This Notice of Funding Opportunity (NOFO) invites Center Core (P30) applications for the National Institute on Aging (NIA) Artificial Intelligence and Technology Collaboratories (AITC) program. The AITC Program promotes the development and implementation of artificial intelligence approaches and technology through research projects for aging and AD/ADRD research. All applications should propose strategies for addressing ethical challenges surrounding artificial intelligence and technologydevelopment and implementation, and to employ, when possible, best practices established in the fields of aging and AD/ADRD.

Funding Opportunity Number: RFA-AG-26-006. Assistance Listing: 93.866. Funding Instrument: G. Category: HL.

Expired RFA-AG-26-006: Artificial Intelligence and Technology Collaboratory (P30 Clinical Trial Optional) This notice has expired. For NIH, in limited situations, applications may be accepted on a case-by-case basis for a short period after expiration to accommodate NIH late or continuous submission policies . Contact the eRA Service Desk for any submission issues.

Check the NIH Guide for active opportunities and notices. Department of Health and Human Services Part 1.

Overview Information Participating Organization(s) National Institutes of Health ( NIH ) Components of Participating Organizations Funding Opportunity Title Artificial Intelligence and Technology Collaboratory (P30 Clinical Trial Optional) April 4, 2024 - Overview of Grant Application and Review Changes for Due Dates on or after January 25, 2025. See Notice NOT-OD-24-084 .

August 31, 2022 - Implementation Changes for Genomic Data Sharing Plans Included with Applications Due on or after January 25, 2023. See Notice NOT-OD-22-198 . August 5, 2022 - Implementation Details for the NIH Data Management and Sharing Policy.

See Notice NOT-OD-22-189 . Funding Opportunity Number (FON) Companion Notice of Funding Opportunity Resource-Related Research Project (Cooperative Agreements) See Section III. 3.

Additional Information on Eligibility . Assistance Listing Number(s) Notice of Funding Opportunity Purpose This Notice of Funding Opportunity (NOFO) invites Center Core (P30) applications for the National Institute on Aging's (NIA) Artificial Intelligence and Technology Collaboratories (AITC) program.

The AITC program promotes the development and implementation of artificial intelligence (AI) approaches and technology through research projects for aging and Alzheimer's Disease (AD) and AD-related dementias (ADRD) research.

All applications should propose strategies for addressing challenges surrounding AI and technology development and implementation, and to employ, when possible, best practices established in the fields of aging and AD/ADRD.

Funding Opportunity Goal(s) To encourage biomedical, social, and behavioral research and research training directed toward greater understanding of the aging process and the diseases, special problems, and needs of people as they age.

Open Date (Earliest Submission Date) Letter of Intent Due Date(s) Renewal / Resubmission / Revision (as allowed) AIDS - New/Renewal/Resubmission/Revision, as allowed All applications are due by 5:00 PM local time of applicant organization. Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.

No late applications will be accepted for this Notice of Funding Opportunity (NOFO). Required Application Instructions It is critical that applicants follow the Multi-Project (M) Instructions in the How to Apply - Application Guide , except where instructed to do otherwise (in this NOFO or in a Notice from the NIH Guide for Grants and Contracts ).

Conformance to all requirements (both in the How to Apply - Application Guide and the NOFO) is required and strictly enforced. Applicants must read and follow all application instructions in the How to Apply - Application Guide as well as any program-specific instructions noted in Section IV. When the program-specific instructions deviate from those in the How to Apply - Application Guide , follow the program-specific instructions.

Applications that do not comply with these instructions may be delayed or not accepted for review. Part 1. Overview Information Part 2.

Full Text of Announcement Section I. Notice of Funding Opportunity Description Section II. Award Information Section III.

Eligibility Information Section IV. Application and Submission Information Section V. Application Review Information Section VI.

Award Administration Information Section VII. Agency Contacts Section VIII. Other Information Part 2.

Full Text of Announcement Section I. Notice of Funding Opportunity Description Key Definitions for this NOFO AITC Program: A collective consisting of individual P30 “Collaboratories” and a single U24 Coordinating Center.

