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Small Business Grants

SBIR, STTR, and other grants designed for small businesses and startups.

25 matching grants

U.S. Department of Defense (DOD) - Air ForceActive

Small Business Innovation Research (SBIR) Phase I - Topic AF252-P1: High Altitude Platforms

Small Business Innovation Research (SBIR) Phase I - Topic AF252-P1: High Altitude Platforms is sponsored by U.S. Department of Defense (DOD) - Air Force. DOD SBIR funds small businesses for high-altitude platform innovations, explicitly including aerostats and buoyant systems for stratospheric operations. This program should be reviewed carefully against your organization's mission, staffing capacity, timeline, and compliance readiness before you commit resources to a full application. Strong submissions usually translate sponsor priorities into concrete objectives, clear implementation milestones, and measurable public benefit. For planning purposes, treat March 20, 2026 as your working submission target unless the sponsor publishes an updated notice. A competitive project plan should include a documented need statement, implementation approach, evaluation framework, risk controls, and a realistic budget narrative. Even when a grant allows broad program design, reviewers still expect credible evidence that the proposed work can be executed within the grant period and with appropriate accountability. Current published award information indicates $75,000 - $150,000 Organizations should verify the final funding range, matching requirements, and allowability rules directly in the official opportunity materials before preparing a budget. Finance and program teams should align early so direct costs, indirect costs, staffing assumptions, procurement timelines, and reporting obligations all remain consistent throughout drafting and post-award administration. Eligibility guidance for this opportunity is: U.S. small businesses If your organization has partnerships, subrecipients, or collaborators, define responsibilities and compliance ownership before submission. Reviewers often look for implementation credibility, so letters of commitment, prior performance evidence, and a clear governance model can materially strengthen the application narrative and reduce concerns about delivery risk. A practical approach is to begin with a focused readiness review, then build a workback schedule from the sponsor deadline. Confirm required attachments, registration dependencies, and internal approval checkpoints early. This reduces last-minute issues and improves submission quality. For the most accurate requirements, always rely on the official notice and primary source links associated with Small Business Innovation Research (SBIR) Phase I - Topic AF252-P1: High Altitude Platforms.

$75,000 - $150,000Deadline: Mar 20, 2026
Empire State Development (NY State)Active

Biomedical Innovation Centers Grants

Biomedical Innovation Centers Grants is sponsored by Empire State Development (NY State). Supports NY-based biotech startups developing medical devices, including implantable drug delivery systems, to advance commercialization and clinical translation. This program should be reviewed carefully against your organization's mission, staffing capacity, timeline, and compliance readiness before you commit resources to a full application. Strong submissions usually translate sponsor priorities into concrete objectives, clear implementation milestones, and measurable public benefit. For planning purposes, treat March 31, 2026 as your working submission target unless the sponsor publishes an updated notice. A competitive project plan should include a documented need statement, implementation approach, evaluation framework, risk controls, and a realistic budget narrative. Even when a grant allows broad program design, reviewers still expect credible evidence that the proposed work can be executed within the grant period and with appropriate accountability. Current published award information indicates $100,000 - $500,000 Organizations should verify the final funding range, matching requirements, and allowability rules directly in the official opportunity materials before preparing a budget. Finance and program teams should align early so direct costs, indirect costs, staffing assumptions, procurement timelines, and reporting obligations all remain consistent throughout drafting and post-award administration. Eligibility guidance for this opportunity is: Small businesses and startups in New York State If your organization has partnerships, subrecipients, or collaborators, define responsibilities and compliance ownership before submission. Reviewers often look for implementation credibility, so letters of commitment, prior performance evidence, and a clear governance model can materially strengthen the application narrative and reduce concerns about delivery risk. A practical approach is to begin with a focused readiness review, then build a workback schedule from the sponsor deadline. Confirm required attachments, registration dependencies, and internal approval checkpoints early. This reduces last-minute issues and improves submission quality. For the most accurate requirements, always rely on the official notice and primary source links associated with Biomedical Innovation Centers Grants.

