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The Genesis Mission: Transforming Science and Energy with AI is sponsored by U.S. Department of Energy (DOE) Office of Science, Office of Critical Minerals and Energy Innovation, Office of Environmental Management, Office of Nuclear Energy, Office of Electricity, and Hydrocarbons and Geothermal Office.
This program seeks applications from interdisciplinary teams using novel artificial intelligence (AI) models and frameworks to address national scientific and technology challenges, including those related to AI-driven autonomous laboratories. The goal is to accelerate scientific discovery and R&D workflows, advance DOE's mission, and ensure America's security and prosperity through science and technology.
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Opportunity Listing - The Genesis Mission: Transforming Science and Energy with AI The Genesis Mission: Transforming Science and Energy with AI Agency: Office of Science Assistance Listings: 81. 049 -- Office of Science Financial Assistance Program Last Updated: April 10, 2026 View version history on Grants.
gov DOE is soliciting new FY26 Phase I small team and Phase II large team applications in the following topic areas: advanced manufacturing, biotechnology, critical materials, nuclear fission, nuclear fusion, quantum information science, semiconductors and microelectronics, discovery science, and energy (see specific focus areas in Section III Program Descriptions).
In addition, this RFA will remain available to allow the recipients of FY26 Phase I awards to apply for larger team Phase II awards. In a few weeks, DOE plans to amend the RFA to clarify the LOI and application guidelines for FY26 Phase II awards.
In FY27, DOE plans to amend the RFA or to issue an alternative funding opportunity to update the topic and focus areas to allow a second competition of Phase I small team applications and Phase II large team applications. Grantor contact information GenesisMissionNOFO@science. doe.
gov GenesisMissionNOFO@science. doe. gov GenesisMissionNOFO@science.
doe. gov File name Description Last updated Genesis_Mission_Phase_I_Application_Template_v2. xlsx Phase I Application Template Apr 10, 2026 01:23 PM UTC Genesis_Mission_Phase_II_LOI_Template_v2.
xlsx Phase II LOI Template Apr 10, 2026 01:23 PM UTC Sample_OT_and_Project_Agreements_for_DE-FOA-0003612. pdf Sample OT and Project Agreements Mar 31, 2026 03:33 PM UTC Genesis_Mission_Phase_II_Application_Template. xlsx Phase II Application Template Apr 10, 2026 01:24 PM UTC DE-FOA-0003612.
000003. pdf DE-FOA-0003612 Apr 20, 2026 09:28 PM UTC Link to additional information Closing: December 17, 2026 Funding opportunity number : Cost sharing or matching requirement : Funding instrument type : Opportunity Category Explanation : Category of Funding Activity : Science technology and other research and development
Based on current listing details, eligibility includes: Interdisciplinary teams from DOE National Laboratories, industry groups, and academia. DOE is soliciting new FY26 Phase I small team and Phase II large team applications. Applicants should confirm final requirements in the official notice before submission.
Current published award information indicates $293,760,000 total. Initial Phase I funding $500,000 - $750,000 (nine months); Phase II awards $6,000,000 - $15,000,000 (three years). Always verify allowable costs, matching requirements, and funding caps directly in the sponsor documentation.
The current target date is rolling deadlines or periodic funding windows. Build your timeline backwards from this date to cover registrations, approvals, attachments, and final submission checks.
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Genesis Mission National Science and Technology Challenges is sponsored by U.S. Department of Energy (DOE) Office of Science, Office of Critical Minerals and Energy Innovation, Office of Environmental Management, Office of Nuclear Energy, Office of Electricity, and Hydrocarbons and Geothermal Office. This NOFO invites applications from interdisciplinary teams addressing the Genesis Mission National Science and Technology Challenges to accelerate scientific discovery and research and development (R&D) workflows using novel artificial intelligence (AI) models and frameworks.
The Genesis Mission: Transforming Science and Energy with AI (DE-FOA-0003612) is sponsored by U.S. Department of Energy (DOE) Office of Science, Office of Critical Minerals and Energy Innovation, Office of Environmental Management, Office of Nuclear Energy, Office of Electricity, and Hydrocarbons and Geothermal Office. This funding opportunity invites interdisciplinary teams to leverage novel AI models and frameworks to address over 20 national challenges spanning advanced manufacturing, biotechnology, critical materials, nuclear energy, and quantum information science.
Academic Grant Program is sponsored by NVIDIA. NVIDIA's Academic Grant Program seeks proposals from full-time faculty members at accredited academic institutions using NVIDIA technology to advance work in Simulation and Modeling, Data Science, and Robotics and Edge AI. Proposals for the NVIDIA Graduate Fellowship Program are also invited, focusing on AI, robotics, and autonomous vehicles.
Manufacturing USA Institute – AI for Resilient Manufacturing is sponsored by National Institute of Standards and Technology (NIST). NIST is seeking applications to establish and operate a Manufacturing USA institute focused on leveraging artificial intelligence to strengthen the resilience of U.S. manufacturers, particularly concerning supply chain networks. The institute will conduct applied R&D projects and cultivate a skilled workforce.
America's Seed Fund (SBIR/STTR) - Cybersecurity and Authentication is sponsored by U.S. National Science Foundation (NSF). Supports startups and small businesses to translate research into products and services, including cybersecurity and authentication, to secure national defense and protect the public. Includes research requiring privacy and security-preserving resources for artificial intelligence.