The program is comprised of the following types of Centers that operate independently, and in cooperation with all the other Centers: AITC: P30 Center(s) that focus on implementation of AI and technology approaches for aging and AD/ADRD research. The Center(s) is/are funded through this NOFO, RFA-AG-26-006. Hereafter, the Centers will also be referred to as “Collaboratory(ies)” or "AITC(s)."

AITC Coordinating Center (AITCC): A center that provides leadership and coordination for the AITC program through a cooperative agreement with NIA. The AITCC is funded through RFA-AG-26-007 , using the U24 (Resource-Related Research Projects – Cooperative Agreements) activity code. Hereafter, the AITC Coordinating Centers will also be referred to as “AITCC” or “Coordinating Center.

” AD/ADRD: ADRD include, but are not limited to, Frontotemporal dementia (FTD), Vascular Contributions to Cognitive Impairment and Dementia (VCID), Lewy Body Dementias (LBD), and Multiple Etiology Dementias (MED). This Notice of Funding Opportunity invites Center Core (P30) applications for the National Institute on Aging (NIA) Artificial Intelligence and Technology Collaboratories (AITC) Program.

The AITC Program promotes the development and implementation of AI approaches and technology through research projects for aging and AD/ADRD research. AI and other emerging technologies have the potential to address pressing issues in aging and AD/ADRD.

The AITC Program supports innovative cross-disciplinary collaborative teams, with investigators from academia, non-profit, and healthcare sectors across a wide range of disciplines working to advance priorities in aging and AD/ADRD research.

Goals of the overall AITC Program are as follows: Serve as a national resource to promote development and implementation of innovative AI and technology approaches to advance aging and AD/ADRD priorities; Support nationwide research projects to develop and implement AI and technology approaches and respond rapidly to emerging priorities in the shifting AI and technology landscape; and Collaborate with a wide range of stakeholders in addressing algorithmic fairness and how to incorporate AI and technology approaches in the special circumstances of individuals experiencing cognitive decline/impairment.

In achieving these goals, it is expected that the Collaboratories will interact with each other and with the AITCC. The AITCC will serve as a hub for the AITC Program and will facilitate and coordinate activities across Collaboratories.

The AITCC will also facilitate a centralized program-wide Stakeholder Engagement Team to ensure that AI approaches and technologies developed by the Collaboratories will be maximally adoptable by and accessible to their end users by soliciting stakeholder input throughout all phases of the development cycle.

The overarching objective of this NOFO and its companion NOFO, RFA-AG-26-007 , are to provide a nimble infrastructure with resources to support collaborative opportunities for innovation in AI and technology approaches to advance aging and AD/ADRD research and improve the health and well-being of older adults, including those living with dementia and their caregivers.

To meet this objective, this NOFO invites applications for AITCs that: Support innovative research projects to inform the design or application of AI and technology approaches relevant to NIA scientific priorities; and Develop infrastructure to enable broad collaboration and participation among investigators from academia, non-profit, and healthcare sectors across a wide range of disciplines.

To address ethical issues that are commonly raised about research in this area, all applications should propose strategies for addressing ethical challenges surrounding AI and technology development and implementation, and to employ, when possible, best practices established in the fields of aging and AD/ADRD.

Each Collaboratory will be comprised of two core components and one optional component: (A) Administrative Core; (B) Research Innovation Core; and (C) Investigator-Initiated Core (optional). Applications will be considered incomplete if they do not include an Administrative Core and Research Innovation Core. Applicants have an option to propose one Investigator-initiated optional Core.

Each Collaboratory must collaborate and engage in activities with the trans-AITC/AITCC Stakeholder Engagement Team led by the AITCC. This core will manage the overall vision and operations of the Collaboratory. Activities include, but are not limited to, the following: Providing a governance structure for the AITC.

