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Small businesses looking for capital that doesn't require giving up equity have a surprisingly deep pool of federal and state programs to draw from. The SBIR and STTR programs alone distribute roughly $4 billion per year across eleven federal agencies, making them the largest source of early-stage non-dilutive R&D funding in the world.
Beyond SBIR/STTR, the SBA administers direct lending programs, microloans, and community advantage loans. State economic development agencies run their own grant programs — New York's Empire State Development, California's CalCompetes, and Texas's Enterprise Fund are among the most active. USDA Rural Business Development Grants fund small businesses in communities under 50,000 population.
Award sizes vary widely. SBIR Phase I grants range from $50,000 to $275,000 for six-to-twelve-month feasibility studies. Phase II awards jump to $750,000-$1.75 million for full R&D. SBA microloans start at $500 and cap at $50,000. State programs typically fall between $10,000 and $500,000 depending on job creation commitments.
The critical first step for any small business pursuing federal grants is registering in SAM.gov and obtaining a Unique Entity ID (UEI). This process can take two to four weeks, so start well before any deadline. From there, identify programs aligned with your technology, market, and growth stage.
SBIR Phase I ($50K-$275K)
Feasibility grants across DOD, NIH, NSF, DOE, NASA, and six more agencies. Funds proof-of-concept R&D for innovative technologies meeting federal needs.
Browse grants →STTR Phase I
Similar to SBIR but requires a formal partnership with a nonprofit research institution. Company performs at least 40% of work, institution at least 30%.
Browse grants →SBA Community Advantage Loans
SBA 7(a) loans up to $350,000 through mission-focused lenders serving underserved markets. Lower barrier to entry than conventional SBA loans.
USDA Rural Business Development Grants
Grants up to $500K for small businesses in rural areas. Funds technical assistance, training, and business development activities.
Browse grants →The NAWCA U.S. Small Grants Program goal is to promote partnerships between public agencies and groups interested in:Protecting, improving, restoring, and managing an appropriate distribution and a variety of wetland ecosystems and other habitats for wetland-associated migratory birds and other fish and wildlife in the U.S.;Maintaining and improving the current distribution of wetlands-associated migratory bird populations; andMaintaining an abundance of waterfowl (ducks, geese, and swans) and other populations of wetlands-associated migratory birds consistent with the objectives of the North American Waterfowl Management Plan, U.S. Shorebird Conservation Plan, Partners in Flight Bird Conservation Plan, and state related plans.The program requires a 1:1 non-federal match. Research projects are not considered an allowable project activity. This program supports the Department of Interior and U.S. Fish and Wildlife Service's mission of protecting and managing the nation's natural resources by collaborating with partners and stakeholders to conserve land and water and to expand outdoor recreation and access.The grant program for wetlands conservation and management is administered by the U.S. Fish and Wildlife Service's Division of Bird Habitat Conservation. Thirteen partner organizations make up the North American Wetlands Conservation (NAWC) Council and participate in the review and assessment of proposals. For a full list of Council members, visit: https://www.fws.gov/partner/north-american-wetlands-conservation-council. Also, for U.S. Small scoring criteria, refer to instructions (page 23) included with this notice of funding opportunity.To view previously successful awarded NAWCA U.S. Small Projects, visit NAWCA's external facing database to query for your viewing: https://www.fws.gov/grantsum/ Funding Opportunity Number: F26AS00007. Assistance Listing: 15.623. Funding Instrument: G. Category: NR. Award Amount: $1K – $250K per award.
Public Health Strategies to Address Alzheimer's Disease and Related Dementias: The National Healthy Brain Initiative, BOLD Public Health Centers of Excellence, and Public Health Adoption Accelerator (CDC-RFA-DP-26-0227) is sponsored by Centers for Disease Control and Prevention (CDC). This initiative aims to enhance public health strategies for Alzheimer's disease and related dementias (ADRD) through three components: the National Healthy Brain Initiative for training and surveillance, BOLD Public Health Centers of Excellence for specialized efforts in risk reduction, early detection, and caregiving, and an ADRD Public Health Adoption Accelerator to disseminate effective strategies.
