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The NCI Informatics Technology for Cancer Research (ITCR) program funds research-driven informatics technology development to address critical needs across cancer research, including machine learning and statistical methods, natural language processing and text mining, analytics and visualization platforms, clinical decision support tools, and interactive modeling environments.
ITCR supports tools across the full development lifecycle and requires that funded software be open-source and freely available to academic and nonprofit researchers. AI and machine learning are central emphases, with awardees expected to collaborate across the ITCR network and participate in annual meetings. Multiple RFAs and announcements are issued across innovative, early-stage, advanced development, and sustainment stages.
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Search similar grants →According to the current listing, eligibility includes: Domestic and foreign higher education institutions, nonprofit and for-profit organizations, and small businesses developing cancer informatics technologies. Specific eligibility depends on the mechanism (U01, U24, R21/R33) and active RFA. Confirm the full requirements in the official notice before applying.
The current listing shows ITCR supports informatics technology development across the cancer research lifecycle through U01 and U24 cooperative agreements (and related R21/R33 mechanisms). Award sizes vary by mechanism and stage, generally ranging from roughly $225,000 to $750,000 per year in direct costs over multi-year project periods. Verify award ceilings, matching requirements, and allowable costs in the official notice.
The published deadline was June 1, 2026, which has passed. Check the official notice for any future application windows before investing time in a proposal.
NCI Informatics Technology for Cancer Research (ITCR) for AI and Machine Learning Cancer Informatics Tools is funded by National Cancer Institute (NCI), National Institutes of Health (NIH). Verify program details on the funder's official page before applying.
Start from the official opportunity page linked in this listing — it carries the sponsor's submission instructions.
Mechanisms that Impact Cancer Risk with Use of Incretin Mimetics (R01 Clinical Trial Optional) is sponsored by National Cancer Institute (NCI), National Institutes of Health (NIH). This funding opportunity invites investigator-initiated studies addressing mechanisms by which incretin mimetics, specifically GLP-1 or dual GLP-1/GIP-1 receptor agonists, impact cancer risk. The focus includes reported effects on thyroid, prostate, and other cancer risks. The NOFO also aims to attract scientists from other fields to study incretin mimetic effects on cancer biology.
Digital Health Technology Derived Biomarkers and Outcome Assessments for Remote Monitoring and Endpoint Development (UG3/UH3 - Clinical Trial Optional) is sponsored by National Cancer Institute (NCI), National Institutes of Health (NIH). Supports the development of biomarkers or clinical outcomes derived from digital health technology for remote monitoring in clinical trials.
NCI SBIR/STTR Omnibus Grant Solicitations is sponsored by National Cancer Institute (NCI), National Institutes of Health (NIH). The NCI SBIR/STTR program provides non-dilutive funding and commercialization support to small businesses developing innovative cancer-related technologies, including immunotherapies. It accelerates the translation of innovative immunotherapy discoveries into clinical applications. The program supports a broad spectrum of technology readiness, from proof-of-concept studies to clinical trials.
NSF TechAccess AI-Ready America is a major new initiative to establish AI-ready Coordination Hubs in every U.S. state and territory to expand access to AI knowledge tools training and capacity building. Announced March 25 2026 the initiative is a joint effort of NSF USDA National Institute of Food and Agriculture (NIFA) Department of Labor and Small Business Administration (SBA). Each Hub will connect local partners and coordinate AI deployment scale proven approaches based on state and local priorities and address three key gaps: workforce AI literacy small business and local government AI adoption and hands-on learning pathways. Up to 56 Hubs will be funded at up to $1 million per year for three years selected through three rounds of competition. An informational webinar is scheduled for April 14 2026. This is distinct from NSF ExpandAI which focuses on institutional AI research capacity building and from NSF Expanding AI Career which targets skilled technical workforce opportunities.
The DARPA Young Faculty Award (YFA) is a flagship program that identifies and engages rising research stars in junior faculty positions at U.S. academic institutions and exposes them to DARPA's mission. The 2026 YFA solicitation (DARPA-RA-25-02 series) explicitly lists AI-relevant research topics including interpretable reinforcement learning, logical AI, knowledge representation and reasoning, neuro-symbolic systems, foundation models for science, AI for the physical world, mathematical foundations of large models, and assured autonomy. Awardees develop their research vision in partnership with a DARPA program manager and are positioned to compete for follow-on DARPA programs. The program provides ~$500,000 over a two-year base period with a possible third-year option, plus a Director's Fellowship of up to $500,000 for outstanding awardees. Strong fit for tenure-track AI, autonomy, and machine learning faculty within seven years of receiving a PhD.
Air Force SBIR topic DAF26BZ03-DV020 seeks advanced AI-driven solutions for a scalable fleet management platform coordinating humanoid, mobile, and industrial robots performing aircraft maintenance and sustainment. Requirements include autonomous AI-based task allocation, real-time monitoring, human-robot collaboration workflows, dynamic scheduling, multi-modal sensor fusion for situational awareness, and operational optimization. Solutions must scale across mixed robotic fleets in active Air Force maintenance environments and contested logistics scenarios.
NIH's June 1 omnibus reset added Direct-to-Phase II to the STTR program for the first time. The change compresses university spinouts' funding timeline from three years to fifteen months, but the 30% research-institution subaward, feasibility-evidence rules, and IP licensing mechanics are not yet sorted at most universities.
Read articleOn May 21, 2026, the National Cancer Institute posted RFA-CA-27-006, RFA-CA-27-007, and RFA-CA-27-008 — the three competitive renewals for the NCI Community Oncology Research Program. Combined FY 2027 commitments reach $147.5 million across roughly 57 awards: $74.5 million for up to 7 Research Bases, $73 million for up to 50 Community and Academic Community Sites. Pre-application webinars run June 16-18 this week. Applications are due August 18, 2026 with six-year project periods. For community hospitals, oncology consortia, and NCI-designated cancer centers, this is the single largest cancer clinical-trials infrastructure decision NCI makes until 2033.
Read articleNIH committed $402 million across 601 multiyear-funded grants in the first eight months of FY 2026 — more than four times the pace of two years ago. The mechanism front-loads obligations into a single fiscal year, leaving less budget for new project starts and squeezing FY 2026 success rates. What researchers and institutions should be doing now.
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