Research to Action: Assessing and Addressing Community Exposures to Environmental Contaminants (R01) is a grant from the National Institute of Environmental Health Sciences (NIEHS) and NIMHD that funds community-engaged research investigating environmental health risks.

Projects must combine community engagement, original research, and a public health action plan to reduce or eliminate harmful exposures such as heavy metals, PFAS, pesticides, or extreme heat. Required teams include health researchers and community-based organization partners working as co-investigators. Eligibility is open to U.S. universities, nonprofits, and research institutions with established community partnerships.

Awards provide up to $500,000 in direct costs per year over a five-year project period, with a deadline of June 5, 2026.

Expired PAR-22-210: Research to Action: Assessing and Addressing Community Exposures to Environmental Contaminants (R01 Clinical Trial Optional) This notice has expired. For NIH, in limited situations, applications may be accepted on a case-by-case basis for a short period after expiration to accommodate NIH late or continuous submission policies . Contact the eRA Service Desk for any submission issues.

Check the NIH Guide for active opportunities and notices. Department of Health and Human Services Part 1.

Overview Information Participating Organization(s) National Institutes of Health ( NIH ) Components of Participating Organizations National Institute of Environmental Health Sciences ( NIEHS ) National Institute on Minority Health and Health Disparities ( NIMHD ) Funding Opportunity Title Research to Action: Assessing and Addressing Community Exposures to Environmental Contaminants (R01 Clinical Trial Optional) R01 Research Project Grant > May 15, 2025 - Notice of Early Expiration of Notices of Funding Opportunities Related to the Simplified Review Framework for NIH Research Grant Applications.

See Notice NOT-OD-25-113 . May 9, 2025 - Notice to Applicants That the Simplified Review Framework Will be Applied to All Relevant Applications for August/October 2025 Councils. See Notice NOT-OD-25-116 .

April 04, 2024 - Overview of Grant Application and Review Changes for Due Dates on or after January 25, 2025.

See Notice NOT-OD-24-084 NOT-OD-23-012 Reminder: FORMS-H Grant Application Forms and Instructions Must be Used for Due Dates On or After January 25, 2023 - New Grant Application Instructions Now Available NOT-OD-22-190 - Adjustments to NIH and AHRQ Grant Application Due Dates Between September 22 and September 30, 2022 Funding Opportunity Announcement (FOA) Number Companion Funding Opportunity See Section III. 3.

Additional Information on Eligibility . Assistance Listing Number(s) Funding Opportunity Purpose This Funding Opportunity Announcement (FOA) encourages multidisciplinary projects to investigate the potential health risks of environmental exposures of concern to a community and to develop and implement an environmental public health action plan based on research findings.

Projects supported under this program will employ community-engaged research methods to conduct research and to translate research findings into public health action. This announcement reflects NIEHS and NIMHD's commitment to supporting biomedical research approaches, including community-engaged research, to understand and address environmental exposures that may lead to adverse health outcomes, and to promote health of all.

This FOA also advances efforts to nurture and sustain trust and bi-directional communication between academic researchers and affected communities. The Research to Action program is part of the National Institute of Environmental Health Sciences (NIEHS) Partnerships for Environmental Public Health (PEPH) network ( https://www. niehs.

nih. gov/research/supported/translational/peph/index. cfm ).

Open Date (Earliest Submission Date) Letter of Intent Due Date(s) The following table includes NIH standard due dates marked with an asterisk. Renewal / Resubmission / Revision (as allowed) All applications are due by 5:00 PM local time of applicant organization. Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.

New Date May 24, 2025 per NOT-OD-25-113 (Originally September 08, 2025) Required Application Instructions It is critical that applicants follow the instructions in the Research (R) Instructions in the SF424 (R&R) Application Guide , except where instructed to do otherwise (in this FOA or in a Notice from NIH Guide for Grants and Contracts ).