Alzheimer's disease, the most common form of dementia, is a progressive condition. It begins with mild memory loss and may lead to the inability to communicate or respond to one's environment. Its prevalence is rising with the aging U.S. population. In 2021, it was the 5th leading cause of death for those 65 and older, with death rates continuing to climb.The CDC Alzheimer's Disease Program, through the National Healthy Brain Initiative (HBI) and funded partners, promotes brain health, addresses cognitive impairment, and supports caregivers using evidence-based approaches. This funding opportunity aligns with the HBI Road Map Series (including the State & Local Road Map 2023–2027 and the Road Map for Indian Country) and fulfills the aims of the Building Our Largest Dementia (BOLD) Infrastructure for Alzheimer"s Act (P.L. 115-406).Funding Structure: Component 1: National Healthy Brain Initiative: Fund at least two (2) organizations to develop & implement public health strategies guided by the HBI Road Map Series. Funded organizations will: Develop evidence-informed training for health care and public health professionals on ADRD and caregiving. Expand the availability & use of public health surveillance data, including adaptation & revision of the Behavioral Risk Factor Surveillance System (BRFSS) subjective cognitive decline & caregiver optional modules. Facilitate the coordination of recipients & national partners to address ADRD. Funding range: $2,500,000 to $3,000,000 per 12-month budget period. Component 2: BOLD Public Health Centers of Excellence: Fund at least two (2) Centers, each specializing in one of three topic-specific areas: dementia risk reduction, early detection and management of dementia, or dementia caregiving. Centers will: Support the needs of the BOLD public health program and other public health agencies. Identify, disseminate, and promote best practices. Translate promising research into practical tools and resources. Increase professional education and develop materials to address specific individual needs to improve health outcomes. Funding range: $750,000 to $1,000,000 per 12-month budget period. Component 3: ADRD Public Health Adoption Accelerator. Fund up to two (2) organizations to serve as public health strategy adaptation accelerator programs. This means using dissemination and implementation of science to spread and put into practice effective public health strategies, tools, and resources to tackle ADRD. Organizations will: Collaborate with CDC and other organizations to create a prioritized list of ADRD approaches & strategies. Use proven strategies to engage partners, health care organizations, and policymakers to enhance uptake and implementation, accelerating the impact of ADRD efforts. Provide technical assistance to Component 1 & 2 recipients. Funding range: $750,000 - $1,200,000 per 12-month budget period. Applicants may apply for multiple components, but must submit a separate application per component. Funding Opportunity Number: CDC-RFA-DP-26-0227. Assistance Listing: 93.334. Funding Instrument: CA. Category: HL. Award Amount: $35M total program funding.
238 matching grants · showing 30
The Office of Naval Research (ONR) is interested in receiving proposals for developing innovative solutions that directly support the development and maintenance of a robust STEM workforce. Successful efforts will be targeted towards one or more of the following: K-12, Undergraduate, Graduate STEM education. The goal of any proposed effort should be to provide "game changing" solutions that will establish and maintain a diverse pipeline of U.S. citizens who are interested in participating in Naval STEM education programs and who ultimately will be interested in STEM careers.This BAA also separately requests proposals for the evaluation of current and future Naval STEM programs. This includes implementing methodologies and processes for data collection, analysis, and reporting, as well as methods for effectively evaluating programs and calculating return on investment for chosen programs.Only proposals invited following review of corresponding white paper will be considered for review. Funding Opportunity Number: ONRBAA13-007. Assistance Listing: 12.330. Funding Instrument: CA,G,PC. Category: ST. Award Amount: $25K – $200K per award.
This FOA issued by the National Eye Institute (NEI), National Institutes of Health (NIH), encourages applications from institutions/organizations that propose to conduct secondary data analyses utilizing existing database resources. Applications may be related to, but must be distinct from, the specific aims of the original data collection. The NEI supports an extensive portfolio of clinical trials and large-scale epidemiologic research projects, wherein numerous data collection activities are required to meet each project's specific aims. The resultant wealth of data generated by these studies often provides unique, cost-effective opportunities to investigate additional research questions or develop new analytical approaches secondary to a project's originally-intended purpose. Data are not limited to those collected under NEI support but such data are of the highest programmatic interest. The R21 may be used to develop new statistical methodologies or to test hypotheses using existing data, but this FOA may not be used to support the collection of new data. Funding Opportunity Number: PAR-13-035. Assistance Listing: 93.867. Funding Instrument: G. Category: HL. Award Amount: Up to $200K per award.