$100,000 - $500,000Deadline: Mar 31, 2026
NIHActive

NIH R01 Research Project Grant

NIH R01 Research Project Grant is sponsored by NIH. The Research Project Grant (R01) is the original and historically oldest grant mechanism used by NIH. The R01 provides support for health-related research and development based on the mission of the NIH. R01s can be investigator-initiated or can be solicited via a Request for Applications. This program should be reviewed carefully against your organization's mission, staffing capacity, timeline, and compliance readiness before you commit resources to a full application. Strong submissions usually translate sponsor priorities into concrete objectives, clear implementation milestones, and measurable public benefit. For planning purposes, treat June 15, 2026 as your working submission target unless the sponsor publishes an updated notice. A competitive project plan should include a documented need statement, implementation approach, evaluation framework, risk controls, and a realistic budget narrative. Even when a grant allows broad program design, reviewers still expect credible evidence that the proposed work can be executed within the grant period and with appropriate accountability. Current published award information indicates Up to $500,000 per year Organizations should verify the final funding range, matching requirements, and allowability rules directly in the official opportunity materials before preparing a budget. Finance and program teams should align early so direct costs, indirect costs, staffing assumptions, procurement timelines, and reporting obligations all remain consistent throughout drafting and post-award administration. Eligibility guidance for this opportunity is: Higher education institutions; Nonprofits with 501(c)(3) status; State and local governments; Small businesses; Independent research organizations If your organization has partnerships, subrecipients, or collaborators, define responsibilities and compliance ownership before submission. Reviewers often look for implementation credibility, so letters of commitment, prior performance evidence, and a clear governance model can materially strengthen the application narrative and reduce concerns about delivery risk. A practical approach is to begin with a focused readiness review, then build a workback schedule from the sponsor deadline. Confirm required attachments, registration dependencies, and internal approval checkpoints early. This reduces last-minute issues and improves submission quality. For the most accurate requirements, always rely on the official notice and primary source links associated with NIH R01 Research Project Grant.

Up to $500,000 per yearDeadline: Jun 15, 2026
Department of DefenseActive

DOD SBIR/STTR Open Topics - Autonomy and Unmanned Systems

DOD SBIR/STTR Open Topics - Autonomy and Unmanned Systems is sponsored by Department of Defense. Open solicitations for AI-driven autonomous swarms, drone tech dual-use for defense and civilian wildfire response. This program should be reviewed carefully against your organization's mission, staffing capacity, timeline, and compliance readiness before you commit resources to a full application. Strong submissions usually translate sponsor priorities into concrete objectives, clear implementation milestones, and measurable public benefit. For planning purposes, treat rolling deadlines or periodic funding windows as your working submission target unless the sponsor publishes an updated notice. A competitive project plan should include a documented need statement, implementation approach, evaluation framework, risk controls, and a realistic budget narrative. Even when a grant allows broad program design, reviewers still expect credible evidence that the proposed work can be executed within the grant period and with appropriate accountability. Current published award information indicates $100,000-$1.8M per phase Organizations should verify the final funding range, matching requirements, and allowability rules directly in the official opportunity materials before preparing a budget. Finance and program teams should align early so direct costs, indirect costs, staffing assumptions, procurement timelines, and reporting obligations all remain consistent throughout drafting and post-award administration. Eligibility guidance for this opportunity is: US small businesses, STTR includes universities If your organization has partnerships, subrecipients, or collaborators, define responsibilities and compliance ownership before submission. Reviewers often look for implementation credibility, so letters of commitment, prior performance evidence, and a clear governance model can materially strengthen the application narrative and reduce concerns about delivery risk. A practical approach is to begin with a focused readiness review, then build a workback schedule from the sponsor deadline. Confirm required attachments, registration dependencies, and internal approval checkpoints early. This reduces last-minute issues and improves submission quality. For the most accurate requirements, always rely on the official notice and primary source links associated with DOD SBIR/STTR Open Topics - Autonomy and Unmanned Systems.