Conformance to all requirements (both in the Application Guide and the FOA) is required and strictly enforced. Applicants must read and follow all application instructions in the Application Guide as well as any program-specific instructions noted in Section IV . When the program-specific instructions deviate from those in the Application Guide, follow the program-specific instructions.

Applications that do not comply with these instructions may be delayed or not accepted for review. Part 1. Overview Information Part 2.

Full Text of Announcement Section I. Funding Opportunity Description Section II. Award Information Section III.

Eligibility Information Section IV. Application and Submission Information Section V. Application Review Information Section VI.

Award Administration Information Section VII. Agency Contacts Section VIII. Other Information Part 2.

Full Text of Announcement Section I. Funding Opportunity Description The National Institute of Environmental Health Sciences (NIEHS) has supported and advanced community-university programs and partnerships to better understand and address environmental health questions and concerns that community groups face from myriad factors.

Since 2009, the NIEHS has invited applications for the Research to Action program to support collaborative projects focused on community-identified environmental health issues. A description of currently funded grants under the Research to Action program can be found at: https://www. niehs.

nih. gov/research/supported/translational/rta/index. cfm .

This program is a key component of the Partnerships for Environmental Public Health (PEPH) network. The PEPH encompasses a variety of research, communication, and training/educational activities to identify, prevent, reduce, or eliminate environmental exposures that are associated with adverse health outcomes in affected communities.

Finally, Research to Action is building upon a long history of shared interests between the NIEHS and the National Institute on Minority Health and Health Disparities (NIMHD) to understand and reduce or eliminate environmental health disparities.

Protecting the public from environmental health risks requires the translation of hypothesis-driven, etiologic research characterizing environmental exposures and exposure-health relationships into action to prevent, reduce or eliminate exposure(s), and disease. To meet the needs of affected communities, authentic community participation in all aspects of the research process is essential.

Developing trusted community-university partnerships in environmental public health research helps ensure that: Communities identify and define problems and risks related to environmental exposures and stressors that are of greatest importance to them.

Communities receive the scientific and financial support necessary to conduct rigorous research in partnership with academic researchers that will accurately characterize the distributions and sources of environmental exposures and exposure-health relationships (if any) in their community and empower all involved to take action to reduce potential health risks.

Communities co-develop training/education, communication, remediation, prevention and interventions with academic researchers and other project partners to reduce or eliminate such exposures and to improve health outcomes.

Training/education, communication, remediation, prevention and interventions are implemented and provided in accessible formats and developed at a literacy level and in language(s) appropriate for members of that community. Community Engaged Research (CEnR) is a continuum that reflects the level of involvement of community members, or representatives of specific subpopulations, in the research process.

The continuum ranges from community consent and outreach to shared leadership of community members in the research design and implementation of the project. Community-based participatory research (CBPR) is one recognized approach in the CEnR spectrum.

For this FOA, we encourage CEnR approaches that include the full participation of community members in the identification of exposures of concern to that community, suitable cohorts and the specific needs of subpopulations; the co-development of the research questions and research design; the translation and dissemination of study results; the co-development and implementation of an environmental action plan; and the co-development of methods for evaluating the success of the project.

Recognizing that communities are not monolithic, CEnR approaches should entail the involvement of sufficient numbers of individuals and community-based organizations to adequately represent all segments of their community.

Involving larger numbers of community members can ensure that projects more effectively reflect the variety of community values, create an welcoming environment for all affected project partners, nurture collaboration, build community capacity to sustain interventions and implementation plans, and increase health and environmental health literacy among those involved.

CEnR approaches are critical when considering social determinants of health (SDOH), which are the conditions in the environments where people are born, live, learn, work, play, worship, and age that affect a wide range of health, functioning, and quality-of-life outcomes and risks.

These conditions such as housing, air, and water quality play important roles in the current and potentially future health of communities across the United States.