Through this announcement, the Administration for Children and Families solicits applications from local public or private non-profit organizations, including community-based and faith-based organizations, or for-profit agencies within a community that wish to compete for funds that are available to provide Migrant and Seasonal Head Start services to children and families residing in Counties within the states of Minnesota and North Dakota. Specifically, the available Minnesota counties are Grant, Ottertail, Traverse, Wilkin, Pope, Stearns, Le Sueur, Rice, Waseca, McLeod, Sibley, Carver, Wright, Marshall, Sherburne, Anoka, Hennepin, Steele, Dodge, Olmsted, Winona, Wabasha, Brown, Watonwan, Renville, Cottonwood, Clay, Redwood, Kandiyohi, Faribault, Martin, Swift, Todd, Lac qui Parle, Chippewa, Yellow Medicine, Nicollet, Meeker, Freeborn, Dakota, Fillmore, Pine, Goodhue, Ramsey, Benton, Blue Earth and Morrison. In North Dakota, the available counties are Walsh, Richland, Grand Forks, Traill, and Pembina. Funds in the amount of $9,259,441 annually will be available to provide Migrant and Seasonal Head Start program services to eligible children and their families. Interested applicants may email the OHS Operations Center at OHSTech@reviewops.org for additional information. Funding Opportunity Number: HHS-2019-ACF-OHS-CM-R12-1539. Assistance Listing: 93.600. Funding Instrument: G. Category: ISS. Award Amount: $500K – $9.3M per award.
This Funding Opportunity Announcement (FOA) will support projects proposing mechanistic studies that will transform our understanding of polysubstance use in addiction. These hypothesis-based, exploratory projects may investigate mechanisms of polysubstance use at the behavioral, cognitive, cellular, circuit, genetic, epigenetic, pharmacological and/or computational levels. Funding Opportunity Number: RFA-DA-23-015. Assistance Listing: 93.279. Funding Instrument: G. Category: ED,HL. Award Amount: Up to $350K per award.
The purpose of this FOA is to support a collection of research networks that promote multidisciplinary mechanistic studies of music-based interventions (MBIs) for pain or Alzheimers disease and Alzheimers disease related dementias (AD/ADRD). These networks are expected to develop compelling research frameworks that will guide future clinical research on MBIs in these health conditions effectively, adopt consistent terminology and taxonomy, support interdisciplinary collaborations, initiate pilot projects testing novel mechanistic hypotheses, and identify strong mechanistic measures, outcomes, biomarkers, as well as relevant novel technologies and methodologies. To accomplish these objectives, applicants can propose activities such as meetings, workshops, conferences, research collaborations, exchange of ideas through visiting scientist arrangements and training opportunities. The research networks would also provide opportunities for development of pilot projects addressing research gaps identified through network meetings and collaborative discussions, providing the necessary preliminary data needed for music and health investigators to compete for more substantial NIH grants. In addition, the networks should also engage in dissemination activities that promote and sustain their scientific impact through publications of research frameworks, common terminologies, reviews, and best practices as well as other outreach and communication strategies. Funding Opportunity Number: RFA-AT-23-006. Assistance Listing: 93.213,93.866. Funding Instrument: CA. Category: HL. Award Amount: Up to $300K per award.
The Administration for Children and Families, Office of Head Start will solicit applications from public or private non-profit organizations, including community-based and faith-based organizations, or for-profit organizations that wish to compete for funds to provide Head Start and/or Early Head Start services to eligible children and families. Funding is available in three individually defined service areas within Alabama. Interested applicants should visit the website noted in the “Link to Additional Information” to view the list of available service areas and their corresponding funding levels in this state. Applicants may email the OHS Operations Center at OHSgrants@koniag-gs.com for additional information. SAM.gov System Alert - Entity Validation Delays Due to high demand, SAM.gov is experiencing a considerable delay in processing entity legal business name and address validation tickets. As needed, please start the process early to avoid interruptions in application submissions. You can find SAM resources related to this process here - https://www.fsd.gov/gsafsd_sp?id=kb_article_view&sysparm_article=KB0058422&sys_kb_id=7bb8810ddba05990060d5425f3961912&spa=1. Funding Opportunity Number: HHS-2023-ACF-OHS-CH-R4-0177. Assistance Listing: 93.600. Funding Instrument: G. Category: ISS. Award Amount: $1M – $14.4M per award.
