Investigators in the Pathogenesis of Infectious Disease Grant Program

Investigators in the Pathogenesis of Infectious Disease Grant Program is sponsored by Burroughs Wellcome Fund. Supports early-career assistant professors studying human infectious diseases.

Investigators in the Pathogenesis of Infectious Disease - Burroughs Wellcome Fund Investigators in the Pathogenesis of Infectious Disease Letter of Intent Deadline Now Accepting Letters of Intent Share this Grant Apply Now The Investigators in the Pathogenesis of Infectious Disease (PATH) program provides opportunities for assistant professors to bring multidisciplinary approaches to studying human infectious diseases.

The program aims to provide accomplished investigators at the assistant professor level with opportunities to study what happens at the points where the systems of humans and potentially infectious agents connect.

The program supports research that sheds light on the fundamentals that affect the outcomes of these encounters: how colonization, infection, commensalism, and other relationships play out at levels ranging from molecular interactions to systemic ones. PATH is a highly competitive award program that provides $505,000 over five years to study pathogenesis.

The program intends to give recipients the freedom and flexibility to pursue new avenues of inquiry, stimulating higher-risk research projects that hold potential for significantly advancing our understanding of how infectious diseases work and how health is maintained. Progress and financial reports are required of all BWF grants and are due on the date(s) specified in the award letter or contract.

The Advisory Committee and staff depend heavily upon progress and financial reports to evaluate progress. Late reports inconvenience advisory committee reviewers and impede BWF's evaluation of its programs. Failure to submit progress or financial reports in a timely fashion will result in payments being withheld, and if submissions are missed repeatedly, the award will be terminated.

BWF provides the following progress report guidelines to assist in preparing and submitting progress reports in an acceptable manner. The progress report and financial updates are to be submitted through Proposal Central. After logging in to Proposal Central, you can find the required deliverables listed on the home page.

Failure to submit any portion of the report by the due date will result in the interruption or cancellation of your funds. Progress Reporting for Awardees The progress report requires the awardee to submit a written report on the progress of the original or approved update to the research project aims, an updated biographical sketch, sources of other funding, and any recent publications.

Details regarding each section are in Proposal Central. The progress report must be submitted annually on August 1st. Awardees are required to update award spending in the Proposal Central budget summary.

Awardees should update the financial report yearly and provide up-to-date spending information from the previous year. Details regarding financial reporting are in Proposal Central. Financial reports are due annually on August 1st.

All progress and financial reporting materials should be submitted through Proposal Central. If you have questions, please contact Kendi Kajogo ( kkajogo@bwfund. org ).

Is the BWF application deadline firm? Can I submit a paper application? No. BWF requires that all applications for this program be submitted electronically.

Paper applications will not be accepted. Can I change my application once submitted? No. Once your application is submitted, it cannot be changed.

Can I receive a copy of my online application form? You can print a copy of your application as you are completing the online application form by clicking the "Printer Friendly Version" link at the top of the page. You may also click the "Email Draft" link to email a copy of the application.

Note that BWF does not accept emailed applications. Can I add papers that have been accepted? Who should write the Institutional Letter of Support?

The Institutional Letter of Support should be written on behalf of the applicant’s institution by the chair, dean, division director, or another senior official who can best communicate the institution’s commitment to the applicant and the applicant’s fit within the institution’s plans and ambitions.

This statement of the institution’s investment in and commitment to the applicant’s scientific, academic, and personal development is a critical part of a successful application for this career development award. Can Letters of Recommendation be sent to BWF separately?

No. Letters of Recommendation (three are required) must be converted to PDF files and uploaded to the application for electronic submission by the Recommender and by the deadline date. It is highly recommended that all Letters of Recommendation be uploaded to the application a week before the deadline date. An application can only be submitted when it is complete.

Can Letters of Collaboration be included in the application? No. Collaborative situations can be described in the five-page Research Plan - there is no need for individual collaborative letters. How serious are you about the page limit on the research plan?

All applicants must stay within the set five-page limit or the application will be rejected. Does the bibliography count toward the five-page maximum Research Plan? No. It is considered part of the required supporting materials.

However, graphs, charts, and diagrams do count toward the five-page maximum. Abbreviations should be limited in the text. What about figures, tables, graphs, diagrams, pictures included in my research plan?

