Purpose. This funding opportunity announcement (FOA) solicits Small Business Innovation Research (SBIR) grant applications that propose to develop novel pharmacologic agents for brain research related to mental disorders, including research aimed at discovering new drugs for these disorders. In addition, this FOA solicits SBIR grant applications that propose to take existing, promising compounds through the next step of drug discovery and development. Finally, this FOA also encourages SBIR grant applications designed to study the effectiveness of novel interventions. Mechanism of Support. This FOA will utilize the SBIR (R43/R44) grant mechanisms for Phase I, Phase II, and Fast-Track applications. Funds Available and Anticipated Number of Awards. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications. The total amount awarded and the number of awards will depend upon the quality, duration, and costs of the applications received. Budget and Project Period. Phase I awards normally may not exceed $100,000 total for a period normally not to exceed 6 months. Phase II awards normally may not exceed $750,000 total for a period normally not to exceed 2 years. However, for this funding opportunity, budgets up to $350,000 total costs per year and time periods up to two years for Phase I may be requested. Budgets up to $600,000 total costs per year and up to three years may be requested for Phase II. Eligible Institutions/Organizations: Only United States SBCs are eligible to receive SBIR applications. A SBC is one that, on the date of award for both Phase I and Phase II funding agreements, meets ALL of the criteria as described in Section III. Eligible Project Directors/Principal Investigators: Individuals with the skills, knowledge, and resources necessary to carry out the proposed research are invited to work with their organization to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support. On an SBIR application, the PD/PI must have his/her primary employment (more than 50%) with the SBC at the time of award and for the duration of the project. Number of Applications: Applicant SBCs may submit more than one application, provided each application is scientifically distinct. Resubmissions: Applicants may submit a resubmission application, but such application must include an Introduction addressing the previous peer review critique (Summary Statement). Number of PDs/PIs. More than one PD/PI, or multiple PDs/PIs, may be designated on the application. Funding Opportunity Number: PA-08-142. Assistance Listing: 93.242. Funding Instrument: G. Category: HL.

This NOFO provides an opportunity to all FY 2018 NIST SBIR Phase I awardees to submit a Phase II application following completion of Phase I. This NOFO provides instructions for FY 2019 NIST SBIR Phase II application preparation and submission requirements. In Phase II, work from Phase I that exhibits potential for commercial application is further developed. Phase II is the R&D or prototype development phase. To apply for a Phase II award, each Phase I awardee will be required to submit a comprehensive application outlining the proposed research and a detailed plan to commercialize the final product. Each NIST Phase II award is for up to $400,000 and up to a 24-month period of performance. One year after completing the Phase II R&D activity, the awardee shall be required to report on its commercialization activities. Up to an additional $6,500 may be requested for Technical and Business Assistance (TABA); see Section 5.11 for more information about TABA. Funding Opportunity Number: 2019-NIST-SBIR-02. Assistance Listing: 11.620. Funding Instrument: CA. Category: ST. Award Amount: Up to $400K per award.

Small Business Innovation Research (SBIR) Program Phase I is sponsored by U.S. Environmental Protection Agency (EPA). The EPA SBIR Phase I Solicitation invites small businesses to submit proposals for projects addressing critical environmental challenges. Awards are for six months to demonstrate proof of concept. Key focus areas include Clean and Safe Water, Air Quality and Climate, Homeland Security, Circular Economy/Sustainable Materials, and Safer Chemicals.

SBA Manufacturing Grants is a grant from the U.S. Small Business Administration (SBA) that funds workforce development and technical assistance programs in key manufacturing industries, including timber, energy, aluminum, steel, digital, and automotive manufacturing. The program, known as Empower To Grow (E2G) Manufacturing in America Grant, supports organizations providing hands-on training in machinery operation, quality control, welding, industrial software, and workplace safety. Eligible applicants include for-profit and nonprofit entities, small businesses, trade associations, and educational institutions that have been in continuous operation for at least three years and have experience providing manufacturing-related training. The application deadline was May 27, 2025.

Digital Projects for the Public is sponsored by National Endowment for the Humanities. This program supports projects that interpret and analyze humanities content in digital platforms and formats, such as websites, mobile applications, interactive touchscreens, games, and virtual environments. Projects should attract broad public audiences and involve humanities scholars and digital media professionals. While not strictly employment-focused, it supports digital media production and can engage diverse communities, including students.

Community Investment Tax Credit Program (CITC) is a grant from the Maryland Department of Housing and Community Development that provides state tax credit allocations to 501(c)(3) nonprofits, enabling them to attract private donations from individuals and businesses. Donors contributing $500 or more to approved projects receive tax credits equal to 50% of their contribution. The program has leveraged nearly $27 million in charitable contributions to approximately 700 projects statewide. Eligible project areas include education, housing, job training, arts and culture, economic development, and services for at-risk populations. Projects must be located in or serve residents of Maryland's Priority Funding Areas. The application period is typically held annually.

