•Note: Each funding opportunity description is a synopsis of information in the Federal Register application notice. For specific information about eligibility, please see the official application notice. The official version of this document is the document published in the Federal Register. Free Internet access to the official edition of the Federal Register and the Code of Federal Regulations is available on GPO Access at: http://www.access.gpo.gov/nara/index.html. Please review the official application notice for pre-application and application requirements, application submission information, performance measures, priorities and program contact information. Purpose of Program: The purpose of this program is to stimulate technological innovation in the private sector, strengthen the role of small business in meeting Federal research or research and development (R/R&D) needs, increase the commercial application of the U.S. Department of Education (Department) supported research results, and improve the return on investment from federally funded research for economic and social benefits to the Nation. Catalog of Federal Domestic Assistance (CFDA) Number: 84.133S-1. If you choose to submit your application electronically, you must use the Governmentwide Grants.gov Apply site at http://www.Grants.gov. Through this site, you will be able to download a copy of the application package, complete it offline, and then upload and submit your application. You may not e-mail an electronic copy of a grant application to us. You may access the electronic grant application for the SBIR Program at: http://www.Grants.gov. You must search for the downloadable application package for this competition by the CFDA number. Do not include the CFDA number's alpha suffix in your search (e.g. , search for 84.133, not 84.133S). The telephone number for the Grants.gov Helpdesk is 1-800-518-4726 or e-mail: support@grants.gov. Funding Opportunity Number: ED-GRANTS-090908-001. Assistance Listing: 84.133. Funding Instrument: G. Category: ED. Award Amount: Up to $75K per award.

Purpose. This Funding Opportunity Announcement (FOA) solicits Small Business Innovation Research (SBIR) grant applications from small business concerns (SBCs) that propose to develop, enhance and validate translational tools to facilitate rigorous study of complementary and alternative medicine (CAM) approaches that are in wide use by the public. Recent data from the National Health Interview Survey [http://www.cdc.gov/nchs/nhis.htm] establish that Americans are utilizing CAM approaches to promote health and well-being, to treat or prevent disease, and for symptom relief. CAM approaches being widely used include massage and manipulative therapies, meditation, yoga, and acupuncture. Health conditions, particularly chronic pain, back pain and musculoskeletal pain, are the most commonly cited reasons for their use. This FOA focuses on encouraging the development of improved tools to study safety, efficacy, and clinical effectiveness of widely used CAM approaches, such as: mind-body interventions, manual therapies, yoga, and acupuncture. This FOA is not focused on tools for the study of natural products, such as herbal therapies. Mechanism of Support. This FOA will utilize the SBIR (R43/R44) grant mechanisms for Phase I, Phase II, and Fast-Track applications and runs in parallel with a FOA of identical scientific scope, RFA-AT-09-002, which solicits applications under the R01 grant mechanism. Funds Available and Anticipated Number of Awards. The estimated amount of funds available for support of 5 projects awarded as a result of this announcement is $1.25 million for fiscal year 2010. Future year amounts will depend on annual appropriations. Funding Opportunity Number: RFA-AT-09-004. Assistance Listing: 93.213. Funding Instrument: G. Category: HL. Award Amount: $1.3M total program funding.

-This Funding Opportunity Announcement (FOA) solicits Small Business Innovation Research (SBIR) grant applications from small business concerns (SBCs) for the modification or development of new screening technologies that are better able to consistently detect mild hearing loss (i.e., less than 40 dB Hearing Level or 40 dB HL) in one or both ears in infants and young children without significantly increasing the number of false positives (i.e., those who fail the screen but do not have hearing loss). -The Early Hearing Detection and Intervention (EHDI) program within the National Center for Birth Defects and Developmental Disabilities (NCBDDD) of the Centers for Disease Control and Prevention (CDC) and the National Institute on Deafness and Other Communication Disorders (NIDCD), NIH, are working to ensure infants and children with mild forms of hearing loss are identified as soon as possible. Part of this effort involves having screening technology available that can reliably detect these hearing losses. -This FOA will utilize the SBIR (R43/R44) grant mechanisms for Phase I, Phase II, and Fast-Track applications and runs in parallel with a FOA of identical scientific scope, PA-06-547, that solicits applications under the Small Business Technology Transfer (STTR [R41/R42]) grant mechanisms. Note,that CDC does not accept STTR applications so is participating only in PA-06-546. Funding Opportunity Number: PA-06-546. Assistance Listing: 93.173,93.283. Funding Instrument: G. Category: HL.

