AI and Data Science Research Initiative

AI and Data Science Research Initiative is sponsored by National Institutes of Health (NIH). This initiative funds faculty-led research advancing artificial intelligence and data science methods with applications to real-world problems.

Cooperative Agreement (U) Grants Collaborative Opportunities for Multidisciplinary, Bold, and Innovative Neuroscience (COMBINE) Supports integrated efforts of three to six PDs/PIs to pursue a bold, impactful, and challenging goal with defined 5-year outcomes within the scope of this program and the NINDS mission.

This defined research goal must only be achievable by an interdisciplinary team approach involving innovative combination of distinct disciplines and/or intellectual viewpoints, synergy in expertise and approaches, and well-managed team interactions. Deadline: September 8, 2024 (LOI), October 8, 2024 (Proposal) Award: RM1, $500K-$1.

5M (direct) for durations up to five years Precision Mental Health: Develop Tools to Inform Treatment Selection in Depression Supports creation of a pipeline to accelerate the development and early validation of predictive tools and/or biomarkers to inform individual-level treatment selection among two or more existing therapeutics for depression.

Deadline: September 18, 2024 (LOI), October 18, 2024 (Full Proposal) Award: UG3/UH3; $500K/year (direct) for one to two years (UG3, phase 1) and $1.

5M/year (direct) for five years (UH3, phase 2) Individually Measured Phenotypes to Advance Computational Translation in Mental Health (IMPACT-MH) Supports research that will use behavioral measures and computational methods to define novel clinical signatures that can be used for individual-level prediction and clinical decision making in mental disorders. Deadline: September 18, 2024 (LOI), October 18, 2024 (Proposal) Award: U01, $2.

5M/year (direct) for durations up to five years Whole Person Research and Coordination Center Supports integration of current and emerging biomedical knowledge about human health, thereby forming a comprehensive, multi-scale human knowledge network. Deadline: October 1, 2024 (LOI), November 1, 2024 (Full Proposal) Award: U24; should not exceed $1.

5M/year (direct) for five years Combined Neuromodulation and Behavioral Treatment Algorithm Development for Stimulant Use Disorder (StUD) Enriched for Vulnerable Phenotype Supports the development of neuromodulatory devices with behavioral treatment component as a treatment for Stimulant Use Disorder (StUD).

Deadline: October 27, 2024 (LOI), November 27, 2024 (Full Proposal) Award: U01; $500K/year (direct) for five years ClinGen Genomic Curation Expert Panels Supports the establishment of Expert Panels that will select genes and genomic variants associated with diseases or conditions of high priority to participating NIH Institutes and Centers (ICs) and systematically determine their clinical significance for diagnosis and treatment of these diseases or conditions.

Deadline: April 25, 2025 (LOI), May 25, 2025 (Proposal) Award: U24, $220K/year (direct) for durations up to three years Early-Stage Development of Informatics Technologies for Cancer Research and Management Supports the development of enabling informatics technologies to improve the acquisition, management, analysis, and dissemination of data and knowledge across the cancer research continuum including cancer biology, cancer treatment and diagnosis, early cancer detection, risk assessment and prevention, cancer control and epidemiology, and/or cancer health disparities.

Deadline: October 15, 2024 (LOI), November 15, 2024 (Proposal) Award: U01, $300K/year (direct) for durations of three years Advanced Development of Informatics Technologies for Cancer Research and Management Supports advanced development and enhancement of emerging informatics technologies to improve the acquisition, analysis, visualization, and interpretation of data across the cancer research continuum including cancer biology, cancer treatment and diagnosis, early cancer detection, risk assessment and prevention, cancer control and epidemiology, and cancer health disparities.

Deadline: October 15, 2024 (LOI), November 15, 2024 (Proposal) Award: U24, $600K/year (direct) for durations of five years HEAL Initiative: Interdisciplinary Team Science to Uncover the Mechanisms of Pain Relief by Medical Devices Supports interdisciplinary research teams of multiple PDs/PIs to investigate the mechanism of action of pain relief by medical devices with the overall goal of optimizing therapeutic outcomes for FDA-approved or -cleared technologies.

