•Note: Each funding opportunity description is a synopsis of information in the Federal Register application notice. For specific information about eligibility, please see the official application notice. The official version of this document is the document published in the Federal Register. Free Internet access to the official edition of the Federal Register and the Code of Federal Regulations is available on GPO Access at: http://www.access.gpo.gov/nara/index.html. Please review the official application notice for pre-application and application requirements, application submission information, performance measures, priorities and program contact information. Purpose of Program: The purpose of this program is to stimulate technological innovation in the private sector, strengthen the role of small business in meeting Federal research or research and development (R/R&D) needs, increase the commercial application of the U.S. Department of Education (Department) supported research results, and improve the return on investment from federally funded research for economic and social benefits to the Nation. Catalog of Federal Domestic Assistance (CFDA) Number: 84.133S-1. If you choose to submit your application electronically, you must use the Governmentwide Grants.gov Apply site at http://www.Grants.gov. Through this site, you will be able to download a copy of the application package, complete it offline, and then upload and submit your application. You may not e-mail an electronic copy of a grant application to us. You may access the electronic grant application for the SBIR Program at: http://www.Grants.gov. You must search for the downloadable application package for this competition by the CFDA number. Do not include the CFDA number's alpha suffix in your search (e.g. , search for 84.133, not 84.133S). The telephone number for the Grants.gov Helpdesk is 1-800-518-4726 or e-mail: support@grants.gov. Funding Opportunity Number: ED-GRANTS-090908-001. Assistance Listing: 84.133. Funding Instrument: G. Category: ED. Award Amount: Up to $75K per award.

Purpose. This Funding Opportunity Announcement (FOA) solicits Small Business Innovation Research (SBIR) grant applications from small business concerns (SBCs) that propose to develop, enhance and validate translational tools to facilitate rigorous study of complementary and alternative medicine (CAM) approaches that are in wide use by the public. Recent data from the National Health Interview Survey [http://www.cdc.gov/nchs/nhis.htm] establish that Americans are utilizing CAM approaches to promote health and well-being, to treat or prevent disease, and for symptom relief. CAM approaches being widely used include massage and manipulative therapies, meditation, yoga, and acupuncture. Health conditions, particularly chronic pain, back pain and musculoskeletal pain, are the most commonly cited reasons for their use. This FOA focuses on encouraging the development of improved tools to study safety, efficacy, and clinical effectiveness of widely used CAM approaches, such as: mind-body interventions, manual therapies, yoga, and acupuncture. This FOA is not focused on tools for the study of natural products, such as herbal therapies. Mechanism of Support. This FOA will utilize the SBIR (R43/R44) grant mechanisms for Phase I, Phase II, and Fast-Track applications and runs in parallel with a FOA of identical scientific scope, RFA-AT-09-002, which solicits applications under the R01 grant mechanism. Funds Available and Anticipated Number of Awards. The estimated amount of funds available for support of 5 projects awarded as a result of this announcement is $1.25 million for fiscal year 2010. Future year amounts will depend on annual appropriations. Funding Opportunity Number: RFA-AT-09-004. Assistance Listing: 93.213. Funding Instrument: G. Category: HL. Award Amount: $1.3M total program funding.

