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SBIR/STTR topics (Biological Technologies) is sponsored by Defense Advanced Research Projects Agency (DARPA). DARPA publishes multiple topic opportunities under the federal Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs.
One specific topic, DPA26BZ03-DV014, seeks to develop a capability to rapidly characterize host-pathogen interactions from pathogen protein sequence alone, enabling timely medical countermeasure prioritization and force health protection against novel or emerging biological threats.
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Department of War organization. As of April 13, 2026, the SBIR & STTR programs have been reauthorized. See the topic listings below for more information.
Active announcement topics Each year, we publish multiple topic opportunities under the federal Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs. All SBIR/STTR topics fall under the current Department of War (DoW) Broad Agency Announcement (BAA) for that program.
Smart Whole Blood Field Transfusion system (SWiFT) Objective: Develop and demonstrate a self-contained, autonomous device capable of blood collection, temporary storage (<4hr), diagnostic testing, and transfusion, with continuous donor/recipient monitoring and alerts to issues, revolutionize safe, efficient and effective blood collection and transfusion in both military and civilian settings.
Tech office: Biological Technologies Pre-release: April 13, 2026 Extremity Platform for On-demand Surgical Implantation and Tissue Integration with Osteochondral Neogenesis Objective: Develop an on-demand regenerative medicine platform for complete finger restoration following trauma, enabling full functional recovery and eliminating the need for traditional finger and joint repair surgeries.
Tech office: Biological Technologies Pre-release: April 13, 2026 Broadening Availability of Regimens for K-9s (BARK) - Open Topic Objective: Develop medical products that are interoperable and compatible across humans and dogs to meet the health needs of both human warfighters and military working dogs.
Tech office: Biological Technologies Pre-release: April 13, 2026 Photonic-electronic Panels Integration (PEPI) Objective: Develop and demonstrate a prototype for photonic-electronic panel technology for the integration of photonic chips (PICs) that contain high-density three-dimensional chip-to-chip and intra-chip optical routing technology developed by the DARPA Heterogeneous Adaptively Produced Photonic Interfaces (HAPPI) program.
Tech office: Microsystems Technology Pre-release: April 13, 2026 Spreaders for Microsystems with Advanced Thermal Resilience (SMART) Objective: To develop passive thermal management technologies for extreme environment and high-power density systems, resulting in a conformal thin-film heat spreader technology with significant improvements compared to conventional copper heat spreaders.
Tech office: Microsystems Technology Nanopore Bioelectronics for Next Generation Proteomics Objective: To develop a next-generation single-molecule sensing and sequencing platform that delivers robust, high-accuracy, high-throughput, and scalable reading of biomolecules.
Tech office: Microsystems Technology Compact Wideband Tunable Filters Objective: Develop and demonstrate wideband, power-efficient and tunable radio frequency (RF) filter technologies that significantly improve spectrum access and signal integrity for Department of War (DoW) communications and electronic warfare (EW) systems Tech office: Microsystems Technology Temperature-Hardened Electronics for Reliable Mission-Critical Applications (THERMAL) Objective: To develop a manufacturable mixed-signal integrated circuit (IC) technology capable of reliable operation in harsh environments, specifically high-temperature conditions up to 800°C.
Tech office: Microsystems Technology Automated Process for Codesign of Radiation Hardening and Security Objective: To develop next generation microelectronics design and integration approaches that simultaneously result in resilience to ionizing radiation and enhanced security. Tech office: Microsystems Technology Objective: This effort will develop commercially viable re-use of existing DoW assets in lieu of new hardware investments.
Tech office: Microsystems Technology Medical Swarm Robotics for Extraction and Life-Saving Interventions Objective: Develop and demonstrate small-robotic swarms capable of autonomous battlefield medical assistance, including short casualty movement, hemorrhage control, fracture stabilization, and medication delivery.
Tech office: Biological Technologies Pre-release: April 13, 2026 Assessing Security of Encrypted Messaging Applications (ASEMA) Objective: Seeking novel approaches to defend SMAs by modeling their security risks and recommending defensive measures to protect these critical platforms. Tech office: Information Innovation Topic #: HR0011SB20254-12 Pre-release: Sept.