Active participation of community members in the formulation of environmental health research questions, and in the conduct and translation of research findings, can increase the use of and appreciation for local knowledge in research, help community members better understand the associated health risks, and empower residents to make informed decisions or to initiate local activities to prevent ongoing chronic and/or cumulative exposures that affect them.

For this FOA, community refers to populations and groups affected by, or with a shared interest in, environmental exposures and related health outcomes. Communities may also be defined by geography, exposure(s), age, occupation, religion, disability, illness, or other health condition. Furthermore, communities may include NIH defined populations that experience health disparities.

The term community-based organization (CBO) is broadly defined. The CBO may be a formally recognized organization, such as a non-profit organization that serves the needs of specific communities or populations facing environmental health disparities, and may also be an established community group or network with a common interest in a particular environmental health concern and that includes representatives of the community.

As noted above, the involvement of more than one CBO may be necessary to represent the interests and concerns of all members of the community. This FOA strengthens and advances NIEHS commitment to community-engaged research projects that respond to the identified needs of community groups and make research actionable. The FOA will also expand the scope and reach of projects supported through the Research to Action program ( https://www.

niehs. nih. gov/research/supported/translational/rta ).

The main objectives of this program remain the same as prior solicitations: 1) promote community engagement in environmental health research, 2) support multi-disciplinary research to collect and characterize information about environmental health concerns of significance to a community, and 3) stimulate research translation and dissemination to community members, public health professionals and/or policymakers to inform an action that will ultimately promote the reduction of exposure(s) and reduce the health impact from environmental stressors.

To meet these stated objectives, applicants must propose CEnR projects that incorporate all three elements: community engagement, research, and public health action. A fourth optional element is evaluation. These elements are discussed in detail below.

Given the advanced scope of the NIH R01 mechanism used for this FOA, it is anticipated the community-research partnerships will already be established and that applicants will be able to demonstrate evidence of successful past collaboration such as, but not limited to, preliminary data from previous research in the community. Element #1: Community-Engagement All projects must demonstrate an authentic community-university partnership.

Research teams must include: Health researcher(s) with a background in environmental health research. Community partner(s). This could include member(s) of affected communities and/or representatives of CBOs (as defined above).

Optional partners could include: Health care and public health professional(s). Housing, education, social service and/or state or local government officials Social science, implementation science and health/risk communication researcher(s). Decision maker(s) from a local or state public health departments and laboratories.

Regional or national organizations whose mission is to address environmental risks to health. The proposed projects should focus on environmental agents or diseases that have been identified by the community as potential or existing public health issues.

Furthermore, the proposed team should appropriately draw upon the unique strengths that each brings to the partnership and demonstrate shared contributions throughout the proposed project period.

Shared responsibilities of the team include, but are not limited to, (a) determining what information and research questions the proposed study can and cannot provide and address, (b) identifying the most appropriate research design, methodology, and budgetary needs, (c) helping communicate study findings to community members in appropriate and accessible formats, and (d) ensuring research findings are translated effectively into public health action.

Community partners serving as co-investigators is strongly encouraged. The use of the multiple PD/PIs leadership plan is strongly encouraged, when feasible and appropriate. The objective of this element is to support research that will 1) increase knowledge of how environmental exposures impact health and disease in communities and 2) directly inform a public health implementation action plan (see Element #3).

Proposed studies must be motivated by the expressed concerns of a community (see Element #1). Research may include: Discovery/exploratory-based studies intended to fill research gaps by characterizing sources of exposures, measure exposure levels, or the prevalence of exposure-related health conditions among members of the community and the community itself.

Hypothesis-driven studies designed to improve understanding of the exposure-health outcome relationship.

For this FOA, environmental exposure is broadly defined and can include a variety of environmental/occupational contaminants such as heavy metals, pesticides, chemicals, extreme heat and other extreme weather conditions, etc. Exposures to infectious diseases, poorly built or maintained housing, or the neighborhood/social environmental conditions (for example poverty, food deserts, density, noise and/or violence) without an environmental co-exposure are outside the scope of this FOA.