-Purpose. This Funding Opportunity Announcement (FOA) encourages Small Business Innovation Research (SBIR) grant applications from small business concerns (SBCs) that propose to develop, standardize, and validate new and innovative assays, integrated strategies, or batteries of assays that determine or predict specific organ toxicities (e.g., ocular, dermal, hematotoxicity, cardiotoxicity, gastrointestinal toxicity, hepatotoxicity, nephrotoxicity, ototoxicity, olfactory loss, bladder toxicity, neurotoxicity, pulmonary toxicity, endocrine toxicity, and pancreatic beta cell toxicity), resulting from both acute and chronic exposures to various chemicals, environmental pollutants, biologics and therapeutic molecules or drugs. In addition, this FOA encourages the development, standardization, and validation of new models of arthritis, convulsion, infection and shock. New approaches for high throughput toxicity screening that involves the use of molecular endpoints, computer modeling, proteomics, genomics and epigenomics and the development of virtual tissues are also encouraged as are development of 3-dimensional organ models for toxicity evaluation. -Mechanism of Support. This FOA will utilize the SBIR (R43/R44) grant mechanisms for Phase I, Phase II, and Fast-Track applications and runs in parallel with a FOA of identical scientific scope, PA-09-007, which encourages applications under the Small Business Technology Transfer (STTR) (R41/R42) grant mechanisms. Funding Opportunity Number: PA-09-006. Assistance Listing: 93.113,93.173,93.361,93.389,93.837,93.846,93.847,93.848,93.849,93.859,93.867. Funding Instrument: G. Category: ED,ENV,FN,HL.

-This Funding Opportunity Announcement (FOA) solicits Small Business Innovation Research (SBIR) grant applications from small business concerns (SBCs) for the modification or development of new screening technologies that are better able to consistently detect mild hearing loss (i.e., less than 40 dB Hearing Level or 40 dB HL) in one or both ears in infants and young children without significantly increasing the number of false positives (i.e., those who fail the screen but do not have hearing loss). -The Early Hearing Detection and Intervention (EHDI) program within the National Center for Birth Defects and Developmental Disabilities (NCBDDD) of the Centers for Disease Control and Prevention (CDC) and the National Institute on Deafness and Other Communication Disorders (NIDCD), NIH, are working to ensure infants and children with mild forms of hearing loss are identified as soon as possible. Part of this effort involves having screening technology available that can reliably detect these hearing losses. -This FOA will utilize the SBIR (R43/R44) grant mechanisms for Phase I, Phase II, and Fast-Track applications and runs in parallel with a FOA of identical scientific scope, PA-06-547, that solicits applications under the Small Business Technology Transfer (STTR [R41/R42]) grant mechanisms. Note,that CDC does not accept STTR applications so is participating only in PA-06-546. Funding Opportunity Number: PA-06-546. Assistance Listing: 93.173,93.283. Funding Instrument: G. Category: HL.

Purpose. This funding opportunity announcement (FOA) solicits Small Business Innovation Research (SBIR) grant applications that propose to develop novel pharmacologic agents for brain research related to mental disorders, including research aimed at discovering new drugs for these disorders. In addition, this FOA solicits SBIR grant applications that propose to take existing, promising compounds through the next step of drug discovery and development. Finally, this FOA also encourages SBIR grant applications designed to study the effectiveness of novel interventions. Mechanism of Support. This FOA will utilize the SBIR (R43/R44) grant mechanisms for Phase I, Phase II, and Fast-Track applications. Funds Available and Anticipated Number of Awards. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications. The total amount awarded and the number of awards will depend upon the quality, duration, and costs of the applications received. Budget and Project Period. Phase I awards normally may not exceed $100,000 total for a period normally not to exceed 6 months. Phase II awards normally may not exceed $750,000 total for a period normally not to exceed 2 years. However, for this funding opportunity, budgets up to $350,000 total costs per year and time periods up to two years for Phase I may be requested. Budgets up to $600,000 total costs per year and up to three years may be requested for Phase II. Eligible Institutions/Organizations: Only United States SBCs are eligible to receive SBIR applications. A SBC is one that, on the date of award for both Phase I and Phase II funding agreements, meets ALL of the criteria as described in Section III. Eligible Project Directors/Principal Investigators: Individuals with the skills, knowledge, and resources necessary to carry out the proposed research are invited to work with their organization to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support. On an SBIR application, the PD/PI must have his/her primary employment (more than 50%) with the SBC at the time of award and for the duration of the project. Number of Applications: Applicant SBCs may submit more than one application, provided each application is scientifically distinct. Resubmissions: Applicants may submit a resubmission application, but such application must include an Introduction addressing the previous peer review critique (Summary Statement). Number of PDs/PIs. More than one PD/PI, or multiple PDs/PIs, may be designated on the application. Funding Opportunity Number: PA-08-142. Assistance Listing: 93.242. Funding Instrument: G. Category: HL.

