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The NSF FDT-BioTech program (NSF 24-561) supports interdisciplinary research at the intersection of AI, computational modeling, and biomedical innovation by funding the mathematical and engineering foundations behind digital twins and synthetic data for healthcare applications.
Digital twins — computational replicas of biological systems, patients, or medical devices — require advanced AI and machine learning methods for their development, calibration, and deployment. The program funds research on methods and algorithms relevant to digital twins and synthetic humans, including AI-driven in silico evaluation of medical devices and treatments.
Projects must be inherently interdisciplinary, combining expertise in mathematics, engineering, computer science, and biomedical domains. Collaborative projects across multiple organizations are encouraged and can receive up to $1 million in total funding over up to 3 years.
The program is administered by multiple NSF directorates including the Division of Mathematical Sciences and the Office of Advanced Cyberinfrastructure, reflecting its cross-cutting nature. The deadline recurs annually on the first Monday in May.
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Search similar grants →According to the current listing, eligibility includes: Principal investigators at U.S. institutions of higher education and nonprofit research organizations. Each PI or Co-PI is limited to one proposal per competition cycle. Collaborative projects involving multiple organizations are accepted. Teams should demonstrate interdisciplinary expertise spanning mathematics, engineering, computer science, and biomedical sciences. Confirm the full requirements in the official notice before applying.
The current listing shows up to $1,000,000 per collaborative project. Total program budget: $4,000,000-$5,000,000 per cycle. Estimated 6-10 awards per cycle. Verify award ceilings, matching requirements, and allowable costs in the official notice.
The published deadline was May 4, 2026, which has passed. Check the official notice for any future application windows before investing time in a proposal.
NSF FDT-BioTech Foundations for Digital Twins as Catalyzers of Biomedical Technological Innovation is funded by National Science Foundation (NSF). Verify program details on the funder's official page before applying.
Start from the official opportunity page linked in this listing — it carries the sponsor's submission instructions.
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