Are they included in the five-page limit or can they be included separately? All figures, tables, graphs, diagrams, pictures, etc., included in your research plan count toward the five-page limit for the plan. Is there a font or margin requirement for the research plan?

Use standard 11- or 12-point type for the text, and no smaller than 9 to 10-point type for figures, legends, tables, and diagrams. The text must be single-spaced, with a one-half inch or larger margins on all sides. The Research Plan is limited to five pages including figures and tables.

What is a “signature block” as required in the Letter of Nomination and Recommendation Letters? A signature block is a legible (typed) identification of the letter writer. It is found at the end of the letter and includes the letter writer’s name, title(s), department(s), and institution.

The signature block should be placed under the letter writer’s signature. For example: Chair and Professor, Department of Medicine Accessing the Application How do I access the full proposal application? Your full application is directly linked to your pre-proposal application.

The link to your full application is in the invitation email sent to you inviting you to submit a full proposal. Do I need to complete a full application in one session? If I’m having trouble with the electronic application, whom can I contact for help?

For questions about the electronic application, please contact Darcy Lewandowski via email or by phone 919-991-5132. Are faxed documents permitted?

Indiana University School of Medicine Mapping Organelle Dynamics Critical for Intracellular Parasite Survival and Pathogenesis From Birds to People: Understanding the Role of Rab11 in Influenza Assembly and Reassortment Deciphering the molecular mechanism by which the malarial moving junction orchestrates host-cell invasion Genetic and immunological mechanisms underlying protective antiretroviral responses University of Texas Southwestern Medical Center A Family of Viral Lipid Metabolism Genes Essential for Diverse Viral Pathogens University of Illinois-Chicago Understanding infection by emerging bacterial pathogens to reveal host defenses Cornelius Taabazuing, PhD University of Pennsylvania, Perelman School of Medicine DIPTAR: A novel platform for uncovering mechanisms of pathogen inactivation of host innate immunity Ajitha Thanabalasuriar, PhD Macrophage Extracellular Traps: An Explosive Defense Strategy Against Streptococcus pneumoniae The Ohio State University College of Medicine Resident nuclear factors drive heterogeneity in the antiviral response Stanford University School of Medicine Antigen acquisition by tuft cells regulates humoral immunity during intestinal parasite infection Fred Hutchinson Cancer Center Challenging the paradigm of maternal IgG: A novel role in subverting infant immunity to enteric infection Samarchith Kurup, DVM, PhD Plasmodium effectors mitigating cell-intrinsic immune responses in hepatocytes Duke University School of Medicine Using tissue-specific Naegleria opportunism to dissect olfactory immunity The Ohio State University Wexner Medical Center Immune evasion strategy of an intracellular parasite University of Massachusetts Chan Medical School Homeostatic regulation of cutaneous antiviral immunity The Children’s Hospital of Philadelphia Reprogramming of the early life gut by Clostridioides difficile Johns Hopkins Bloomberg School of Public Health Utilizing a 3D human abscess model to uncover antibiotic persistence mechanisms How mechanisms of pathogenesis arise from environmental battlegrounds Johns Hopkins Bloomberg School of Public Health Role of extravascular spaces in Trypanosoma brucei antigenic variation Discovery and functional analysis of novel virulence factors in Candida auris David Geffen School of Medicine at University of California-Los Angeles Organellar sensing of microbes Host-pathogen interactions that drive Mycobacterium tuberculosis persistence in caseum University of Pennsylvania, Perelman School of Medicine Gut-brain communication in enteric infection University of Colorado Boulder From humans to bacteria, how do cells resist viral infections?

Mariana Byndloss, DVM.

, PhD Role of diet-microbiota interactions during Salmonella gastroenteritis University of Pennsylvania Uncovering in situ structural mechanisms of key activities driving apicomplexan parasites’ invasion into human cells for their infection Tamia Harris-Tryon, MD, PhD University of Texas Southwestern Medical Center-Dallas Determining the Impact of Androgens on Staphylococcus aureus Pathogenesis University of Pennsylvania Tuft cell-neuron interactions in helminth infection New York University School of Medicine Decoding mechanisms of infection-associated tissue repair University of Massachusetts Medical School Regulation of intestinal humoral immunity by cholesterol metabolites Marta Rodriguez-Garcia, MD.

