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Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) Programs (NIH Omnibus Solicitation) is sponsored by National Institutes of Health (NIH). The NIH SBIR and STTR programs provide non-dilutive funding for small businesses to engage in research and development with the potential for commercialization, aligning with NIH's mission to improve health.
The NIH has committed to increasing investments in small business innovations focused on women's health research through these programs. The Office of Research on Women's Health (ORWH) encourages applications with a central focus on women's health, including those that address sex-linked biology, gender-related factors, or utilize advanced computational tools and AI/ML methods for women's health research.
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U.S. Department of Health and Human Services National Institutes of Health NIH has no active Small Business Innovation Research (SBIR) or Small Business Technology Transfer (STTR) Notices of Funding Opportunity (NOFOs); therefore, there is no April 5, 2026 receipt date (see NOT-OD-26-006 ). Any future NOFOs will be forecasted at Grants. gov prior to opening for applications.
Learn if your company is eligible for NIH SBIR or STTR funding, how to apply , and what to expect during each step of the application process. Multiple registrations are required to prepare your application and apply for funding.
Small Business Program Basics Understanding SBIR and STTR Foreign Disclosure and Risk Management SBIR and STTR Grants (NOFO s ) SBIR Contract Solicitations Commercialization Readiness Pilot (CRP) Small Business Transition Grant for New Entrepreneurs Navigate NIH's Research Areas Applicant Assistance Programs --> Transition Award (Coming Soon) Our team can help you maximize the benefits from NIH programs and resources which help you bring your innovations to life.
NIH's Technical and Business Assistance (TABA) Partnering & Investment Opportunities Concept to Clinic Commercializing Innovation (C3i) The NIH is actively turning discovery into health by helping small businesses develop innovative technologies that improve health and save lives. See how .
Small Business Portfolio Overview Active Small Business Awards Research Evaluation and Commercialization Hubs (REACH) Search Technologies from Academic Centers and Hubs Our team can help you maximize the benefits from NIH programs and resources which help you bring your innovations to life. We value biomedical innovation and strive to empower scientists and entrepreneurs to bring their discoveries to patients.
HHS Small Business Program Managers Non-dilutive funding for early-stage research and development. [ Omnibus Solicitations ] [ Specific Opportunities ] More information on HHS SBIR contracts is available on the NIH SBIR contracts webpage . NIH has committed $20 million to support academic product development and innovation.
Learn more about the five new Research Evaluation and Commercialization Hubs (REACH) in the funding opportunity announcement (RFA-OD-23-005) Read Program Descriptions and Research Topics . Refer to SBA-approved waiver eligible topics . Watch this NIH SBIR/STTR webinar from June 2025 .
Omnibus Solicitations (Parent Announcements) Read the Program Descriptions and Research Topics to understand the awarding components, their topics of interest, and staff contacts. For topics that require additional funding to reach the marketplace, please refer to our list of SBA-approved waiver-eligible topics . Standard Application Due Dates are September 5, January 5, and April 5.
Due dates that fall on weekends or Federal holidays are moved to the next business day. No SBIR/STTR Omnibus Solicitations (Parent Announcements) found. Some SBIR/STTR grant solicitations are focused on specific research areas.
Some specific NOFOs, identified as RFAs (Requests for Applications) or PASs (Program Announcements with Set-aside funds), have funding set-aside in the Institute/Center's budget for that targeted program. No SBIR/STTR Omnibus Solicitations (Parent Announcements) found. National Institutes of Health Product Development Support Looking for the NIH SBIR & STTR site?
The new seed. nih. gov has everything you’re looking for about the NIH small business research and development programs (SBIR & STTR) .
In addition, you can learn about other types of product development and commercialization support for NIH award recipients . Questions? Check out About the NIH SEED Office or email us at [email protected] .
Based on current listing details, eligibility includes: U.S.-based small business concerns (SBCs). Must meet SBA size standards. Specific eligibility for clinical trials and other aspects can be found in the detailed solicitations (PA-24-245, PA-24-246, PA-24-247, PA-24-248). Applicants should confirm final requirements in the official notice before submission.
Current published award information indicates Phase I: up to $314,363 (typically 6-12 months); Phase II: up to $2,095,748 (up to 2 years) Always verify allowable costs, matching requirements, and funding caps directly in the sponsor documentation.
The current target date is rolling deadlines or periodic funding windows. Build your timeline backwards from this date to cover registrations, approvals, attachments, and final submission checks.
Federal grant success rates typically range from 10-30%, varying by agency and program. Build a strong proposal with clear objectives, measurable outcomes, and a well-justified budget to improve your chances.
Requirements vary by sponsor, but typically include a project narrative, budget justification, organizational capability statement, and key personnel CVs. Check the official notice for the complete list of required attachments.
Yes — AI tools like Granted can help research funders, draft proposal sections, and check compliance. However, always review and customize AI-generated content to reflect your organization's unique strengths and the specific requirements of the solicitation.
Review timelines vary by funder. Federal agencies typically take 3-6 months from submission to award notification. Foundation grants may be faster, often 1-3 months. Check the program's timeline in the official solicitation for specific dates.
Many federal programs offer multi-year funding or allow competitive renewals. Check the official solicitation for continuation and renewal policies. Non-competing continuation applications are common for multi-year awards.
Past winners and funding trends for this program
PHS 2025-2 Omnibus Solicitation of the NIH, CDC, and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44]) is sponsored by National Institutes of Health (NIH). This flagship program provides non-dilutive funding to small businesses to support the research and development of innovative biomedical technologies, including novel therapeutics and drug delivery systems.
NIH SBIR/STTR Omnibus Solicitation (Parent R43/R44 and R41/R42) is sponsored by National Institutes of Health (NIH). The primary federal vehicle for funding small business medical technology development, supporting feasibility (Phase I) and full R&D (Phase II) across all health domains. This investigator-initiated program covers everything from diagnostics to medical devices and therapeutics.