$100,000-$1.8M per phaseDeadline: Rolling
National Science FoundationActive

Small Business Innovation Research (SBIR) Phase I - Manufacturing

Small Business Innovation Research (SBIR) Phase I - Manufacturing is sponsored by National Science Foundation. Supports innovative manufacturing technologies involving design engineering for small businesses. This program should be reviewed carefully against your organization's mission, staffing capacity, timeline, and compliance readiness before you commit resources to a full application. Strong submissions usually translate sponsor priorities into concrete objectives, clear implementation milestones, and measurable public benefit. For planning purposes, treat rolling deadlines or periodic funding windows as your working submission target unless the sponsor publishes an updated notice. A competitive project plan should include a documented need statement, implementation approach, evaluation framework, risk controls, and a realistic budget narrative. Even when a grant allows broad program design, reviewers still expect credible evidence that the proposed work can be executed within the grant period and with appropriate accountability. Current published award information indicates $275,000 Organizations should verify the final funding range, matching requirements, and allowability rules directly in the official opportunity materials before preparing a budget. Finance and program teams should align early so direct costs, indirect costs, staffing assumptions, procurement timelines, and reporting obligations all remain consistent throughout drafting and post-award administration. Eligibility guidance for this opportunity is: Small businesses in the US If your organization has partnerships, subrecipients, or collaborators, define responsibilities and compliance ownership before submission. Reviewers often look for implementation credibility, so letters of commitment, prior performance evidence, and a clear governance model can materially strengthen the application narrative and reduce concerns about delivery risk. A practical approach is to begin with a focused readiness review, then build a workback schedule from the sponsor deadline. Confirm required attachments, registration dependencies, and internal approval checkpoints early. This reduces last-minute issues and improves submission quality. For the most accurate requirements, always rely on the official notice and primary source links associated with Small Business Innovation Research (SBIR) Phase I - Manufacturing.

$275,000Deadline: Rolling
National Science FoundationActive

NSF Small Business Innovation Research (SBIR) Program - Environmental Technologies

NSF Small Business Innovation Research (SBIR) Program - Environmental Technologies is sponsored by National Science Foundation. Funds innovative R&D in AI, robotics, and autonomous systems for environmental monitoring and disaster response including wildfires. This program should be reviewed carefully against your organization's mission, staffing capacity, timeline, and compliance readiness before you commit resources to a full application. Strong submissions usually translate sponsor priorities into concrete objectives, clear implementation milestones, and measurable public benefit. For planning purposes, treat rolling deadlines or periodic funding windows as your working submission target unless the sponsor publishes an updated notice. A competitive project plan should include a documented need statement, implementation approach, evaluation framework, risk controls, and a realistic budget narrative. Even when a grant allows broad program design, reviewers still expect credible evidence that the proposed work can be executed within the grant period and with appropriate accountability. Current published award information indicates $275,000 Phase I; up to $1.8M Phase II Organizations should verify the final funding range, matching requirements, and allowability rules directly in the official opportunity materials before preparing a budget. Finance and program teams should align early so direct costs, indirect costs, staffing assumptions, procurement timelines, and reporting obligations all remain consistent throughout drafting and post-award administration. Eligibility guidance for this opportunity is: US small businesses If your organization has partnerships, subrecipients, or collaborators, define responsibilities and compliance ownership before submission. Reviewers often look for implementation credibility, so letters of commitment, prior performance evidence, and a clear governance model can materially strengthen the application narrative and reduce concerns about delivery risk. A practical approach is to begin with a focused readiness review, then build a workback schedule from the sponsor deadline. Confirm required attachments, registration dependencies, and internal approval checkpoints early. This reduces last-minute issues and improves submission quality. For the most accurate requirements, always rely on the official notice and primary source links associated with NSF Small Business Innovation Research (SBIR) Program - Environmental Technologies.

$275,000 Phase I; up to $1.8M Phase IIDeadline: Rolling
National Institute of Allergy and Infectious Diseases (NIAID/NIH)Active