This Funding Opportunity Announcement (FOA) solicits Small Business Innovation Research (SBIR) grant applications from small business concerns (SBCs) that propose the development and translation of technologies to improve hearing healthcare outcomes. Responsive applications must seek to increase utilization of hearing health care technology by underserved patients and thus reduce health disparities. Funding Opportunity Number: RFA-DC-12-001. Assistance Listing: 93.173. Funding Instrument: G. Category: HL. Award Amount: Up to $150K per award.

Purpose. This Funding Opportunity Announcement (FOA), issued by the National Cancer Institute (NCI), National Institutes of Health (NIH), invites Small Business Innovation Research (SBIR) cooperative agreement applications from small business concerns (SBCs) that propose to develop new, or to improve existing application(s) of nanotechnology-based therapeutics or/and in vivo diagnostics. This FOA will specifically support pre-clinical optimization and testing of these cancer-relevant nanotechnology applications against the intended cancer type. The proposed projects must be milestone-driven and must be clearly directed toward development of an ultimate commercial product. The outcomes are expected to advance the discovery and pre-clinical optimization phase so that an Investigational New Drug (IND) or Investigational Device Exemptions (IDE) application could be submitted to the Food and Drug Administration (FDA) by the end or shortly after completion of the Phase II project period. To facilitate these steps, the NCI will assist the awardees in various ways, including the support through the NCI-sponsored Nanotechnology Characterization Laboratory. This FOA will NOT support basic research projects, studies on disease mechanisms, and clinical trials. Mechanism of Support. This FOA will utilize the SBIR (U43/U44) cooperative agreement mechanisms for Phase I and Phase II applications. Funds Available and Anticipated Number of Awards. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications. The total amount awarded and the number of awards will depend upon the quality, duration, and costs of the applications received. Funding Opportunity Number: PAR-10-286. Assistance Listing: 93.393,93.394,93.395,93.396. Funding Instrument: CA. Category: ED,HL. Award Amount: Up to $150K per award.

NIST invites applications for a program involving technical and business engagement activities directed at small businesses participating in NIST’s Small Business Innovation Research Program. The TCAP recipient will provide NIST SBIR Phase I and/or Phase II recipients with technical and business expertise and resources to identify optimum pathways to promote successful transition of the Phase I and/or Phase II results to commercialization. Funding Opportunity Number: 2014-NIST-SBIR-02. Assistance Listing: 11.620. Funding Instrument: CA. Category: ST.

This Funding Opportunity Announcement (FOA) invites Small Business Innovation Research (SBIR) grant applications from small business concerns (SBCs) for funding to perform research leading to the development of innovative technologies that may advance progress for early detection and assessment of individuals at risk and for early diagnosis, prognosis and follow-up of type 1 diabetes (T1D). Funding Opportunity Number: RFA-DK-15-024. Assistance Listing: 93.847. Funding Instrument: G. Category: FN,HL. Award Amount: $2M total program funding.

This initiative will stimulate and support innovative research by small business concerns that may lead to the development of novel technologies for the early diagnosis, monitoring and treatment of micro and macro vascular complications of diabetes which are associated with significant morbidity and mortality of the disease and high costs to the health care system. Funding Opportunity Number: PA-14-058. Assistance Listing: 93.847. Funding Instrument: G. Category: FN,HL.

