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PHS 2023 Omnibus Solicitation of the NIH and CDC for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Not Allowed) is sponsored by National Institutes of Health (NIH) and Centers for Disease Control and Prevention (CDC). This omnibus solicitation invites SBIR grant applications for investigator-initiated research that aligns with the missions of NIH and CDC, including various areas of digital health and behavioral interventions.
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PA-23-230 - PHS 2023-2 Omnibus Solicitation of the NIH, CDC and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Not Allowed) is used for the submission of applications to the following Notices of Special Interest (NOSIs) | Grants & Funding U.S. Department of Health and Human Services National Institutes of Health PA-23-230 - PHS 2023-2
Omnibus Solicitation of the NIH, CDC and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Not Allowed) is used for the submission of applications to the following Notices of Special Interest (NOSIs) Notice of Change to correct ORIPs listing under Components of Participating Organizations for PA-23-080, PA-23-230, PA-23-232, PAR-23-138, RFA-NS-23-006, and RFA-NS-23-007 R41/R42, R43/R44, S10,
T35 Notice of Special Interest (NOSI): Epigenetic Modulation of HBV cccDNA and integrated HBV DNA (iDNA): Implications for Epigenetic Treatment Strategies Against HBV in HIV/HBV Co-Infection R41/R42, R43/R44, R01, R21 Notice of Special Interest (NOSI): Improving Adherence to Treatment and Prevention Regimens and Maintenance of Health Behaviors to Promote Health OBSSR, NCCIH, NCI, NEI, NHLBI, NIA, NIDA, NIMH, NIMHD, NINR,
OAR, ODP, ORWH P01, P30, R01, R03, UG3/UH3, R34, U24, R41/R42, R21, R43/R44, R21/R33, R61 Notice of Special Interest (NOSI): Translating Biomaterials-Based Technologies to Commercially Viable Products NIBIB, NCATS, NCCIH, NHLBI, NIDCR Notice of Special Interest (NOSI): Research to Stimulate Development of Diagnostics, Therapeutics, and Vaccines for Herpes Simplex Virus (HSV) R21, R41/R42, R43/R44, R03, R01 Notice of Special Interest:
Womens Health Research ORWH, FIC, NCATS, NCCIH, NCI, NEI, NHGRI, NHLBI, NIA, NIAAA, NIAID, NIAMS, NIBIB, NICHD, NIDA, NIDCD, NIDCR, NIDDK, NIEHS, NIGMS, NIMH, NIMHD, NINDS, NINR, NLM, OAR, OBSSR, ODP, ODS, ODSS R15, R01, K01, R16, K08, R21, K43, F31, R43/R44, R41/R42, F30, R03, K23, F32, R34 Notice of Special Interest (NOSI): Development of Imaging Techniques for High Resolution
and Functional Scanning of In Vivo Human Sensory and Communication Systems R01, U01, R43/R44, R41/R42, R21 Notice of Special Interest (NOSI): Validation of Digital Health and Artificial Intelligence/Machine Learning Tools for Improved Assessment in Biomedical and Behavioral Research NCI, NHLBI, NIA, NIDA, NIMH, NINR, OBSSR, ODSS R61/R33, R01, R21, R43/R44, R34, R41/R42 Notice of Special Interest (NOSI): Innovative Technologies for
Research on Climate Change and Human Health NIEHS, NCATS, NCCIH, NEI, NHLBI, NIA, NIAID, NIAMS, NLM Notice of Special Interest (NOSI): Advancing Genomic Medicine Research through Small Businesses Notice of Special Interest (NOSI): RNA Delivery Technologies to Allow Specific Tissue Target Homing (RNA-DASH) Notice of Special Interest (NOSI): Translation of BRAIN Initiative Technologies to the Marketplace NIMH, NCCIH, NEI, NIA,
NIAAA, NIBIB, NICHD, NIDA, NIDCD, NINDS Notice of Special Interest (NOSI): Advancing Genomic Technology Development for Research and Clinical Application R01, R21, R43/R44, R41/R42 Notice of Special Interest (NOSI): SBIR/STTR High-Priority Areas for Digital Mental Health Innovations Notice of Special Interest (NOSI): SBIR/STTR Program Priorities to Bridge Gaps in Advancing the NIMH Mission Notice of Special Interest (NOSI): Using Targeted
