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National Institute on Drug Abuse Helping to End Addiction Long-term (HEAL) Initiative is sponsored by Department of Health And Human Services. Since its launch with the support of Congress in 2018, the NIH HEAL Initiative has made the nation’s largest ever investment in research to end the national overdose crisis.
Overdose fatalities account for tens of thousands of deaths annually and there are nearly 9 million Americans ages 12 and older who misused opioids in the past year, and an estimated 5.7 million with opioid use disorder (OUD), which is likely an undercount of how many people are actually affected. In parallel, chronic pain affects 50 million adults in the United States with nearly 20 million living daily with chronic pain that interferes with their lives and if improperly treated, puts them at risk for illicit opioid misuse alongside the risk of OUD and overdoses.
The NIH HEAL Initiative was launched through specific Congressional funding to the National Institute on Drug Abuse (NIDA) and the National Institute of Neurological Disorders and Stroke (NINDS) to address these challenges using a multifaceted evidence-based approach that brings together scientists, healthcare providers, patient advocates, community members, the private sector, and multiple levels of government – all sharply focused on developing and deploying scientific solutions with the ultimate goal of preventing all overdoses and developing safer, nonaddictive treatments for pain.
(1) Advance research to prevent and treat OUD and overdoses including overdoses that result from the use of multiple substances simultaneously.
(2) Advance cross-cutting research to prevent and treat OUD and overdoses in the context of chronic pain and other mental health conditions that commonly occur in people who experience OUD.
These research objectives incorporate other cross-cutting goals, including enhancing women’s and children’s health; addressing public health challenges across the lifespan; promoting collaborative science; and leveraging data science for biomedical discovery. This listing is currently active. Program number: 93.DAH. Last updated on 2026-01-28.
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Or search similar grants →According to the current listing, eligibility includes: Eligible organizations determined at the NOFO level Eligible applicant types include: Municipality or Township government (inclusive of cities, towns, boroughs (except in Alaska), and villages), U.S. Territory (or Possession) Government (including freely-associated states), U.S. Federal Government, Other Local Government Consortium, Regional Organization (Intrastate), or Other Local Government Combination, Indian/Native American/Alaska Native Tribal Government (Other than Federally Recognized), School District, Public Housing Authority, Tribally Designated Housing Authority. Confirm the full requirements in the official notice before applying.
The current listing shows recent federal obligations suggest $135,143,480 (2026). Verify award ceilings, matching requirements, and allowable costs in the official notice.
Yes — National Institute on Drug Abuse Helping to End Addiction Long-term (HEAL) Initiative is offered by Department of Health And Human Services and this listing comes from SAM.gov, an official U.S. federal source. Federal applications generally require registrations (for example SAM.gov or an agency submission portal), so allow extra lead time.
Start from the official opportunity page linked in this listing — it carries the sponsor's submission instructions.
Past winners and funding trends for this program
This Funding Opportunity Announcement (FOA) invites Small Business Innovation Research (SBIR) grant applications from small business concerns (SBCs) for funding to perform research leading to the development of innovative technologies that may advance progress for early detection and assessment of individuals at risk and for early diagnosis, prognosis and follow-up of type 1 diabetes (T1D). Funding Opportunity Number: RFA-DK-15-024. Assistance Listing: 93.847. Funding Instrument: G. Category: FN,HL. Award Amount: $2M total program funding.
This initiative will stimulate and support innovative research by small business concerns that may lead to the development of novel technologies for the early diagnosis, monitoring and treatment of micro and macro vascular complications of diabetes which are associated with significant morbidity and mortality of the disease and high costs to the health care system. Funding Opportunity Number: PA-14-058. Assistance Listing: 93.847. Funding Instrument: G. Category: FN,HL.
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