America's Seed Fund (SBIR/STTR) - Cybersecurity and Authentication is sponsored by U.S. National Science Foundation (NSF). Supports startups and small businesses to translate research into products and services, including cybersecurity and authentication, to secure national defense and protect the public. Includes research requiring privacy and security-preserving resources for artificial intelligence.

Innovations in Graduate Education (IGE) Program is sponsored by U.S. National Science Foundation (NSF). The IGE Program encourages the development and implementation of bold, new, and potentially transformative approaches to STEM graduate education training. It supports piloting, testing, and validating novel models or activities and examining systemic innovations with high potential to enrich and extend the knowledge base on effective graduate education approaches. The program addresses both workforce development and institutional capacity-building needs in graduate education.

The Pathways to Career Opportunities Grant (PCOG) is a grant from the Florida Department of Education that funds the establishment, operation, and expansion of registered apprenticeship and preapprenticeship programs for students and workers in Florida. The program is funded through the 2025-2026 Florida General Appropriations Act and supports workforce development through structured on-the-job training pathways. Eligible applicants include high schools, school district career centers, Florida College System institutions, school district charter technical career colleges, and other entities authorized to sponsor apprenticeship or preapprenticeship programs. Total program funding is $5,000,000. The application deadline was September 26, 2025; applicants should monitor the Florida Division of Career and Technical Education for upcoming cycles.

This notice announces the availability of funds and solicits proposals from eligible entities, including nonprofit organizations, to deliver environmental workforce development and job training programs that recruit, train, and place local, unemployed and under-employed residents with the skills needed to secure full-time employment in the environmental field, with a focus on solid and hazardous waste remediation, environmental health and safety, and wastewater-related training. In Fiscal Year 2015 (FY15), EPA anticipates providing some funding preference to applicants who choose to deliver other types of environmental training, beyond brownfields hazardous waste, as referenced in Section I.B and as referenced in Section V.C. Funding Opportunity Number: EPA-OSWER-OBLR-15-01. Assistance Listing: 66.815. Funding Instrument: CA. Category: ENV. Award Amount: Up to $200K per award.

Through this Notice of Funding Opportunity (NOFO), the National Institutes of Health (NIH) aims to facilitate the career development and transition of investigators new to entrepreneurship with an interest in small business by simultaneously supporting their entrepreneurial development and the conduct of research and development under their direction.This NOFO supports small business concerns (SBCs) in employing and developing researchers as entrepreneurial Program Directors/Principal Investigators (PDs/PIs). In addition to augmenting scientific research staff and supporting research and development efforts at SBCs, a major component of this NOFO is entrepreneurial training, mentoring, and career development of the PD/PI. Optimal PDs/PIs for this award are scientists and professionals with strong research, technology development, and/or healthcare delivery skills and experience, but limited entrepreneurial and independent research project leadership experience. PDs/PIs are expected to grow their entrepreneurial skillset while working in a small business to develop promising technologies and products that align with NIH's mission to improve health and save lives. Funding Opportunity Number: PAR-24-133. Assistance Listing: 93.113,93.121,93.172,93.173,93.213,93.233,93.273,93.279,93.350,93.361,93.837,93.838,93.839,93.840,93.846,93.859,93.865,93.866,93.867,93.879. Funding Instrument: G. Category: ED,ENV,HL,ISS.

Medical Education Innovation Grants is an internal grant program from the University of Wisconsin-Madison Department of Medicine that funds educational innovation and scholarship within the department. Beginning in 2026, awards are granted for a two-year period to allow applicants adequate time to develop, implement, and study their innovations. Grants of up to $20,000 support projects focused on teaching skill development, curriculum and program development, educational scholarship, and career development in clinical settings. Eligible applicants include Department of Medicine faculty holding a primary DOM appointment and trainees who have an identified DOM faculty sponsor. The application deadline is January 23, 2026.

NSF SaTC 2.0 (Security Privacy and Trust in Cyberspace) is the largest open solicitation for university-led cybersecurity research in the federal portfolio now expanded with AI security as an explicit priority area. The 2.0 reboot added generative AI security open-source software security quantum computing security and supply chain security as topics of interest addressing the bidirectional role of AI as both a cybersecurity threat and a defensive tool. Research awards support adversarial machine learning and attacks on AI systems AI weaponization against people information and systems privacy-preserving machine learning and responsible AI use for detecting and responding to cyber threats. The program funds three award types: Research awards up to $1.2M for four years Education awards up to $500K for three years and Seedling awards up to $300K for two years through Dear Colleague Letters. Proposals are accepted on a recurring annual basis with two windows per year. This is distinct from NSF CyberAICorps which focuses on scholarship and workforce development and from NSF AIMing which focuses on AI formal methods and mathematical reasoning.