Projects should focus on environmental exposures that meet all the following criteria: The exposure(s) is considered a significant environmental health issue of concern to the community. The exposure(s) is suspected to be associated with a health effect that has a large public health burden and/or is an emerging or re-emerging/legacy environmental agent(s) with potential widespread exposure.

The researcher and community are lacking information needed to support the proposed public health action, such as data on exposure levels, sources, or potential health effects. Specific examples of research topics that are of interest for this FOA include, but are not limited to: Cumulative health impacts of exposure to multiple environmental/occupational stressors on health risks.

Examples include, but are not limited to, examination of long-term health effects from exposure to multiple endocrine disruptors; the combined effect/interaction between physical, social, and neighborhood-level environmental stressors; diet, and environmental/occupational exposures on health. Burden on human health from land use and planning decisions.

For example, understanding health impacts from siting a new school, housing development, or community center near a known location of a toxic waste site, nuclear facility, chemical plant, or energy resource extraction site (such as oil drilling, hydraulic fracturing, mining, etc).

Exposure to mixtures of toxic substances and associated health impacts among populations that may experience higher exposure or particular sensitivity to exposure (for example emergency response personnel exposed to disaster recovery or mitigation sites). Health impacts from weather and natural disasters.

Research in partnership with communities or populations most at risk of the impacts of extreme weather (for example coastal or flood prone communities, tribal communities, the elderly, and children). Disproportionate impact of emerging and ongoing exposures affecting the health of a community and its residents.

Exposures can include, for example, chemicals in personal care products, microplastics, PFAS/PFOAs, and legacy exposures such as lead or other heavy metals. While it is anticipated that research will entail primary data collection, projects could build upon previous research conducted with the community and existing findings.

Proposals may also take advantage of existing data sources assuming such resources can adequately address the research question(s) and produce new information needed for a public health action plan.

Projects that propose to include methodologies for integrating local knowledge about the environment or locally gathered data (such as Tribal Ecological Knowledge approaches and/or citizen science efforts) along with traditional research approaches, are encouraged.

Projects evaluating the intersection of SDOH with environmental exposures are strongly encouraged to utilize the Social Determinants of Health Collection of the PhenX Toolkit (www. phenxtoolkit. org).

Element #3: Public Health Action The environmental public health action element incorporates knowledge gained through the research element of the project. This evidence-based plan should be designed to support change that improves the health of a community through a reduction of exposure levels and ultimately leading to improved quality of life.

Ideally, this environmental public health action plan should be multi-level, creating lasting public health impact from the individual to the population level. The National Institute on Minority Health and Health Disparities (NIMHD) Research Framework is one example of a multi-level framework ( https://www. nimhd.

nih. gov/about/overview/research-framework/ ) that could guide a public health action plan. Applicants applying to this FOA may also wish to consider the incorporation of implementation science theories, models, frameworks, and outcomes.

Applicants can refer to the NIEHS Implementation Science in Environmental Health website for resources ( https://www. niehs. nih.

gov/research/supported/translational/implementation/index. cfm ). Community members should be co-developers of this public health action plan.

For the purposes of this FOA, examples of environmental public health action include, but are not limited to: Campaigns to change individuals behaviors that will lead to exposure reduction. Educational programs for community health care providers about the health risks associated with a prevalent environmental exposure in their community.

Communication training for researchers to engage with and disseminate research findings to community partners more effectively. Local, regional, or national strategies to raise policymaker awareness of the link between environmental/occupational exposures and adverse health outcomes. Evidence-based communications about recognizing, mitigating or preventing local environmental risks.

Community programs that focus on health promotion and disease prevention related to health risks in environmental exposures. Community programs that enhance the quality of life in individuals with chronic disease related to environmental exposures.

Community-based tailored communication and outreach programs to educate community members about potential sources of exposure, the potential associated health risks, and how they might reduce their exposure. Exposure reduction or prevention strategies.