Providing a public website for communication and sharing of the activities, events, and resources of the program. Organizing and implementing an annual national competition for research projects, in conjunction with the AITCC, to include recommendations of meritorious research projects to NIA. Providing organizational and logistical support for the activities of the AITC Cores.

Supporting standards and mechanisms to publicly share data, resources, and codes developed and utilized in AITC research projects. Collaborate with the AITCC to develop the theme, agenda, and logistics for an annual AITC Symposium to highlight progress of research project awardees. The AITCC will provide logistic and financial support for the annual AITC Symposium and the Collaboratories will engage with the AITCC in planning.

B. Research Innovation Core This core will support innovative research projects to inform the design or application of AI and technology approaches to advance aging and AD/ADRD research and improve the health and well-being of older adults, including those living with AD/ADRD and their caregivers.

This core will collaborate with the AITCC to hold annual national competitions to fund and facilitate research projects consistent with the goals and scope of the AITC. Research projects can range in objectives, but must address topics related to aging and AD/ADRD. Each Collaboratory is expected to devote a minimum of 80% of its innovation budget toward AD/ADRD research projects.

All research projects selected by the Collaboratory must be within the scope of the Collaboratory and require prior approval from NIA Program and Grants Management Staff. Applicants should propose a consolidated or centralized institutional review board (IRB) approach consistent with the NIH single IRB policy and the revised Common Rule (rCR) cooperative research provision (45 CFR 46.

114) for multi-site research for trial oversight to facilitate both appropriate and timely study implementation. C. Investigator-Initiated Core (Optional) Applicants have an option to propose one investigator-initiated optional core.

This core is expected to serve the full AITC Program and should be beneficial to the research project awardees and applicants and may include focus areas such as study design, data science, technical support, ethics and privacy, or clinical translation. Successful applications may be required to revise aims of the Investigator-Initiated Core in order to avoid overlap of activities with other Collaboratories.

Each Collaboratory must promote a sustainable research and infrastructure development program in one or more thematic areas that have the potential to serve all NIA scientific interests. Illustrative topic areas for the Collaboratories may include the following: Resources to promote AI and machine learning (ML)-ready datasets.

Design and modification of technology by incorporating AI applications into human factors problems/design associated with aging and AD/ADRD. Resources to promote integration of experimental and AI/ML approaches to better understand basic processes in the aging brain and AD/ADRD. Computational and informatics tools applied to the study of aging mechanisms.

AI, ML, or health monitoring technologies in aging and AD/ADRD. AI-driven systems and computational biology. Imaging and image analysis.

Clinical decision support tools using AI to enable personalized care for older adults with multiple chronic conditions. Common Evaluation Metrics and Information Sharing The continued success and sustainability of NIA’s AITC Program requires that Collaboratories demonstrate their value and impact in line with the program goals stated above.

Collaboratories must cooperate and collaborate, under the purview of the AITCC, in sharing of AITC Program information and using common metrics and processes to inform future AITC Program evaluations by the NIA.

Common metrics and processes may include the following: Number and characteristics of research projects awarded each cycle; Representation of states and U.S. territories of applicants and awardees; Distribution of awardees across academia, industry, etc.; Number of research project awardees that go on to submit R01 or small business innovation research (SBIR) applications (or other outcomes of research project awards such as commercialization or business development); Distribution of project focus areas across NIA’s scientific portfolio; Innovation (e.g., are the research projects similar to the current NIA portfolio or do they stand out as different/innovative?)

; Number and nature of collaborations with other Collaboratories; Products resulting from collaborations with other Collaboratories; Number and nature of collaborations with other NIA or NIH funded projects; Products resulting from collaborations with other NIA or NIH funded projects; Number and nature of collaborations with organizations outside NIH; and Products resulting from collaborations with organizations outside NIH.

Collaboratories must cooperate and collaborate with the AITCC and the other Collaboratories in the development, utilization, and sharing of these metrics and processes.

The AITC Program and its constituent parts will be evaluated by the Office of Planning, Analysis, and Evaluation at NIA on the extent to which they meet the overall goals of the program, and make recommendations regarding progress of the AITC Program, including changes, if any, that would benefit the program.