This Funding Opportunity Announcement (FOA) encourages Small Business Innovation Research (SBIR) grant applications that propose to continue the process of developing complex instrumentation, clinical research tools, or behavioral interventions and mental disorders. This FOA specifically invites applications for the competing renewal of previously funded Phase II SBIR grants to further develop the aforementioned types of technologies. Funding Opportunity Number: PA-14-219. Assistance Listing: 93.242. Funding Instrument: G. Category: HL. Award Amount: Up to $800K per award.

Since its inception in 1953, SBA has served to aid, counsel, assist and protect the interests of small businesses. While SBA is best known for its financial support of small businesses through its many lending programs, the Agency also plays a critical role in providing funding to organizations that deliver technical assistance in the form of counseling and training to small business concerns and nascent entrepreneurs in order to promote growth, expansion, innovation, increased productivity and management improvement. The mission of SBA’s Office of Innovation & Technology, which bears responsibility for administering the FAST Program, is to strengthen the technological competitiveness of small businesses across the country through coordination of the Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs. The FAST program focuses on increasing the participation of small firms in the innovation and commercialization of high risk technologies, keeping the United States on the cutting edge of next generation research and development. The Federal and State Technology (FAST) Partnership Program provides one year funding to organizations to execute state/regional programs that increase the number of SBIR/STTR proposals (through outreach and financial support); increase the number of SBIR/STTR awards (through technical assistance and mentoring); and better prepare SBIR/STTR awardees for commercialization success (through technical assistance and mentoring). Funding Opportunity Number: FAST-2018-R-0012A. Assistance Listing: 59.058. Funding Instrument: G. Category: BC,ST. Award Amount: $50K – $125K per award.

This NOFO provides an opportunity to all FY 2018 NIST SBIR Phase I awardees to submit a Phase II application following completion of Phase I. This NOFO provides instructions for FY 2019 NIST SBIR Phase II application preparation and submission requirements. In Phase II, work from Phase I that exhibits potential for commercial application is further developed. Phase II is the R&D or prototype development phase. To apply for a Phase II award, each Phase I awardee will be required to submit a comprehensive application outlining the proposed research and a detailed plan to commercialize the final product. Each NIST Phase II award is for up to $400,000 and up to a 24-month period of performance. One year after completing the Phase II R&D activity, the awardee shall be required to report on its commercialization activities. Up to an additional $6,500 may be requested for Technical and Business Assistance (TABA); see Section 5.11 for more information about TABA. Funding Opportunity Number: 2019-NIST-SBIR-02. Assistance Listing: 11.620. Funding Instrument: CA. Category: ST. Award Amount: Up to $400K per award.

All Phase II projects must have previously completed a successful USDA Phase I project before applying for a Phase II grant. Success rates for applicants have been 50-60% for Phase II. Projects dealing with agriculturally-related manufacturing and alternative and renewable energy technologies are encouraged across all 2018 SBIR topic areas. USDA SBIR's flexible research areas ensure innovative projects consistent with USDA's vision of a healthy and productive nation in harmony with the land, air, and water. USDA SBIR has awarded over 2000 research and development projects since 1983, allowing hundreds of small businesses to explore their technological potential and providing an incentive to profit from the commercialization of innovative ideas. Click below for more SBIR information. Funding Opportunity Number: USDA-NIFA-SBIR-008080. Assistance Listing: 10.212. Funding Instrument: G. Category: AG. Award Amount: Up to $650K per award.

Research on Circular Economy, Smart Manufacturing, and Energy-Efficient Microelectronics is sponsored by U.S. Department of Energy (DOE) Advanced Materials & Manufacturing Technologies Office (AMMTO). This funding opportunity supports innovative technology R&D across the manufacturing sector with a focus on circular economy, smart manufacturing, and energy-efficient microelectronics. While the stated deadline for full applications has passed, AMMTO frequently issues similar solicitations, and this highlights a relevant area of interest for the DOE.