Degradation of Protein and non-Protein Targets for the Development of Novel Anti-Infectives R03, R01, R21, R41/R42, R43/R44 Notice of Special Interest (NOSI): Advancing Genomic Medicine Research through Small Businesses Notice of Special Interest: Encouraging Small Businesses to Partner with Resource-Limited Institutions (RLIs) on Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) Program Applications Notice of Special Interest
(NOSI): The Road to Prevention of Stillbirth F31, R03, R15, K08, R01, R21, F30, U24, R43/R44, K23, R41/R42, R25, S06, F32, U01 Notice of Special Interest (NOSI): Quantum Sensing in Biomedical Applications (SBIR/STRR) Notice of Special Interest (NOSI): Small Business Initiatives for Innovative tools and Technologies for Improving Outcomes for Maternal Health NIBIB, NCATS, NHLBI, NIAMS, NIMH, NIMHD, NINDS, ORWH
Notice of Special Interest (NOSI): Innovative Technologies to develop novel tools to prevent and treat HIV in underserved populations Notice of Special Interest (NOSI): Advancing Biomedical Research in Pulmonary Non-Tuberculous Mycobacterial (NTM) Infections R21, R41/R42, R43/R44, R01, U44 Notice of Special Interest (NOSI): Using Targeted Degradation of Protein and non-Protein Targets for the Development of Novel Anti-Infectives R03, R01, R41/R42,
R43/R44, R21 Notice of Special Interest (NOSI): Promoting Research and Development of Vaccines Against Enteric Viruses R01, R43/R44, U44, R41/R42, R21 Notice of Special Interest (NOSI): Developmentally Tailored HIV Prevention and Care Research for Adolescents and Young Adults K43, R41/R42, R21, K08, R25, K99/R00, T32, K01, F30, R34, R03, F31, R15, R43/R44, K24, K23, F32, R01 Notice of Special Interest
(NOSI): Synthetic Biology for Biomedical Applications. NIBIB, NCCIH, NCI, NHLBI, NIA, NIAID, NICHD, NIGMS R01, R21, R35, R41/R42, R43/R44 Notice of Special Interest (NOSI): Development of Innovative Informatics and Data Science Technologies, Tools, and Methods for Vision Research Notice of Special Interest (NOSI): Promoting Language and Communication in Minimally Verbal/Non-Speaking Individuals with Autism R13, R15, R01, U01, R21, R43/R44, R41/R42,
R03 Notice of Special Interest (NOSI): Advancing Research Needed to Develop a Coccidioidomycosis (Valley fever) Vaccine R01, R41/R42, R43/R44, R21, U44 Notice of Special Interest (NOSI): Small Business Digital Technologies for Early Detection, Characterization and Monitoring of Senescence-Related Changes Notice of Special Interest (NOSI): Development of Functional Assay Sites to Evaluate Candidate -Omics Variants Associated with Heart, Lung, Blood, or
Sleep Disease (R01, R41, R42, R43, R44) Notice of Special Interest (NOSI): Optimization of Data Storage and Utilization for the Sequence Read Archive (SRA) R41/R42, R43/R44, R01, K08, RM1, R21, K25, K99/R00, K23, F30, F32, F33, F31, R16, R35, R15 Notice of Special Interest (NOSI): Advancing Research Needed to Develop a Coccidioidomycosis (Valley fever) Vaccine R21, R41/R42, R43/R44, R01 Notice
of Special Interest (NOSI): Advancing Research for Tickborne Diseases (TBDs) NIAID, NIAMS, NIMH, NINDS R43/R44, R15, R01, R21, R03, R41/R42 Notice of Special Interest (NOSI): Advancing Development of Rapid Point-of-Care Hepatitis C Virus Diagnostics R01, R41/R42, R43/R44, R21 Notice of Special Interest (NOSI): Utilization of Cohorts and Prospective Study Designs for Liquid Biopsy Assay Validation for Early Detection of Cancers
R43/R44, R21, R01, UH2/UH3, R41/R42, U01 Notice of Special Interest (NOSI): Towards Developing a Cure for HBV in HIV/HBV Co-Infection R01, R41/R42, R21, R43/R44 Notice of Special Interest (NOSI): Technological Innovations for Advancing Clinical SPECT Imaging R21, F30, K01, R13, K23, K25, R43/R44, K08, R01, K99/R00, R41/R42, F32, R03, F31 Notice of Special Interest (NOSI): Research Addressing Eye and Vision