An External Advisory Panel (EAP) for the AITC Program will be established, in conjunction with the AITCC, to review the progress of all components of the program and provide recommendations to the AITC and AITCC Project Directors and/or Principle Investigator (PD(s)/PI(s)).

EAP Membership: Membership may include study investigators, representatives from relevant federal agencies (cannot include NIA or NIH representatives), and independent scientific experts in areas appropriate to the multidisciplinary content of the Collaboratory. The EAP is expected to have 5-7 permanent members; however, membership may expand permanently or on an ad hoc basis as needed.

The AITCC is expected to propose suitable EAP members to NIA for final approval. EAP Meeting Logistics: The EAP will meet twice a year to evaluate and comment on the progress of the AITC Program. The meetings will alternate between virtual and in-person formats.

The in-person meeting should be planned in conjunction with the annual AITC Symposium to be held at an NIA-approved federal or non-federal location. EAP Meeting Content: During the EAP meeting, AITC and AITCC PIs are expected to present annual accomplishments and future directions. The EAP will make recommendations, in writing, regarding progress of the AITC Program, including changes, if any, that would benefit the program.

The following types of applications will be considered non-responsive and will be withdrawn prior to review: Applications that do not propose a focus area in the field of AI and technology. Applications that do not address aging and AD/ADRD. Applications that do not address ethical issues in AI and technology development and implementation.

Applications that do not identify a PD/PI with a degree in computer science, computational biology, or other field closely related to AI and technology Clinical Research Operations Management System NIA utilizes a central resource to NIA staff and extramural investigators to facilitate/support the conduct and management of clinical research.

NIA Clinical Research Operations & Management System (CROMS) is a comprehensive data management system to support the business functions, management, and oversight responsibilities of NIA grants that support the conduct of clinical research with human subjects.

NIA investigators of grants, contracts, and cooperative agreements that are active as of July 1, 2021 and support human subjects research as defined by the DHS HHS OHRP regulations at 45 CFR 46 will be required to interact with and use existing and future components of CROMS as required by NIA throughout the lifecycle of the grant and as described in NOT-AG-23-017 .

Data to be submitted to NIA CROMS includes those elements reported in the standard NIH requirement annual progress report (GPS 4. 1. 15.

7). Details regarding the standard operating procedures for CROMS can be found on the NIA CROMS website . When applicable, all NIA grantees must ensure: 1.

The study’s Informed Consent Document (ICD) lists “The National Institutes of Health (NIH) and its authorized representatives” as one of the organizations that may look at or receive copies of information in participants’ study records. According to DHS HHS OHRP 45 CFR 46 §46. 116 , all ICDs must contain “A statement describing the extent, if any, to which confidentiality of records identifying the participant will be maintained.

” If using the NIA informed consent template please see Section 6: Statement of Confidentiality. 2. An assigned NIH ClinicalTrials.

gov identifier (NCT number) is reported in its respective CROMS study record within three months after assignment, and the reporting of final enrollment data to CROMS is consistent with final enrollment data reported in ClinicalTrials. gov. Investigators proposing NIH-defined clinical trials may refer to the Research Methods Resources website for information about developing statistical methods and study designs. See Section VIII.

Other Information for award authorities and regulations. Section II. Award Information Grant: A financial assistance mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity.

Application Types Allowed The OER Glossary and the How to Apply - Application Guide provides details on these application types. Only those application types listed here are allowed for this NOFO. Optional: Accepting applications that either propose or do not propose clinical trial(s).

Need help determining whether you are doing a clinical trial? Funds Available and Anticipated Number of Awards NIA intends to commit $19,600,000 in FY 2026 to fund 4 awards. Each award is limited to $4,900,000 in total costs per year.

Application budgets are limited to $4,000,000 in direct costs per year. The maximum project period is 5 years. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.

Section III.