Internet Freedom Programs is sponsored by U.S. Department of State, Bureau of Democracy, Human Rights, and Labor (DRL). DRL announces a Request for Statements of Interest (RSOI) from organizations interested in submitting Statements of Interest (SOI) for programs that support Internet Freedom. The goal is to protect the open, interoperable, secure, and reliable Internet by promoting fundamental freedoms, human rights, and the free flow of information online through integrated support to civil society for technology, digital safety, policy and advocacy, and applied research programs.

Preventive Health and Health Services (PHHS) Block Grant Program is sponsored by Centers for Disease Control and Prevention (CDC). The PHHS Block Grant Program allows recipients to address their own unique public health needs and challenges with innovative and community-driven methods. Recipients set their own goals and program objectives and implement local strategies to address Healthy People 2030 priorities.

AWS Imagine Grant program - Momentum to Modernize Award is sponsored by Amazon Web Services (AWS). This award provides funding for transformational infrastructure projects, helping nonprofit organizations enhance their core mission operations with technology. This includes foundational technology projects, such as migrating servers to the cloud and modernizing new and existing applications.

Science Education Partnership Award (SEPA) is sponsored by National Institute of General Medical Sciences (NIGMS), National Institutes of Health (NIH). The Science Education Partnership Award (SEPA) Program funds grants for innovative educational programs that create partnerships among biomedical and clinical researchers and K-12 teachers and schools, museums and science centers, media experts, and other educational organizations. The program aims to improve STEM literacy through innovative P-12 and informal science education. Projects can be classroom-based or informal science education projects in venues such as science centers, museums, and libraries.

The Small Business Innovation Research (SBIR) Program for CHIPS for America – CHIPS Metrology seeks applications from eligible applicants to explore the technical merit or feasibility of an innovative idea or technology with the aim of developing a viable product or service that will be introduced to the commercial microelectronics marketplace. This NOFO contains multiple topics on research projects for critically needed measurement services, tools, and instrumentation; innovative manufacturing metrologies; novel assurance and provenance technologies and advanced metrology research and development (R&D) testbeds to help secure U.S. leadership in the global semiconductor industry. Funding Opportunity Number: 2024-SBIR-CHIPS-01. Assistance Listing: 11.042,11.620. Funding Instrument: CA. Category: ST.

SBIR/STTR Programs (Defense Health Agency) is sponsored by Department of Defense (DOD) - Defense Health Agency (DHA). The DHA SBIR/STTR Programs fund biomedical and health-focused technologies that enhance medical readiness, clinical care delivery, force health protection, operational medicine, and military healthcare modernization. Priority research domains include digital health systems, AI-enabled triage, and physiological analytics.

Small Business Innovation Research (SBIR) Program Phase I is sponsored by U.S. Environmental Protection Agency (EPA). The EPA SBIR Phase I Solicitation invites small businesses to submit proposals for projects addressing critical environmental challenges. Awards are for six months to demonstrate proof of concept. Key focus areas include Clean and Safe Water, Air Quality and Climate, Homeland Security, Circular Economy/Sustainable Materials, and Safer Chemicals.

Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs is sponsored by Environmental Protection Agency (EPA). The EPA SBIR program supports the development and commercialization of innovative environmental technologies that address the Agency's mission. This includes projects focused on climate change solutions, air quality, circular economy/sustainable materials, and other environmental threats.

Small Business Innovation Research (SBIR) / Small Business Technology Transfer (STTR) Programs (Phase I) is sponsored by U.S. Department of Agriculture (USDA) National Institute of Food and Agriculture (NIFA). The USDA SBIR/STTR programs focus on transforming scientific discovery into products and services with commercial potential and/or societal benefit in agriculturally-related areas. This can include app development for agricultural technology, rural development, and smart farming. Phase I aims to demonstrate technical feasibility.

Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) Programs Phase I (FY 2025) is sponsored by U.S. Department of Agriculture (USDA) National Institute of Food and Agriculture (NIFA). The USDA SBIR/STTR programs focus on transforming scientific discovery into products and services with commercial potential and/or societal benefit. Projects dealing with agriculturally-related manufacturing and alternative and renewable energy technologies are encouraged across all SBIR/STTR topic areas.

