Preventive Health and Health Services (PHHS) Block Grant Program is sponsored by Centers for Disease Control and Prevention (CDC). The PHHS Block Grant Program allows recipients to address their own unique public health needs and challenges with innovative and community-driven methods. Recipients set their own goals and program objectives and implement local strategies to address Healthy People 2030 priorities.

Orphan Products Grants Program is sponsored by U.S. Food and Drug Administration (FDA). This program awards grants to clinical investigators to support the development of safe and effective medical products (drugs, biologics, medical devices, and foods for medical purposes) for patients with rare diseases or conditions, defined as those affecting fewer than 200,000 persons in the United States. Urea cycle disorders fall under this definition. The program funds clinical trials and natural history studies.

Social disconnection and Suicide Risk in Late Life (R01 Clinical Trial Optional) is sponsored by National Institute of Mental Health (NIMH), National Institutes of Health (NIH). This funding opportunity is a companion to the R21 mechanism and also aims to stimulate research to understand the link between social disconnection and suicidal thoughts and behaviors in late life. It focuses on identifying mechanisms by which social disconnection confers risk for, and social integration protects against, suicidal thoughts and behaviors in late life. This R01 mechanism is appropriate for applications with preliminary data.

Accelerating Solutions to Improve Access and Quality of Empirically-Supported Practices for Youth Mental Health (R01 Clinical Trial Optional) is sponsored by National Institute of Mental Health (NIMH) / NIH. This funding opportunity encourages research focused on optimizing and testing school-based mental and behavioral health interventions and service delivery models. It seeks applications that will study methods to increase access to evidence-based interventions and services for youth mental health, particularly in under-resourced areas. Research areas include optimizing assessment, intervention and service strategies, overcoming workforce shortages, and integrating preventive interventions into settings like schools.