and program. Build a strong proposal with clear objectives, measurable outcomes, and a well-justified budget to improve your chances.
Requirements vary by sponsor, but typically include a project narrative, budget justification, organizational capability statement, and key personnel CVs. Check the official notice for the complete list of required attachments.
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Review timelines vary by funder. Federal agencies typically take 3-6 months from submission to award notification. Foundation grants may be faster, often 1-3 months. Check the program's timeline in the official solicitation for specific dates.
Many federal programs offer multi-year funding or allow competitive renewals. Check the official solicitation for continuation and renewal policies. Non-competing continuation applications are common for multi-year awards.
Spinal Cord Injury Research Program (SCIRP) Anticipated Funding Opportunities for Fiscal Year 2026 (FY26) is sponsored by Department of Defense (DoD), Congressionally Directed Medical Research Programs (CDMRP). The SCIRP funds research and development efforts to advance the treatment and management of spinal cord injury (SCI) and ameliorate its consequences. The program emphasizes the involvement of individuals with lived SCI experience in the research process.
Traumatic Brain Injury and Psychological Health Research Program (TBIPHRP) Anticipated Funding Opportunities for Fiscal Year 2026 (FY26) is sponsored by Department of Defense (DoD), Congressionally Directed Medical Research Programs (CDMRP). The TBIPHRP funds research to understand, prevent, and treat psychological health conditions and/or traumatic brain injuries, with the goal of improving the health and healthcare of Service Members, their Families, Veterans, and the American public.
Ovarian Cancer Clinical Trial Academy - Early-Career Investigator Award (FY26) is sponsored by Department of Defense (DoD), Congressionally Directed Medical Research Programs (CDMRP). The intent of this award is to enhance knowledge within the next generation of Early-Career Investigators (ECIs) in clinical trial research and to produce effective treatments and cures for ovarian cancer. It enables the ECI to pursue funding for ovarian cancer clinical trial research under the guidance of a Designated Mentor.
Broad Agency Announcement (BAA) Call N0001425SBC03 For Office of Naval Research (ONR) Global Opportunity: GlobalX Innovation Joint Challenge: AI for Advancing Maritime Security is sponsored by Office of Naval Research (ONR) Global. This BAA Call seeks proposals for the GlobalX Innovation Joint Challenge: AI for Advancing Maritime Security. It funds the development of artificial intelligence solutions for maritime security applications, focusing on innovative AI algorithms for challenging maritime scene perception scenarios using real-world or synthetic data from UxV platforms. The program aims to accelerate the traditional knowledge generation cycle, leading to revolutionary dual-use capability for the U.S. Navy and Marine Corps and the commercial marketplace. White papers are highly encouraged and due May 23, 2025, with full proposals due June 23, 2025.
Operation Stonegarden (OPSG) is a federal grant program administered by FEMA through the Office of the Governor's Public Safety Office that funds enhanced border security cooperation among Customs and Border Protection (CBP), U.S. Border Patrol, and state, local, tribal, and territorial law enforcement agencies. The program supports joint operations to secure land and water border routes, improve intelligence sharing, and expand 287(g) screening operations within correctional facilities. In 2025, the national priority is Supporting Border Crisis Response and Enforcement, covering training, operational coordination, and risk management. Eligible expenses include operational overtime costs, staffing support for screening activities, and training programs in immigration law, civil rights protections, and 287(g) procedures.