California Apprenticeship Initiative (CAI) New and Innovative Grant Program FY 2025-26 is a grant from the California Community Colleges Chancellor's Office that funds community colleges, public universities, local educational agencies, and workforce partners to develop new and innovative apprenticeship and pre-apprenticeship programs across California. The program is funded with Proposition 98 dollars and supports the Governor's goal of serving 500,000 earn-and-learn apprenticeships by 2029. Eligible applicants include community colleges, public universities, local educational agencies, and partners working collaboratively with community colleges on apprenticeship program development. Funding amounts are not publicly specified per award; see the Chancellor's Office for details. The application deadline for the FY 2025-26 cycle was January 30, 2026.

CyberAICorps Scholarship for Service (CyberAI SFS) is sponsored by National Science Foundation (NSF). Addresses AI and cybersecurity education and workforce development, specifically focusing on using AI in cybersecurity and ensuring the security and resilience of AI systems. The Scholarship Track funds academic institutions to award scholarships to students who agree to work in an AI or cybersecurity mission for a government organization. The Innovation Track supports projects that enhance the preparation of AI and/or cybersecurity professionals.

YouthBuild is sponsored by U.S. Department of Labor (DOL), Employment and Training Administration (ETA). This program awards grants to eligible public or private non-profit organizations or Tribal entities to provide pre-apprenticeship occupational skills training, education, and job placement services to opportunity youth aged 16-24. YouthBuild programs prepare participants for quality jobs in various industry sectors, including construction, advanced manufacturing, information technology, and healthcare, and include wrap-around supportive services. It also requires applicants to incorporate AI literacy skills in the education component.

Improving Veteran Mental Health Grant Program is a grant from The Cigna Group Foundation that funds nonprofits providing housing stability and wraparound support services to improve the mental health of military veterans. The Foundation committed $9 million over three years addressing housing instability and its mental health impacts, as an estimated 40,000 veterans go without shelter nightly and 1.5 million are at risk of homelessness. Funded programs include mortgage and rental assistance, employment re-entry training, and housing development for veterans. Eligible nonprofits must leverage evidence-informed programs and align with at least one goal: increasing permanent housing, improving housing affordability, or enhancing wraparound services for veterans transitioning from shelters.

DDA Innovation Grant is sponsored by Tennessee Department of Disability and Aging (DDA). These one-time grants fund projects that develop innovative approaches aligned with the DDA's mission, with a strong emphasis on increasing independence for individuals with disabilities and/or older adults aged 60 and over. Priority is given to proposals advancing Technology First, Employment First, workforce development, person-centered practices, quality of life improvements, and increased independence.

Museum Grants for American Latino History and Culture (2026) is a grant from the Institute of Museum and Library Services that awards between $5,000 and $500,000 to build the capacity of American Latino history and culture museums to serve their communities and advance professional workforce development. Grant periods run one to three years with no cost share requirement. Eligible applicants include American Latino museums, cultural institutions, museum service organizations, institutions of higher education, and museum professionals. The program aims to strengthen organizational capacity and support career growth within the American Latino museum field. The application deadline was March 13, 2026.

The LinkedIn Future of Work Fund 2026 is a global philanthropic grant initiative that doubled its commitment to $3 million for 2026 to help nonprofit organizations prepare young people for a rapidly changing labor market shaped by artificial intelligence. Building on the inaugural 2025 round, the fund provides unrestricted grants of $200,000-$300,000 to organizations demonstrating clear approaches to AI literacy and digital skills training, career pathways using AI-enabled tools, and workforce adaptability programs. The fund prioritizes organizations serving young adults aged 18-24 facing structural barriers to employment, with geographic focus on France, Germany, India, United Kingdom, and United States. Selected organizations receive monetary grants plus strategic assistance from LinkedIn's workforce development ecosystem. Applications are reviewed by LinkedIn's Social Impact team along with an external panel of workforce development and AI experts.

Enabling Accessibility Fund is a grant from Employment and Social Development Canada that funds projects making workplaces and communities across Canada more accessible for persons with disabilities. The 2026 call for proposals provides between $500,000 and $1,000,000 per project for durations up to 24 months. Funded projects create opportunities for persons with disabilities to access and maintain employment, and remove accessibility barriers in Indigenous workplaces and communities. Eligible applicants include not-for-profit organizations, for-profit organizations, Indigenous organizations, and municipal and territorial governments. The application period ran from January 16 to March 12, 2026. Virtual information sessions in English and French were provided to assist applicants with the process.

San Diego County District Attorney's Community Grant Program (2026) is a grant from the San Diego County District Attorney that funds community safety and crime prevention initiatives in San Diego County. The two-step application process begins with a 90-second video pitch summarizing the proposed project, target population, and anticipated outcomes. Grants are available for up to $50,000. Eligible applicants include businesses and nonprofits with at least one year of operation in San Diego County, valid licenses and permits, and compliance with employment and safety laws. The application deadline was March 16, 2026.