Health Equity/Health Disparities R01, UG1, F31, R21, 333, K99/R00, K08, F30, K23, R43/R44, R34, R41/R42, F32 Notice of Special Interest (NOSI): Addressing Accessibility Inequities with COVID Home-Based Testing for Individuals with Visual Impairment R41/R42, R15, 333, R01, R43/R44, R21 Notice of Special Interest (NOSI): Validation of Digital Health and Artificial Intelligence Tools for Improved Assessment in Epidemiological, Clinical, and Intervention
Research NCI, NHLBI, NIA, NIDA, NIMH, NINR, OBSSR R01, R03, R21, R43/R44, R41/R42, R33, R34, R61/R33 Notice of Special Interest (NOSI): Advancing NEI AGI Research on newly Identified Factors Into Models of Visual System Regeneration R43/R44, R21, R15, R41/R42, R01, R24 Notice of Special Interest: Development and Implementation of Clinical Informatics Tools to Enhance Patients Use of Genomic Information R01,
R21, U24, R43/R44, R41/R42 Notice of Special Interest (NOSI): Advancing Innovative Non-invasive Physiologic Monitoring To Improve Fetal Assessment R03, R01, R41/R42, R43/R44, R21 Notice of Special Interest: Research on Pain, Pain Management, and Opioids in Aging F31, P01, K99/R00, K08, R01, K01, R43/R44, F32, 332, F33, F99/K00, R15, K24, R21, K02, K25, R25, F30, K23, R36, R41/R42, SB1, K76, K22,
K07, R13, R21/R33, U19 Notice of Special Interest (NOSI): Methods Development for Genomic Studies of Genetic Variation, Function, and Disease R41/R42, R01, R43/R44, R21 Notice of Special Interest (NOSI): Epidemiology and Prevention of Alcohol Misuse in Understudied Young Adult Populations; Military, Workforce, and Community College R21, R03, R01, R43/R44, R41/R42 Notice of Special Interest: SBIR Technology Transfer (R43/R44 Clinical Trial
Not Allowed) NINDS, NIDCR, NEI, NCI, NIA Notice of Special Interest (NOSI): Advancing Imaging, Device Production, and Clinical Capabilities in Digital Dentistry (R41/R42, R43/R44 Clinical Trial Not Allowed) Notice of Special Interest (NOSI): Genomics Education Interactive Digital Media Resources (SBIR/STTR) Notice of Special Interest (NOSI): National Cancer Institute SBIR/STTR Program Announcement Regarding Cancer Prevention, Diagnosis, and Treatment Technologies for Low-Resource
Settings Notice of Special Interest (NOSI): Navigating Pediatric to Adult Health Care: Lost in Transition NICHD, NIAAA, NCI, NIMH, NIAMS, OBSSR, NIBIB, NIDCR R01, R21, R43/R44, R41/R42 Notice of Special Interest (NOSI): HIV Drug Resistance Assays and Actionable Data Dissemination Strategies R01, R21, U01, U24, R41/R42, R43/R44 Notice of Special Interest: NIDCD Health Disparities and Inequities Research R01, R21, P50,
F30, F31, F32, F99/K00, K01, K08, K18, K23, K24, K25, K99/R00, 333, R41/R42, R43/R44 Notice of Special Interest (NOSI): Improving Patient Adherence to Treatment and Prevention Regimens to Promote Health OBSSR, NIMHD, NIDA, NIMH, ORWH, NIDCD, SGMRO, ODP, NIA, NHLBI, NCI, NINR, NCCIH, NEI, NICHD R01, R21, R03, R41/R42, R43/R44, R21/R33, UG3/UH3, R34 Notice of Special Interest (NOSI): Translation of
BRAIN Initiative Technologies to the Marketplace NIMH, NIA, NIAAA, NIBIB, NINDS, NIDA, NEI, NCCIH, NICHD, NIDCD Notice of Special Interest (NOSI): Hearing Healthcare for Adults: Improving Access and Affordability R01, R21, U01, R43/R44, R41/R42 Notice of Special Interest (NOSI): Understanding the effects of cancer and cancer treatment on aging trajectories and aging outcomes R21, R03, R01, U01, P01, K99/R00, K08,
