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Historical funding: Not specified
Prior eligibility: Global innovators; specific eligibility details available on the Grand Challenges website.
Novel Interventions Targeting Placental and Gut Inflammation to Improve Fetal Growth is sponsored by Bill & Melinda Gates Foundation. This Grand Challenges grant is for novel interventions targeting placental and gut inflammation with the goal of improving fetal growth. It is part of the Gates Foundation's initiatives to address global health and development challenges.
MacKenzie Scott's Yield Giving has moved more than $26 billion — including roughly $7 billion in 2025, over a third of all U.S. megagifts — through unrestricted, trust-based grants with no application. Melinda French Gates's Pivotal Ventures has committed $2 billion to women's health and economic power. The Bezos philanthropies have moved billions more. As the Buffett–Gates era winds down, this new class of megadonor is rewriting the rules of major giving. Here is what changes for nonprofits, and how to become the kind of organization this money finds.
Read articleThe Gates Foundation committed at least $1 billion over two years to equitable AI alongside its 10th Goalkeepers Report — 40% education, 40% health, 10% agriculture, 10% digital infrastructure. Five days later, 60 organizations signed a five-year goal to reach 3.4 billion speakers of underrepresented languages. Here is how implementing nonprofits should read both.
Read articleGates committed $540.2 million over a decade to the Institute for Health Metrics and Evaluation — the largest gift in University of Washington history — while IHME's federal grant income falls from $7.3 million to a projected $4.8 million. The gift is a case study in the anchor-funder model: what it can do that federal money cannot, and the concentration risk it quietly underwrites.
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