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PROactive Solutions for Prolonging Resilience (PROSPR) Program is sponsored by Advanced Research Projects Agency for Health (ARPA-H), U.S. Department of Health and Human Services (HHS). This program focuses on developing tools and therapies aimed at extending 'healthspan,' or the number of years people live in good health, by detecting and intervening on the earliest changes associated with aging.
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Proactive Solutions for Prolonging Resilience What if we had therapies to extend healthspan and prevent the onset of age-related diseases? Despite recent increases in average lifespan across the U.S., there has not been a corresponding increase in healthspan – the amount of time a person remains in good health and free from long-term disease or disability.
Currently, 80% of all adults over the age of 65 have at least one chronic condition, and 30% of the same population are considered “pre-frail,” which is associated with a higher risk of mortality in the next five years. Americans with symptoms of aging such as fatigue, reduced cognitive ability, pain, reduced hearing and vision, and sleep disruption have very few treatment options.
With this aging demographic expected to only increase, health care costs will rise significantly. In response to these issues, the PROactive Solutions for Prolonging Resilience (PROSPR) program aims to identify biochemical and physiological markers and develop assessment tools that will allow researchers to better understand and target the underlying causes of age-related disease.
To achieve this goal, PROSPR will pioneer in-home data collection and clinical trial protocols that can assess age-associated health outcomes in just three years instead of decades of study, accelerating the availability of new therapies. If successful, PROSPR will build a new therapeutic industry with interventions focused on maintaining health during aging.
A revolutionary approach to extending the healthspan of people across the U.S. requires a comfort with calculated research that only a funding agency such as ARPA-H can provide. Research teams to add more healthy years to Americans’ lives as they age ARPA-H launches new program aimed at extending the healthspan of Americans
Based on current listing details, eligibility includes: Research teams (awarded through contracts, not grants) focusing on innovative approaches to extend healthspan. Performer teams are led by various institutions. Applicants should confirm final requirements in the official notice before submission.
Current published award information indicates Up to $144 million over five years (awarded as contracts, varying per awardee based on milestones). Always verify allowable costs, matching requirements, and funding caps directly in the sponsor documentation.
The current target date is rolling deadlines or periodic funding windows. Build your timeline backwards from this date to cover registrations, approvals, attachments, and final submission checks.
Federal grant success rates typically range from 10-30%, varying by agency and program. Build a strong proposal with clear objectives, measurable outcomes, and a well-justified budget to improve your chances.
Requirements vary by sponsor, but typically include a project narrative, budget justification, organizational capability statement, and key personnel CVs. Check the official notice for the complete list of required attachments.
Yes — AI tools like Granted can help research funders, draft proposal sections, and check compliance. However, always review and customize AI-generated content to reflect your organization's unique strengths and the specific requirements of the solicitation.
Review timelines vary by funder. Federal agencies typically take 3-6 months from submission to award notification. Foundation grants may be faster, often 1-3 months. Check the program's timeline in the official solicitation for specific dates.
Many federal programs offer multi-year funding or allow competitive renewals. Check the official solicitation for continuation and renewal policies. Non-competing continuation applications are common for multi-year awards.
STOMP: Systematic Targeting Of MicroPlastics is a research grant from the Advanced Research Projects Agency for Health (ARPA-H) at HHS that funds multidisciplinary teams to develop methods for detecting, characterizing, and removing microplastics from the human body. The two-phase program will first develop lab-based measurement tools and image microplastics in animal tissue to understand toxicity mechanisms, then translate those tools into clinical settings and develop removal solutions. STOMP prioritizes protecting vulnerable populations including pregnant women, children, patients with chronic disease, and workers with high occupational exposure. Eligible applicants include academic institutions, nonprofits, and for-profit organizations. Total program funding is $144,000,000. Deadline is May 6, 2026.
Agentic AI-Enabled Cardiovascular Care Transformation (ADVOCATE) program is sponsored by Advanced Research Projects Agency for Health (ARPA-H), U.S. Department of Health and Human Services (HHS). The ADVOCATE program aims to develop FDA-authorized, agentic AI technology to provide 24/7 specialty care for cardiovascular disease. This includes systems that connect to patient records, assist in scheduling, provide recommendations, and support diagnoses.
NCI Continuing Umbrella of Research Experiences (CURE) Academic Career Excellence (ACE) Award (K32) is a grant from the National Cancer Institute (NCI) that funds early postdoctoral fellows from diverse backgrounds, including underrepresented groups, to pursue research training in cancer-related fields. The K32 award supports fellows within 12 months prior to transitioning into, or within the first two years of, a postdoctoral position. The program, operated through NCI's Center to Reduce Cancer Health Disparities (CRCHD), aims to enhance the pool of qualified diverse cancer researchers. Beginning with the June 12, 2025 due date, the CURE ACE Award is available in both Independent Clinical Trial Required and Independent Clinical Trial Not Allowed versions. Eligible applicants must be U.S. citizens or permanent residents at time of award.
AAI Career Awards is a grant from the American Association of Immunologists (AAI) that honors members for outstanding research and career achievement. Through multiple award tracks — including the Lifetime Achievement Award, Distinguished Service Award, Distinguished Fellows program, Public Service Award, and Vanguard Award — AAI recognizes immunologists at every career stage who have made exceptional scientific, institutional, or public-policy contributions. Nominations originate from the AAI Council and designated committees. The program celebrates careers defined by scientific excellence, service to the immunology community, and contributions to public advocacy, minority recruitment in the sciences, and disease research. Deadline is September 10, 2025.