Small Business Innovation Research - Food Science and Nutrition (SBIR 8.5) is sponsored by USDA National Institute of Food and Agriculture (NIFA). This program supports innovations in food manufacturing technologies and strengthening agricultural systems. It focuses on improving production, storage, and quality of foods through research, education, and extension. Projects can address emerging food safety, food processing, and nutrition issues, including developing systems for rapid detection of pathogens and chemical hazards, and technologies for climate-smart food systems. The outcome of a successful project is a proof of concept for a marketable product or patented process.

Agricultural Technologies (AG) - NSF SBIR/STTR is sponsored by National Science Foundation (NSF). The Agricultural Technologies topic supports innovations enabling farm production ecosystems that support the proper utilization of natural resources. Such technologies may encompass systems-level and multidisciplinary solutions to enable complex agricultural practices that support increased biodiversity balanced with yield production. Sub-topics include food waste mitigation, resilient supply & distribution, and other agricultural technologies.

Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) Programs (USDA NIFA) is sponsored by U.S. Department of Agriculture (USDA) National Institute of Food and Agriculture (NIFA). The USDA SBIR/STTR programs offer grants for small businesses to conduct high-quality research related to important scientific problems and opportunities in agriculture, with an emphasis on transforming scientific discovery into commercial products and services. This includes advanced technologies and software solutions relevant to agriculture. The FY 2025 Phase I funding opportunity has a closing date of September 17, 2024.

Small Business Innovation Research (SBIR) Program is sponsored by NOAA. This program provides seed funding to small businesses for research and development of innovative technologies across NOAA's mission areas, including climate change adaptation and mitigation, coastal resilience, and extreme weather events. Phase I awards fund a six-month period for conducting feasibility and proof of concept research.

The JAMS IPT is seeking wide-ranging Aircraft Survivability Equipment (ASE) technologies at Technical Readiness Level (TRL) 3 and higher, for accelerated development in relation to modern missile threat systems.OverviewGlobal advancement and the pace of adversary missile threat-system development highlights an immediate need to improve U.S. airborne asset protection and survivability, against current and future threats.The JAMS IPT is a joint working group focused on defensive air survivability against modern air threats that are stressing ASE on current and future air platforms. The mission of JAMS is to maintain a warfighting advantage, by identifying, evaluating, and rapidly deploying innovative solutions for U.S. aircraft in emergent operational Areas of Responsibility (AORs), seizing upon opportunities that will benefit the services across the DoD. There is a strong desire within the ASE community to share costs and provide common solutions across platforms as much as possible.While most are familiar with red kill chains, there is a corollary for blue ASE protection. The JAMS IPT is broadly looking for technologies in the ASE protection chain, including:Threat Detection: Sensing and identifying a threat;Fix: Geo-location and threat avoidance;Signature: Tactics and procedures to reduce signatures but also equipment that can modify or alter an aircraft’s signature;Defeat: This includes traditional jammers, expendables, towed decoys but also new solutions launched from the aircraft or escort aircraft to degrade, seduce or confuse a threat; andAssess: The ability to evaluate the effects of avoidance, signature management or defeat.However, beyond these protection capabilities, are enabling tools required for developing, testing and fielding solutions, particularly in Modeling and Simulation (M&S), and Test and Evaluation (T&E) activities.This announcement seeks revolutionary ideas and technology demonstrators that offer potential material solutions, M&S solutions, and T&E solutions at a TRL 3 or higher with a robust plan to achieve TRL 6. Solutions with an open architecture will be favored. A classified secret addendum with examples of stressing adversarial technologies can be requested on SIPRNET at betsy.l.marschand1@navy.smil.mil. Funding Opportunity Number: N0016425SNB10. Assistance Listing: 12.910. Funding Instrument: G. Category: ST.