Ripple Digital Leap Forward Accelerator is a grant from Ripple/Accion Opportunity Fund that funds small business owners looking to adopt digital tools and grow their operations. Developed by Accion Opportunity Fund (AOF) with support from Ripple, this 8-week fully virtual accelerator provides expert-led sessions covering digital tools, automation, payments (including stablecoin), marketing, inventory management, HR, and financial systems. Participants also receive a personalized digital assessment and roadmap, dedicated capital preparedness support, and peer networking opportunities. Eligible applicants must have operated their business for at least one year, generate ,000–,500,000 in annual revenue, employ 1–5 staff, maintain a functioning business website and business bank account, and commit to full program participation. Upon completion, participants receive a ,000 grant.

Regional Coordination Project PY 25-26 is a grant from the California Employment Development Department (EDD) in coordination with the California Labor and Workforce Development Agency that provides up to $1,000,000 to support regional workforce development partnerships between local workforce boards, community colleges, and adult schools. The program implements California's Master Plan for Career Education by funding coordinated, industry-aligned credential programs grounded in regional labor market data. Up to 13 organizations will be funded from a $10 million pool. Applicants must leverage at least 20% of their budget from other sources. The deadline was March 17, 2026.

AFRI Education and Workforce Development: Food and Agricultural Non-formal Education (FANE) is a grant from USDA National Institute of Food and Agriculture (NIFA) supporting non-formal education programs that cultivate interest and skills in food, agriculture, natural resources, and human sciences. Eligible applicants include universities, community organizations, and nonprofits developing programs such as 4-H, extension education, and hands-on agricultural learning experiences. Grants strengthen the pipeline of future agricultural professionals by engaging youth and adult learners outside traditional classroom settings.

reVISION Action Grant is a competitive grant from the Nebraska Department of Education that funds efforts to improve, modernize, and expand Career and Technical Education (CTE) programs aligned with Nebraska's economic priorities and workforce needs. The program draws on federal Perkins funding and supports eligible secondary school districts, postsecondary institutions such as community colleges, and Educational Service Units (ESUs) in Nebraska that have completed the reVISION planning process. Award amounts are competitive and vary based on project scope. Priority is given to projects that advance CTE program quality, expand student access to career pathways, and respond to regional labor market demands. Applications were due March 20, 2026.

BGE Community Grants is a grant from Baltimore Gas and Electric (BGE), an Exelon company, supporting small businesses in central Maryland through the Energizing Small Business Grant program. Offered in partnership with Hello Alice and the Global Entrepreneurship Network, the program provides $20,000 grants to for-profit businesses that have operated for at least one year, employ 25 or fewer full-time employees, and hold annual gross revenues under $7 million. Applicants must be existing BGE electric or gas customers in good standing in Maryland. Since 2021, BGE has invested over $14.86 million across 741 businesses. This program is designed to help local businesses grow, innovate, and strengthen the regional economy.

The DC Growth Fund, administered by the Office of the Deputy Mayor for Planning and Economic Development (DMPED), supports entrepreneurs, startups, and small businesses relocating to or expanding in Washington, DC. The program encourages job creation and commercial office space occupancy, with a focus on growth-stage startups ready to scale. Eligible applicants must occupy or plan to occupy commercial space in DC, have at least 5 employees at the site, and commit to creating at least 5 new jobs over two years. Preference is given to businesses in the central business district and in high-growth sectors including consulting, business services, and communications and design. Recipients must maintain at least 50% on-site work hours and participate in workforce development programs benefiting DC residents. Both for-profit and non-profit entities may apply.

SBIR CBD254-005: Complex Geometries for Extended Wear Respirators Towards Regenerable Particulate Matter Protection is sponsored by Chemical and Biological Defense (CBD). DOD SBIR topic CBD254-005: Complex Geometries for Extended Wear Respirators Towards Regenerable Particulate Matter Protection. Component: Chemical and Biological Defense (CBD). Command: CBD. Solicitation: DoD SBIR 2025.4. Phase(s): I, II, SPII. Status: Pre-Release. Open date: 3/4/2026.

SBIR DMEA254-P001: RF Frontend Design (RFE) on Gallium Nitride on Silicon (GaN-on-Si) Open Topic is sponsored by Department of Defense (DMEA). DOD SBIR topic DMEA254-P001: RF Frontend Design (RFE) on Gallium Nitride on Silicon (GaN-on-Si) Open Topic. Component: Department of Defense (DMEA). Command: DMEA. Solicitation: DoD SBIR 2025.4. Phase(s): I, II, SPII. Status: Pre-Release. Open date: 3/4/2026.