PhD Tufts University Innate lymphoid cell control of mucosal HIV infection Jing Yan, PhD Yale University Deciphering Molecular Mechanism Underlying Biofilm Adhesion Jonathan Abraham, MD, PhD Molecular evolution of viral receptor-binding domains Salvador Almagro-Moreno, PhD University of Central Florida Disentangling pathoadaptations in emergent pathogens: The Vibrio vulnificus paradigm Dynamics and role of DNA accumulation in Salmonella persisters during infection Weill Medical College of Cornell University Epigenetic regulation of immunity: molecular mechanisms of inflammatory priming and altered hematopoiesis Emory University School of Medicine Keratinocyte pyroptosis guards against invasive bacteria University of Texas Medical Branch The Role of Glycosylation in Coronavirus Spreading Events University of Texas Southwestern Medical Center – Dallas Mechanisms of self-assembly and dynamics of the Apicomplexan apical invasion & secretion machinery California Institute of Technology Novel host factors for viral membrane protein biogenesis Biology of afucosylated SARS-CoV-2 IgGs University of Alabama-Birmingham Interactions between the human host and M.

tb during subclinical tuberculosis Dietary strategies for enhancing bacterial pathogen resistance in the gut University of California-San Diego Finding the pressure points: Evolution-guided discovery of novel host-virus conflicts Elizabeth S Egan, MD, PhD Stanford University School of Medicine Dissecting host-parasite interactions between Plasmodium falciparum and the bone marrow Decoding T cell mediated mechanisms underpinning sterilizing immunity without adverse pathology at mucosal barriers Mechanisms of tissue resident memory T cell protection against enteric infection Duke University School of Medicine Hormone mediated regulation of antiviral immune responses Role of spatial metabolic heterogeneity in disease tropism University of North Carolina-Chapel Hill Host Range Determinants of Emerging Flaviviruses Massachusetts Institute of Technology Mapping pathogen coevolution through host diversity University of Washington School of Medicine Establishment, maintenance, and antigen specificity of T cell memory in helminth infection Role of adenosine-containing alarmones in commensal and pathogenic bacteria Megan T Baldridge, MD, PhD Washington University School of Medicine Unbiased identification of novel antiviral effectors against enteric viral pathogens using CRISPR screening University of North Carolina-Chapel Hill Antibiotic tolerance induced by the innate immune response Memorial Sloan Kettering Cancer Center The microbiota sets the stage for proper immunity to intestinal pathogens University of Illinois, Urbana-Champaign Characterizing the antiviral secretome of pathogenic staphylococci Weill Medical College of Cornell University Gastrointestinal Fungal Infections: What Should The Immune System Watch For?

Mechanism of CD-NTase signaling in bacterial pathogenesis and host-microbe interactions University of Minnesota Medical School Genome Plasticity in Fungal Adaptation and Pathogenesis University of Pennsylvania Deciphering how lentiviruses hijack the 3D genome architecture of host cells Type III interferons at the crossroads between tissue tolerance and immune resistance in lung superinfections Theresa Alenghat, DVM.

, PhD Dietary regulation of innate intestinal immunity Loyola University-Chicago Deciphering how bacterial pathogens evade innate immunity Neuronal regulation of influenza virus infection Maternal gut bacteria, viral infection and neurodevelopmental disorder Regulation of mucosal infections by innate lymphoid cells Washington State University Remain confined or break free?

Intracellular niche selection by Gram-negative bacteria Michigan State University Enter the goliaths: structure and function of giant virus entry mechanisms University of Texas Southwestern Medical Center-Dallas Genetic dissection of innate immune pathways that modulate viral infection University of California - Berkeley The impact of fluctuating microenvironments on phage-bacteria interactions in the human intestinal tract University of Michigan-Ann Arbor The molecular physiology of long-range electrical communication in bacterial biofilms Targeting an ancient endosymbiosis in modern-day parasites Hunting host factors critical for viral infection University of Texas Southwestern Medical Center-Dallas Defining regulators of schistosome reproductive development Jorge Henao-Mejia, M.

D. , Ph. D.

University of Pennsylvania Perelman School of Medicine Regulation of white adipose tissue by the microbiota Icahn School of Medicine at Mount Sinai Role of nuclear granules in viral pathogenesis University of Wisconsin-Madison The war within: identification and characterization of antibacterial cell instrinsic defenses in the host cell cytosol Tufts University School of Medicine Role of a conserved DNA methyltransferase during Clostridium difficile infection Michael Shiloh, M.