Risk communication strategies that use informational materials to educate policymakers about potential sources of exposure and the associated potential health risks and economic burden resulting from such exposures.

Community-based training to increase environmental health literacy, and/or health promotion Focused community-based training for local policymakers, disaster and emergency response personnel, or for specific segments of the affected community (such as local K-12 educators, community health workers/promotores de salud, faith-based leaders, etc.).

Medical and continuing medical education training modules in conjunction with local providers to improve awareness and environmental health literacy among health care and public health professionals on the role of the environmental exposure in disease etiology or exacerbation.

Education modules may be developed or adapted to address the specific educational needs of nurses, occupational therapists, lay community health workers, and other health care specialties. Element #4: Evaluation (optional) Evaluations help community-university partners assess the effectiveness and impact of their projects as well as factors that led to program success (or failure).

In addition, evaluations can supply ongoing, systematic information that strengthens projects during their life cycle. Evaluations should be designed to reflect program goals, milestones, and objectives. The NIEHS PEPH program has developed an Evaluation Metrics Manual to serve as a resource for applicants in developing and implementing an evaluation plan for environmental public health research projects.

The complete Evaluation Metrics Manual can be accessed electronically at: http://www. niehs. nih.

gov/pephmetrics . Key areas addressed in the Manual include community-university partnerships, the translation and dissemination of messages based on research findings, education and training, and capacity building. Applicants are encouraged to review the Evaluation Metrics Manual for guidance on development of an evaluation plan or to include evaluation scientific expertise on the study team.

Examples of potential measures for evaluating the project's success (activities and outputs) may include: Number, type, and/or location of interactions among various partners in the project. Number, cost, content, and/or level of community involvement in development and dissemination of education and training information.

Number of people (community members, researchers, and health care providers) trained to use a specific approach or tool). Number and/or type of additional support/resources CBOs and Communities are able to garner after completion of training activities.

Proportion of participants reporting attitudinal changes based on the usefulness of materials developed, increases in awareness, knowledge and behavior related to environmental exposure examined by the project. Proportion of participants reporting lower exposure to hazardous contaminant targeted by the program. The number of local or regional policies or public health practices that were informed by the project’s efforts.

Applicants are encouraged to include social scientists in the development of these quantitative and qualitative tools to assess progress and programmatic achievements. Applicants are encouraged to implement evaluation during any and all phases of the study. The development and use of a project logic model(s) are also encouraged for evaluation planning (see the Evaluation Metrics Manual, Chapter 7 at https://www.

niehs. nih. gov/research/supported/assets/docs/j_q/peph_evaluation_metrics_manual_chapter_7_508.

pdf for more information on logic models). In addition, the PEPH Evaluation Metrics Manual, applicants may wish to use the Environmental Health Translational Research Framework to describe how their research will address research gaps and inform practice. The Translational Research Framework and supporting resources can be found online.

( https://www. niehs. nih.

gov/research/programs/translational/framework-details/index. cfm ) Since this FOA requires demonstrated community-university partnerships, proposals solely focused on capacity building activities to establish a new community-university partnership, or to develop training and educational programs, will not be considered responsive to this FOA.

However, educational and training activities that complement the engagement, research, and public health action efforts, as well as help to sustain the project beyond the funding period, would be responsive. Capacity building activities could include: Bi-directional training component to enhance established partnerships between academic institutions and community-based organizations.

Implementation of training component to improve institutional capacity of CBOs to apply for and manage NIH grants and sustain interventions to address placed-based environmental health concerns. Implementation of activities or programs to strengthen the ability of community members or CBOs to conduct and sustain citizen science to help improve environmental health in their own communities.

Partnerships for Environmental Public Health As noted, the Research to Action program is a critical part of the PEPH Network. Therefore, participation in PEPH events is encouraged. PEPH meetings involve grantees from many NIEHS programs, including Research to Action, and allow opportunities for networking, interaction, and collaboration across programs.