Award: RM1, generally $1. 5M/year (direct) for durations up to five years Research Grants - R01 Activities BRAIN Initiative: Targeted BRAIN Circuits Projects- TargetedBCP Supports research projects that seek to understand how circuit activity gives rise to mental experience and behavior using innovative, methodologically-integrated approaches.

Deadline: September 2, 2024 (LOI), October 2, 2024 (Proposal), recurring on October 2, 2024 Award: R01, approximately $750K/year for durations up to five years Leveraging Health Information Technology (Health IT) to Address and Reduce Health Care Disparities Supports research that examines the impact of leveraging health information technology (health IT) to reduce disparities in access to and utilization of health care services, patient-clinician communication, and health outcomes for populations that experience health disparities in the U.S. Deadline: September 5, 2024 (LOI), October 5, 2024 (Proposal); annually in February, June, and October through Feb 2025 Award: R01, budget must align with the project scope, for durations up to five years Accelerating the Pace of Child Health Research Using Existing Data from the Adolescent Brain Cognitive Development (ABCD) Study Supports the analysis of the Adolescent Brain Cognitive Development (ABCD) dataset to increase knowledge of adolescent health and development.

Deadline: September 5, 2024 (LOI), October 5, 2024 (Proposal); annually in February, June, October through Feb 2025 Award: R01, $250K/year (direct) for durations up to five years ( R21 also available) NLM Research Grants in Biomedical Informatics and Data Science Supports innovative research and development in biomedical informatics and data science.

This funding opportunity focuses on biomedical discovery and data-powered health, integrating streams of complex and interconnected research outputs that can be translated into scientific insights, clinical care, public health practices, and personal wellness.

Deadline: September 5, 2024 (LOI), October 5, 2024 (Proposal); annually in February, June, and October through 2025 Award: R01, $250K/year (direct) for durations up to four years Secondary Analysis and Integration of Existing Data to Elucidate Cancer Risk and Related Outcomes Supports secondary data analysis and integration of existing datasets and database resources, with the ultimate aim to elucidate cancer risk and related outcomes (e.g., risk prediction or reduction, survival, or response to treatment, etc.).

Deadline: September 5, 2024 (LOI), October 5, 2024 (Proposal); recurring annually in February, June, and October through June 2026 Award: R01, $350K/year (direct) for durations of up to five years ( R21 also available) Addressing the Impact of Structural Racism and Discrimination on Minority Health and Health Disparities Supports intervention research that addresses structural racism and discrimination (SRD) in order to improve minority health or reduce health disparities.

Deadline: September 9, 2024 (LOI), October 9, 2024 (Proposal), recurring October 9, 2025 Award: R01, $500K/year (direct) for durations up to five years BRAIN Initiative: Research on the Ethical Implications of Advancements in Neurotechnology and Brain Science Supports efforts addressing core ethical issues associated with research focused on the human brain and resulting from emerging technologies and advancements supported by the BRAIN Initiative.

Deadline: September 11, 2024 (LOI), October 11, 2024 (Proposal); recurring on October 10, 2025 and October 9, 2026 Award: R01, $300K/year (direct) for durations up to four years; R21 Opportunity is also available.

Modular R01s in Cancer Control and Population Sciences Supports research efforts on novel scientific ideas that have the potential to substantially advance cancer research in statistical and analytic methods, epidemiology, cancer survivorship, cancer-related behaviors and behavioral interventions, health care delivery, digital health and data science, and implementation science.

Deadline: October 5, 2024 Award: R01, $250K/year (direct) for durations up to five years Investigator Initiated Research in Computational Genomics and Data Science Supports a broad range of research efforts in computational genomics, data science, statistics, and bioinformatics relevant to one or both of basic or clinical genomic science, and broadly applicable to human health and disease.

Deadline: October 5, 2024 Award: R01, $500K/year (direct) for durations of up to five years ( R21 also available) Focused Technology Research and Development Supports projects that focus solely on the development of technologies with the potential to enable acquisition of biomedical knowledge. Projects should be justified in terms of technical innovation and utility of such technical innovation for impacting future biomedical research.