-Purpose. This Funding Opportunity Announcement (FOA) encourages Small Business Innovation Research (SBIR) grant applications from small business concerns (SBCs) that propose to develop, standardize, and validate new and innovative assays, integrated strategies, or batteries of assays that determine or predict specific organ toxicities (e.g., ocular, dermal, hematotoxicity, cardiotoxicity, gastrointestinal toxicity, hepatotoxicity, nephrotoxicity, ototoxicity, olfactory loss, bladder toxicity, neurotoxicity, pulmonary toxicity, endocrine toxicity, and pancreatic beta cell toxicity), resulting from both acute and chronic exposures to various chemicals, environmental pollutants, biologics and therapeutic molecules or drugs. In addition, this FOA encourages the development, standardization, and validation of new models of arthritis, convulsion, infection and shock. New approaches for high throughput toxicity screening that involves the use of molecular endpoints, computer modeling, proteomics, genomics and epigenomics and the development of virtual tissues are also encouraged as are development of 3-dimensional organ models for toxicity evaluation. -Mechanism of Support. This FOA will utilize the SBIR (R43/R44) grant mechanisms for Phase I, Phase II, and Fast-Track applications and runs in parallel with a FOA of identical scientific scope, PA-09-007, which encourages applications under the Small Business Technology Transfer (STTR) (R41/R42) grant mechanisms. Funding Opportunity Number: PA-09-006. Assistance Listing: 93.113,93.173,93.361,93.389,93.837,93.846,93.847,93.848,93.849,93.859,93.867. Funding Instrument: G. Category: ED,ENV,FN,HL.

Purpose. This funding opportunity announcement (FOA) solicits Small Business Innovation Research (SBIR) grant applications that propose to develop novel pharmacologic agents for brain research related to mental disorders, including research aimed at discovering new drugs for these disorders. In addition, this FOA solicits SBIR grant applications that propose to take existing, promising compounds through the next step of drug discovery and development. Finally, this FOA also encourages SBIR grant applications designed to study the effectiveness of novel interventions. Mechanism of Support. This FOA will utilize the SBIR (R43/R44) grant mechanisms for Phase I, Phase II, and Fast-Track applications. Funds Available and Anticipated Number of Awards. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications. The total amount awarded and the number of awards will depend upon the quality, duration, and costs of the applications received. Budget and Project Period. Phase I awards normally may not exceed $100,000 total for a period normally not to exceed 6 months. Phase II awards normally may not exceed $750,000 total for a period normally not to exceed 2 years. However, for this funding opportunity, budgets up to $350,000 total costs per year and time periods up to two years for Phase I may be requested. Budgets up to $600,000 total costs per year and up to three years may be requested for Phase II. Eligible Institutions/Organizations: Only United States SBCs are eligible to receive SBIR applications. A SBC is one that, on the date of award for both Phase I and Phase II funding agreements, meets ALL of the criteria as described in Section III. Eligible Project Directors/Principal Investigators: Individuals with the skills, knowledge, and resources necessary to carry out the proposed research are invited to work with their organization to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support. On an SBIR application, the PD/PI must have his/her primary employment (more than 50%) with the SBC at the time of award and for the duration of the project. Number of Applications: Applicant SBCs may submit more than one application, provided each application is scientifically distinct. Resubmissions: Applicants may submit a resubmission application, but such application must include an Introduction addressing the previous peer review critique (Summary Statement). Number of PDs/PIs. More than one PD/PI, or multiple PDs/PIs, may be designated on the application. Funding Opportunity Number: PA-08-142. Assistance Listing: 93.242. Funding Instrument: G. Category: HL.