The Administration for Children and Families, Office of Head Start will solicit applications from public or private non-profit organizations, including community-based and faith-based organizations, or for-profit organizations that wish to compete for funds to provide Head Start and/or Early Head Start services to eligible children and families. Funding is available in one individually defined service area within Wisconsin. Interested applicants should visit the website noted in the “Link to Additional Information” to view the list of available service areas and their corresponding funding levels in this state. Applicants may email the OHS Operations Center at OHSgrants@koniag-gs.com for additional information. SAM.gov System Alert - Entity Validation Delays Due to high demand, SAM.gov is experiencing a considerable delay in processing entity legal business name and address validation tickets. As needed, please start the process early to avoid interruptions in application submissions. You can find SAM resources related to this process here - https://www.fsd.gov/gsafsd_sp?id=kb_article_view&sysparm_article=KB0058422&sys_kb_id=7bb8810ddba05990060d5425f3961912&spa=1. Funding Opportunity Number: HHS-2023-ACF-OHS-CH-R5-0184. Assistance Listing: 93.600. Funding Instrument: G. Category: ISS. Award Amount: $1M – $3.5M per award.
The Administration for Children and Families, Office of Head Start will solicit applications from public or private non-profit organizations, including community-based and faith-based organizations, or for-profit organizations that wish to compete for funds to provide Head Start and/or Early Head Start services to eligible children and families. Funding is available in one individually defined service area within Colorado. Interested applicants should visit the website noted in the “Link to Additional Information” to view the list of available service areas and their corresponding funding levels in this state. Applicants may email the OHS Operations Center at OHSgrants@koniag-gs.com for additional information. SAM.gov System Alert - Entity Validation Delays Due to high demand, SAM.gov is experiencing a considerable delay in processing entity legal business name and address validation tickets. As needed, please start the process early to avoid interruptions in application submissions. You can find SAM resources related to this process here - https://www.fsd.gov/gsafsd_sp?id=kb_article_view&sysparm_article=KB0058422&sys_kb_id=7bb8810ddba05990060d5425f3961912&spa=1. Funding Opportunity Number: HHS-2023-ACF-OHS-CH-R8-0178. Assistance Listing: 93.600. Funding Instrument: G. Category: ISS. Award Amount: $1M – $11.2M per award.
Through this Funding Opportunity Announcement (FOA), NCI, NIDA, and NCCIH invite Cooperative Agreement (U01) applications that propose prospective research studies to assess the benefits and harms of cannabis and cannabinoid use among adult cancer patients during active treatment. NCI, NIDA, and NCCIH are seeking well-designed prospective cohort studies of cancer patients with solid or hematologic tumors currently receiving treatment. Studies are expected to compare cancer patients who use cannabis/cannabinoids with cancer patients that do not use cannabis and/or cannabinoids. Research studies including diverse populations by age, sex, race/ethnicity, tumor types, and/or geography and propose population-based recruitment strategies using cancer registries are strongly encouraged. This FOA is published in parallel with RFA-CA-22-053 "Coordinating Center for Cannabis and Cannabinoid Use in Adult Cancer Patients During Treatment: Assessing Benefits and Harms (U24 Clinical Trial Not Allowed). New prospective studies and the coordinating center funded under these FOAs will work together with NIH program staff. Funding Opportunity Number: RFA-CA-22-052. Assistance Listing: 93.213,93.279,93.393. Funding Instrument: CA. Category: ED,HL. Award Amount: Up to $500K per award.