In addition, Research to Action projects are expected to add materials and tools to the PEPH Resource Center, which is a central repository of materials and resources developed by grantees within the PEPH Network. The mission of the NIMHD is to lead scientific research to improve minority health and reduce health disparities. NIMHD-designated populations with health disparities can be found here https://www.

nimhd. nih. gov/resources/understanding-health-disparities/minority-health-and-health-disparities-definitions.

html. NIMHD encourages holistic research projects that considers contextual factors to understand and address health disparities (see the NIMHD Research Framework, https://www. nimhd.

nih. gov/about/overview/research-framework. html ).

Studies using animal models or exclusively basic science, or studies based outside the U.S. or its territories will not be supported by NIMHD under this FOA. Applications are required to involve a formal collaboration with a CBO serving one or more populations that experiences health disparities.

Potential research topics include, but are not limited to the following among populations that experience health disparities: Integrated interventions to prevent or reduce the impact of environmental exposures Studies to address food deserts and barriers associated with food insecurity Examine the combined effects or interactions of environmental exposures and barriers Applications Not Responsive to the FOA: Proposals focused solely on capacity building to establish new partnerships.

Proposals that do not address all three of the required elements of the Research to Action FOA. Proposals with research focused on exposures to infectious diseases, poorly built or maintained housing, or the neighborhood/social environmental conditions (for example poverty, food deserts, density, noise and/or violence) without an environmental co-exposure. Non-responsive applications will be withdrawn without review.

All interested applicants are strongly encouraged to consult with the NIEHS Scientific/Research contacts for this FOA prior to submitting a proposal. See Section VIII. Other Information for award authorities and regulations.

Investigators proposing NIH-defined clinical trials may refer to the Research Methods Resources website for information about developing statistical methods and study designs. Section II. Award Information Grant: A support mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity.

Application Types Allowed The OER Glossary and the SF424 (R&R) Application Guide provide details on these application types. Only those application types listed here are allowed for this FOA. Optional: Accepting applications that either propose or do not propose clinical trial(s).

Need help determining whether you are doing a clinical trial? Funds Available and Anticipated Number of Awards The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications. Application budgets are limited to $500K Direct Cost.

The maximum project period is 5 years. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this FOA. Section III.

Eligibility Information Higher Education Institutions Public/State Controlled Institutions of Higher Education Private Institutions of Higher Education Nonprofits Other Than Institutions of Higher Education Nonprofits with 501(c)(3) IRS Status (Other than Institutions of Higher Education) Nonprofits without 501(c)(3) IRS Status (Other than Institutions of Higher Education) For-Profit Organizations (Other than Small Businesses) City or Township Governments Special District Governments Indian/Native American Tribal Governments (Federally Recognized) Indian/Native American Tribal Governments (Other than Federally Recognized) Eligible Agencies of the Federal Government U.S. Territory or Possession Independent School Districts Public Housing Authorities/Indian Housing Authorities Native American Tribal Organizations (other than Federally recognized tribal governments) Faith-based or Community-based Organizations Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply.

Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement , are not allowed. Applicant organizations must complete and maintain the following registrations as described in the SF 424 (R&R) Application Guide to be eligible to apply for or receive an award.

All registrations must be completed prior to the application being submitted. Registration can take 6 weeks or more, so applicants should begin the registration process as soon as possible. The NIH Policy on Late Submission of Grant Applications states that failure to complete registrations in advance of a due date is not a valid reason for a late submission.

System for Award Management (SAM) Applicants must complete and maintain an active registration, which requires renewal at least annually . The renewal process may require as much time as the initial registration. SAM registration includes the assignment of a Commercial and Government Entity (CAGE) Code for domestic organizations which have not already been assigned a CAGE Code.

NATO Commercial and Government Entity (NCAGE) Code Foreign organizations must obtain an NCAGE code (in lieu of a CAGE code) in order to register in SAM. Unique Entity Identifier (UEI)- A UEI is issued as part of the SAM. gov registration process.