3, 2025 Pulsed High-power Laser Accelerators to Study radiation Hardening (PHLASH) Objective: Demonstrate a prototype scalable laser driver for electron beam generation and design a 100-GeV system to fit within a 250 m3 footprint. Tech office: Microsystems Technology Topic #: HR0011SB20254-13 Pre-release: Sept.
3, 2025 Unbiased Behavioral Discovery Platforms Objective: Develop unguided behavioral discovery technologies to accelerate detection and medical countermeasure development against current and future threats. Tech office: Biological Technologies Topic #: HR0011SB20254-15 Pre-release: Sept.
3, 2025 ALIAS Missionized Autonomy for Emergency Services - SBIR XL Objective: Focuses on development and demonstration of missionized autonomy for emergency services, initially focusing on autonomous wildfire response using autonomous Manned-Unmanned Teaming (MUM-T) and integrated sensing technologies. Tech office: Tactical Technology Topic #: HR0011SB20254XL-01 Pre-release: Sept.
3, 2025 Closed announcement topics Objective : Develop field-portable, low size, weight, and power (SWaP) technology for non-destructive viral identification.
Tech office: Biological Technologies Topic #: HR0011SB20254-01 Language Models for Veteran Suicide Prevention (LM4VSP) Objective: Develop a conversational artificial intelligence (AI) clinical co-pilot, based on Language Models, to augment the ability of mental health care professionals to care for and interact with patients at risk of suicide.
Tech office: Information Innovation Topic #: HR0011SB20254-02 Multi-factor Continuous Authentication for Wearable Defense Equipment (MCAWDE) Objective: Develop and demonstrate novel, continuous, multi-factor authentication solutions for small weight and power devices.
Tech office: Information Innovation Topic #: HR0011SB20254-03 Turbo Facility Clearance (TurboFCL) Description: Develop a prototype software application, based on language models, to learn the Defense Counterintelligence and Security Agency (DCSA) facility and personnel clearance process.
Tech office: Strategic Technology Office Topic #: HR0011SB20254-04 On-Chip Wavelength Generation for DWDM Photonic Transceivers Objective: Develop and demonstrate prototype integrated photonic Dense Wavelength Division Multiplexing (DWDM) transceivers with on-chip wavelength generation.
Tech office: Microsystems Technology Topic #: HR0011SB20254-05 Cooperative Heuristics for Additive Manufacturing Processing (CHAMP) Objective : Develop field-portable, low size, weight, and power (SWaP) technology for non-destructive viral identification.
Tech office: Strategic Technology Topic #: HR0011SB20254-06 Improving Battle Planning through AI Objective : Develop innovative technologies for federated course of action (COA) planning and accelerated COA adjudication using customized reduced order models (ROMs). Tech office: Strategic Technology Topic #: HR0011SB20254-07 Inertially Scaled Aircraft (ISaAc) Objective : Develop and flight test a small (55 to 300 lbs.)
unmanned air vehicle (UAV) that is inertially scaled to a tactically relevant target aircraft. Tech office: Tactical Technology Topic #: HR0011SB20254-08 Turbulent Boundary Layer Drag Reduction via Surface Actuators Objective : Develop and flight test turbulent boundary layer drag reduction using surface actuators.
Tech office: Tactical Technology Topic #: HR0011SB20254-09 Predictive Psychological Architectures for Decision-Making (PPADM) Objective : This effort aims to understand the association between decision-maker characteristics and behavior to improve human and algorithmic decision-making, delegation, and trust.
Tech office: Information Innovation Topic #: HR0011SB20254-10 High Power Fiber Amplifier (HPFA) Power Scaling Objective: Develop and demonstrate novel concepts for scaling individual high power fiber amplifiers (HPFAs) to power levels >10 kW with good beam quality. Tech office: Strategic Technology Topic #: HR0011SB20254-11 Topic & Proposal Resources DARPA SBIR & STTR 2026 BAA: FAQ DARPA SBIR 25. 4 & STTR 25.
