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NIH SBIR/STTR Omnibus Grant Solicitations (NCI) is a grant program from the National Cancer Institute, part of the National Institutes of Health, that funds investigator-initiated small business innovation research across a broad spectrum of health and cancer research topic areas.
The program encompassed both Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) mechanisms through Phase I (R43/R41) and Phase II (R44/R42) awards, with options for both clinical trial and non-clinical trial research.
Eligible applicants are U.S. small business concerns with research capabilities and technological expertise relevant to NIH's mission, including those majority-owned by venture capital operating companies, hedge funds, or private equity firms. Note that the legislative authority for the SBIR/STTR programs expired on October 1, 2025, and NIH currently has no active solicitations.
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NCI SBIR/STTR Omnibus Grant Solicitations - NCI NIH has no active Small Business Innovation Research (SBIR) or Small Business Technology Transfer (STTR) solicitations because the legislative authority for the programs expired on October 1, 2025. Current recipients should direct any questions to their Program Officer. See NOT-OD-26-006 .
NCI SBIR/STTR Omnibus Grant Solicitations The Small Business Innovation Research (SBIR)/Small Business Technology Transfer (STTR) Omnibus Solicitations are intended to support small business innovation research across a broad spectrum of topic areas.
U.S. small businesses that have the research capabilities and technological expertise to contribute to the research and development missions of the awarding components identified in the Omnibus Solicitation are encouraged to submit investigator-initiated SBIR & STTR grant applications in response to the identified topics.
Applicants may also consider other areas of research within the mission of any of the awarding components and submit an SBIR & STTR application Small business concerns that are majority-owned by multiple venture capital operating companies (VCOCs), hedge funds and/or private equity firms continue to be eligible to apply to the CDC and NIH SBIR program and compete for up to 15% and 25% respectively of each agency's SBIR set-aside.
Omnibus Solicitation Opportunities This funding opportunity was updated to align with agency priorities. Carefully reread the full funding opportunity and make any needed adjustments to your application prior to submission.
SBIR Program: PA-24-245 (Clinical Trial Not Allowed) PHS 2024-2 Omnibus Solicitation of the NIH, CDC, and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44]) Standard Receipt Dates: September 5, 2024; January 5, 2025; April 5, 2025; September 5, 2025 SBIR Program: PA-24-246: (Clinical Trial Required) PHS 2024-2 Omnibus Solicitation of the NIH and CDC for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44]) Standard Receipt Dates: September 5, 2024; January 5, 2025; April 5, 2025; September 5, 2025 STTR Program: PA-24-247 (Clinical Trial Not Allowed) PHS 2024-2 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42]) Standard Receipt Dates: September 5, 2024; January 5, 2025; April 5, 2025; September 5, 2025 STTR Program: PA-24-248 (Clinical Trial Required) PHS 2024-2 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42]) Standard Receipt Dates: September 5, 2024; January 5, 2025; April 5, 2025; September 5, 2025 Online HTML Application Guide SF424 (R&R) Application Guide for SBIR/STTR Grant Applications (Version H) Annotated SF424 SBIR/STTR Form Set NIH Matchmaker - Use NIH Matchmaker to conduct keyword searches on a particular topic area to identify NIH Institutes or Centers (ICs) that have previously funded research area.
Based on current listing details, eligibility includes: Small business concerns engaged in research and development activities within the health and life sciences sectors, aligning with NIH's mission. Applicants should confirm final requirements in the official notice before submission.
Current published award information indicates Funding amounts vary based on project scope and sponsor guidance. Always verify allowable costs, matching requirements, and funding caps directly in the sponsor documentation.
The current target date is rolling deadlines or periodic funding windows. Build your timeline backwards from this date to cover registrations, approvals, attachments, and final submission checks.
Federal grant success rates typically range from 10-30%, varying by agency and program. Build a strong proposal with clear objectives, measurable outcomes, and a well-justified budget to improve your chances.
Requirements vary by sponsor, but typically include a project narrative, budget justification, organizational capability statement, and key personnel CVs. Check the official notice for the complete list of required attachments.
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Review timelines vary by funder. Federal agencies typically take 3-6 months from submission to award notification. Foundation grants may be faster, often 1-3 months. Check the program's timeline in the official solicitation for specific dates.
Many federal programs offer multi-year funding or allow competitive renewals. Check the official solicitation for continuation and renewal policies. Non-competing continuation applications are common for multi-year awards.