The same UEI must be used for all registrations, as well as on the grant application. eRA Commons - Once the unique organization identifier is established, organizations can register with eRA Commons in tandem with completing their full SAM and Grants. gov registrations; all registrations must be in place by time of submission.

eRA Commons requires organizations to identify at least one Signing Official (SO) and at least one Program Director/Principal Investigator (PD/PI) account in order to submit an application. Grants. gov Applicants must have an active SAM registration in order to complete the Grants.

gov registration. Program Directors/Principal Investigators (PD(s)/PI(s)) All PD(s)/PI(s) must have an eRA Commons account. PD(s)/PI(s) should work with their organizational officials to either create a new account or to affiliate their existing account with the applicant organization in eRA Commons.

If the PD/PI is also the organizational Signing Official, they must have two distinct eRA Commons accounts, one for each role. Obtaining an eRA Commons account can take up to 2 weeks.

Eligible Individuals (Program Director/Principal Investigator) Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with his/her organization to develop an application for support.

For institutions/organizations proposing multiple PDs/PIs, visit the Multiple Program Director/Principal Investigator Policy and submission details in the Senior/Key Person Profile (Expanded) Component of the SF424 (R&R) Application Guide. This FOA does not require cost sharing as defined in the NIH Grants Policy Statement. 3.

Additional Information on Eligibility Applicant organizations may submit more than one application, provided that each application is scientifically distinct. The NIH will not accept duplicate or highly overlapping applications under review at the same time, per 2. 3.

7. 4 Submission of Resubmission Application . This means that the NIH will not accept: A new (A0) application that is submitted before issuance of the summary statement from the review of an overlapping new (A0) or resubmission (A1) application.

A resubmission (A1) application that is submitted before issuance of the summary statement from the review of the previous new (A0) application. An application that has substantial overlap with another application pending appeal of initial peer review (see 2. 3.

9. 4 Similar, Essentially Identical, or Identical Applications ) Section IV. Application and Submission Information 1.

Requesting an Application Package The application forms package specific to this opportunity must be accessed through ASSIST, Grants. gov Workspace or an institutional system-to-system solution. Links to apply using ASSIST or Grants.

gov Workspace are available in Part 1 of this FOA. See your administrative office for instructions if you plan to use an institutional system-to-system solution. 2.

Content and Form of Application Submission It is critical that applicants follow the instructions in the Research (R) Instructions in the SF424 (R&R) Application Guide except where instructed in this funding opportunity announcement to do otherwise. Conformance to the requirements in the Application Guide is required and strictly enforced.

Applications that are out of compliance with these instructions may be delayed or not accepted for review. All page limitations described in the SF424 Application Guide and the Table of Page Limits must be followed.

Instructions for Application Submission Note: Effective for due dates on or after January 25, 2023, the Data Management and Sharing (DMS) Plan will be attached in the Other Plan(s) attachment in FORMS-H and subsequent application forms packages.

For due dates on or before January 24, 2023, the Data Sharing Plan and Genomic Data Sharing Plan GDS) will continue to be attached in the Resource Sharing Plan attachment in FORMS-G application forms packages. The following section supplements the instructions found in the SF424 (R&R) Application Guide and should be used for preparing an application to this FOA. All instructions in the SF424 (R&R) Application Guide must be followed.

SF424(R&R) Project/Performance Site Locations All instructions in the SF424 (R&R) Application Guide must be followed. SF424(R&R) Other Project Information All instructions in the SF424 (R&R) Application Guide must be followed. SF424(R&R) Senior/Key Person Profile All instructions in the SF424 (R&R) Application Guide must be followed.

All instructions in the SF424 (R&R) Application Guide must be followed. All instructions in the SF424 (R&R) Application Guide must be followed. PHS 398 Cover Page Supplement All instructions in the SF424 (R&R) Application Guide must be followed.

Note: Effective for due dates on