Deadline: October 5, 2024; recurring in February, June, and October through February 2025 Award: R01, budget must reflect actual needs of the proposed project, durations up to five years R21 Opportunity also available.

Imaging, Biomarkers and Digital Pathomics for the Early Detection of Premetastatic Cancer and Precancerous Lesions Associated with Lethal Phenotypes Supports the development of state-of-the-art projects that integrate imaging, biomarkers, digital pathomics, glycomics, metabolomics, other omic information and/or meta data obtained from platforms including but not limited to lower resolution diagnostic acquisitions and systemic biomarker results to high resolution single-cell analytics / imaging applied to the characterization of heterogeneous cell populations within tumor for improving current approaches for: (1) the early detection of organ confined premetastatic aggressive cancer, and, (2) identifying precancerous lesions associated with the development of a subsequent lethal phenotype.

Deadline: October 5, 2024; recurring annually in February, June, and October through June 2025 Award: R01, budget must reflect actual needs of the proposed project, durations up to five years NIDCR Research Grants for Analyses of Existing Genomics Data Supports meritorious research projects that address research questions relevant to human dental, oral, or craniofacial (DOC) biology, and diseases and conditions, through analysis of existing and publicly available genomic data, with or without other types of complementary data, using statistical and computational approaches.

Deadline: October 5, 2024, recurring annually in February, June, and October through February 2026 Award: R01, budget must align with the project scope, for durations of up to three years. ( R03 Opportunity also available.)

Personal Health Informatics for Delivering Actionable Insights to Individuals Supports development of novel informatics and data science approaches that can help individuals understand and improve their health through actionable insights.

Deadline: October 5, 2024, recurring annually in February, June, and October through October 2026 Award: R01, $250K/year (direct) for durations of up to four years Academic-Industrial Partnerships (AIP) to Translate and Validate In Vivo Imaging Systems Supports translation of scientific discoveries and engineering developments in imaging, data science and/or spectroscopic technologies into methods or tools that address contemporary problems in understanding the fundamental biology, potential risk of development, diagnosis, or treatment of cancer.

Deadline: October 5, 2024, recurring annually in February, June, and October through October 2026 Award: R01, $500K/year (direct) for durations of up to five years New Approaches for Measuring Brain Changes Across Longer Timespans Supports multidisciplinary investigators to develop new approaches or apply existing approaches in novel ways to measure brain activity, connectivity, genomics, or other aspects across the age spectrum of neurodevelopment.

Deadline: October 5, 2024; recurring in February, June, and October through February 2027 Award: R01, budget must reflect actual needs of the proposed project, durations up to five years; R21 opportunity also open B-INSPIRE: Research on Behavioral Interventions that Promote Careers in the Biomedical Research Enterprise Supports research designed to conduct studies of behavioral interventions to enhance research-oriented individuals’ interest, motivation, persistence and preparedness for careers in the biomedical research workforce.

Applications that propose conducting secondary data analysis of rigorous interventions, leveraging existing intervention cohorts, using new or advanced methods of analysis of rigorous intervention datasets, or general novel combinations and integration of rigorous intervention datasets for analysis, are also encouraged.

Deadline: October 17, 2024; October 15, 2025; October 14, 2026 Award: R01, budgets over $500K/year require notification 6 weeks prior to deadline, durations up to five years Ethical, Legal and Social Implications (ELSI) Research Supports the study of the ethical, legal and social implications (ELSI) of human genome research, using either single or mixed methods.

Deadline: October 21, 2024; recurring annually in February, June, and October through October 2026 Award: R01, budget must align with the project scope, for durations of three to five years ( R21 and R03 also available) Advancing Genomic Medicine Research Supports proposals that stimulate innovation and advance understanding of when, where, and how best to implement the use and sharing of genomic information and technologies in clinical care provided to all persons irrespective of racial/ethnic background or socioeconomic status.

Deadline: February 11, 2025 Award: R01, $500K/year (direct) for durations up to five years( R21 Opportunity also available) Standardizing Data and Metadata from Wearable Devices Supports the creation of standards for data as well as metadata and related coordination activities that will allow researchers to easily access data from personal tracking devices and integrate those data for subsequent data analysis.