D. , Ph. D.

University of Texas Southwestern Medical Center-Dallas Effect of mycobacterial lipid mediators on nociceptive neurons and cough induction Gregory F. Sonnenberg, Ph. D.

Weill Medical College of Cornell University Innate immune regulation of host-microbe interaction Peter J. Turnbaugh, Ph. D.

University of California-San Francisco Koch's postulates revisited: microbiome editing to prove the microbial etiology of human disease Characterization of the mechanisms of Nipah virus entry into host cells and humoral immune response Gabriel D. Victora, Ph. D.

How prior antigenic exposure constrains the response to influenza vaccination Sebastian E. Winter, Ph. D.

University of Texas Southwestern Medical Center-Dallas Metabolic host-microbe interactions in the intestinal tract Training natural killer cells to fight HIV Harvard School of Public Health The impact of human red blood cell heterogeneities and dynamics on malaria parasite virulence A functional metagenomic screen to systematically identify human-bacteria interactions University of Pennsylvania Skin microbiome functions in colonization resistance to pathogens Duke University Medical Center Regulation of antiviral host response by RNA modifications University of Michigan-Ann Arbor The evolution of pathogen virulence and transmissibility Defining the functional landscape between intracellular pathogens and the host The development and function of Plasmodium-specific memory B cells Influence of the microbiota on neuro-inflammation Mohammad R.

Seyedsayamdost, PhD Deciphering the small molecule vocabulary of human microbiome Streptococci Consequences of neutrophil-mycobacteria interactions Mapping host-microbe and inter-microbial networks at ultra-high spatial resolution Jörn Coers, D. Phil. , Ph.

D. Host-mediated lysis of cytoplasmic pathogens Host factors conferring susceptibility to Clostridium difficile toxins Christine M. Dunham, Ph.

D. Emory University School of Medicine Characterization of pathways involved in bacterial persistence and antibiotic resistence A new class of retrogenes modulating pathogenesis University of Pennsylvania Effect of maternal antibodies on the neonatal immune response to influenza virus Audrey R. Odom, M.

D. , Ph. D.

Insights into the chemical ecology of malaria parasites Breaking species barriers of human hepatotropic pathogens Rutgers University-Rutgers Biomedical and Health Sciences-New Jersey Medical School Mechanisms of bidirectional innate cell licensing in antifungal immunity University of Pennsylvania Perelman School of Medicine Overcoming pathogen-mediated translation inhibition to enable robust immune defense Memorial Sloan-Kettering Cancer Center Natural killer cell control of cytomegalovirus infection Understanding the stochasticity of viral infection at the level of single cells University of Pennsylvania The role of chemokine-chemokine receptor interactions in anti-bacterial protective immunity New York University School of Medicine Gene-microbe interactions in inflammatory bowel disease Matthew James Evans, Ph.

D. Icahn School of Medicine at Mount Sinai Determinants of hepatitis C virus persistence Understanding pathogen-commensal interaction in the earliest stages of infection University of California-Los Angeles Deciphering the interactions between skin-penetrating nematodes and bacteria Mechanism for dsRNA-dependent and -independent activation of the antiviral gene, PKR Rahul Manu Kohli, M. D.

, Ph. D. University of Pennsylvania Tuning evolution and antibiotic resistance by modulating the SOS pathway University of Massachusetts-Amherst Supernumerary chromosomes and pathogenicity of opportunistic fungal infections Luciano A.

Marraffini, Ph. D. Effect of type III CRISPR-Cas immunity on phage-mediated staphylococcal pathogenesis Adaptation of immune cells to the gut tissue: consequences for immunity and tolerance University of Texas Southwestern Medical Center-Dallas Innate immune sensing and pathogenesis of cytosolic bacteria Bioenergetics and microbial pathogenesis sufficiency Michael A.

Fischbach, Ph. D. University of California-San Francisco Novel microbiota-derived molecules that modulate the host immune response De'Broski R.

Herbert, Ph. D. University of California-San Francisco Trefoil factor proteins modulate host immunity against hookworms Tobias M.

Hohl, M. D. , Ph.

D. Memorial Sloan-Kettering Cancer Center Tracing innate control over respiratory and systemic fungal infection Alexei V. Korennykh, Ph.

D. Systems analysis of pathogen defense mediated by 2', 5'-linked isoRNA Cellular communication in malaria parasites Erika L. Pearce, D.

Phil. , Ph. D.

