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New applications due February 12, June 12, October 12; resubmissions March 12, July 12, November 12; AIDS applications May 7, September 7, January 7.
NIH Pathway to Independence Award (K99/R00) is sponsored by National Institute of Mental Health (NIMH) / NIH. The NIH Pathway to Independence Award is designed to provide an accelerated route for the most promising postdoctoral researchers to transition to independent research careers. NIMH supports research in human behavior and mental health.
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NIH Pathway to Independence Award (K99/R00) - National Institute of Mental Health (NIMH) Due to current HHS and NIH restructuring, some content on nimh. nih. gov is not being updated regularly.
Please refer to clinicaltrials. gov and nih. gov for up-to-date information on NIH research.
Opportunities & Announcements Funding Strategy for Grants Grant Writing & Approval Process NIH Pathway to Independence Award (K99/R00) The NIH Pathway to Independence Award offers an opportunity for highly promising postdoctoral scientists to receive both mentored and independent research support from the same award.
This award provides 1-2 years for mentored postdoctoral career development (K99 phase) followed by up to 3 years of independent research support (R00 phase).
PA-24-193: NIH Pathway to Independence Award (Parent K99/R00 – Independent Clinical Trial Required) PA-24-194: NIH Pathway to Independence Award (Parent K99/R00 – Independent Clinical Trial Not Allowed) PA-24-195: NIH Pathway to Independence Award (Parent K99/R00 Independent Basic Experimental Studies with Humans Required) Learn more about NIH’s Definition of a Clinical Trial .
New Applications: February 12, June 12, October 12 Resubmissions: March 12, July 12, November 12 AIDS applications: May 7, September 7, January 7 K99/R00 applicants must have no more than 4 years of postdoctoral research experience at the time of application regardless of whether it is a new or resubmission application. Applicants must be in mentored, postdoctoral training positions to be eligible to apply to the K99/R00 program.
Postdoctoral research is defined as any time spent conducting research or publishing research results following completion of all degree requirements, which may not correspond with the date of the graduation ceremony. This includes any time spent at the institution where the doctoral degree was completed prior to starting an official postdoctoral position.
If an applicant achieves independence (any faculty or non-mentored research position) before a K99 award is made, neither the K99, nor the R00 award, will be made. There is no citizenship requirement for K99 applicants.
U.S. domestic institutions Foreign components allowed Given that the K99 phase is intended for mentored career development, a well-justified and feasible set of mentored career development goals for the K99 phase that complements the applicant’s current skill set is an expected component of the application. Applications lacking a well-reasoned set of mentored career development goals generally do not receive favorable reviews.
Awardees are expected to complete at least one full year of mentored training under the K99 phase before transitioning to the second (R00) phase. The R00 phase will provide up to 3 years of independent research support, which is contingent on satisfactory progress during the K99 phase and an approved, independent, tenure-track (or equivalent) faculty position.
K99/R00 transition guidance The two award phases are intended to be continuous in time. Transition from the K99 phase to the R00 phase is not automatic and is subject to NIMH administrative review of the K99 awardee’s accomplishments during the K99 phase and the materials submitted in support of the R00 phase application (including the faculty job offer).
To activate the independent phase of the grant, individuals must have been offered and accepted a tenure-track, full-time assistant professor position (or equivalent) by the end of the K99 project period. The faculty position may not be contingent upon receipt of an R00 award.
K99 awardees are strongly encouraged to contact their Program Officer as they begin to interview for tenure-track faculty positions and to provide regular status updates on their job search. Such communication will allow staff to provide appropriate technical assistance during the job search and negotiation.
K99 awardees are expected to notify their Program Officer upon receipt of any tenure-track faculty job offer (and prior to acceptance of an offer) so that the Program Officer may address questions concerning NIMH’s expectations for transition to the R00 phase. Individuals should allow three months for NIMH review of R00 phase applications.
R00 applications submitted after July 15 annually will generally not be reviewed until the next fiscal year (after October 1). Independent investigator phase (R00) expectations Award recipients are expected to apply for independent R01 support from the NIMH during the R00 award period. Salary and research costs Salary support: Up to $75,000 plus fringe benefits per year.
Practicing physician-scientists may be eligible for up to $100,000 salary plus fringe benefits per year. Research support: Up to $20,000 per year The total cost for the independent phase (R00) may not exceed $249,000. This amount includes salary, fringe benefits, research costs, and applicable indirect costs.
The requested salary must be consistent both with the established salary structure at the institution and with salaries provided by the institution from its own funds to other staff members with equivalent qualifications, rank, and responsibilities in the department concerned. The total salary may not exceed the legislatively mandated salary cap. See the NIH Salary Cap Summary .
Potential applicants are strongly encouraged to review the notice of funding opportunity, NIH New Investigators Program FAQs , and the FAQs below prior to contacting the appropriate NIMH Research Training and Career Development representative for additional information. To compare across K mechanisms (i.e., salary support, effort, etc.), see the Table of K Parameters . Have additional questions?
Career Development Programs (K-Series) NIH Research Training and Career Development FAQs NIMH Guidance for Responsible Conduct of Research (RCR) Training Requirements Q: From what point is the 4-year eligibility window calculated for NIMH? A: The K99/R00 eligibility window begins on the date you complete your PhD requirements.
Any time spent conducting research or publishing research results following completion of all degree requirements counts as postdoctoral experience. NIMH strongly encourages potential K99/R00 applicants to apply as soon as they have developed a conceptual framework for their independent research program and have accumulated preliminary data to document general feasibility of the proposed research program.
It is not recommended that applicants defer application until the end of the eligibility window should they be strong candidates prior to this time. Q: Should I request a specific study section for my K99/R00 application? A: No. All NIMH K99/R00 applications are assigned to an NIMH study section.