Eligibility Information Higher Education Institutions - Includes all types Public/State Controlled Institutions of Higher Education Private Institutions of Higher Education Nonprofits Other Than Institutions of Higher Education Nonprofits with 501(c)(3) IRS Status (Other than Institutions of Higher Education) Nonprofits without 501(c)(3) IRS Status (Other than Institutions of Higher Education) For-Profit Organizations (Other than Small Businesses) City or Township Governments Special District Governments Indian/Native American Tribal Governments (Federally Recognized) Indian/Native American Tribal Governments (Other than Federally Recognized) Eligible Agencies of the Federal Government U.S. Territory or Possession Independent School Districts Public Housing Authorities/Indian Housing Authorities Native American Tribal Organizations (other than Federally recognized tribal governments) Faith-based or Community-based Organizations Foreign Organizations/ International Collaborations NIH will no longer issue awards (new, renewal, or non-competing continuation) to domestic or foreign entities that involve foreign subawards/subcontracts.

All NIH-funded research involving foreign subawards/subcontracts must be submitted in response to a NOFO that is specifically designated for funded international collaborations. This new requirement was effective, May 1, 2025. Applications involving foreign subawards/subcontracts submitted in response to this NOFO will be deemed noncompliant and will not be considered for funding.

This policy applies to all monetary international collaborations resulting in foreign subawards/subcontracts, however, it does not preclude unfunded international collaborations or foreign components , funding for foreign consultants, or procurement of unique equipment or supplies from foreign vendors. Non-domestic (non-U.S.) Entities (Foreign Organization) are not eligible to apply.

Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement , are allowed. Applicant organizations must complete and maintain the following registrations as described in the How to Apply- Application Guide to be eligible to apply for or receive an award.

All registrations must be completed prior to the application being submitted. Registration can take 6 weeks or more, so applicants should begin the registration process as soon as possible. Failure to complete registrations in advance of a due date is not a valid reason for a late submission, please reference NIH Grants Policy Statement Section 2.

3. 9. 2 Electronically Submitted Applications for additional information.

System for Award Management (SAM) – Applicants must complete and maintain an active registration, which requires renewal at least annually . The renewal process may require as much time as the initial registration. SAM registration includes the assignment of a Commercial and Government Entity (CAGE) Code for domestic organizations which have not already been assigned a CAGE Code.

NATO Commercial and Government Entity (NCAGE) Code – Foreign organizations must obtain an NCAGE code (in lieu of a CAGE code) in order to register in SAM. Unique Entity Identifier (UEI) - A UEI is issued as part of the SAM. gov registration process.

The same UEI must be used for all registrations, as well as on the grant application. eRA Commons - Once the unique organization identifier is established, organizations can register with eRA Commons in tandem with completing their Grants. gov registration; all registrations must be in place by time of submission.

eRA Commons requires organizations to identify at least one Signing Official (SO) and at least one Program Director/Principal Investigator (PD/PI) account in order to submit an application. Grants. gov – Applicants must have an active SAM registration in order to complete the Grants.

gov registration. Program Directors/Principal Investigators (PD(s)/PI(s)) All PD(s)/PI(s) must have an eRA Commons account. PD(s)/PI(s) should work with their organizational officials to either create a new account or to affiliate their existing account with the applicant organization in eRA Commons.

If the PD/PI is also the organizational Signing Official, they must have two distinct eRA Commons accounts, one for each role. Obtaining an eRA Commons account can take up to 2 weeks.

Eligible Individuals (Program Director/Principal Investigator) Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with his/her organization to develop an application for support.

For institutions/organizations proposing multiple PDs/PIs, visit the Multiple Program Director/Principal Investigator Policy and submission details in the Senior/Key Person Profile (Expanded) Component of the How to Apply - Application Guide . This NOFO does not require cost sharing as defined in the NIH Grants Policy Statement Section 1. 2- Definitions of Terms.

3. Additional Information on Eligibility Only one application per institution (normally identified by having a unique DUNS number or NIH IPF number) is allowed. The NIH will not accept duplicate or highly overlapping applications under review at the same time per NIH Grants Policy Statement Section 2.