Cellular metabolism in immunity to infection University of California-Irvine Characterization of novel populations of neutrophils during bacterial infection Why do DNA viruses cause cancer?

Washington University School of Medicine Molecular basis for and inhibition of red blood cell invasion by Plasmodium parasites New York University School of Medicine Staphylococcus aureus pore-forming toxins: leukocyte killing and beyond Phagocytes block fungal dimorphism to defend the epithelial barrier Abraham Brass, M. D. , Ph.

D. University of Massachusetts Medical School Defining dengue virus’s dependencies: discovery and characterization of host factors required for viral replication University of Pennsylvania Evolution of original antigenic sin in Lyme disease University of Illinois-Chicago Interspecies communication among commensal and pathogenic bacteria Fungal communication and pathogenicity Suzanne Noble, M. D.

, Ph. D.

University of California-San Francisco Discovery of a cell type switch that drives fungal-mammalian commensalism University of Texas-Austin Genetics of viral species tropism University of California-San Diego Microsporidia virulence factors exploit host cell physiology Novel RNAi-like system controls bacterial innate immune evasion and virulence University of Texas Southwestern Medical Center TLR-independent host resistance to protozoan parasites Environmental impact on host-pathogen interaction University of Texas Southwestern Medical Center Systems architecture of bacterial effector/host membrane interactions University of California-San Francisco School of Medicine Pregnancy-related pathogenicity determinants of Listeria monocytogenes Juliane Bubeck Wardenburg, M.

D. , Ph. D.

Tuning of the host-bacterial interaction by a pore-forming toxin University of Pittsburgh School of Medicine Actin cytoskeleton and antiviral innate immune signaling Quick change: polarity, diversity and virulence in Mycobacterium tuberculosis Chyi-Song Hsieh, M. D. , Ph.

D. Washington University School of Medicine Host discrimination between pathogenic and commensal bacteria in the colon Novel approaches to study RIG-I like receptor mediated antiviral immunity University of Texas Southwestern Medical Center How gut microbes enhance enteric virus infectivity Christopher S. Sullivan, Ph.

D. University of Texas-Austin Herpes virus immune evasion via non-coding RNA regulatory elements Sing Sing Way, M. D.

, Ph. D. University of Minnesota Medical School Maternal regulatory T cells control the immune pathogenesis of prenatal infection University of Michigan-Ann Arbor Prostaglandin E2 synthesis and signaling in the pathogenesis of puerperal Group A Streptococcus infections University of California-Berkeley Interactions between TLRs and intracellular pathogens Julie Magarian Blander, Ph.

D. Mount Sinai School of Medicine Innate immune recognition of vita-PAMPs: a new class of pathogen associated molecular patterns that signifies microbial viability University of Pennsylvania Systems biology of Alphavirus infection Characterization of a novel family of receptors mediating metazoan recognition of microbes Ekaterina Heldwein, Ph. D.

Tufts University School of Medicine Structural mechanism of herpes virus egress Sarkis K. Mazmanian, Ph. D.

California Institute of Technology Novel probiotic therapy for microbial infections Breaching the commensal barrier to infection with type VI secretion Justin L. Sonnenburg, Ph. D.

Stanford University School of Medicine Mechanisms of intestinal microbiota-conferred protection from enteric pathogen Benjamin R. tenOever, Ph. D.

Mount Sinai School of Medicine Small RNA-mediated control of microbes Jen-Tsan Ashley Chi, M. D. , Ph.

D.

Duke University Medical Center Sequence determinant of the Plasmodium falciparum gene regulation by human microRNAs New York University School of Medicine Ubiquitin-like proteins in bacterial pathogens Host-pathogen interactions during persistent Salmonella infection Regulation and molecular mechanisms of NLR-mediated innate immunity Scripps Research Institute Arenavirus GP: architecture, receptor binding sites, and immune recognition University of California-Berkeley Innate immune cytosolic immunosurveillance pathways for sensing bacterial pathogens University of Pennsylvania Tracking helminth-specific immune responses in vivo Phenotypic variation and host adaptation by the human fungal pathogen Candida albicans University of North Carolina-Chapel Hill Identification of in vivo-secreted proteins of Mycobacterium tuberculosis with roles in host-pathogen interactions MHC-independent recognition of infected cells by natural killer cells of the innate immune system The Nod-like receptor Nod9 links mitochondrial dynamics and innate immunity to bacterial pathogens How Staphylococcus aureus senses host immune defenses University of California-Los Angeles Cell-cell communication and social motility in pathogenesis and development of African trypanosomes Vanderbilt University Medical Center Structural mechanisms of Heliobacter pylori pathogenesis Yale University School of Medicine Immune control of human phagosomal pathogens by a novel GTPase superfamily University of Alabama-Birmingham Carbon monoxide and Mycobacterium tuberculosis persistence Timothy L.