Small Business Innovation Research (SBIR) - NIAID Drug Delivery Systems

Small Business Innovation Research (SBIR) - NIAID Drug Delivery Systems is sponsored by National Institute of Allergy and Infectious Diseases (NIAID/NIH). Supports development of implantable devices for sustained drug release to combat infectious diseases, with emphasis on long-term delivery efficacy. This program should be reviewed carefully against your organization's mission, staffing capacity, timeline, and compliance readiness before you commit resources to a full application. Strong submissions usually translate sponsor priorities into concrete objectives, clear implementation milestones, and measurable public benefit. For planning purposes, treat rolling deadlines or periodic funding windows as your working submission target unless the sponsor publishes an updated notice. A competitive project plan should include a documented need statement, implementation approach, evaluation framework, risk controls, and a realistic budget narrative. Even when a grant allows broad program design, reviewers still expect credible evidence that the proposed work can be executed within the grant period and with appropriate accountability. Current published award information indicates $50,000 - $1,800,000 Organizations should verify the final funding range, matching requirements, and allowability rules directly in the official opportunity materials before preparing a budget. Finance and program teams should align early so direct costs, indirect costs, staffing assumptions, procurement timelines, and reporting obligations all remain consistent throughout drafting and post-award administration. Eligibility guidance for this opportunity is: U.S. small businesses If your organization has partnerships, subrecipients, or collaborators, define responsibilities and compliance ownership before submission. Reviewers often look for implementation credibility, so letters of commitment, prior performance evidence, and a clear governance model can materially strengthen the application narrative and reduce concerns about delivery risk. A practical approach is to begin with a focused readiness review, then build a workback schedule from the sponsor deadline. Confirm required attachments, registration dependencies, and internal approval checkpoints early. This reduces last-minute issues and improves submission quality. For the most accurate requirements, always rely on the official notice and primary source links associated with Small Business Innovation Research (SBIR) - NIAID Drug Delivery Systems.

$50,000 - $1,800,000Deadline: Rolling
Defense Advanced Research Projects Agency (DARPA)Active

Small Business Innovation Research (SBIR) - Topic H: Bioinspired Materials

Small Business Innovation Research (SBIR) - Topic H: Bioinspired Materials is sponsored by Defense Advanced Research Projects Agency (DARPA). Funds SBIR projects on bioinspired structural materials for revolutionary defense technologies. This program should be reviewed carefully against your organization's mission, staffing capacity, timeline, and compliance readiness before you commit resources to a full application. Strong submissions usually translate sponsor priorities into concrete objectives, clear implementation milestones, and measurable public benefit. For planning purposes, treat rolling deadlines or periodic funding windows as your working submission target unless the sponsor publishes an updated notice. A competitive project plan should include a documented need statement, implementation approach, evaluation framework, risk controls, and a realistic budget narrative. Even when a grant allows broad program design, reviewers still expect credible evidence that the proposed work can be executed within the grant period and with appropriate accountability. Current published award information indicates $50,000 - $1,750,000 Organizations should verify the final funding range, matching requirements, and allowability rules directly in the official opportunity materials before preparing a budget. Finance and program teams should align early so direct costs, indirect costs, staffing assumptions, procurement timelines, and reporting obligations all remain consistent throughout drafting and post-award administration. Eligibility guidance for this opportunity is: Small businesses If your organization has partnerships, subrecipients, or collaborators, define responsibilities and compliance ownership before submission. Reviewers often look for implementation credibility, so letters of commitment, prior performance evidence, and a clear governance model can materially strengthen the application narrative and reduce concerns about delivery risk. A practical approach is to begin with a focused readiness review, then build a workback schedule from the sponsor deadline. Confirm required attachments, registration dependencies, and internal approval checkpoints early. This reduces last-minute issues and improves submission quality. For the most accurate requirements, always rely on the official notice and primary source links associated with Small Business Innovation Research (SBIR) - Topic H: Bioinspired Materials.

$50,000 - $1,750,000Deadline: Rolling
U.S. Department of Energy (DOE)Active

Small Business Innovation Research (SBIR) Phase I - Advanced Materials for Energy Technologies