3. 7. 4 Submission of Resubmission Application .

This means that the NIH will not accept: A new (A0) application that is submitted before issuance of the summary statement from the review of an overlapping new (A0) or resubmission (A1) application. A resubmission (A1) application that is submitted before issuance of the summary statement from the review of the previous new (A0) application.

An application that has substantial overlap with another application pending appeal of initial peer review (see NIH Grants Policy Statement 2. 3. 9.

4 Similar, Essentially Identical, or Identical Applications ). Section IV. Application and Submission Information 1.

Requesting an Application Package The application forms package specific to this opportunity must be accessed through ASSIST or an institutional system-to-system solution. A button to apply using ASSIST is available in Part 1 of this NOFO. See the administrative office for instructions if planning to use an institutional system-to-system solution.

2. Content and Form of Application Submission It is critical that applicants follow the Multi-Project (M) Instructions in the How to Apply - Application Guide , except where instructed in this notice of funding opportunity to do otherwise and where instructions in the How to Apply - Application Guide are directly related to the Grants. gov downloadable forms currently used with most NIH opportunities.

Conformance to the requirements in the How to Apply - Application Guide is required and strictly enforced. Applications that are out of compliance with these instructions may be delayed or not accepted for review. All page limitations described in the How to Apply- Application Guide and the Table of Page Limits must be followed.

Component Type for Submission Investigator-Initiated Core Instructions for the Submission of Multi-Component Applications The following section supplements the instructions found in How to Apply- Application Guide and should be used for preparing a multi-component application. When preparing the application, use Component Type ‘Overall’.

All instructions in the How to Apply - Application Guide must be followed, with the following additional instructions, as noted. SF424(R&R) Cover (Overall) PHS 398 Cover Page Supplement (Overall) Note: Human Embryonic Stem Cell lines from other components should be repeated in cell line table in Overall component. Research & Related Other Project Information (Overall) Follow standard instructions.

Project/Performance Site Locations (Overall) A summary of Project/Performance Sites in the Overall section of the assembled application image in eRA Commons compiled from data collected in the other components will be generated upon submission.

Research and Related Senior/Key Person Profile (Overall) Include only the Project Director/Principal Investigator (PD/PI) and any multi-PDs/PIs (if applicable to this NOFO) for the entire application.

The Collaboratory Director is expected to have a technical (e.g., degree in computer science, engineering, or computational biology) or statistical (e.g., degree in applied mathematics or statistics) background and to have worked collaboratively (e.g., demonstrated experience or a plan) with a team of geriatricians, neurologists, neuroscientists, biologists, and other core leaders from different backgrounds.

The proposed team must have the appropriate breadth of expertise, which may include, but is not limited to, the following: Degree in computer science, engineering, computational biology, or other similar fields, and/or relevant working experience in the AI/technology industry; Expertise in geriatrics, bioinformatics, computational biology, systems biology, biology of aging, and/or neurology and neuroscience; Expertise in study coordination, data management, and statistics; Experience conducting prototype development studies relevant to proposed areas of emphasis; Demonstrated knowledge of workflows and practices of technological innovation to improve healthcare delivery, adopted by industry or commercialized; Knowledge and understanding of the strengths and weaknesses of AI (e.g., current data models, algorithms, and approaches used by various studies and its implications) and emerging technologies; Project management experience in translating an idea to a product; Creativity and innovation (e.g., designing for adaptation of technology for older adults) to solve technical and project challenges that respect and promote participation by all relevant communities.

The activities of this award demand complex management and coordination. Therefore, the PD(s)/PI(s) must commit and sustain 3 person-months of effort per year throughout the award to manage the Collaboratory. It is anticipated that a multi-PI structure may be proposed; in such structures, each PI should contribute a minimum of 3 person-months of effort.

Multi-PD/PI leadership is highly encouraged. Core Directors must commit and sustain 3 person-months of effort to manage these cross-institutional and cross-organizational activities across all years of funding. The Executive Director for the Collaboratory must contribute 9 person-months of effort across all years of funding.