This Funding Opportunity Announcement (FOA) solicits Small Business Innovation Research (SBIR) grant applications from small business concerns (SBCs) that propose the development and translation of technologies to improve hearing healthcare outcomes. Responsive applications must seek to increase utilization of hearing health care technology by underserved patients and thus reduce health disparities. Funding Opportunity Number: RFA-DC-12-001. Assistance Listing: 93.173. Funding Instrument: G. Category: HL. Award Amount: Up to $150K per award.

The United States Agency for International Development (USAID)’s Bureau for Food Security (BFS) under the management of the Office of Country Strategy and Implementation Support (CSI) is continuing USAID’s long-term support for the Farmer-to-Farmer (F2F) Program. This RFA is issued to solicit applications to manage F2F volunteer programs under Leader with Associate Cooperative Agreements (LWAs). The LWAs resulting from this RFA will enable USAID to continue its support for US voluntary assistance for economic growth in the agricultural sector at regional and country levels. The LWA mechanism will facilitate USAID Mission funding to expand volunteer assistance and impact on agricultural program element objectives.Issuance of this RFA does not constitute an award commitment on the part of the Government, nor does it commit the Government to pay for costs incurred in the preparation and/or submission of an application. Applicants who come under consideration for an award that have never received USAID funding will be subject to a pre-award audit to determine fiscal responsibility, ensure adequacy of financial controls, and establish an indirect cost rate (if applicable). For the purposes of this RFA, the term “Grant” is synonymous with “Cooperative Agreement”; "Grantee" is synonymous with "Recipient;" and "Grant Officer" is synonymous with "Agreement Officer". The authority for this RFA is found in the Foreign Assistance Act of 1961, as amended. USAID intends to award up to eight (8) Leader with Associate Awards in the form of Cooperative Agreements with each base program in the amount of $8 Million subject to the availability of funds. Each Leader Award will have a period of performance of up to five (5) years. Applicants may propose implementation periods of less than five (5) years (cost efficiencies and project effectiveness should be considered) but no more than five (5) years. Additional associate award(s) may be placed at a future time under a separate RFA process. Projects proposed with an implementation period of more than five (5) years will not be considered. Competition under this RFA will be conducted in two phases: • Phase I: Concept Note • Phase II: Full ApplicationEach applicant shall initially provide USAID with a Concept Note. The Concept Note shall be competitively evaluated against the pre-determined evaluation criterion. The most highly technically qualified Concept Notes will be invited to submit Part II Full Application under this RFA. Unsuccessful applicants will be notified in a timely manner and provided written feedback. Funding Opportunity Number: SOL-OAA-13-00006. Assistance Listing: 98.009. Funding Instrument: CA. Category: AG. Award Amount: Up to $8M per award.

Purpose. This Funding Opportunity Announcement (FOA), issued by the National Cancer Institute (NCI), National Institutes of Health (NIH), invites Small Business Innovation Research (SBIR) cooperative agreement applications from small business concerns (SBCs) that propose to develop new, or to improve existing application(s) of nanotechnology-based therapeutics or/and in vivo diagnostics. This FOA will specifically support pre-clinical optimization and testing of these cancer-relevant nanotechnology applications against the intended cancer type. The proposed projects must be milestone-driven and must be clearly directed toward development of an ultimate commercial product. The outcomes are expected to advance the discovery and pre-clinical optimization phase so that an Investigational New Drug (IND) or Investigational Device Exemptions (IDE) application could be submitted to the Food and Drug Administration (FDA) by the end or shortly after completion of the Phase II project period. To facilitate these steps, the NCI will assist the awardees in various ways, including the support through the NCI-sponsored Nanotechnology Characterization Laboratory. This FOA will NOT support basic research projects, studies on disease mechanisms, and clinical trials. Mechanism of Support. This FOA will utilize the SBIR (U43/U44) cooperative agreement mechanisms for Phase I and Phase II applications. Funds Available and Anticipated Number of Awards. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications. The total amount awarded and the number of awards will depend upon the quality, duration, and costs of the applications received. Funding Opportunity Number: PAR-10-286. Assistance Listing: 93.393,93.394,93.395,93.396. Funding Instrument: CA. Category: ED,HL. Award Amount: Up to $150K per award.