Deadline: May 10, 2025 (LOI), June 10, 2025 (Proposal); recurring on June 10, 2026 Award: R01, budget must align with the project scope, for durations of four years Research Grants - Other Activities Research Experience in Genomic Research for Data Scientists Supports educational activities that encourage individuals from diverse backgrounds, including those from groups underrepresented in the biomedical and behavioral sciences, to pursue further studies or careers in research.

Deadline: Anticipated May 2024 Award: R25, $250K/year (direct) for durations up to five years Examining the Impact of Artificial Intelligence (AI) on Healthcare Safety Supports healthcare safety by determining (1) whether and how certain breakthrough uses of Artificial Intelligence (AI) systems can affect patient safety; and (2) how AI systems can be safely implemented and used.

AI has the potential to improve the safety, effectiveness, efficiency, accessibility, and affordability of healthcare.

Deadline: Estimated to be Fall 2024 Award: R18; Additional details coming wtih announcement BRAIN Initiative: Targeted BRAIN Circuits Planning Projects – TargetedBCPP Supports research projects that offer a limited scope of aims and an approach that will establish feasibility, validity, or other technically qualifying results that, if successful, would support, enable, and/or lay the groundwork for a potential, subsequent Targeted BRAIN Circuits Projects - Targeted BCP R01.

Deadline: September 2, 2024 (LOI), October 2, 2024 (Proposal) Award: R34, $450K for durations up to two years Examining the Impact of Artificial Intelligence (AI) on Healthcare Safety Supports healthcare safety by determining (1) whether and how certain breakthrough uses of Artificial Intelligence (AI) systems can affect patient safety; and (2) how AI systems can be safely implemented and used.

Deadline: September 25, 2024, recurring in January, May, and September on the 25th through May 26, 2027 Award: R18, $1M (total) for durations up to two years Enhancing Mechanistic Research on Precision Probiotic Therapies Supports highly innovative mechanistic research to accelerate the development of effective precision probiotic interventions using a milestone-driven, biphasic award mechanism.

Deadline: October 1, 2024; recurring on June 2, 2025, February 2, 2026, October 1, 2026, June 2, 2027 Award: R61/R33; $350K/year (direct) for total duration up to five years (with one to two years for R61) NEI Research Grant for Vision-Related Secondary Data Analysis Supports vision-related secondary data analyses utilizing existing database resources.

Deadline: October 16, 2024 annually in February, June, and October through Feb 2025 Award: R21, $275K (direct) for durations up to two years Developing Novel Theory and Methods for Understanding the Genetic Architecture of Complex Human Traits Supports applications for novel theory and methods development that enable better understanding of how genetic and non-genetic factors contribute to complex trait variation across individuals, families, and populations.

Deadline: October 16, 2024, recurring February, June, and October 16 through October 2026 Award: R21, $275K total (direct) for durations up to two years D-START: Data Science Track Award for Research Transition (D/START) Supports investigators interested in applying cutting-edge data science techniques to address timely and challenging research questions related to substance use and/or substance use disorder (SUD) in all areas of research supported by the National Institute on Drug Abuse (NIDA).

Deadline: October 16, 2024, recurring February, June, and October 16 through June 2027 Award: R03, $100K/year (direct) for durations up to two years Secondary Analysis of Existing Datasets in Heart, Lung, and Blood Diseases and Sleep Disorders Supports secondary analyses using existing human datasets in areas relevant to the National Heart, Lung, Blood Diseases and Sleep Disorders Institute (NHLBI) scientific mission.

Deadline: October 28, 2024; recurring in February and October through 2025 Award: R21, $75K/year (direct) for durations up to two years Building Sustainable Software Tools for Open Science Supports sustainability and impact of research software tools by enabling the use of best practices and design principles in software development and by leveraging continuing advances in computing.

Deadline: November 4, 2024 (LOI), December 4, 2024 (Proposal); recurring on June 4 and December 4 through 2026 Award: R03, $300K (direct) for durations up to two years Research Software Engineer (RSE) Award Supports salary for exceptional Research Software Engineers (RSEs) that contribute their skills to the development and dissemination of biomedical, behavioral or health related software, tools, and algorithms as well as to the training of prospective users of these tools.

