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Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative is sponsored by Department of Health And Human Services. To provide extramural research support for the Brain Research Through Advancing Innovative Neurotechnologies® (BRAIN) Initiative’s aim of revolutionizing our understanding of the brain and its function in unprecedented detail.
The NIH BRAIN Initiative’s focus is foundational development of new technologies and tools to map, monitor, and modulate brain circuits in model systems and humans – toward the ultimate goal of treating and curing human brain disorders. BRAIN Initiative research adheres to open, and ethical science.
BRAIN-supported research areas include comprehensive cataloguing, mapping, accessing and characterization of brain cell types ; probing neural circuits that interact and produce behavior, cognition, and emotion; developing and employing new technologies to monitor function and connectivity of synapses, circuits, and whole brains; partnering with human research participants, including utilizing neurotechnologies in first-in-human clinical studies, to study the human brain in the context of brain injury and brain disorders; and establishing data-sharing platforms and computational models that help decode brain processes and functions.
Within these scientific focus areas, the Initiative supports research project grants, cooperative agreements, workforce development awards and Small Business Innovation Research awards. Research supported by the Initiative has a strong commitment to broad dissemination of newly developed technologies, and to considering neuroethical issues related to studying the human brain and the neuroscience advances that follow from this research.
New frontiers for BRAIN research will adhere to, and build on, what has been learned to date and adapt to the rapidly changing scientific landscape and neuroscience ecosystem. This listing is currently active. Program number: 93.
BZ1. Last updated on 2026-01-28.
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The Brain Research Through Advancing Innovative Neurotechnologies ® (BRAIN) Initiative Revolutionizing our understanding of the human brain Image Courtesy of Andrew Janson, University of Utah Scientific Computing and Imaging Institute (Show Us Your BRAINs! Photo & Video Contest 2019) Image Courtesy of Andrew Janson, University of Utah Scientific Computing and Imaging Institute (Show Us Your BRAINs!
Photo & Video Contest 2019) Latest from The BRAIN Blog The BRAIN Blog covers updates and announcements on BRAIN Initiative research, events, and news. The BRAIN Initiative congratulates BRAIN contributors Dr. Nancy Kanwisher, Dr. Winrich Freiwald, and Dr. Doris Tsao, co-recipients of the 2024 Kavli Prize in Neuroscience. The winners of the 2024 photo and video contest have been announced!
Art meets science in this year's colorful and creative submissions. NIH BRAIN Initiative Director Dr. John Ngai discusses the impact of BRAIN-funded research and the importance of innovation and technology in revolutionizing our understanding of the human brain. In his Director's Corner, you'll find insights on BRAIN-funded studies, news stories of interest, and multimedia highlights.
Explore Director's Corner 2026 BRAIN Initiative Conference BRAIN Multi-Council Working Group (MCWG) Meeting – May 2026 Brain Cell Atlas: From Data to Knowledge Workshop Last reviewed on July 02, 2025
According to the current listing, eligibility includes: Public, private, -profit, or nonprofit agencies (including State and local government agencies), eligible Federal agencies, universities, colleges, hospitals, and academic or research institutions may apply for research grants. SBIR grants can be awarded only to domestic small businesses, and STTR grants can be awarded only to domestic small businesses which "partner" with a research institution in cooperative research and development. An applicant for individual predoctoral fellowship support must be enrolled in a research doctoral degree program by the proposed activation date of the fellowship. A postdoctoral applicant must have received a Ph.D., Psy.D., M.D., D.D.S., Sc.D., D.N.S., D.O., D.S.W., or equivalent degree from an accredited institution to be eligible for an individual postdoctoral fellowship. All research training awards are made to appropriate domestic research centers, medical schools, departments of psychiatry, non-medical academic departments, psychiatric hospitals or hospitals with psychiatric services, community mental health centers, and biomedical research institutes on behalf of individuals who need the opportunity to realize research potential. Except for the NIH Pathway to Independence (PI) Award (K99/R00), the individuals must be citizens or nationals of the United States or have been lawfully admitted for permanent residence. The NIH Pathway to Independence (PI) Award (K99/R00) is open to both U.S. citizens and non-U.S. citizens. Individuals must qualify by scholastic degree and previous training and/or experience. Eligible applicant types include: Nonprofit Organization, Tribal, Foreign Non-Government Not-for-Profit Organization, Foreign Non-Governmental For-Profit Organization, International Organization, Not-for-Profit Organization, For-Profit Organization, Foreign Non-Government Nonprofit Organization. Confirm the full requirements in the official notice before applying.
The current listing shows recent federal obligations suggest $248,797,978 (2026). Verify award ceilings, matching requirements, and allowable costs in the official notice.
Yes — Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative is offered by Department of Health And Human Services and this listing comes from SAM.gov, an official U.S. federal source. Federal applications generally require registrations (for example SAM.gov or an agency submission portal), so allow extra lead time.
Start from the official opportunity page linked in this listing — it carries the sponsor's submission instructions.
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This Funding Opportunity Announcement (FOA) invites Small Business Innovation Research (SBIR) grant applications from small business concerns (SBCs) for funding to perform research leading to the development of innovative technologies that may advance progress for early detection and assessment of individuals at risk and for early diagnosis, prognosis and follow-up of type 1 diabetes (T1D). Funding Opportunity Number: RFA-DK-15-024. Assistance Listing: 93.847. Funding Instrument: G. Category: FN,HL. Award Amount: $2M total program funding.
This initiative will stimulate and support innovative research by small business concerns that may lead to the development of novel technologies for the early diagnosis, monitoring and treatment of micro and macro vascular complications of diabetes which are associated with significant morbidity and mortality of the disease and high costs to the health care system. Funding Opportunity Number: PA-14-058. Assistance Listing: 93.847. Funding Instrument: G. Category: FN,HL.
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