The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) and participating components invite grant applications for research on the development of safe, real-time, non-invasive (or minimally invasive), in vivo methods to assess the development and function of the human placenta. Funding Opportunity Number: RFA-HD-14-005. Assistance Listing: 93.286,93.865. Funding Instrument: G. Category: HL,ISS.

This Funding Opportunity Announcement (FOA) invites Small Business Innovation Research (SBIR) grant applications from small business concerns (SBCs) for funding to perform research leading to the development of innovative technologies that may advance progress for early detection and assessment of individuals at risk and for early diagnosis, prognosis and follow-up of type 1 diabetes (T1D). Funding Opportunity Number: RFA-DK-15-024. Assistance Listing: 93.847. Funding Instrument: G. Category: FN,HL. Award Amount: $2M total program funding.

The purpose of this modification is to incorporate changes to the Funding Opportunity Announcement, DE-FOA-0001429. Accordingly this modification, • Changes Submission Deadline for Replies to Reviewer Comments to 5 PM ET, April 19, 2016. To obtain a copy of the Funding Opportunity Announcement (FOA) please go to the ARPA-E website at https://arpa-e-foa.energy.gov. ARPA-E will not review or consider concept papers or full applications submitted through other means. For detailed guidance on using ARPA-E eXCHANGE, please refer to the ARPA-E eXCHANGE User Guide (https://arpa-e-foa.energy.gov/Manuals.aspx). Funding Opportunity Number: DE-FOA-0001429. Assistance Listing: 81.135. Funding Instrument: CA. Category: ST. Award Amount: $225K – $3.2M per award.

This initiative will stimulate and support innovative research by small business concerns that may lead to the development of novel technologies for the early diagnosis, monitoring and treatment of micro and macro vascular complications of diabetes which are associated with significant morbidity and mortality of the disease and high costs to the health care system. Funding Opportunity Number: PA-14-058. Assistance Listing: 93.847. Funding Instrument: G. Category: FN,HL.

This Funding Opportunity Announcement (FOA) encourages Small Business Innovation Research (SBIR) grant applications that propose to continue the process of developing complex instrumentation, clinical research tools, or behavioral interventions and mental disorders. This FOA specifically invites applications for the competing renewal of previously funded Phase II SBIR grants to further develop the aforementioned types of technologies. Funding Opportunity Number: PA-14-219. Assistance Listing: 93.242. Funding Instrument: G. Category: HL. Award Amount: Up to $800K per award.

Since its inception in 1953, SBA has served to aid, counsel, assist and protect the interests of small businesses. While SBA is best known for its financial support of small businesses through its many lending programs, the Agency also plays a critical role in providing funding to organizations that deliver technical assistance in the form of counseling and training to small business concerns and nascent entrepreneurs in order to promote growth, expansion, innovation, increased productivity and management improvement. The mission of SBA’s Office of Innovation & Technology, which bears responsibility for administering the FAST Program, is to strengthen the technological competitiveness of small businesses across the country through coordination of the Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs. The FAST program focuses on increasing the participation of small firms in the innovation and commercialization of high risk technologies, keeping the United States on the cutting edge of next generation research and development. The Federal and State Technology (FAST) Partnership Program provides one year funding to organizations to execute state/regional programs that increase the number of SBIR/STTR proposals (through outreach and financial support); increase the number of SBIR/STTR awards (through technical assistance and mentoring); and better prepare SBIR/STTR awardees for commercialization success (through technical assistance and mentoring). Funding Opportunity Number: FAST-2018-R-0012A. Assistance Listing: 59.058. Funding Instrument: G. Category: BC,ST. Award Amount: $50K – $125K per award.