Tellinghuisen, Ph. D.

The Scripps Research Institute Subversion of a host kinase and vesicle trafficking components for the production of infectious hepatitis C virus Washington University School of Medicine A genomics-based approach to novel viral etiologies of diarrhea University of Texas-Austin Mechanistic insight into host modulation of bacterial group activities Washington University School of Medicine Modulation of the DNA damage response by human cytomegalovirus Benjamin K.

Chen, M. D. , Ph.

D. Mount Sinai School of Medicine Dissemination of HIV through virological synapses New York University School of Medicine Mechanisms of Pseudomonas aeruginosa tolerance to secretin-induced stress during host infection Parallel identification of obligate viral receptors University of California-Berkeley Global modulation of cellular gene expression by an oncogenic human herpesvirus Karen J. Guillemin, Ph.

D. Regulation of gut epithelial cell homeostasis by the microbiota University of Texas Southwestern Medical Center Innate immune responses to commensal bacteria at gut epithelial surfaces Case Western Reserve University Molecular mechanisms of pathogen identification by the pattern recognition receptors RIG-I and MDA5 Barbara I. Kazmierczak, M.

D. , Ph. D.

The role of injury in Pseudomonas aeruginosa pulmonary infection Global analysis of the Plasmodium falciparum metabolome Evolution-based identification and functional study of intracellular host-virus interactions Dorian B. McGavern, Ph. D.

The Scripps Research Institute Chemical and molecular approaches to probe viral pathogenesis in real time Cell entry and innate immune recognition of flaviviruses University of Massachusetts Medical School Intracellular bacterial recognition in the Drosophila innate immune respons Raphael H. Valdivia, Ph. D.

Duke University Medical Center The role of secreted bacterial proteases in chlamydial pathogenesis Andres Vazquez-Torres, D. V. M.

, Ph. D. University of Colorado-Denver and Health Sciences Center-Fitzsimons Campus Effects of nitrosative stress on bacterial two component regulatory systems in innate host defense Viral hijacking of host ubiquitin ligase machinery Choukri Ben Mamoun, Ph.

D. University of Connecticut Health Center Function and regulation of host and parasite nutrient transporters during malaria infection Helen E. Blackwell, Ph.

D. University of Wisconsin-Madison Interception of bacterial quorum sensing with synthetic ligands University of North Carolina-Chapel Hill Role of viral signaling proteins in the pathogenesis of Kaposi's sarcoma-associated herpes virus (KSHV) Manoj T Duraisingh, Ph. D.

Harvard School of Public Health Epigenetic control of virulence gene expression in Plasmodium falciparum Peter J. Espenshade, Ph. D.

Johns Hopkins University School of Medicine Oxygen-sensing and adaptation to host tissue hypoxia in the human fungal pathogen Cryptococcus neoformans University of Wisconsin-Madison Cellular and viral determinants of human cytomegalovirus lytic and latent replication cycles Regulation of macroautophagy by viral infection University of Texas Southwestern Medical Center VopL, a Vibrio effector that nucleates actin New York University School of Medicine The role of hypoxanthine degradation in malaria-induced pathogenesis Karla Fullner Satchell, Ph.

D. A mouse model for the role of toxins in cholera pathogenesis Luis M Schang, D. V.

M. , Ph. D.

Silencing and antisilencing in the regulation of viral gene expression Vanderbilt University Medical Center In vivo identification of Staphylococcus aureus proteins that defend against host neutrophils University of Texas Southwestern Medical Center Interkingdom signaling in bacterial pathogenesis University of Michigan Medical School How cholera toxin hijacks cellar machineries to transport across the ER membrane Jody L. Baron, M. D.

, Ph. D.

University of California-San Francisco School of Medicine Understanding immunopathogenesis of Hepatitis B virus Stanford University School of Medicine Chemical mapping of proteolytic networks involved in Toxoplasma gondii pathogenesis Recognition of bacteria in the cytosol of mammalian cells by protein conjugation systems Albert Einstein College of Medicine of Yeshiva University Entry and intracellular trafficking of Hepatitis C virus Michael S.