Small Business Innovation Research (SBIR) Phase I - Advanced Materials for Energy Technologies is sponsored by U.S. Department of Energy (DOE). Supports SMEs developing innovative materials for energy including perovskite-based circular PV pilots, recycling, and sustainable manufacturing processes. This program should be reviewed carefully against your organization's mission, staffing capacity, timeline, and compliance readiness before you commit resources to a full application. Strong submissions usually translate sponsor priorities into concrete objectives, clear implementation milestones, and measurable public benefit. For planning purposes, treat rolling deadlines or periodic funding windows as your working submission target unless the sponsor publishes an updated notice. A competitive project plan should include a documented need statement, implementation approach, evaluation framework, risk controls, and a realistic budget narrative. Even when a grant allows broad program design, reviewers still expect credible evidence that the proposed work can be executed within the grant period and with appropriate accountability. Current published award information indicates $200,000 - $1.1 million (Phases I/II) Organizations should verify the final funding range, matching requirements, and allowability rules directly in the official opportunity materials before preparing a budget. Finance and program teams should align early so direct costs, indirect costs, staffing assumptions, procurement timelines, and reporting obligations all remain consistent throughout drafting and post-award administration. Eligibility guidance for this opportunity is: U.S. small businesses (<500 employees) If your organization has partnerships, subrecipients, or collaborators, define responsibilities and compliance ownership before submission. Reviewers often look for implementation credibility, so letters of commitment, prior performance evidence, and a clear governance model can materially strengthen the application narrative and reduce concerns about delivery risk. A practical approach is to begin with a focused readiness review, then build a workback schedule from the sponsor deadline. Confirm required attachments, registration dependencies, and internal approval checkpoints early. This reduces last-minute issues and improves submission quality. For the most accurate requirements, always rely on the official notice and primary source links associated with Small Business Innovation Research (SBIR) Phase I - Advanced Materials for Energy Technologies.

$200,000 - $1.1 million (Phases I/II)Deadline: Rolling
National Institutes of Health (NIH)Active

SBIR/STTR Phase I: AI-Powered Mental Health Interventions for Youth

SBIR/STTR Phase I: AI-Powered Mental Health Interventions for Youth is sponsored by National Institutes of Health (NIH). Supports small businesses developing innovative AI technologies for youth mental health, including therapeutic chatbots or apps for kids. Official opportunity description and requirements excerpt: SBIR and STTR Funding Opportunities | Seed An official website of the United States government U.S. Department of Health and Human Services National Institutes of Health Official websites use .gov A .gov website belongs to an official government organization in the United States. Secure .gov websites use HTTPS ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, NIH is not accepting Small Business Innovation Research (SBIR) or Small Business Technology Transfer (STTR) applications because the legislative authority for the programs expired on October 1, 2025. Active awardees should direct any questions to their Program Officer. See NOT-OD-26-006 . Learn if your company is eligible for NIH SBIR or STTR funding, how to apply , and what to expect during each step of the application process. Multiple registrations are required to prepare your application and apply for funding. Small Business Program Basics Understanding SBIR and STTR Foreign Disclosure and Risk Management Open Funding Opportunities SBIR and STTR Grants (NOFO s ) SBIR Contract Solicitations Commercialization Readiness Pilot (CRP) Small Business Transition Grant for New Entrepreneurs Navigate NIH's Research Areas Applicant Assistance Programs --> Transition Award (Coming Soon) PRODUCT DEVELOPMENT SUPPORT PRODUCT DEVELOPMENT SUPPORT Our team can help you maximize the benefits from NIH programs and resources which help you bring your innovations to life. NIH's Technical and Business Assistance (TABA) Partnering & Investment Opportunities Concept to Clinic Commercializing Innovation (C3i) The NIH is actively turning discovery into health by helping small businesses develop innovative technologies that improve health and save lives. See how . Small Business Portfolio Overview Active Small Business Awards Research Evaluation and Commercialization Hubs (REACH) Search Technologies from Academic Centers and Hubs We value biomedical innovation and strive to empower scientists and entrepreneurs to bring their discoveries to patients. HHS Small Business Program Managers SBIR and STTR Funding Opportunities Non-dilutive funding for early-stage research and development. [ Omnibus Solicitations ] [ Specific Opportunities ] SBIR and STTR grant funding opportunities offer small business entrepreneurs a chance to obtain non-dilutive funding for early-stage research and development. Applications are accepted three times a year. NIH advertises the availability of grant support through notices of funding opportunities (NOFOs), previously referred to as funding opportunity announcements (FOAs). More information on HHS SBIR contracts is available on the NIH SBIR contracts webpage . NIH has committed $20 million to support academic product development and innovation. Learn more about the five new Research Evaluation and Commercialization Hubs (REACH) in the funding opportunity announcement (RFA-OD-23-005) Follow these Application snapshot: target deadline rolling deadlines or periodic funding windows; published funding information $300,000 (Phase I); eligibility guidance Small businesses in the U.S. Use the official notice and source links for final requirements, attachment checklists, allowable costs, and submission instructions before applying.

$300,000 (Phase I)Deadline: Rolling

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