This NOFO provides an opportunity to all FY 2018 NIST SBIR Phase I awardees to submit a Phase II application following completion of Phase I. This NOFO provides instructions for FY 2019 NIST SBIR Phase II application preparation and submission requirements. In Phase II, work from Phase I that exhibits potential for commercial application is further developed. Phase II is the R&D or prototype development phase. To apply for a Phase II award, each Phase I awardee will be required to submit a comprehensive application outlining the proposed research and a detailed plan to commercialize the final product. Each NIST Phase II award is for up to $400,000 and up to a 24-month period of performance. One year after completing the Phase II R&D activity, the awardee shall be required to report on its commercialization activities. Up to an additional $6,500 may be requested for Technical and Business Assistance (TABA); see Section 5.11 for more information about TABA. Funding Opportunity Number: 2019-NIST-SBIR-02. Assistance Listing: 11.620. Funding Instrument: CA. Category: ST. Award Amount: Up to $400K per award.

The purpose of this Funding Opportunity Announcement (FOA) is to encourage applications from small business concerns (SBCs) to the newly re-authorized Commercialization Readiness Pilot (CRP) program. The FOA aims to facilitate the transition of previously funded SBIR and STTR Phase II and Phase IIB projects to the commercialization stage by providing additional support for technical assistance not typically supported through Phase II or Phase IIB grants or contracts. This may include preparation of documents for a Food and Drug Administration (FDA) submission, development of an intellectual property strategy, and/or planning for a clinical trial. Although a significant amount of the work in a CRP award may be subcontracted to other organizations, the SBC is expected to maintain oversight and management of the R and D throughout the award. Clinical trials not accepted under this FOA. Funding Opportunity Number: PAR-19-334. Assistance Listing: 93.113,93.121,93.172,93.173,93.233,93.242,93.273,93.286,93.350,93.393,93.394,93.395,93.396,93.399,93.837,93.838,93.839,93.840,93.846,93.847,93.855,93.859,93.866,93.867. Funding Instrument: G. Category: ED,ENV,FN,HL.

All Phase II projects must have previously completed a successful USDA Phase I project before applying for a Phase II grant. Success rates for applicants have been 50-60% for Phase II. Projects dealing with agriculturally-related manufacturing and alternative and renewable energy technologies are encouraged across all 2018 SBIR topic areas. USDA SBIR's flexible research areas ensure innovative projects consistent with USDA's vision of a healthy and productive nation in harmony with the land, air, and water. USDA SBIR has awarded over 2000 research and development projects since 1983, allowing hundreds of small businesses to explore their technological potential and providing an incentive to profit from the commercialization of innovative ideas. Click below for more SBIR information. Funding Opportunity Number: USDA-NIFA-SBIR-008080. Assistance Listing: 10.212. Funding Instrument: G. Category: AG. Award Amount: Up to $650K per award.

The Small Business Innovation Research (SBIR) Program for CHIPS for America – CHIPS Metrology seeks applications from eligible applicants to explore the technical merit or feasibility of an innovative idea or technology with the aim of developing a viable product or service that will be introduced to the commercial microelectronics marketplace. This NOFO contains multiple topics on research projects for critically needed measurement services, tools, and instrumentation; innovative manufacturing metrologies; novel assurance and provenance technologies and advanced metrology research and development (R&D) testbeds to help secure U.S. leadership in the global semiconductor industry. Funding Opportunity Number: 2024-SBIR-CHIPS-01. Assistance Listing: 11.042,11.620. Funding Instrument: CA. Category: ST.

Small Business Innovation Research (SBIR) Program Phase I is sponsored by U.S. Environmental Protection Agency (EPA). The EPA SBIR Phase I Solicitation invites small businesses to submit proposals for projects addressing critical environmental challenges. Awards are for six months to demonstrate proof of concept. Key focus areas include Clean and Safe Water, Air Quality and Climate, Homeland Security, Circular Economy/Sustainable Materials, and Safer Chemicals.

Small Business Innovation Research (SBIR) / Small Business Technology Transfer (STTR) Programs (Phase I) is sponsored by U.S. Department of Agriculture (USDA) National Institute of Food and Agriculture (NIFA). The USDA SBIR/STTR programs focus on transforming scientific discovery into products and services with commercial potential and/or societal benefit in agriculturally-related areas. This can include app development for agricultural technology, rural development, and smart farming. Phase I aims to demonstrate technical feasibility.

