AHRQ Digital Healthcare Solutions (R21/R33) is a grant from the Agency for Healthcare Research and Quality (AHRQ) that funds research to improve patient safety and outcomes through digital health technologies. The program uses a two-phase structure: the R21 exploratory phase provides up to $280,000 over two years, and the R33 development phase provides up to $720,000 over three years. AHRQ focuses on research related to the safe design, implementation, and usability of digital healthcare tools; AI impact on patient safety; disability-inclusive healthcare; and health equity. Eligible lead applicants are U.S.-based public or nonprofit institutions; for-profit organizations may participate as subawardees or consortium partners. Applications are submitted through Grants.gov.

AI for Health is sponsored by Microsoft. A philanthropic program supporting nonprofits, researchers, and organizations working on global health challenges. It provides access to AI technology and expertise in population health, imaging analytics, and genomics & proteomics. The program aims to accelerate medical research, enhance research capabilities, increase global health insights, and address health inequities.

Digital Healthcare Solutions (R21/R33) is a grant from the Agency for Healthcare Research and Quality (AHRQ) that funds research on innovative digital tools and health information technology to improve quality and safety at the point of care. The program uses a two-phase structure: R21 awards support feasibility and development work with budgets up to $275,000, while R33 awards support efficacy testing with funding up to $1,000,000. Not all R21 awardees advance to the R33 phase, and proposals must be designed to account for this contingency. Funded projects have addressed clinical decision support systems, mobile health applications, machine learning tools for laboratory test optimization, remote therapeutic monitoring, and AI-based solutions for maternal health. Clinical trials are optional under this grant mechanism. The application deadline is August 1, 2026.

Digital Health Innovation Program is a grant from the U.S. Department of Health and Human Services (HHS), administered by the Agency for Healthcare Research and Quality (AHRQ), that funds research testing promising digital healthcare interventions at the point of care to improve the quality of healthcare services delivery. Using the Phased Innovation Award (R21/R33) mechanism, the program provides up to 2 years of initial R21 support for feasibility and up to 3 years of R33 support for clinical implementation research. Awards are available up to $500,000. Eligible applicants include small businesses in the U.S. with fewer than 500 employees, as well as academic and research institutions.

Digital Healthcare Solutions R21/R33 Grants 2026 is a funding opportunity from the National Institutes of Health (NIH) and Agency for Healthcare Research and Quality (AHRQ) that supports innovative digital healthcare solutions to improve quality at the point of care. The program funds research and development of digital health tools that enhance clinical decision-making, care coordination, and patient outcomes. Eligible applicants include researchers, providers, digital health startups, and research institutions. Awards range from up to $275,000 in direct costs over two years (R21) to up to $1,000,000 in direct costs over three years (R33). Note: PA-24-266 has expired; check NIH Guide for active successor opportunities.

Digital4Health (D4H) is a grant program from Alberta Innovates that funds partnerships between Alberta's health system and digital health innovators to accelerate adoption of innovative, technology-driven care models. The program catalyzes the deployment of digital health solutions that improve patient outcomes, enhance care delivery efficiency, and strengthen Alberta's health system. Awards of up to $200,000 per project over 24 months are available. Eligible applicants are Alberta-based organizations including academic institutions, government entities, multinationals, non-profits, and small and medium-sized enterprises. Projects must partner a health system delivery organization with a technology solution provider. Applicants should check the Alberta Innovates website for current intake status, as the program alternates between active and inactive periods.

The AHRQ R21/R33 Digital Healthcare Solutions program (PA-24-266) supports research on innovative digital health technologies deployed at the point of care, with a strong emphasis on AI-driven solutions. This is a two-phase Phased Innovation Award mechanism distinct from AHRQ's separate R18 program examining the impact of AI on healthcare safety (PA-24-261). The R21 phase provides up to 2 years of exploratory support for developing and pilot-testing digital healthcare interventions, while the R33 phase provides up to 3 years of expanded support for interventions that demonstrate promise. Eligible focus areas include AI-driven clinical workflow solutions using natural language processing and machine learning, patient-centered digital health technologies incorporating wearables, sensors, and mobile health apps, and clinical decision support systems integrating patient-generated health data. The program emphasizes solutions that improve quality of care and care delivery while addressing health equity and reducing healthcare disparities. This phased mechanism provides a structured pathway from exploratory development to expanded research, offering researchers an opportunity to prove concept before scaling with larger funding.

Leading Edge Acceleration Projects (LEAP) in Health Information Technology (Health IT) (Fiscal Year 2024) is sponsored by Office of the National Coordinator for Health Information Technology (ONC). This program offers funding for projects that improve the quality of healthcare data through AI tools and support the integration of health IT into behavioral health, helping to ensure health data enhances patient care.

Digital Health Hub Foundation Awards is a grant from the Digital Health Hub Foundation that recognizes and funds innovations in digital health technologies with the potential to transform healthcare delivery and improve patient outcomes. The program supports projects and organizations developing digital tools, platforms, and applications that address significant healthcare challenges, expand access to care, or improve the efficiency and quality of health services. Eligible applicants include startups, nonprofit organizations, and research institutions working on digital health solutions in areas such as remote patient monitoring, telehealth, artificial intelligence in clinical decision support, and patient engagement. Award recipients receive both financial support and access to the foundation's network of mentors, partners, and investors to support growth and impact.