This notice announces the opportunity to apply for funding under the Delta States Rural Development Network Program (Delta Program). The Delta Program provides grant funding to support the planning, development, and implementation of integrated health care networks that collaborate in order to (i) achieve efficiencies; (ii) expand access to, coordinate, and improve the quality of basic health care services and associated health outcomes in rural areas within the eight rural Mississippi Delta Region states (Alabama, Arkansas, Illinois, Kentucky, Louisiana, Mississippi, Missouri, and Tennessee); and (iii) strengthen the rural health care system as a whole. The goals of the Delta Program are to: • Expand access to care resources in the designated Mississippi Delta counties/parishes; • Utilize evidence-based, promising practice, or value-based care models known to improve health outcomes, and enhance the delivery of health care services; • Collaborate with network partners in the planning, delivery, and evaluation of health care services to increase access to care and reduce chronic disease; and • Implement sustainable health care programs that improve population health, health outcomes, and demonstrate value to the local rural communities. The Delta Program supports and encourages innovative strategies to address delivery of preventative or clinical health services for individuals with, or at risk of developing chronic diseases that disproportionally affect the rural Mississippi Delta communities. This includes populations who have historically experienced poorer health outcomes, health disparities, and other inequities such as racial and ethnic minorities, people experiencing homelessness, pregnant women, disabled individuals, youth, and adolescents, etc. Due to the high disparities in the Mississippi Delta region1, applicants are required to propose a project based on no more than two of the following focus areas: 1) diabetes, 2) cardiovascular disease, 3) obesity, 4) acute ischemic stroke, 5) chronic lower respiratory disease, 6) cancer, or 7) unintentional injury/substance use. The Federal Office of Rural Health Policy (FORHP) selected these focus areas in an effort to address the underlying factors that are driving growing rural health disparities related to the five leading causes of avoidable death (heart disease, cancer, unintentional injury/substance use, chronic lower respiratory disease, and stroke).2 Projects are required to identify and implement an evidence-based or promising practice model and tailor the model to effectively address the needs of their community with respect to the organization’s capacity. You may find evidence-based toolkits (e.g., obesity prevention, care coordination, mental health and substance use disorder, etc.) and program models at https://www.ruralhealthinfo.org/community-health. Applicants should consider how their proposed activities can facilitate value-based care models and reimbursement strategies for their rural network partners to improve overall health outcomes and reduce costs. Funding Opportunity Number: HRSA-23-031. Assistance Listing: 93.912. Funding Instrument: G. Category: HL. Award Amount: $12M total program funding.
The purpose of the RRTCs, which are funded through the Disability and Rehabilitation Research Projects and Centers Program, is to achieve the goals of, and improve the effectiveness of, services authorized under the Rehabilitation Act through well-designed research, training, technical assistance, and dissemination activities in important topical areas as specified by NIDILRR. These activities are designed to benefit people with disabilities, family members or caregivers, rehabilitation service providers, policymakers and other research stakeholders. The purpose of this particular RRTC is to contribute to improving the community living and participation outcomes of individuals with severe mental illness (SMI) by conducting research activities and serving as a national resource center for training, technical assistance and dissemination. NIDILRR plans to make one grant under this opportunity in FY 2023. The grant will have a 60-month project period, with five 12-month budget periods. Funding Opportunity Number: HHS-2023-ACL-NIDILRR-RTCP-0023. Assistance Listing: 93.433. Funding Instrument: G. Category: ST. Award Amount: $870K – $875K per award.
The purpose of this FOA is to support basic research on signaling pathways and mechanisms including HIV-host protein interactions and post-translational modifications by which addictive drugs and HIV infection converge to induce changes in brain function and cause neuropathological alterations and neurocognitive dysfunctions. This FOA also aims to promote discovery and development of novel chemical and biological approaches for prevention or mitigation of CNS complications associated with HIV infection and substance use disorders. Funding Opportunity Number: RFA-DA-24-014. Assistance Listing: 93.279. Funding Instrument: G. Category: ED,HL. Award Amount: Up to $275K per award.
The purpose of this initiative is to advance hematopoietic cell transplantation (HCT) for all patients, but particularly for patients with rare and difficult to treat non-malignant blood diseases and hematological malignancies. This will be accomplished by supporting a clinical trials network to evaluate novel cell therapy (CT) and HCT approaches. A Data Coordinating Center (DCC) and core clinical sites will be supported by funds requested as part of this initiative, as well as a limited number of trials. Additional studies and trials will be funded through collaborations with R01-funded grantees, industry, and foundations. Multiple factors extend the duration of most HCT and CT trials beyond 5 years, including rare patient populations (and hence accrual periods of up to 5 years), complex cell manufacturing processes, and composite endpoints such as disease-free survival and chronic graft versus-host disease free survival that occur 2 or more years post-transplant. A seven year program to support these activities is needed. Funding Opportunity Number: RFA-HL-24-010. Assistance Listing: 93.395,93.839. Funding Instrument: CA. Category: ED,HL. Award Amount: Up to $150K per award.
The purpose of this RFA is to stimulate research on the development and evaluation of tobacco cessation interventions for adolescents, with an emphasis on ages 14-20. We have chosen to focus on this developmental period because it represents the area of greatest need with respect to the existing evidence on use patterns and treatment gaps. It also targets the developmental risk period for which we will see the maximum benefit from early intervention. Funding Opportunity Number: RFA-CA-22-042. Assistance Listing: 93.279,93.393. Funding Instrument: G. Category: ED,HL. Award Amount: Up to $450K per award.