Small Business Innovation Research and Technology Transfer Programs (SBIR/STTR) is sponsored by USDA National Institute of Food and Agriculture (NIFA). The USDA SBIR/STTR programs focus on transforming scientific discovery into products and services with commercial potential and/or societal benefit, particularly in agriculturally-related manufacturing and alternative and renewable energy technologies. These programs support small businesses in the creation of innovative, disruptive technologies and enable the application of research advancements from conception into the market.

The importance of prevention in combatting the opioid crisis is clear identifying and implementing effective strategies to prevent the onset of opioid misuse and use disorder and reducing the need to treat disorders yields positive individual, societal, and financial benefits. In 2020, 9.5 million people aged 12 or older misused opioids in the past year (NSDUH, 2021), suggesting that there are millions of people whose trajectories could have been changed, had they been exposed to an effective prevention strategy. Currently funded HEAL studies are testing whether existing programs shown to prevent or treat non-opioid substance use disorders might generalize to opioids. However, there remain many gaps in knowledge about how to deploy prevention services. Often effective strategies are not adopted, implemented, or scaled-up, limiting their reach and impact. There is a critical need for research to develop innovative strategies to implement and sustain prevention services that are affordable, practical, sustainable, and designed in partnership with end-users. To address these gaps, we propose an RFA with multiple receipt dates calling for investigator-initiated research that will address priorities in the implementation and sustainability of prevention services, and the creation of a prevention infrastructure. Funding Opportunity Number: RFA-DA-24-067. Assistance Listing: 93.213,93.279,93.866. Funding Instrument: G. Category: ED,HL.

This Brain-Behavior Quantification and Synchronization notice of funding opportunity (NOFO) seeks applications that bring together transdisciplinary teams and aim to 1) develop, validate, and apply cutting-edge tools and methods for minimally invasive, multi-dimensional, high-resolution objective measurement of behavior at the organismal level, with synchronous capture of dynamic environmental data; 2) develop advanced analytic approaches to integrate multidimensional behavioral, neural and environmental data; and 3) develop and test new theoretical and computational models aiming to advance understanding of behavior as a complex dynamic system. Proposed projects are expected to be designed with the capacity to integrate synchronously recorded neural data and/or inform existing models of neurobehavioral function, such as those developed with the support of the NIH BRAIN Initiative.This BRAIN Initiative NOFO is specifically soliciting applications proposing basic research involving human subjects aiming to reveal and understand fundamental principles underlying behavioral function, including research limited to observational studies or analysis of human data. Applications proposing research using exclusively non-human animal models should apply under the companion NOFO, RFA-DA-24-041. Funding Opportunity Number: RFA-DA-24-040. Assistance Listing: 93.213,93.242,93.273,93.279,93.286,93.853,93.865,93.866,93.867. Funding Instrument: CA. Category: ED,HL,ISS.

SBA Manufacturing Grants is a grant from the U.S. Small Business Administration (SBA) that funds workforce development and technical assistance programs in key manufacturing industries, including timber, energy, aluminum, steel, digital, and automotive manufacturing. The program, known as Empower To Grow (E2G) Manufacturing in America Grant, supports organizations providing hands-on training in machinery operation, quality control, welding, industrial software, and workplace safety. Eligible applicants include for-profit and nonprofit entities, small businesses, trade associations, and educational institutions that have been in continuous operation for at least three years and have experience providing manufacturing-related training. The application deadline was May 27, 2025.

Small Business Innovation Research (SBIR) Program Phase I is sponsored by Environmental Protection Agency (EPA). The EPA SBIR program funds small businesses to develop and commercialize innovative environmental technologies in broad focus areas such as clean and safe water, air quality, and sustainable materials management. Proposals should be responsive to annual topics, and Phase I awards support proof-of-concept projects. Past awards have supported app development for recycling and waste management.

America's Seed Fund (SBIR/STTR) - Cybersecurity and Authentication is sponsored by U.S. National Science Foundation (NSF). Supports startups and small businesses to translate research into products and services, including cybersecurity and authentication, to secure national defense and protect the public. Includes research requiring privacy and security-preserving resources for artificial intelligence.