Glickman, M. D. Memorial Sloan-Kettering Cancer Center Regulated intramembrane proteolysis in controlling Mycobacterium tuberculosis virulence and cell envelope composition Stromal cell contributions in innate and adaptive immune responses to mucosal viral infection John S.

Parker, B. V. M.

S. , Ph. D.

Cornell University College of Veterinary Medicine Reovirus-induced apoptosis: the role of the viral outer-capsid protein mu1 Lalita Ramakrishnan, M. D. , Ph.

D.

University of Washington School of Medicine Forward genetic screens in the zebrafish to identify host determinants of susceptibility to tuberculosis Northwestern University Feinberg School of Medicine Coordination of herpes virus assembly and transport in axons of sensory neurons University of Colorado Health Sciences Center Analyzing tumor suppressors in the control of virus infection and inflammation Exploration of the interaction of RNA viruses with their host cells University of Florida College of Medicine Identification of neuron-specific factors that regulate HSV-1 chromatin structure and transcription during latency University of Minnesota-Twin Cities Control of phenotypic switching and pathogenesis by the Mds3 protein Albert Einstein College of Medicine of Yeshiva University Plasmodium falciparum transmembrane proteins and their role in parasite susceptibility to heme-binding antimalarials Michael J.

Gale, Jr. Ph. D. University of Texas Southwestern Medical Center Control of hepatitis C virus replication Emory University School of Medicine Transgenic analysis of prokaryotic effector proteins in the eukaryote, Drosophila melanogaster Eric J.

Rubin, M. D. , Ph.

D. Harvard School of Public Health Cell signaling by bacterial cytokines in Mycobacterium tuberculosis University of Washington School of Medicine Innate immunity: how do Toll-like receptors recognize microbial pathogens? Medical College of Wisconsin Mycobacterium tuberculosis regulators modulating reactivation Barbara A.

Burleigh, Ph. D. Harvard School of Public Health Functional characterization of the role of the host cell fibrogenic response in Trypanosoma cruzi infection University of Texas Southwestern Medical Center Roles of TRAF5-regulated IKK activators in innate immunity Medical University of South Carolina-College of Medicine Roles for inositol phosphoryl ceramide synthase 1 (IPC1) in fungal-host interaction Heidi Goodrich-Blair, Ph.

D. University of Wisconsin-Madison Pathogenesis of Xenorhabdus nematophilus in insects: a model for the innate immune response to bacterial pathogens Washington University-School of Medicine Mechanisms of Shiga toxin translocation and intoxication within host cells Margarethe (Meta) J. Kuehn, Ph.

D.

Duke University Medical Center Toxin trafficking via vesicles Structural studies of bacterial virulence factors University of California-Los Angeles-School of Medicine Identification of cellular factors that determine the fate of herpes virus infection: latency versus lytic replication Johns Hopkins University School of Medicine The identification of human genes associated with hepatitis B virus outcomes Chief, Division of Infectious Diseases Professor of Cell Biology Professor in Molecular Genetics and Microbiology Duke University Medical Center Professor and Chair of Microbiology and Immunology University of North Carolina-Chapel Hill John W.

Eckman Professor of Medical Science Department of Microbiology University of Pennsylvania Professor, Departments of Medicine and Microbiology and Immunology Chief, Division of Infectious Disease Co-Director, Integrative Microbiology program University of California San Francisco Michael Glickman, MD (Co-Chair) Member, Immunology Program Attending Physician, Infectious Diseases Memorial Sloan Kettering Cancer Center Christopher A.

Hunter, PhD (Co-Chair) Professor of Pathobiology Department of Microbiology University of Pennsylvania School of Veterinary Medicine Ernest C. Pollard Priofessor in Biotechnology Professor of Biochemistry and Molecular Biology and Chemistry Pennsylvania State University Carolina B.

López Zalaquett, PhD Professor and BJC Investigator Department of Molecular Microbiology Washington University School of Medicine Professor and Investigator, Howard Hughes Medical Institute Laboratory of Mucosal Immunology The Rockefeller University Professor; HHMI Investigator Department of Molecular & Cell Biology University of California-Berkeley Additional members may be added to the committee.

Letter of Intent Deadline Invitation to Submit a Full Proposal