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PCORI's Cycle 2 2026 Improving Methods funding announcement includes a dedicated track for Methods to Improve the Use of Artificial Intelligence (AI) and Machine Learning (ML) in Patient-Centered Comparative Effectiveness Research (CER). This track funds applications of AI/ML to augment or transform research methodologies or processes, and approaches using AI/ML to enhance health communication.
Individual awards provide up to $750,000 in direct costs over 3 years. Letters of intent are due April 28, 2026, with invited full applications due September 1, 2026. PCORI's broader Cycle 2 2026 also includes Broad Pragmatic Studies (up to $12M per project, $120M total), Phased Large Awards for Comparative Effectiveness Research (PLACER), and retrospective observational studies tracks.
All proposals must meaningfully engage patients and stakeholders in the research process. This represents a significant federal investment in validating and improving AI/ML methods for clinical research that directly impacts patient care decisions.
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Search similar grants →Based on current listing details, eligibility includes: U.S.-based and international research institutions, universities, and organizations capable of conducting patient-centered outcomes research. All applicants must address PCORI's Foundational Expectations for Partnerships in Research and meaningfully engage patients and stakeholders. Multi-site collaborations are encouraged. Applicants should confirm final requirements in the official notice before submission.
Current published award information indicates Individual awards up to $750,000 in direct costs over up to 3 years. Total available through Cycle 2 2026 Methods track: up to $12 million. PCORI also offers Broad Pragmatic Studies up to $12 million per project from $120 million total pool. Always verify allowable costs, matching requirements, and funding caps directly in the sponsor documentation.
The current target date is April 28, 2026. Build your timeline backwards from this date to cover registrations, approvals, attachments, and final submission checks.
Federal grant success rates typically range from 10-30%, varying by agency and program. Build a strong proposal with clear objectives, measurable outcomes, and a well-justified budget to improve your chances.
Requirements vary by sponsor, but typically include a project narrative, budget justification, organizational capability statement, and key personnel CVs. Check the official notice for the complete list of required attachments.
Yes — AI tools like Granted can help research funders, draft proposal sections, and check compliance. However, always review and customize AI-generated content to reflect your organization's unique strengths and the specific requirements of the solicitation.
Review timelines vary by funder. Federal agencies typically take 3-6 months from submission to award notification. Foundation grants may be faster, often 1-3 months. Check the program's timeline in the official solicitation for specific dates.
Many federal programs offer multi-year funding or allow competitive renewals. Check the official solicitation for continuation and renewal policies. Non-competing continuation applications are common for multi-year awards.
This is a Follow-on project to expand an existing partnership to include more grade levels and implement a student summer science program which combines hands-on science education, trail maintenance and habitat enhancement project activities. SUSD will assist BLM in developing and presenting site-specific hands-on, interactive natural and heritage resource educational programs and products for K-12 audiences. Programs will be correlated to California State Educational standards, and shall be developed in collaboration with BLM and partner technical experts to be culturally relevant to the student population and accurately and respectfully interpret local Native American culture. SUSD will utilize the expertise of its Native American Education program and shall work closely with local tribes and BLM to develop programs to meet mutual goals. Programs and products will emphasize Tread Lightly! and Leave No Trace principles and practices in order to foster a new generation of responsible outdoor recreationists and land users. Funding Opportunity Number: CA-NOI-08-0013. Assistance Listing: 15.225. Funding Instrument: CA. Category: ED. Award Amount: $30K – $374K per award.
The Bureau of Land Management, Wyoming State Office, intends to award a cooperative agreement with the Colorado State University to investigate the distribution, abundance, and habitat use of hornyhead chub in the Lower Laramie River Drainage. The anticipated length of the project is a 3 year period. The BLM will consider continued funding for the project upon (a) the recipient showing progress satisfactory to the BLM toward program goals and the determination by the BLM that continuation of the program would be in the best interest of the Government or (b) the availability of funds. The total project period for this award will not exceed 37 months. Funding Opportunity Number: WY-NOI08-9018. Assistance Listing: 15.231. Funding Instrument: CA. Category: NR. Award Amount: Up to $77K per award.