State and Local Cybersecurity Grant Program (SLCGP) is sponsored by Department of Homeland Security (DHS) / FEMA / CISA. This program provides funding to eligible state, local, tribal, and territorial governments to address cybersecurity risks and threats to information systems. States are required to distribute at least 80% of funds to local governments, which may include initiatives that benefit small businesses indirectly through broader local cybersecurity improvements.

NOFO Number: DE-FOA-0003593 – Reliable Ore Characterization with Keystone Sensing SBIR/STTR (ROCKS SBIR/STTR)To obtain a copy of the Notice of Funding Opportunity (NOFO) please go to ARPA-E eXCHANGE at https://arpa-e-foa.energy.gov. To apply to this NOFO, Applicants must register with and submit application materials through ARPA-E eXCHANGE (https://arpa-e-foa.energy.gov/Registration.aspx). For detailed guidance on using ARPA-E eXCHANGE, please refer to the ARPA-E eXCHANGE User Guide (https://arpa-e-foa.energy.gov/Manuals.aspx). ARPA-E will not review or consider application materials submitted through other means. For problems with ARPA-E eXCHANGE, email ExchangeHelp@hq.doe.gov (with NOFO name and number in the subject line). Questions about this NOFO? Check the Frequently Asked Questions available at http://arpa-e.energy.gov/faq. For questions that have not already been answered, email ARPA-E-CO@hq.doe.gov. Agency Overview: The Advanced Research Projects Agency – Energy (ARPA-E), an organization within the Department of Energy (DOE), is chartered by Congress in the America COMPETES Act of 2007 (P.L. 110-69), as amended by the America COMPETES Reauthorization Act of 2010 (P.L. 111-358), as further amended by the Energy Act of 2020 (P.L. 116-260): “(A) to enhance the economic and energy security of the United States through the development of energy technologies that— (i) reduce imports of energy from foreign sources; (ii) reduce energy-related emissions, including greenhouse gases; (iii) improve the energy efficiency of all economic sectors; (iv) provide transformative solutions to improve the management, clean-up, and disposal of radioactive waste and spent nuclear fuel; and (v) improve the resilience, reliability, and security of infrastructure to produce, deliver, and store energy; and (B) to ensure that the United States maintains a technological lead in developing and deploying advanced energy technologies.” ARPA-E issues this Notice of Funding Opportunity (NOFO) under its authorizing statute codified at 42 U.S.C. § 16538. The NOFO and any cooperative agreements or grants made under this NOFO are subject to 2 C.F.R. Part 200 as supplemented by 2 C.F.R. Part 910. ARPA-E funds research on, and the development of, transformative science and technology solutions to address the energy and environmental missions of the Department. The agency focuses on technologies that can be meaningfully advanced with a modest investment over a defined period of time in order to catalyze the translation from scientific discovery to early-stage technology. For the latest news and information about ARPA-E, its programs and the research projects currently supported, see: http://arpa-e.energy.gov/. ARPA-E funds transformational research. Existing energy technologies generally progress on established “learning curves” where refinements to a technology and the economies of scale that accrue as manufacturing and distribution develop drive improvements to the cost/performance metric in a gradual fashion. This continual improvement of a technology is important to its increased commercial deployment and is appropriately the focus of the private sector or the applied technology offices within DOE. In contrast, ARPA-E supports transformative research that has the potential to create fundamentally new learning curves. ARPA-E technology projects typically start with cost/performance estimates well above the level of an incumbent technology. Given the high risk inherent in these projects, many will fail to progress, but some may succeed in generating a new learning curve with a projected cost/performance metric that is significantly better than that of the incumbent technology. ARPA-E will provide support at the highest funding level only for submissions with significant technology risk, aggressive timetables, and careful management and mitigation of the associated risks. ARPA-E funds technology with the potential to be disruptive in the marketplace. The mere creation of a new learning curve does not ensure market penetration. Rather, the ultimate value of a technology is determined by the marketplace, and impactful technologies ultimately become disruptive – that is, they are widely adopted and displace existing technologies from the marketplace or create entirely new markets. ARPA-E understands that definitive proof of market disruption takes time, particularly for energy technologies. Therefore, ARPA-E funds the development of technologies that, if technically successful, have clear