D BAA: FAQ DoW SBIR/STTR Interactive Participation Guide Phase I Template – Volume 2: Technical Volume Phase I Template – Volume 3: Cost Proposal Phase II Proposal Instructions Phase II Template – Volume 3: Cost Proposal Direct to Phase II Template – Volume 2: Feasibility Documentation and Technical Proposal Direct to Phase II Template – Volume 3: Cost Proposal HR0011SB20254-10 Direct to Phase II Cost Proposal HR0011SB20254-10 Other Transactions for Prototypes Agreement Template HR0011SB20254-14 Cost Proposal Template HR0011SB20254XL-01 Cost Proposal Template Other Transaction (OT) Certifications Enhancement Program Instructions Technical Summary Quad Chart Template Monthly Progress Report Template Monthly Financial Report Template Transition & commercialization support RSS feed for Opportunities
According to the current listing, eligibility includes: Small businesses (fewer than 500 employees) located in the United States, with at least 50% equity owned by U.S. citizens or permanent residents. Confirm the full requirements in the official notice before applying.
Applications for SBIR/STTR topics (Biological Technologies) are due July 22, 2026. Build your timeline backwards from this date to cover registrations, approvals, and final submission checks.
SBIR/STTR topics (Biological Technologies) is funded by Defense Advanced Research Projects Agency (DARPA). Verify program details on the funder's official page before applying.
Yes — this listing is flagged as national in scope, so applicants across the U.S. may apply, subject to the sponsor's other eligibility criteria.
Applications go through the funder's official portal — the Apply Now link on this page goes there directly.
Past winners and funding trends for this program
The OCRP Outcomes Consortium Development Award supports a multi-institutional research effort conducted by leading ovarian cancer researchers and consumer advocates that specifically focuses on identifying and understanding predictors of disease outcomes in ovarian cancer patients. This effort will be executed through a two-stage approach using two separate award mechanisms: this FY12 Outcomes Consortium Development Award, which will enable the consortium to lay the groundwork for the research project, including proof of concept, and the FY14 Outcomes Consortium Award, which will support the execution of the full research project. Funding Opportunity Number: W81XWH-12-OCRP-OCDA. Assistance Listing: 12.420. Funding Instrument: CA,G. Category: ST. Award Amount: $1.3M total program funding.
Small Business Innovation Research (SBIR) Program 25.1 Solicitation is sponsored by Department of Homeland Security (DHS) Science and Technology Directorate (S&T). The DHS SBIR Program invites U.S. small businesses to submit research proposals addressing technology needs in fentanyl source profiling, data analysis tools, digital injection attack prevention, and wired interconnection cables or adapters.
Operation Stonegarden (OPSG) is a federal grant program administered by FEMA through the Office of the Governor's Public Safety Office that funds enhanced border security cooperation among Customs and Border Protection (CBP), U.S. Border Patrol, and state, local, tribal, and territorial law enforcement agencies. The program supports joint operations to secure land and water border routes, improve intelligence sharing, and expand 287(g) screening operations within correctional facilities. In 2025, the national priority is Supporting Border Crisis Response and Enforcement, covering training, operational coordination, and risk management. Eligible expenses include operational overtime costs, staffing support for screening activities, and training programs in immigration law, civil rights protections, and 287(g) procedures.
DARPA and NSF launched a joint program on June 1 to fund university work on AI interpretability, control, and adversarial robustness. Awards run $750K to $3M+ per project, the forum launches this summer, and the universities listed in the AI Forge repository will sit closest to the money. The Request for Information closes June 22.
Read articleDARPA MTO opened six FY26 SBIR topics on May 27 with a June 24 deadline — nanopore proteomics, compact RF filters, 800°C ICs, passive thermal spreaders, radiation-hardened codesign, and low-resource computing. The topics read like a wishlist for the next decade of contested-environment microelectronics. Here is what each one is actually asking for, and how small businesses should triage the four-week window.
Read articleOn June 3, 2026 DARPA's Defense Sciences Office and Biological Technologies Office pre-released five FY26 SBIR/STTR topics — MANTRAS, Engineering Sleep for Cognitive Performance, ExCAIPE, Real-Time Pathogen-Host Interactome Prediction, and Biomanufacturing of Hierarchical Biocomposites — that open June 24 and close July 22 at noon Eastern. Here is what the five-topic drop signals about DARPA's continuous-release cadence and how small teams should plan.
Read article