The intersection of criminal-legal and community-based health systems is a critical target for addressing the overdose crisis. To support research on effective interventions and implementation strategies, the National Institute on Drug Abuse intends to continue the Justice Community Overdose Innovation Network (JCOIN) Phase II. The purpose of the network is to bring together a national consortium of investigators and practitioner partners to conduct an array of research and capacity building activities to address the overdose epidemic among individuals involved in the criminal-legal system. The structure of the network shall consist of three highly integrated components - (1) Research Hubs; (2) a single, central Coordination and Translation Center; and (3) a single, central Methodology and Advanced Analytics Resource Center. This NOFO solicits applications for a Coordination and Translation Center. This NOFO runs in parallel with a companion NOFO for the Methodology and Advanced Analytics Resource Center (NOT-DA-24-068); a NOFO for Research Hubs is anticipated at a future date (NOT-DA-25-025). Funding Opportunity Number: RFA-DA-24-069. Assistance Listing: 93.279,93.865. Funding Instrument: CA. Category: ED,HL,ISS.
This Notice of Funding Opportunity (NOFO) invites applications to continue critical ongoing network and infrastructure support for advancing development in a specific high-priority area of behavioral and social research on Alzheimers disease (AD) and AD-related dementias (ADRD): The Harmonized Cognitive Assessment Protocol (HCAP) International AD/ADRD Research Network. Network/infrastructure-building activities include but are not limited to meetings to develop novel research areas and interact on the development of infrastructure; small-scale pilots to test or tailor measures in new populations or contexts; development of guidance on selected topics such as biomarkers, diagnosis and classification of dementia, protocol development, fieldwork challenges, statistical harmonization, and analytic methods; educational activities such as intensive summer institutes, series of workshops and related network activities, or advanced seminars on methodology; dissemination and outreach activities; and coordinate activities with other related networks on AD/ADRD. Funding Opportunity Number: RFA-AG-24-035. Assistance Listing: 93.866. Funding Instrument: CA. Category: HL. Award Amount: Up to $385K per award.
As part of the NIH's Helping to End Addiction Long-term (HEAL) Initiative, the Eunice Kennedy Shriver National Institute of Child Health and Human Development and participating NIH Institutes and Centers invite applications to this U01 Cooperative Agreement funding opportunity to support innovative, multi-site, large-scale investigator-initiated clinical trials to advance the understanding, assessment, measurement, treatment, and prevention of acute pain in infants, children, and adolescents, including those with disabilities and/or experiencing health disparities. Clinical trials testing behavioral interventions to manage pain as the primary outcome(s) will not be considered as high priority projects. This Notice of Funding Opportunity (NOFO) runs in parallel with a companion NOFO (RFA-HD-24-012) that invites applications for a single HEAL KIDS Pain Resource and Data Center (RDC) to provide the following: leadership in data management, data curation, data harmonization, and the development of data standards; administrative and logistical support including oversight of NIH HEAL-related requirements; and coordination of shared research-related resources for all of the HEAL KIDS Pain research activities. Funding Opportunity Number: RFA-HD-24-011. Assistance Listing: 93.121,93.213,93.233,93.361,93.395,93.396,93.399,93.837,93.838,93.839,93.840,93.846,93.847,93.853,93.865,93.866. Funding Instrument: CA. Category: ED,FN,HL,ISS.
Reissue of RFA-NS-19-011: The purpose of the NIH Blueprint and BRAIN Initiative Diversity Specialized Predoctoral to Postdoctoral Advancement in Neuroscience (D-SPAN) Award is to support a defined pathway across career stages for outstanding graduate students who are from backgrounds that are nationally underrepresented in neuroscience research. This two-phase award will facilitate completion of the doctoral dissertation and transition of talented graduate students to strong neuroscience research postdoctoral positions, and will provide career development opportunities relevant to their long-term career goal of becoming independent neuroscience researchers. Funding Opportunity Number: RFA-NS-21-012. Assistance Listing: 93.113,93.121,93.213,93.242,93.273,93.279,93.286,93.853,93.865,93.866,93.867. Funding Instrument: G. Category: ED,ENV,HL,ISS.
Under this particular DRRP funding opportunity, applicants must propose to conduct development and knowledge translation activities to facilitate the efficient development and distribution of mobile applications for use by people with disabilities. Mobile applications developed and distributed under this priority must be used to improve outcomes among people with disabilities in one or more of NIDILRR’s outcome domains: (1) community living and participation, (2) health and function, and (3) employment. This grant will have a 60-month project period with five 12-month budget periods. Funding Opportunity Number: HHS-2024-ACL-NIDILRR-DPGE-0084. Assistance Listing: 93.433. Funding Instrument: G. Category: ST. Award Amount: $595K – $600K per award.
