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PCORI Cycle 2 2026 Methods Funding Announcement specifically prioritizes Methods to Improve the Use of Artificial Intelligence (AI) and Machine Learning (ML) in Patient-Centered Comparative Effectiveness Research (CER).
The program funds studies addressing high-impact methodological gaps, with AI/ML topics including applications of AI/ML to augment or transform research methodologies or processes and approaches using AI/ML to enhance health communication. Additional priority areas include Methods to Support Use of Real-World Data in Multi-Site Patient-Centered CER and Methods to Improve Study Design.
Awards provide up to $750,000 in direct costs for up to 3 years from a total program budget of $12 million. Applicants must address PCORI Foundational Expectations for Partnerships in Research, ensuring patients and stakeholders meaningfully contribute lived experience. Letter of Intent deadline is April 28, 2026, with full applications due September 1, 2026.
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Search similar grants →According to the current listing, eligibility includes: Open to domestic and international organizations including academic institutions, healthcare systems, nonprofits, and for-profit entities. Must demonstrate meaningful patient and stakeholder engagement per PCORI Foundational Expectations for Partnerships in Research framework. Patients and research partners must contribute lived experience or professional expertise to advance patient-centered studies. Confirm the full requirements in the official notice before applying.
The current listing shows up to $750,000 in direct costs per award for up to 3 years. Total program funding of $12 million for the cycle. Verify award ceilings, matching requirements, and allowable costs in the official notice.
Applications for PCORI Methods for AI and Machine Learning in Patient-Centered Clinical Effectiveness Research Cycle 2 2026 are due September 1, 2026. Build your timeline backwards from this date to cover registrations, approvals, and final submission checks.
PCORI Methods for AI and Machine Learning in Patient-Centered Clinical Effectiveness Research Cycle 2 2026 is funded by Patient-Centered Outcomes Research Institute (PCORI). Verify program details on the funder's official page before applying.
Start from the official opportunity page linked in this listing — it carries the sponsor's submission instructions.
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