The applicant must provide evidence of how the planned collaboration will work among a team with potentially very different scientific backgrounds. Note on Key Personnel: To avoid establishing conflicts of interest throughout the field, applicants are strongly encouraged to limit the number of key personnel.

Except for those key personnel listed on the application, participation in Collaboratory activities, including presentation at workshops and conferences or receiving pilot funding, will not constitute formal collaboration from the perspective of NIH. A summary of Senior/Key Persons followed by their Biographical Sketches in the Overall section of the assembled application image in eRA Commons will be generated upon submission.

The only budget information included in the Overall component is the Estimated Project Funding section of the SF424 (R&R) Cover. The applicant must include funds for Collaboratory key personnel (e.g., PD(s)/PI(s) and Core Leaders) to attend an annual meeting in the Bethesda, MD area.

A budget summary in the Overall section of the assembled application image in eRA Commons compiled from detailed budget data collected in the other components will be generated upon submission. PHS 398 Research Plan (Overall) Introduction to Application: For Resubmission and Revision applications, an Introduction to Application is required in the Overall component.

Describe the aims of the Collaboratory and outline how different core components will contribute to these aims. Each Collaboratory must promote a sustainable research and infrastructure development program in one or more thematic areas which should be stated in the application and around which the goals, Specific Aims, and topic areas of the Collaboratory and of the Collaboratory Cores should be designed.

All Collaboratory applications must address the general aging and AD/ADRD research areas they will pursue in the Research Innovation Core. It is recommended that each applicant provide detailed milestones for each core for 5 years of proposed activities. Describe a strategic vision for the Collaboratory, addressing the overall objectives, long-term goals, and milestones of the Collaboratory.

Describe how the proposed approach will advance AI and technology approaches to benefit AD/ADRD and general aging research and/or improve the health of older adults and persons living with AD/ADRD and their caregivers.

Explain how the Collaboratory will employ principles of creativity and flexibility to facilitate innovation in the rapidly changing AI and technology research landscape, including research implementation strategies, and use of novel theoretical concepts, approaches or methodologies, or tools. Describe how different core components will interact to help accomplish the Collaboratory aims.

Where appropriate, provide timelines and organizational charts. Describe how the Collaboratory will collaborate with research project recipients. Describe how the Collaboratory will uphold best practices for responsible use of AI and emerging technologies and address issues such as algorithmic fairness and improving access and delivery of care in rural areas.

Describe plans to identify and address barriers to implementing AI and technology approaches. Explain how the proposed activities will facilitate flexible, modular, and scalable policies, practices, and tools to enable broad collaboration and participation among AI and technology researchers beyond academia.

Describe how the Collaboratory will engage nationally and work with other Collaboratories and the AITCC to stay abreast of emerging experience, regulations, and technical advances to inform approaches, methods, processes, policies, and tools used in this program. Successful Collaboratory grant applications are required to cooperate and work with the AITCC to be funded via RFA-AG-26-007 .

(PLEASE NOTE: This may require revision of the aims, data, and resource sharing statement in order to avoid overlap of activities with the AITCC.) Describe how the Collaboratory will engage in activities with the AITC/AITCC-wide Stakeholder Engagement Team led by the AITCC.

The objective of the AITCC-led Stakeholder Engagement Team is to ensure that AI approaches and technologies developed by the Collaboratories will be maximally adoptable by and accessible to their end users by soliciting stakeholder input throughout all phases of the development cycle. Progress Report for Renewal Applications Renewal applications must include descriptions of Collaboratory activities since the last competitive review.

Progress reports must be fit into the Approach section of the Research Strategy within the prescribed page limits. Individuals are required to comply with the instructions for the Resource Sharing Plans as provided in the How to Apply - Application Guide .

All instructions in the How to Apply- Application Guide must be followed, with the following additional instructions: All applicants planning research (funded or conducted in whole or in part by NIH) that results in the generation of scientific data are required to comply with the instructions