The Small Business Innovation Research (SBIR) Program for CHIPS for America – CHIPS Metrology seeks applications from eligible applicants to explore the technical merit or feasibility of an innovative idea or technology with the aim of developing a viable product or service that will be introduced to the commercial microelectronics marketplace. This NOFO contains multiple topics on research projects for critically needed measurement services, tools, and instrumentation; innovative manufacturing metrologies; novel assurance and provenance technologies and advanced metrology research and development (R&D) testbeds to help secure U.S. leadership in the global semiconductor industry. Funding Opportunity Number: 2024-SBIR-CHIPS-01. Assistance Listing: 11.042,11.620. Funding Instrument: CA. Category: ST.
This Notice of Funding Opportunity (NOFO) invites grant applications from institutions/organizations that propose to build a Medical Rehabilitation Research Center. The centers will have a specific rehabilitation research theme and be comprised of a research project supported by 3 cores. The 3 cores will have functions within the center as well as functions nationwide. Together, the cores will support: administrative functions (including an optional pilot program), resource sharing, and community engagement and outreach. The Medical Rehabilitation Research Centers will contribute tomedical rehabilitation research infrastructure by developing and disseminating techniques, data, theories, research programs, and expertise with the goal of enhancing the capability of medical rehabilitation investigators to understand mechanisms of functional recovery, develop therapeutic strategies, identify clinical care gaps, and improve the lives of people with disabilities. Applications must include a plan for inclusion of People with Lived Experience (as a required other attachment) that is relevant to the research theme of the center and increases the potential impact of the center. Funding Opportunity Number: RFA-HD-25-001. Assistance Listing: 93.173,93.213,93.279,93.286,93.865. Funding Instrument: G. Category: ED,HL,ISS.
Small Business Innovation Research (SBIR) / Small Business Technology Transfer (STTR) Programs (Phase I) is sponsored by U.S. Department of Agriculture (USDA) National Institute of Food and Agriculture (NIFA). The USDA SBIR/STTR programs focus on transforming scientific discovery into products and services with commercial potential and/or societal benefit in agriculturally-related areas. This can include app development for agricultural technology, rural development, and smart farming. Phase I aims to demonstrate technical feasibility.
(Reissue of RFA-NS-16-021, PAR-18-413, RFA-NS-19-039) Diffuse brain white matter disease is highly prevalent in the elderly, and has been clinically associated with vascular contributions to cognitive impairment and dementia (VCID) in both men and women. Diffuse white matter disease is thought to include a variety of pathologies including demyelination and/or fiber loss due to multifocal infarction and local ischemia. It is often accompanied by arteriosclerosis in deep penetrating arteries, multiple infarcts in the basal ganglia, brainstem or cerebellum. Though most commonly extending out from the periventricular surfaces, it may also occur in subcortical white matter. Diffuse white matter disease is typically detected in clinical settings as hyperintensity on magnetic resonance imaging (MRI) or signal loss on computed tomography x-ray (CT) scan; diffuse white matter disease can be detected histologically as well, for example in human pathology and in studies using animal models. Despite the prevalence and potential significance of white matter disease for cerebrovascular disease etiology and cognitive outcomes, much remains to be learned about the cellular and molecular causes, regional vulnerability, and progression over time. The physiological consequences of diffuse white matter disease on local axon and neural circuit function are almost completely unknown. The purpose of this FOA is to address some of the many gaps in knowledge of the biologic mechanisms of the commonly occurring, cerebrovascular disease and age-related diffuse white matter disease at the molecular, cellular, tissue and brain circuit level. The ultimate goal of this fundamental research is to inform future efforts to reduce the burden of illness due to age-related vascular contributions to cognitive impairment and dementia. Funding Opportunity Number: PAR-24-196. Assistance Listing: 93.853,93.866. Funding Instrument: G. Category: HL. Award Amount: Up to $500K per award.
The goal of this Notice of Funding Opportunity (NOFO) is to accelerate the establishment ofeffective and reliable biomarkers of Alzheimers disease (AD) and AD-related dementias (ADRD) for usein therapy/medical product discovery and development, clinical trials and/or clinical practice. Specifically, this NOFO willsupport analytical and/or clinical validationof a biomarker, composite biomarker or biomarker signature, withrigor comparable with the expectations described in the Food and Drug Administration (FDA)Biomarker Qualification Program (BQP) or recommended by other FDA regulatory pathways. Funding Opportunity Number: PAR-23-258. Assistance Listing: 93.866. Funding Instrument: CA. Category: HL.