disruptive potential, e.g., by demonstrating capability for manufacturing at competitive cost and deployment at scale. ARPA-E funds applied research and development (R&D). The Office of Management and Budget defines “applied research” as an “original investigation undertaken in order to acquire new knowledge…directed primarily towards a specific practical aim or objective” and defines “experimental development” as “creative and systematic work, drawing on knowledge gained from research and practical experience, which is directed at producing new products or processes or improving existing products or processes.” Applicants interested in receiving financial assistance for basic research (defined by the Office of Management and Budget as “experimental or theoretical work undertaken primarily to acquire new knowledge of the underlying foundations of phenomena and observable facts”) should contact the DOE’s Office of Science (http://science.energy.gov/). Office of Science national scientific user facilities (http://science.energy.gov/user-facilities/) are open to all researchers, including ARPA-E Applicants and awardees. These facilities provide advanced tools of modern science including accelerators, colliders, supercomputers, light sources and neutron sources, as well as facilities for studying the nanoworld, the environment, and the atmosphere. Projects focused on early-stage R&D for the improvement of technology along defined roadmaps may be more appropriate for support through the DOE applied energy offices including: the Office of Energy Efficiency and Renewable Energy (http://www.eere.energy.gov/), the Office of Fossil Energy and Carbon Management (https://www.energy.gov/fecm/office-fossil-energy-and-carbon-management), the Office of Nuclear Energy (http://www.energy.gov/ne/office-nuclear-energy), and the Office of Electricity (https://www.energy.gov/oe/office-electricity). ARPA-E encourages submissions stemming from ideas that still require proof-of-concept R&D efforts as well as those for which some proof-of-concept demonstration already exists. Submissions can propose a project with the end deliverable being an extremely creative, but partial solution. Program Overview: Rare earth elements (REEs) and critical minerals are essential for modern energy technologies. REEs are key to high-performance magnets and motors, superconductors, and catalysts—critical components to energy production, transmission, and conversion systems necessary for U.S. energy security. Affordable and secure domestic critical mineral supply chains will advance future energy competitiveness. The U.S. possesses significant domestic resources of REEs and other critical minerals but operates only one productive REE mine. The development of new mines is a multistage process that typically requires years to complete. Prospect evaluation and feasibility assessment of a hard rock mine can alone take years or even decades. The goal of the Reliable Ore Characterization with Keystone Sensing (ROCKS) program is to develop tools to evaluate the feasibility of an ore deposit in months, rather than years. This will enable rapid scoping of alternate and untapped resources. By accelerating and improving characterization, the program will enable earlier, more accurate, and lower-cost deposit assessments. A transformative increase in this capability will aid not only the development of abundant domestic REE deposits, but that of all critical minerals. Lower-cost, accurate resource characterization will enable more efficient mining with less waste rock and streamline the entire mineral processing and refining supply chain.To view the NOFO in its entirety, please visit https://arpa-e-foa.energy.gov. Funding Opportunity Number: DE-FOA-0003593. Assistance Listing: 81.135. Funding Instrument: CA,G. Category: EIC,OZ,ST. Award Amount: $314K – $4.5M per award.

The purpose of this Notice of Funding Opportunity (NOFO) is to support a Human Tissue and Organ Research Resource program to enable the continued availability of human tissues and organs to biomedical researchers. The overall goal of the research resource is to provide a wide variety of human tissues and organs, both diseased and normal, to investigators. The research resource is expected to facilitate the procurement and preservation of human tissues and organs as well as the distribution of these materials to qualified biomedical researchers. Funding Opportunity Number: PAR-24-258. Assistance Listing: 93.173,93.233,93.351,93.837,93.838,93.839,93.840,93.846,93.847,93.855,93.867. Funding Instrument: CA. Category: FN,HL.

NICHD Small Research Grant Program (R03 Basic Experimental Studies with Humans Required) is sponsored by Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). Supports clinical trials that prospectively assign human participants to conditions to assess biomedical or behavioral outcomes, focusing on fundamental aspects of phenomena without specific application towards processes or products in mind.