Q: Can I apply if I am a non-US citizen on a temporary visa? A: There is no citizenship requirement for K99 applicants. An applicant may be a citizen or a non-citizen national of the United States, have been lawfully admitted for permanent residence (i.e., possess a currently valid Permanent Resident Card USCIS Form I-551, or other legal verification of such status), or be a non-U.S. citizen.
For applications submitted on behalf of non-U.S. citizens with temporary U.S. visas, visa status during each phase of the K99/R00 award must allow the PD/PI to conduct the proposed research at the applicant institution. Q: Is it possible to request a waiver to the 4-year eligibility window? A: NIMH will grant an eligibility waiver on a case-by-case basis.
An exception may be considered when a significant break in training has occurred as a result of family responsibilities, medical leave, or military service, or when a significant change in fields of study has occurred, such as moving from physical science to life science research.
Investigators are expected to contact NIMH staff to discuss issues regarding eligibility prior to applying and to learn if their circumstance warrants an exception (see K Award Eligibility Extension page ). Q: For the R00 phase, what constitutes an eligible position? A: An eligible position is a tenure-track, full-time assistant professor position (or equivalent).
Based on current listing details, eligibility includes: Postdoctoral researchers with maximum 4 years postdoctoral experience at application time; must be in a mentored postdoctoral training position; no citizenship requirement; U.S. domestic institutions required. Applicants should confirm final requirements in the official notice before submission.
Current published award information indicates Varies Always verify allowable costs, matching requirements, and funding caps directly in the sponsor documentation.
The current target date is rolling deadlines or periodic funding windows. Build your timeline backwards from this date to cover registrations, approvals, attachments, and final submission checks.
Federal grant success rates typically range from 10-30%, varying by agency and program. Build a strong proposal with clear objectives, measurable outcomes, and a well-justified budget to improve your chances.
Requirements vary by sponsor, but typically include a project narrative, budget justification, organizational capability statement, and key personnel CVs. Check the official notice for the complete list of required attachments.
Yes — AI tools like Granted can help research funders, draft proposal sections, and check compliance. However, always review and customize AI-generated content to reflect your organization's unique strengths and the specific requirements of the solicitation.
Review timelines vary by funder. Federal agencies typically take 3-6 months from submission to award notification. Foundation grants may be faster, often 1-3 months. Check the program's timeline in the official solicitation for specific dates.
Many federal programs offer multi-year funding or allow competitive renewals. Check the official solicitation for continuation and renewal policies. Non-competing continuation applications are common for multi-year awards.
-Purpose. This Funding Opportunity Announcement (FOA) encourages Small Business Innovation Research (SBIR) grant applications from small business concerns (SBCs) that propose to develop, standardize, and validate new and innovative assays, integrated strategies, or batteries of assays that determine or predict specific organ toxicities (e.g., ocular, dermal, hematotoxicity, cardiotoxicity, gastrointestinal toxicity, hepatotoxicity, nephrotoxicity, ototoxicity, olfactory loss, bladder toxicity, neurotoxicity, pulmonary toxicity, endocrine toxicity, and pancreatic beta cell toxicity), resulting from both acute and chronic exposures to various chemicals, environmental pollutants, biologics and therapeutic molecules or drugs. In addition, this FOA encourages the development, standardization, and validation of new models of arthritis, convulsion, infection and shock. New approaches for high throughput toxicity screening that involves the use of molecular endpoints, computer modeling, proteomics, genomics and epigenomics and the development of virtual tissues are also encouraged as are development of 3-dimensional organ models for toxicity evaluation. -Mechanism of Support. This FOA will utilize the SBIR (R43/R44) grant mechanisms for Phase I, Phase II, and Fast-Track applications and runs in parallel with a FOA of identical scientific scope, PA-09-007, which encourages applications under the Small Business Technology Transfer (STTR) (R41/R42) grant mechanisms. Funding Opportunity Number: PA-09-006. Assistance Listing: 93.113,93.173,93.361,93.389,93.837,93.846,93.847,93.848,93.849,93.859,93.867. Funding Instrument: G. Category: ED,ENV,FN,HL.
Purpose. This Funding Opportunity Announcement (FOA), issued by the National Cancer Institute (NCI), National Institutes of Health (NIH), invites Small Business Innovation Research (SBIR) cooperative agreement applications from small business concerns (SBCs) that propose to develop new, or to improve existing application(s) of nanotechnology-based therapeutics or/and in vivo diagnostics. This FOA will specifically support pre-clinical optimization and testing of these cancer-relevant nanotechnology applications against the intended cancer type. The proposed projects must be milestone-driven and must be clearly directed toward development of an ultimate commercial product. The outcomes are expected to advance the discovery and pre-clinical optimization phase so that an Investigational New Drug (IND) or Investigational Device Exemptions (IDE) application could be submitted to the Food and Drug Administration (FDA) by the end or shortly after completion of the Phase II project period. To facilitate these steps, the NCI will assist the awardees in various ways, including the support through the NCI-sponsored Nanotechnology Characterization Laboratory. This FOA will NOT support basic research projects, studies on disease mechanisms, and clinical trials. Mechanism of Support. This FOA will utilize the SBIR (U43/U44) cooperative agreement mechanisms for Phase I and Phase II applications. Funds Available and Anticipated Number of Awards. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications. The total amount awarded and the number of awards will depend upon the quality, duration, and costs of the applications received. Funding Opportunity Number: PAR-10-286. Assistance Listing: 93.393,93.394,93.395,93.396. Funding Instrument: CA. Category: ED,HL. Award Amount: Up to $150K per award.