R43/R44, R41/R42, R13, R21/R33, K01, K23 Notice of Special Interest (NOSI): Advancing Genomic Technology Development for Research and Clinical Application R01, R21, R43/R44, R41/R42 Notice of Special Interest: Kidney Precision Medicine Technology Development and Translation Notice of Special Interest (NOSI): Development and/or Validation of Devices or Electronic Systems to Monitor or Enhance Mind and Body Interventions (SBIR/STTR) Notice of Special
Interest (NOSI): Methods Development in Natural Products Research (SBIR/STTR) Notice of Special Interest (NOSI) of NIDCR in Supporting Dental, Oral, and Craniofacial Research Using Bioinformatic, Computational, and Data Science Approaches R01, R21, R03, R41/R42, F99/K00, F30, F31, F32, F33, K01, K08, K23, K25, K22, K99/R00, K43, K18, R15, R43/R44 Notice of Special Interest: NIGMS Priorities for Small Business Development of
Sepsis Diagnostics and Therapeutics For technical issues E-mail OER Webmaster
Based on current listing details, eligibility includes: U.S.-based small business concerns (SBCs) with fewer than 500 employees, at least 51% owned by U.S. citizens or permanent residents. Applicants should confirm final requirements in the official notice before submission.
Current published award information indicates Phase I: up to $314,363; Phase II: up to $2,095,748 Always verify allowable costs, matching requirements, and funding caps directly in the sponsor documentation.
The current target date is rolling deadlines or periodic funding windows. Build your timeline backwards from this date to cover registrations, approvals, attachments, and final submission checks.
Federal grant success rates typically range from 10-30%, varying by agency and program. Build a strong proposal with clear objectives, measurable outcomes, and a well-justified budget to improve your chances.
Requirements vary by sponsor, but typically include a project narrative, budget justification, organizational capability statement, and key personnel CVs. Check the official notice for the complete list of required attachments.
Yes — AI tools like Granted can help research funders, draft proposal sections, and check compliance. However, always review and customize AI-generated content to reflect your organization's unique strengths and the specific requirements of the solicitation.
Review timelines vary by funder. Federal agencies typically take 3-6 months from submission to award notification. Foundation grants may be faster, often 1-3 months. Check the program's timeline in the official solicitation for specific dates.
Many federal programs offer multi-year funding or allow competitive renewals. Check the official solicitation for continuation and renewal policies. Non-competing continuation applications are common for multi-year awards.
Past winners and funding trends for this program
PHS 2024-2 Omnibus Solicitation of the NIH and CDC for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Required) is sponsored by National Institutes of Health (NIH) and Centers for Disease Control and Prevention (CDC). This omnibus solicitation supports small businesses in developing promising technologies and products that align with the mission of NIH and CDC to improve health and save lives, specifically for applications that include clinical trials.
Small Business Innovation Research (SBIR) / Small Business Technology Transfer (STTR) is sponsored by National Institutes of Health (NIH) and Centers for Disease Control and Prevention (CDC). The NIH and CDC SBIR/STTR programs solicit proposals from small business concerns with R&D expertise to conduct innovative research contributing to NIH or CDC mission needs. These programs aim to stimulate technological innovation, strengthen the role of small business in meeting Federal R&D needs, encourage participation by socially and economically disadvantaged small businesses, and increase private sector commercialization of innovations.