Deadline: November 4, 2024 (LOI), December 4, 2024 (Proposal); recurring on June 4 and December 4 through 2026 Award: R50, $300K (direct) for durations up to three years Education Activities for Responsible Analyses of Complex, Large-Scale Data Supports training and educational activities for responsible analyses of complex large-scale data involving brain, behavioral, genomic, and socioenvironmental data that complement and/or enhance the training of a workforce to meet the nation’s biomedical, behavioral, and clinical research needs.

Deadline: November 18, 2024 (LOI), December 18, 2024 (Proposal) Award: R25, $300K/year (direct) for durations up to three years Research on Bioethical Issues Related to Bionic and Robotic Device Development and Translation Supports greater integration of bioethics within research and develop a robust bioethics research evidentiary base to inform policy and program decision-making.

Deadline: January 21, 2025 Award: R21, $275K direct for durations up to two years BRAIN Initiative: Data Archives for the BRAIN Initiative Supports applications to develop web-accessible data archives to capture, store, and curate data related to the Brain Research Through Advancing Innovative Neurotechnologies® (BRAIN) Initiative activities.

Deadline: June 24, 2025; recurring June 24, 2026 Award: R24; budget must align with the project scope, for durations of up to five years NHLBI TOPMed: Omics Phenotypes of Heart, Lung, and Blood Disorders Supports use of NHLBI-funded TransOmics for Precision Medicine (TOPMed) program to generate a large volume of integrated genetic and multi-omics data to facilitate discovery of the molecular mechanisms of Heart, Lung, Blood, and Sleep (HLBS) disorders.

Deadline: September 17, 2024 (LOI), October 17, 2024 (Proposal) Award: X01, access to data resource for up to three years Diagnostic Centers of Excellence Supports access to resources provided by the Data Management Coordinating Center for Diagnostic Centers of Excellence (RFA-NS-22-051), as part of the next phase of the Undiagnosed Diseases Network.

Deadline: April 15, 2025 (LOI), May 15, 2025 (Proposal) Award: X01, access to data resource for up to three to five years Notices of Special Interest and Requests for Information Notice of Information: Enabling Research, Training, and Career Development by Analyzing Data Collected by the All of Us Research Program Clinical and Translational Science Award (CTSA) Program: Collaborative and Innovative Acceleration Award (UG3/UH3) (Clinical Trial Optional) for Advancing Recruitment through Trial Innovation Network (AR-TIN) expires October 18, 2024.

High-Priority Interest to Enhance Data Science Research Training in Addiction Research expires December 9, 2024. IDEA2Health: Innovative Data Evaluation and Analysis to Health expires January 8, 2025. Validation of Digital Health and Artificial Intelligence/Machine Learning Tools for Improved Assessment in Biomedical and Behavioral Research expires July 6, 2025.

Competitive Revision Supplements to Existing T32 Programs to Include Institutional Research Training in Data Science for Infectious and Immune Mediated Diseases , expires January 8, 2025. Leveraging Data Science to Bring Actionable Insights for Substance Use Prevention and Treatment expires September 8, 2025.

Development and Implementation of Clinical Informatics Tools to Enhance Patients Use of Genomic Information expires September 25, 2025. HEAL Initiative: Leveraging Inpatient Medical or Surgical Hospitalizations to Improve Outcomes for People Who Use Drugs expires November 13, 2025. Optimization of Data Storage and Utilization for the Sequence Read Archive (SRA) expires December 19, 2025.

Computational and Statistical Methods to Enhance Discovery from Health Data expires January 8, 2026. Explainable Artificial Intelligence for Decoding and Modulating Neural Circuit Activity Linked to Behavior expires February 6, 2026. Applications of Data Science in Translational Dental, Oral, and Craniofacial Research expires May 8, 2026.

Secondary Analyses of Existing Alcohol Research Data expires September 6, 2026. Promoting Data Reuse for Health Research expires November 4, 2026. Notice of Special Interest: R13 Support for Conferences and Scientific Meetings to Support Consensus Building for Autoimmune Disease Research Related Common Data Elements , expires December 14, 2026.

Funding Opportunity Resources