NOAA SBIR Program is sponsored by National Oceanic and Atmospheric Administration (NOAA) SBIR. The NOAA SBIR Program funds small businesses developing innovative products with strong commercial potential that align with NOAA's mission areas. High priority is given to proposals integrating NOAA Science & Technology Focus Areas like Uncrewed Systems, Artificial Intelligence, Data and Cloud Computing. The FY25 Phase I solicitation is closed.
The Advanced Research Projects Agency for Health (ARPA-H) is posting this Innovative Solutions Opening (ISO) in support of the Emerging Health Innovators (EHI) Initiative. ARPA-H anticipates that multiple awards and award types will result from this announcement.Interested parties are invited to review the attached EHI Innovative Solutions Opening (ISO) ARPA-H-SOL-25-118 and associated Attachments. Funding Opportunity Number: ARPA-H-SOL-25-118. Assistance Listing: 93.384. Funding Instrument: CA,O. Category: ST. Award Amount: $1 – $700K per award.
The National Marine Fisheries Service (NMFS) is soliciting competitive applications for the Fiscal Year (FY) 2025 Pacific Islands Region Marine Education and Training (MET) Mini-Grant Program. Projects are being solicited to improve communication, education, and training on marine resource issues throughout the region and increase scientific education for marine related professions among coastal community residents, including indigenous Pacific islanders, Native Hawaiians, and other underserved communities in the region. Funding Opportunity Number: NOAA-NMFS-PIR-2025-29397. Assistance Listing: 11.452. Funding Instrument: CA,G. Category: ENV,NR,ST. Award Amount: $10K – $15K per award.
This notice of funding opportunity (NOFO) invites applications from eligible organizations to establish the New Approach Methodologies (NAMs) Data Hub and Coordinating Center (NDHCC) for the NIH Common Fund Complement Animal Research In Experimentation (Complement-ARIE) program. The goal of Complement-ARIE is to implement better models for understanding human health and disease outcomes across a broad array of populations that complement traditional models and make biomedical research more efficient and effective. The award made through this announcement will support Complement-ARIE by providing a centralized data hub, building a searchable repository for various NAMs data types, establishing standards for data reporting and model credibility, developing and implementing an Integrated Testing Strategies (ITS), developing strategies for interoperability, sustainability data reuse, and developing tools for data analytics, dissemination, and sharing. The awardee will also serve as the coordinating center for the overall Complement-ARIE program. Funding Opportunity Number: RFA-RM-24-013. Assistance Listing: 93.310. Funding Instrument: CA. Category: HL.
Pre-exposure prophylaxis, also known as PrEP, is a safe, highly effective medication for preventing transmission of HIV from sex or injection drug use. Despite PrEPs high efficacy and its availability for over a decade, the awareness, uptake, and adherence of PrEP, especially among people who use substances remain suboptimal. The goal of this concept is to support research to examine and address systemic and structural factors that impede or facilitate the PrEP awareness, uptake, and adherence, among people who use substances. Projects will develop, implement, and evaluate effective strategies that meet the needs of people who use substances to improve the PrEP care continuum. Funding Opportunity Number: RFA-DA-26-003. Assistance Listing: 93.279,93.307,93.310,93.313. Funding Instrument: G. Category: ED,HL. Award Amount: Up to $500K per award.
The purpose of the NHLBI Career Pathway to Independence in Blood Science Award for Physician Scientists (R00) is to increase and maintain a strong cohort of new and talented, NHLBI supported, independent investigators in blood science. This program is designed to facilitate a timely transition of outstanding blood science researchers with a clinical doctorate degree from mentored research positions to independent, tenure-track or equivalent faculty positions. This NOFO offers the opportunity for current RFA-HL-20-001 or RFA-HL-20-002 K99 awardees to apply for the independent phase (R00) of the program. In the R00 phase, successful blood science physician scientist scholars will receive up to three years of funding to continue their research activity with support from this FOA, which will require updated research plans and a limited competition review. Funding Opportunity Number: RFA-HL-26-001. Assistance Listing: 93.838. Funding Instrument: G. Category: HL. Award Amount: Up to $250K per award.
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